{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:54:12Z","timestamp":1789167252644,"version":"build-2803163510"},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:00:00Z","timestamp":1624060800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,11,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objectives<\/jats:title>\n                  <jats:p>International data on listeriosis during infancy from large populations are essential to guide evidence-based empiric antibiotic guidelines for sepsis in infancy. We aimed to determine the incidence, clinical manifestations, and outcome of listeriosis in infants &amp;lt;6 months of age in Canada and Switzerland.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Prospective, active surveillance of listeriosis in infants &amp;lt;6 months of age was conducted through the Canadian Paediatric Surveillance Program (May 2015 to April 2017) and the Swiss Paediatric Surveillance Unit (April 2017 to March 2018). Confirmed and probable cases were included.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>In Canada, eight sporadic listeriosis cases were reported (incidence, 1.1\/100,000 live births\/year). In Switzerland, four cases were reported (incidence, 4.5\/100,000 live births\/year) of which three were part of a confirmed outbreak with an unclear source. In the two countries, eight of the 12 cases (66.6%) presented as early-onset disease (within the first 7 days of life) and none presented after 28 days life.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>Neonatal listeriosis is rare. Infants presenting with sepsis, especially after 4 weeks of life, may not routinely require empiric antibiotic coverage for listeriosis. Outbreak-related cases still occur. Continued surveillance is important.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pch\/pxab035","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T00:58:47Z","timestamp":1624064327000},"page":"e277-e282","source":"Crossref","is-referenced-by-count":5,"title":["Listeriosis in infants: Prospective surveillance studies in Canada and Switzerland"],"prefix":"10.1093","volume":"26","author":[{"given":"Bahaa","family":"Abu-Raya","sequence":"first","affiliation":[{"name":"Vaccine Evaluation Center, British Columbia Children\u2019s Hospital, Department of Pediatrics, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne","family":"Jost","sequence":"additional","affiliation":[{"name":"Federal Office of Public Health, Department of communicable diseases, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A","family":"Bettinger","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, British Columbia Children\u2019s Hospital, Department of Pediatrics, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Bortolussi","sequence":"additional","affiliation":[{"name":"Dalhousie University, IWK Health Centre, Halifax, Nova Scotia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janet","family":"Grabowski","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Manitoba, Winnipeg, Manitoba, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thierry","family":"Lacaze-Masmonteil","sequence":"additional","affiliation":[{"name":"Department of Paediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9831-5681","authenticated-orcid":false,"given":"Joan L","family":"Robinson","sequence":"additional","affiliation":[{"name":"University of Alberta, Edmonton, Alberta, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klara M","family":"Posfay-Barbe","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Pediatric Infectious Diseases Unit, University Hospitals of Geneva, Geneva, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleni","family":"Galanis","sequence":"additional","affiliation":[{"name":"British Columbia Centre for Disease Control, Vancouver, British Columbia, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7678-9202","authenticated-orcid":false,"given":"Elizabeth","family":"Schutt","sequence":"additional","affiliation":[{"name":"Public Health Agency of Canada, Guelph, Ontario, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirjam","family":"M\u00e4usezahl","sequence":"additional","affiliation":[{"name":"Federal Office of Public Health, Department of communicable diseases, Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias R","family":"Kollmann","sequence":"additional","affiliation":[{"name":"Vaccine Evaluation Center, British Columbia Children\u2019s Hospital, Department of Pediatrics, Division of Infectious Diseases, University of British Columbia, Vancouver, British Columbia,Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,6,19]]},"reference":[{"key":"2021120508080128700_CIT0001","article-title":"Listeriosis.","volume-title":"Feigin and Cherry\u2019s Textbook of Pediatric Infectious Diseases","author":"Kollmann","year":"2013","edition":"7th ed."