{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T10:20:03Z","timestamp":1770027603429,"version":"3.49.0"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Institutional Fund Projects","award":["IFPRC-186-140-2020"],"award-info":[{"award-number":["IFPRC-186-140-2020"]}]},{"name":"Ministry of Education and King Abdulaziz University, Jeddah, Saudi Arabia"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,2,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Epilepsy and systemic autoimmune disorders (SADs) are significant in pediatric populations, yet most research focuses on adults.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective analysis of the National Inpatient Sample (2016\u20132020) for pediatric patients (\u226418 years) with SADs. Patients with and without epilepsy were compared by demographics and clinical factors. Multivariate logistic regression assessed associations. To account for multiple testing, a Bonferroni correction set the adjusted significance threshold at \u03b1 = 0.002.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 4,816,131 pediatric patients, 5371 had both SADs and epilepsy. Multivariate analysis confirmed a strong association between SADs and epilepsy (OR: 2.79, 95% CI: 2.71\u20132.87). Addison's disease (OR: 10.09, 95% CI: 8.12\u201312.55), hypothyroidism (OR: 9.14, 95% CI: 8.8\u20139.48), vitiligo (OR: 3.29, 95% CI: 2.26\u20134.87), and autoimmune thyroiditis (OR: 3.25, 95% CI: 2.8\u20133.77) were the strongest independent predictors (P &amp;lt; 0.0001).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Pediatric epilepsy is significantly associated with several SADs, highlighting the need for multidisciplinary approaches to manage these conditions.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pch\/pxaf097","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T15:42:15Z","timestamp":1762962135000},"page":"56-62","source":"Crossref","is-referenced-by-count":0,"title":["Insights into pediatric epilepsy and systemic autoimmune disorders: A study using the national inpatient database"],"prefix":"10.1093","volume":"31","author":[{"given":"Reem","family":"Alyoubi","sequence":"first","affiliation":[{"name":"Department of Pediatrics, Faculty of Medicine, King Abdulaziz University , Jeddah ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2286-2181","authenticated-orcid":false,"given":"Ahmed","family":"Abu-Zaid","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine, College of Medicine, Alfaisal University , Riyadh ,","place":["Saudi Arabia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,11,12]]},"reference":[{"key":"2026020118521689600_pxaf097-B1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.seizure.2019.12.015","article-title":"Epilepsy and autoimmune diseases: Comorbidity in a national patient cohort","volume":"75","author":"Wie 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