{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T17:05:41Z","timestamp":1789578341328,"version":"build-2803163510"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T00:00:00Z","timestamp":1782777600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010090","name":"Women and Children's Health Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010090","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Stollery Children's Hospital Foundation"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,9,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>Newborn screening (NBS) for hemoglobinopathies continues to grow in Canada. This study aims to describe the current diagnostic rates of hemoglobinopathies and hemoglobinopathy carriers through NBS programs in Canada, which has never been reviewed comprehensively across the country.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We requested collaboration from provincial or territorial NBS programs in Canada on this cross-sectional study which included screening data from January 1, 2020 to December 31, 2023, inclusive. The data collection encompassed screening for hemoglobinopathies (including sickle cell disease, thalassemia, and other variants), hemoglobinopathy carriers, and relevant laboratory information.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>90% of Canadian newborns were screened for hemoglobinopathies by NBS between the study dates. On average, 1 in 2000 newborns is diagnosed with a hemoglobinopathy by NBS across Canada. Sickle cell disease (SCD) (including HbS\/S, HbS\/C, HbS\/\u03b20, HbS\/\u03b2+, and HbS\/HPFH) was the most common outcome, affecting 1 in 2700 newborns. Thalassemia (including Hb\u03b20\/\u03b20, HbE\/E, HbE\/\u03b20, and HBH) is diagnosed by NBS at a rate of 1 in 10,000 newborns. NBS additionally identifies 1 in 72 newborns as a carrier of a hemoglobinopathy. Sickle cell trait is identified in 1 in 118 newborns.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>This study established hemoglobinopathy and carrier identification rates among children born in Canada essential in establishing the epidemiology of SCD, Thalassemia, and other hemoglobinopathies. When compared with previous publications, the findings of this study suggest an increase in the incidence of SCD in Canadian newborns over time.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pch\/pxag038","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T11:52:37Z","timestamp":1777377157000},"page":"647-653","source":"Crossref","is-referenced-by-count":0,"title":["Newborn screening for hemoglobinopathies: a review of Canadian data from 2020 to 2023"],"prefix":"10.1093","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-2167-8618","authenticated-orcid":false,"given":"Shauna","family":"Peng","sequence":"first","affiliation":[{"name":"Department of Pediatrics, University of Alberta , Edmonton ,","place":["Canada"]},{"name":"Stollery Children's Hospital, Alberta Health Services, Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ross","family":"Ridsdale","sequence":"additional","affiliation":[{"name":"Newborn Metabolic Screening and Biochemical Genetics Laboratory, University of Alberta Hospital, Alberta Precision Laboratories , Edmonton ,","place":["Canada"]},{"name":"Department of Medical Genetics, University of Alberta, Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iveta","family":"Sosova","sequence":"additional","affiliation":[{"name":"Newborn Metabolic Screening and Biochemical Genetics Laboratory, University of Alberta Hospital, Alberta Precision Laboratories , Edmonton ,","place":["Canada"]},{"name":"Department of Medical Genetics, University of Alberta, Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3827-7147","authenticated-orcid":false,"given":"Lauren","family":"MacNeil","sequence":"additional","affiliation":[{"name":"Newborn Metabolic Screening and Biochemical Genetics Laboratory, University of Alberta Hospital, Alberta Precision Laboratories , Edmonton ,","place":["Canada"]},{"name":"Department of Medical Genetics, University of Alberta, Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Lilley","sequence":"additional","affiliation":[{"name":"Newborn Metabolic Screening and Biochemical Genetics Laboratory, University of Alberta Hospital, Alberta Precision Laboratories , Edmonton ,","place":["Canada"]},{"name":"Department of Medical Genetics, University of Alberta, Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8649-2628","authenticated-orcid":false,"given":"Janet","family":"Marcadier","sequence":"additional","affiliation":[{"name":"Newborn Screening Ontario , Ottawa ,","place":["Canada"]},{"name":"Children's Hospital of Eastern Ontario Research Institute, University of Ottawa, Ottawa ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yves","family":"Gigu\u00e8re","sequence":"additional","affiliation":[{"name":"Newborn Screening Ontario , Ottawa ,","place":["Canada"]},{"name":"Children's Hospital of Eastern Ontario Research Institute, Department of Pediatrics, University of Ottawa, Ottawa ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Th\u00e9r\u00e8se","family":"Berthier","sequence":"additional","affiliation":[{"name":"Newborn Screening Ontario , Ottawa ,","place":["Canada"]},{"name":"Children's Hospital of Eastern Ontario Research Institute, Department of Pediatrics, University of Ottawa, Ottawa ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Chouaibou","sequence":"additional","affiliation":[{"name":"Newborn Screening Ontario , Ottawa ,","place":["Canada"]},{"name":"Children's Hospital of Eastern Ontario Research Institute, Department of Pediatrics, University of Ottawa, Ottawa ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3815-2005","authenticated-orcid":false,"given":"Graham","family":"Sinclair","sequence":"additional","affiliation":[{"name":"BC Newborn Screening Program, Department of Pathology and Laboratory Medicine, British Columbia Children's Hospital , Vancouver ,","place":["Canada"]},{"name":"Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaiping","family":"Liu","sequence":"additional","affiliation":[{"name":"Division