},{"issue":"10","key":"2021120508080128700_CIT0002","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.micinf.2007.05.011","article-title":"The epidemiology of human listeriosis","volume":"9","author":"Swaminathan","year":"2007","journal-title":"Microbes Infect"},{"issue":"4","key":"2021120508080128700_CIT0003","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0002-9378(79)90061-9","article-title":"Perinatal listeriosis\u2013\u2013a review of twelve patients","volume":"133","author":"Halliday","year":"1979","journal-title":"Am J Obstet Gynecol"},{"issue":"10","key":"2021120508080128700_CIT0004","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1017\/S0950268810000294","article-title":"Pregnancy\u2013associated listeriosis","volume":"138","author":"Jackson","year":"2010","journal-title":"Epidemiol Infect"},{"key":"2021120508080128700_CIT0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1471-2334-13-11","article-title":"What is the incubation period for listeriosis?","volume":"13","author":"Goulet","year":"2013","journal-title":"BMC Infect Dis"},{"key":"2021120508080128700_CIT0006","doi-asserted-by":"crossref","first-page":"712150","DOI":"10.1155\/2011\/712150","article-title":"Choice and duration of antimicrobial therapy for neonatal sepsis and meningitis","volume":"2011","author":"Sivanandan","year":"2011","journal-title":"Int J Pediatr"},{"issue":"10","key":"2021120508080128700_CIT0007","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1093\/pch\/12.10.893","article-title":"Management of the infant at increased risk for sepsis","volume":"12","author":"Jefferies","year":"2007","journal-title":"Paediatr Child Health"},{"issue":"3","key":"2021120508080128700_CIT0008","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/S0022-3476(76)80273-9","article-title":"Neonatal listeriosis: Distribution of serotypes in relation to age at onset of disease","volume":"1976","author":"Albritton","journal-title":"J Pediatr"},{"issue":"6","key":"2021120508080128700_CIT0009","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/S0022-3476(70)80098-1","article-title":"Ampicillin treatment of listeriosis","volume":"77","author":"Gordon","year":"1970","journal-title":"J Pediatr"},{"issue":"4","key":"2021120508080128700_CIT0010","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1093\/pch\/pxx023","article-title":"Management of term infants at increased risk for early-onset bacterial sepsis","volume":"22","author":"Jefferies","year":"2017","journal-title":"Paediatr Child Health"},{"key":"2021120508080128700_CIT0011","first-page":"F257","article-title":"Late-onset neonatal sepsis: Recent developments","volume-title":"Arch Dis Child Fetal Neonatal Ed","author":"Dong","year":"2015"},{"issue":"5","key":"2021120508080128700_CIT0012","doi-asserted-by":"crossref","first-page":"1006","DOI":"10.1542\/peds.2012-0541","article-title":"Management of neonates with suspected or proven early-onset bacterial sepsis","volume":"129","author":"Polin","year":"2012","journal-title":"Pediatrics"},{"issue":"5 Pt 1","key":"2021120508080128700_CIT0013","doi-asserted-by":"crossref","first-page":"964","DOI":"10.1542\/peds.111.5.964","article-title":"Serious bacterial infections in febrile infants younger than 90 days of age: The importance of ampicillin-resistant pathogens","volume":"111","author":"Byington","year":"2003","journal-title":"Pediatrics"},{"issue":"3","key":"2021120508080128700_CIT0014","doi-asserted-by":"crossref","first-page":"e590","DOI":"10.1542\/peds.2011-1546","article-title":"Changing epidemiology of bacteremia in infants aged 1 week to 3 months","volume":"129","author":"Greenhow","year":"2012","journal-title":"Pediatrics"},{"issue":"6","key":"2021120508080128700_CIT0015","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1542\/peds.2013-1759","article-title":"Epidemiology of bacteremia in febrile infants in the United States","volume":"2013","author":"Biondi","journal-title":"Pediatrics"},{"issue":"8","key":"2021120508080128700_CIT0016","doi-asserted-by":"crossref","first-page":"e12448","DOI":"10.1371\/journal.pone.0012448","article-title":"Changing epidemiology of serious bacterial infections in febrile infants without localizing signs","volume":"5","author":"Watt","year":"2010","journal-title":"PLoS One"},{"issue":"4","key":"2021120508080128700_CIT0017","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1542\/hpeds.2015-0187","article-title":"A meta-analysis of the rates of Listeria monocytogenes and Enterococcus in febrile infants","volume":"6","author":"Leazer","year":"2016","journal-title":"Hosp Pediatr"},{"issue":"1 Pt 1","key":"2021120508080128700_CIT0018","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1542\/peds.105.1.21","article-title":"Risk factors and opportunities for prevention of early-onset neonatal sepsis: A multicenter case-control study","volume":"105","author":"Schuchat","year":"2000","journal-title":"Pediatrics"},{"key":"2021120508080128700_CIT0019","author":"Statistics Canada"},{"key":"2021120508080128700_CIT0020","author":"Federal Statistical Office"},{"issue":"3","key":"2021120508080128700_CIT0021","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.jinf.2016.11.007","article-title":"Neonatal listeriosis in the UK 2004-2014","volume":"74","author":"Sapuan","year":"2017","journal-title":"J Infect"},{"issue":"14","key":"2021120508080128700_CIT0022","first-page":"366","article-title":"Preliminary FoodNet data on the incidence of infection with pathogens transmitted commonly through food--10 states, 2007","volume":"57","author":"Centers for Disease Control and Prevention (CDC)","year":"2008","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"2021120508080128700_CIT0023","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1093\/cid\/ciu504","article-title":"Pregnancy-associated listeriosis: Clinical characteristics and geospatial analysis of a 10-year period in Israel","volume":"59","author":"Elinav","year":"2014","journal-title":"Clin Infect Dis"},{"issue":"4","key":"2021120508080128700_CIT0024","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1086\/511006","article-title":"Reduction in the incidence of invasive