{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T04:48:42Z","timestamp":1777697322088,"version":"3.51.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2024,3,17]],"date-time":"2024-03-17T00:00:00Z","timestamp":1710633600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,11,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Craniosynostosis is a congenital abnormality resulting in the premature fusion of one or more cranial sutures and usually requires surgical correction in the first year of life. While the majority of craniosynostosis cases represent isolated, nonsyndromic defects, approximately 25% are linked to a genetic diagnosis. Craniosynostosis has been associated with developmental delay. Therefore, historically in Manitoba, all children with surgically managed craniosynostosis were referred to the Child Development Clinic (CDC) for developmental assessment. There are currently prolonged wait times for neurodevelopmental assessments at CDC, leading to the need to better prioritize children who require neurodevelopmental assessment. The aim of the study was then to determine the developmental outcomes of preschool children requiring craniosynostosis surgery in Manitoba from July 1, 2016 through December 1, 2021. In this retrospective cohort study, clinical records were reviewed to evaluate the developmental outcomes of patients who were assessed at CDC for surgically managed craniosynostosis. Out of 67 children included in this study, 18% demonstrated global developmental delay, 24% demonstrated mild developmental delay, and 58% were developmentally appropriate across all levels. The presence of a genetic syndrome, multisutural craniosynostosis, and parental socioeconomic status were associated with risk of global developmental delay. The findings of this study suggest that while not all children with craniosynostosis present with developmental delay, those with suspected or confirmed syndromic involvement, multisutural cranyosinostosis, and\/or low SES, should be referred for neurodevelopmental evaluation.<\/jats:p>","DOI":"10.1093\/pch\/pxae009","type":"journal-article","created":{"date-parts":[[2024,3,18]],"date-time":"2024-03-18T04:05:50Z","timestamp":1710734750000},"page":"361-366","source":"Crossref","is-referenced-by-count":2,"title":["Developmental outcomes of preschool children requiring craniosynostosis surgery in Manitoba: a cohort study"],"prefix":"10.1093","volume":"29","author":[{"given":"Yael","family":"Ripstein","sequence":"first","affiliation":[{"name":"Max Rady College of Medicine, University of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy","family":"Pylypjuk","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology and Reproductive Sciences, University of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra","family":"Conway","sequence":"additional","affiliation":[{"name":"Childrens Hospital Research Institute of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M Florencia","family":"Ricci","sequence":"additional","affiliation":[{"name":"Department of Pediatrics and Child Health, Section of Child Development, University of Manitoba , Winnipeg ,","place":["Canada"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,3,17]]},"reference":[{"key":"2024111301264020400_CIT0001","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.pediatrneurol.2019.01.018","article-title":"Recent advances in craniosynostosis","volume":"99","author":"Yilmaz","year":"2019","journal-title":"Pediatr Neurol"},{"key":"2024111301264020400_CIT0002","first-page":"110","article-title":"Craniosynostosis\u2014Recognition, clinical characteristics, and treatment","volume":"18","author":"Kajdic","year":"2018","journal-title":"Bosn J Basic Med Sci"},{"key":"2024111301264020400_CIT0003","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1016\/j.jcms.2016.07.007","article-title":"Increase in prevalence of craniosynostosis","volume":"44","author":"Cornelissen","year":"2016","journal-title":"J Craniomaxillofac Surg"},{"key":"2024111301264020400_CIT0004","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1002\/ajmg.a.32208","article-title":"A population-based study of craniosynostosis in metropolitan Atlanta, 1989\u20132003","volume":"146A","author":"Boulet","year":"2008","journal-title":"Am J Med Genet"},{"key":"2024111301264020400_CIT0005","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.pediatrneurol.2015.07.006","article-title":"Craniosynostosis","volume":"53","author":"Governale","year":"2015","journal-title":"Pediatr Neurol"},{"key":"2024111301264020400_CIT0006","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cps.2018.11.009","article-title":"Syndromic craniosynostosis","volume":"46","author":"Sawh-Martinez","year":"2019","journal-title":"Clin Plast Surg"},{"key":"2024111301264020400_CIT0007","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1097\/SCS.0000000000002016","article-title":"Guideline