{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T20:08:32Z","timestamp":1792613312133,"version":"4.5.0"},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2024,11,1]],"date-time":"2024-11-01T00:00:00Z","timestamp":1730419200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,12,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n               <jats:p>Congenital syphilis can result in pregnancy loss and substantial morbidity in newborns. The current epidemic of congenital syphilis in Canada (especially Western Canada) is a preventable public health emergency. Rates indicate a lack of control of syphilis within the community and insufficient public health resources to prevent spread that predate the COVID-19 pandemic. Risk factors include lack of prenatal care, methamphetamine and other substance use, and unstable housing. The cornerstone of prevention is identification, treatment, and follow-up during pregnancy, including of partners. Clinicians caring for newborns need to consider aspects of maternal treatment, reinfection risk, the results of paired maternal and infant syphilis serology, and infant clinical assessment. A complete risk assessment will guide effective management and follow-up of infants exposed in utero to syphilis.<\/jats:p>","DOI":"10.1093\/pch\/pxae044","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:02:41Z","timestamp":1734066161000},"page":"472-479","source":"Crossref","is-referenced-by-count":12,"title":["Diagnosis and management of congenital syphilis: Avoiding missed opportunities"],"prefix":"10.1093","volume":"29","author":[{"given":"Sergio","family":"Fanella","sequence":"first","affiliation":[{"name":"Canadian Paediatric Society, Infectious Diseases and Immunization Committee , Ottawa, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Bitnun","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Infectious Diseases and Immunization Committee , Ottawa, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle","family":"Barton","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Infectious Diseases and Immunization Committee , Ottawa, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Sauv\u00e9","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Infectious Diseases and Immunization Committee , Ottawa, Ontario,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"2024121305021527600_CIT0001","author":"Public Health Agency of Canada"},{"key":"2024121305021527600_CIT0002","author":"Public Health Agency of Canada"},{"issue":"23","key":"2024121305021527600_CIT0003","doi-asserted-by":"publisher","first-page":"52","DOI":"10.14745\/ccdr.v48i23a01","article-title":"Rising syphilis rates in Canada, 2011\u20132020","volume":"47","author":"Aho","year":"2022","journal-title":"Can Comm Dis Rep"},{"key":"2024121305021527600_CIT0004","author":"Manitoba Health, Seniors and Active Living","year":"2019"},{"issue":"Suppl A","key":"2024121305021527600_CIT0005","doi-asserted-by":"publisher","first-page":"6A","DOI":"10.1155\/2015\/983425","article-title":"Canadian Public Health Laboratory Network laboratory guidelines for the use of serological tests (excluding point-of-care tests) for the diagnosis of syphilis in Canada","volume":"26","author":"Levett","year":"2015","journal-title":"Can J Infect Dis Med Microbiol"},{"key":"2024121305021527600_CIT0006","author":"Public Health Agency of Canada"},{"issue":"4","key":"2024121305021527600_CIT0007","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1053\/j.spid.2005.06.005","article-title":"Syphilis in children: Congenital and acquired","volume":"16","author":"Woods","year":"2005","journal-title":"Semin Pediatr Infect Dis"},{"issue":"1","key":"2024121305021527600_CIT0008","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1016\/j.idc.2017.11.007","article-title":"Syphilis in children","volume":"32","author":"Heston","year":"2018","journal-title":"Infect Dis Clin North Am"},{"issue":"7","key":"2024121305021527600_CIT0009","doi-asserted-by":"publisher","first-page":"e173","DOI":"10.1016\/S1473-3099(20)30268-1","article-title":"Congenital syphilis, the great imitator\u2014Case report and review","volume":"20","author":"Keuning","year":"2020","journal-title":"Lancet Infect Dis"},{"issue":"3","key":"2024121305021527600_CIT0010","doi-asserted-by":"publisher","first-page":"e2020049080","DOI":"10.1542\/peds.2020-049080","article-title":"Congenital syphilis diagnosed beyond the neonatal period in the United States: 2014\u20132018","volume":"148","author":"Kimball","year":"2021","journal-title":"Pediatrics"},{"key":"2024121305021527600_CIT0011","author":"Bitnun"},{"key":"2024121305021527600_CIT0012","author":"Centers for Disease Control and Prevention","year":"2021"},{"issue":"1","key":"2024121305021527600_CIT0013","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1186\/s12887-021-02502-9","article-title":"Outcomes of infants born to pregnant women with syphilis: A nationwide study in Korea","volume":"21","author":"Lim","year":"2021","journal-title":"BMC Pediatr"},{"issue":"7","key":"2024121305021527600_CIT0014","doi-asserted-by":"publisher","first-page":"412","DOI":"10.1097\/00007435-200107000-00009","article-title":"Congenital syphilis and fluorescent treponemal antibody test reactivity after the age of 1 year","volume":"28","author":"Rawstron","year":"2001","journal-title":"Sex Transm Dis"},{"issue":"3","key":"2024121305021527600_CIT0015","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1097\/INF.0b013e318273599c","article-title":"Seroreversion of treponemal tests in infants meeting Canadian surveillance criteria for confirmed early congenital syphilis","volume":"32","author":"Singh","year":"2013","journal-title":"Pediatr Infect Dis J"},{"issue":"1","key":"2024121305021527600_CIT0016","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1542\/peds.47.1.27","article-title":"Congenital syphilis: Resurgence of an old problem","volume":"47","author":"Wilkinson","year":"1971","journal-title":"Pediatrics"},{"issue":"2","key":"2024121305021527600_CIT0017","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1016\/j.clp.2021.03.005","article-title":"Syphilis in neonates and infants","volume":"48","author":"Medoro","year":"2021","journal-title":"Clin Perinatol"},{"key":"2024121305021527600_CIT0018","author":"Canadian Paediatric Society","year":"2023"}],"container-title":["Paediatrics &amp; Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/29\/7\/472\/61101240\/pxae044.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/29\/7\/472\/61101240\/pxae044.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T05:02:44Z","timestamp":1734066164000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/29\/7\/472\/7922845"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,11]]},"references-count":18,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2024,12,12]]},"published-print":{"date-parts":[[2024,12,12]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/pxae044","relation":{},"ISSN":["1205-7088","1918-1485"],"issn-type":[{"value":"1205-7088","type":"print"},{"value":"1918-1485","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2024,11]]},"published":{"date-parts":[[2024,11]]}}}