listeriosis in foodborne diseases active surveillance network sites, 1996-2003","volume":"44","author":"Voetsch","year":"2007","journal-title":"Clin Infect Dis"},{"issue":"4","key":"2021120508080128700_CIT0025","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1097\/INF.0b013e3182867fa0","article-title":"Do we really need to worry about Listeria in newborn infants?","volume":"32","author":"Okike","year":"2013","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"2021120508080128700_CIT0026","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.jinf.2015.12.015","article-title":"Reductions in neonatal listeriosis: \u201cCollateral benefit\u201d of Group B streptococcal prophylaxis?","volume":"72","author":"Lee","year":"2016","journal-title":"J Infect"},{"key":"2021120508080128700_CIT0027","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1097\/AOG.0b013e318280d4f6","article-title":"Effectiveness of intrapartum antibiotic prophylaxis for prevention of early-onset group B streptococcal disease","volume":"121","author":"Fairlie","year":"2013","journal-title":"Obstet Gynecol"},{"issue":"5","key":"2021120508080128700_CIT0028","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1128\/AAC.13.5.854","article-title":"Antibiotic susceptibility of clinical isolates of Listeria monocytogenes","volume":"13","author":"Wiggins","year":"1978","journal-title":"Antimicrob Agents Chemother"},{"issue":"6","key":"2021120508080128700_CIT0029","doi-asserted-by":"crossref","first-page":"2728","DOI":"10.1128\/AAC.01557-09","article-title":"Antimicrobial resistance of Listeria monocytogenes strains isolated from humans in France","volume":"54","author":"Morvan","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"issue":"10","key":"2021120508080128700_CIT0030","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1046\/j.1469-0691.2000.00168.x","article-title":"Natural antibiotic susceptibility of Listeria species: L. grayi, L. innocua, L. ivanovii, L. monocytogenes, L. seeligeri and L. welshimeri strains","volume":"6","author":"Troxler","year":"2000","journal-title":"Clin Microbiol Infect"},{"issue":"8","key":"2021120508080128700_CIT0031","doi-asserted-by":"crossref","first-page":"e665","DOI":"10.1016\/j.jogc.2018.05.032","article-title":"No. 298-The prevention of early-onset neonatal group B streptococcal disease","volume":"40","author":"Money","year":"2018","journal-title":"J Obstet Gynaecol Can"},{"issue":"10","key":"2021120508080128700_CIT0032","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1701-2163(15)30818-5","article-title":"The prevention of early-onset neonatal group B streptococcal disease","volume":"35","author":"Money","year":"2013","journal-title":"J Obstet Gynaecol Can"},{"key":"2021120508080128700_CIT0033","first-page":"13873","article-title":"Recommendations for term and late preterm infants at risk for perinatal bacterial infection","volume":"143","author":"Stocker","year":"2013","journal-title":"Swiss Med Wkly"},{"issue":"1","key":"2021120508080128700_CIT0034","doi-asserted-by":"crossref","first-page":"e20170476","DOI":"10.1542\/peds.2017-0476","article-title":"The epidemiology, management, and outcomes of bacterial meningitis in infants","volume":"140","author":"Ouchenir","year":"2017","journal-title":"Pediatrics"},{"key":"2021120508080128700_CIT0035","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1080\/20469047.2017.1408738","article-title":"Reviewing the WHO guidelines for antibiotic use for sepsis in neonates and children","volume":"38","author":"Fuchs","year":"2018","journal-title":"Paediatr Int Child Health"},{"issue":"5","key":"2021120508080128700_CIT0036","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/00365540601087574","article-title":"Listeriosis in Norway 1977-2003","volume":"39","author":"Antal","year":"2007","journal-title":"Scand J Infect Dis"},{"key":"2021120508080128700_CIT0037","article-title":"Feigin and Cherry\u2019s Textbook of Pediatric Infectious Diseases","author":"Way","year":"2019","edition":"9th ed"},{"issue":"1","key":"2021120508080128700_CIT0038","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3201\/eid1901.120393","article-title":"Listeriosis outbreaks and associated food vehicles, United States, 1998-2008","volume":"19","author":"Cartwright","year":"2013","journal-title":"Emerg Infect Dis"},{"issue":"3","key":"2021120508080128700_CIT0039","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1097\/00006454-199103000-00003","article-title":"Outbreak of neonatal listeriosis associated with mineral oil","volume":"10","author":"Schuchat","year":"1991","journal-title":"Pediatr Infect Dis J."}],"container-title":["Paediatrics &amp; Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/26\/7\/e277\/41483624\/pxab035.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/26\/7\/e277\/41483624\/pxab035.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,12,5]],"date-time":"2021-12-05T08:08:40Z","timestamp":1638691720000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/26\/7\/e277\/6305145"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,19]]},"references-count":39,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2021,6,19]]},"published-print":{"date-parts":[[2021,11,11]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/pxab035","relation":{},"ISSN":["1205-7088","1918-1485"],"issn-type":[{"value":"1205-7088","type":"print"},{"value":"1918-1485","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,11,1]]},"published":{"date-parts":[[2021,6,19]]}}}