for care of patients with the diagnoses of craniosynostosis: Working Group on craniosynostosis","volume":"26","author":"Mathijssen","year":"2015","journal-title":"J Craniofac Surg"},{"key":"2024111301264020400_CIT0008","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1001\/archpediatrics.2011.1800","article-title":"Multicenter study of neurodevelopment in 3-year-old children with and without single-suture craniosynostosis","volume":"166","author":"Starr","year":"2012","journal-title":"Arch Pediatr Adolesc Med"},{"key":"2024111301264020400_CIT0009","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1097\/SCS.0000000000006973","article-title":"Craniofacial Collaboration UK: Developmental outcomes in 5-year-old children with sagittal synostosis","volume":"32","author":"Care","year":"2021","journal-title":"J Craniofac Surg"},{"key":"2024111301264020400_CIT0010","doi-asserted-by":"crossref","first-page":"e2121937","DOI":"10.1001\/jamanetworkopen.2021.21937","article-title":"Sagittal synostosis and its association with cognitive, behavioral, and psychological functioning: A meta-analysis","volume":"4","author":"Osborn","year":"2021","journal-title":"JAMA Netw Open"},{"key":"2024111301264020400_CIT0011","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1097\/SCS.0000000000007035","article-title":"Updated guideline on treatment and management of craniosynostosis","volume":"32","author":"Mathijssen","year":"2021","journal-title":"J Craniofac Surg"},{"key":"2024111301264020400_CIT0012","volume-title":"Bridging the Gaps: Achieving Substantive Equality for Children with Disabilities in Manitoba","author":"Manitoba Advocate for Children and Youth","year":"2021"},{"key":"2024111301264020400_CIT0013","volume-title":"The Bayley Scales of Infant and Toddler Development, Screening Test","author":"Bayley","year":"2012","edition":"3"},{"key":"2024111301264020400_CIT0014","author":"Centers for Disease Control","year":"2023"},{"key":"2024111301264020400_CIT0015","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1111\/j.1755-618X.1987.tb00639.x","article-title":"The 1981 socioeconomic index for occupations in Canada","volume":"24","author":"Blishen","year":"1987","journal-title":"Can Rev Soc\/Revue canadienne de sociologie"},{"key":"2024111301264020400_CIT0016","volume-title":"SPSS Statistics, version 28.0.1.1","author":"IBM"},{"key":"2024111301264020400_CIT0017","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1097\/01.prs.0000172763.71043.b8","article-title":"Speech, cognitive, and behavioral outcomes in nonsyndromic craniosynostosis","volume":"116","author":"Becker","year":"2005","journal-title":"Plast Reconstr Surg"},{"key":"2024111301264020400_CIT0018","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.spen.2004.12.001","article-title":"Cognitive impact of craniosynostosis","volume":"11","author":"Lekovic","year":"2004","journal-title":"Semin Pediatr Neurol"},{"key":"2024111301264020400_CIT0019","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1111\/dmcn.12643","article-title":"Predicting developmental delay in a longitudinal cohort of preschool children with single-suture craniosynostosis: Is neurobehavioral assessment important","volume":"57","author":"Gray","year":"2015","journal-title":"Dev Med Child Neurol"},{"key":"2024111301264020400_CIT0020","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1080\/87565641.2014.886690","article-title":"Neurodevelopmental outcomes in infants and children with single-suture craniosynostosis: A systematic review","volume":"39","author":"Knight","year":"2014","journal-title":"Dev Neuropsychol"},{"key":"2024111301264020400_CIT0021","doi-asserted-by":"crossref","first-page":"7623","DOI":"10.1016\/j.vaccine.2019.05.027","article-title":"Neurodevelopmental delay: Case definition & guidelines for data collection, analysis, and presentation of immunization safety data","volume":"37","author":"Villagomez","year":"2019","journal-title":"Vaccine"}],"container-title":["Paediatrics &amp; Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/29\/6\/361\/60630474\/pxae009.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/29\/6\/361\/60630474\/pxae009.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,11,13]],"date-time":"2024-11-13T11:42:32Z","timestamp":1731498152000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/29\/6\/361\/7630609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3,17]]},"references-count":21,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2024,3,17]]},"published-print":{"date-parts":[[2024,11,12]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/pxae009","relation":{},"ISSN":["1205-7088","1918-1485"],"issn-type":[{"value":"1205-7088","type":"print"},{"value":"1918-1485","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,9]]},"published":{"date-parts":[[2024,3,17]]}}}