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Also, using umbilical cord blood sampling for initial blood work in preterm infants, whenever feasible, and avoiding routine blood work whenever possible, help to minimize blood loss and transfusion need. In very preterm and very low birth weight infants, a restrictive red cell transfusion strategy stratified by respiratory support and postnatal age is recommended. In late preterm and term neonates who are hemodynamically unstable or in acute severe hypoxemia, blood transfusion strategies should be individualized based on clinical condition. In stable preterm infants without fetal intracranial hemorrhage or major active bleeding, a platelet transfusion threshold of &amp;lt;25 \u00d7 109\/L should be used.<\/jats:p>","DOI":"10.1093\/pch\/pxaf130","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T12:54:09Z","timestamp":1765025649000},"page":"377-383","source":"Crossref","is-referenced-by-count":1,"title":["Minimizing blood loss and need for transfusions in newborns"],"prefix":"10.1093","volume":"31","author":[{"given":"Souvik","family":"Mitra","sequence":"first","affiliation":[{"name":"Canadian Paediatric Society, Fetus and Newborn Committee , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emer","family":"Finan","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Fetus and Newborn Committee , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepak","family":"Manhas","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Fetus and Newborn Committee , Ottawa, Ontario ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,4,29]]},"reference":[{"issue":"6","key":"2026060810565449300_pxaf130-B1","doi-asserted-by":"publisher","first-page":"1340","DOI":"10.1111\/trf.12998","article-title":"Temporal changes in blood product usage in preterm neonates born at less than 30 weeks\u2019 gestation in Canada","volume":"55","author":"Keir","year":"2015","journal-title":"Transfusion"},{"issue":"1","key":"2026060810565449300_pxaf130-B2","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1038\/s41390-020-01273-w","article-title":"Transfusions and neurodevelopmental outcomes in extremely low gestation neonates enrolled in the PENUT trial: A randomized clinical trial","volume":"90","author":"Vu","year":"2021","journal-title":"Pediatr Res"},{"issue":"8","key":"2026060810565449300_pxaf130-B3","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1093\/pch\/20.8.451","article-title":"Minimizing blood loss and the need for transfusions in very premature infants","volume":"20","author":"Lemyre","year":"2015","journal-title":"Paediatr Child Health"},{"issue":"4","key":"2026060810565449300_pxaf130-B4","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1093\/pch\/19.4.213","article-title":". 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