{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T16:23:34Z","timestamp":1787588614150,"version":"build-2736575974"},"reference-count":41,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T00:00:00Z","timestamp":1657411200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"CIHR Institute of Human Development"},{"DOI":"10.13039\/501100020867","name":"Montreal Children\u2019s Hospital Foundation","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100020867","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,10,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Objective<\/jats:title>\n                  <jats:p>This study was aimed to assess the incidence of and risk factors for autism spectrum disorder (ASD) among preterm infants born &amp;lt;29 weeks\u2019 gestational age (GA).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A retrospective cohort study of infants born &amp;lt;29 weeks\u2019 GA admitted to two tertiary neonatal intensive care units (2009 to 2017) and followed \u226518 months corrected age (CA) at a neonatal follow-up clinic. The primary outcome was ASD, diagnosed using standardized testing or provisional diagnosis at \u226518 months CA. Patient data and 18-month CA developmental outcomes were obtained from the local Canadian Neonatal Follow Up Network database and chart review. Stepwise logistic regression assessed factors associated with ASD.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Among 300 eligible infants, 26 (8.7%) were diagnosed with confirmed and 21 (7.0%) with provisional ASD for a combined incidence of 15.7% (95% confidence interval [CI] 11.7 to 20.3). The mean follow-up duration was 3.9 \u00b1 1.4 years and the mean age of diagnosis was 3.7 \u00b1 1.5 years. Male sex (adjusted odds ratio [aOR] 4.63, 95% CI 2.12 to 10.10), small for gestational age status (aOR 3.03, 95% CI 1.02 to 9.01), maternal age \u226535 years at delivery (aOR 2.22, 95% CI 1.08 to 4.57) and smoking during pregnancy (aOR 5.67, 95% CI 1.86 to 17.29) were significantly associated with ASD. Among ASD infants with a complete 18-month CA developmental assessment, 46% (19\/41) had no neurodevelopmental impairment (Bayley-III&amp;lt;70, deafness, blindness, or cerebral palsy).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusions<\/jats:title>\n                  <jats:p>ASD is common among infants born &amp;lt;29 weeks\u2019 GA and possibly associated with identified risk factors. Such findings emphasize the importance of ASD evaluation among infants &amp;lt;29 weeks\u2019 GA and for continued reporting of developmental outcomes beyond 18-months of corrected age.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pch\/pxac065","type":"journal-article","created":{"date-parts":[[2022,7,10]],"date-time":"2022-07-10T10:36:15Z","timestamp":1657449375000},"page":"346-352","source":"Crossref","is-referenced-by-count":5,"title":["Incidence and risk factors for autism spectrum disorder among infants born &amp;lt;29 weeks\u2019 gestation"],"prefix":"10.1093","volume":"27","author":[{"given":"Andr\u00e9e-Anne","family":"Busque","sequence":"first","affiliation":[{"name":"McGill University , Montreal, Quebec , Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias","family":"Jabbour","sequence":"additional","affiliation":[{"name":"McGill University Health Center, Research Institute , Montreal, Quebec , 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