{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:39:41Z","timestamp":1787996381027,"version":"build-2784847793"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T00:00:00Z","timestamp":1595376000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,7,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Aim<\/jats:title>\n                  <jats:p>To evaluate the impact of outreach education targeting neuroprotection on outcomes of outborn infants with moderate-to-severe hypoxic ischemic encephalopathy (HIE).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort study of infants admitted with moderate-to-severe HIE was conducted following the implementation of outreach education in January 2016. Key interventions were early identification and referral of infants with encephalopathy utilizing telemedicine and a centralized communication system, hands-on simulation, and interactive case discussion and dissemination of clinical management guidelines and educational resources. The association between the intervention and a composite outcome of death and\/or severe brain injury on brain magnetic resonance imaging (MRI) was tested controlling for the confounding factors.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 165 neonates, 37 (22.4%) died and\/or had a severe brain injury. This outcome decreased from 35% (27\/77) to 11% (10\/88) following the implementation of outreach education (P&amp;lt;0.001). Eligible infants not undergoing therapeutic hypothermia within 6 hours from birth decreased from 19.5% (15\/77) to 4.5% (4\/88). The use of inotropes decreased from 49.3% (38\/77) to 19.6% (13\/88). Any core temperature below 33\u00b0C was recorded for 20\/53 (38%) before and 16\/78 (21%) after, while those within the target range of 33\u00b0C to 34\u00b0C at admission to a tertiary care facility increased from (15\/53) 28% to (51\/88) 58%. Outreach education was independently associated with decreased composite outcome of death and\/or severe brain injury on MRI (adjusted odds ratio 0.2; 95% confidence interval 0.07 to 0.52).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Outreach education targeting neuroprotection for infants with moderate-to-severe HIE was associated with a reduction in death and\/or severe brain injury.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pch\/pxaa075","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T10:48:28Z","timestamp":1595414908000},"page":"e215-e221","source":"Crossref","is-referenced-by-count":24,"title":["Impact of outreach education program on outcomes of neonates with hypoxic ischemic encephalopathy"],"prefix":"10.1093","volume":"26","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3568-7282","authenticated-orcid":false,"given":"Khorshid","family":"Mohammad","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Calgary, Cumming School of Medicine, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh","family":"Dharel","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Calgary, Cumming School of Medicine, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman","family":"Abou Mehrem","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Calgary, Cumming School of Medicine, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Esser","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Calgary, Cumming School of Medicine, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renee","family":"Paul","sequence":"additional","affiliation":[{"name":"Foothills Medical Centre, Alberta Health Services, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hussein","family":"Zein","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Calgary, Cumming School of Medicine, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James N","family":"Scott","sequence":"additional","affiliation":[{"name":"Department of Radiology, University of Calgary, Calgary, Alberta"},{"name":"Department of Clinical Neurosciences, University of Calgary, Calgary, Alberta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elsa","family":"Fiedrich","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Calgary, Cumming School of Medicine, Calgary, 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