of Clinical Biochemistry & Maritime Newborn Screening, Department of Pathology and Laboratory Medicine, Dalhousie University, IWK Health Centre, Halifax ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Van Caeseele","sequence":"additional","affiliation":[{"name":"Manitoba Newborn Screening Program, Cadham Provincial Laboratory , Winnipeg, Manitoba"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aisha","family":"Bruce","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, University of Alberta , Edmonton ,","place":["Canada"]},{"name":"Stollery Children's Hospital, Alberta Health Services, Edmonton ,","place":["Canada"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,6,30]]},"reference":[{"key":"2026091612564122600_pxag038-B1","author":"CDC"},{"issue":"2","key":"2026091612564122600_pxag038-B2","doi-asserted-by":"publisher","DOI":"10.1101\/CSHPERSPECT.A011684","article-title":"Classification of the disorders of hemoglobin","volume":"3","author":"Forget","year":"2013","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"6","key":"2026091612564122600_pxag038-B3","doi-asserted-by":"crossref","first-page":"480","DOI":"10.2471\/BLT.06.036673","article-title":"Public health reviews global epidemiology of haemoglobin disorders","volume":"86","author":"Modell","year":"2008","journal-title":"Bull World Health Organ"},{"key":"2026091612564122600_pxag038-B4","author":"NHLBI, NIH"},{"key":"2026091612564122600_pxag038-B5","author":"Association d'an\u00e9mie Falciforme du Canada"},{"issue":"1","key":"2026091612564122600_pxag038-B6","doi-asserted-by":"publisher","first-page":"16","DOI":"10.3390\/IJNS5010016","article-title":"Thalassemias: An overview","volume":"5","author":"Angastiniotis","year":"2019","journal-title":"Int J Neonatal Screen"},{"issue":"6","key":"2026091612564122600_pxag038-B7","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1542\/peds.81.6.749","article-title":"Newborn screening for sickle cell disease: Effect on mortality","volume":"81","author":"Vichinsky","year":"1988","journal-title":"Pediatrics"},{"issue":"4","key":"2026091612564122600_pxag038-B8","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1093\/PCH\/11.4.223","article-title":"Newborn screening for sickle cell disease: A 1988\u20132003 Quebec experience","volume":"11","author":"Robitaille","year":"2006","journal-title":"Paediatr Child Health"},{"issue":"5","key":"2026091612564122600_pxag038-B9","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1542\/peds.83.5.858","article-title":"Georgia's experience with newborn screening: 1981 to 1985","volume":"83","author":"Harris","year":"1989","journal-title":"Pediatrics"},{"issue":"4","key":"2026091612564122600_pxag038-B10","doi-asserted-by":"publisher","first-page":"36","DOI":"10.3390\/ijns4040036","article-title":"Newborn screening for SCD in the USA and Canada","volume":"4","author":"El-Haj","year":"2018","journal-title":"Int J Neonatal Screen"},{"key":"2026091612564122600_pxag038-B11","author":"CanHaem"},{"key":"2026091612564122600_pxag038-B12","author":"Alberta Newborn Screening Program"},{"issue":"3","key":"2026091612564122600_pxag038-B13","doi-asserted-by":"publisher","first-page":"238","DOI":"10.1053\/J.SEMPERI.2015.03.008","article-title":"Newborn screening for sickle cell diseases in the United States: A review of data spanning 2 decades","volume":"39","author":"Therrell","year":"2015","journal-title":"Semin Perinatol"},{"issue":"4","key":"2026091612564122600_pxag038-B14","doi-asserted-by":"publisher","first-page":"37","DOI":"10.3390\/ijns5040037","article-title":"Newborn screening: Current status in Alberta, Canada","volume":"5","author":"De Souza","year":"2019","journal-title":"Int J Neonatal Screen"},{"issue":"4","key":"2026091612564122600_pxag038-B15","doi-asserted-by":"publisher","first-page":"E725","DOI":"10.9778\/CMAJO.20220145","article-title":"Sickle cell disease in Ontario, Canada: An epidemiologic profile based on health administrative data","volume":"11","author":"Pendergrast","year":"2023","journal-title":"CMAJ Open"},{"key":"2026091612564122600_pxag038-B16","author":"Statistics Canada"},{"key":"2026091612564122600_pxag038-B17","author":"Canada's Drug Agency"},{"issue":"4","key":"2026091612564122600_pxag038-B18","doi-asserted-by":"publisher","first-page":"39","DOI":"10.3390\/IJNS4040039","article-title":"Newborn screening for sickle cell disease and other hemoglobinopathies: A short review on classical laboratory methods\u2014isoelectric focusing, HPLC, and capillary electrophoresis","volume":"4","author":"Fr\u00f6mmel","year":"2018","journal-title":"Int J Neonatal Screen"},{"issue":"5","key":"2026091612564122600_pxag038-B19","doi-asserted-by":"publisher","first-page":"341","DOI":"10.1016\/S0009-9120(75)93618-8","article-title":"The human hemoglobin variants in Canada","volume":"8","author":"Vella","year":"1975","journal-title":"Clin Biochem"},{"issue":"1","key":"2026091612564122600_pxag038-B20","doi-asserted-by":"publisher","first-page":"49","DOI":"10.2450\/2008.0020-08","article-title":"Recommendations for the transfusion of red blood cells","volume":"7","author":"Liumbruno","year":"2009","journal-title":"Blood Transfus"},{"issue":"4","key":"2026091612564122600_pxag038-B21","doi-asserted-by":"publisher","first-page":"78","DOI":"10.3390\/IJNS7040078","article-title":"The Alberta newborn screening approach for sickle cell disease: The advantages of molecular testing","volume":"7","author":"Zhou","year":"2021","journal-title":"Int J Neonatal Screen"},{"issue":"2","key":"2026091612564122600_pxag038-B22","doi-asserted-by":"publisher","first-page":"171","DOI":"10.3109\/03630269.2011.555220","article-title":"Bilirubin peak can be mistaken as Hb Bart\u2019s or Hb H on high-performance liquid chromatography","volume":"35","author":"Kar","year":"2011","journal-title":"Hemoglobin"}],"container-title":["Paediatrics &amp; Child Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/31\/6\/647\/68654181\/pxag038.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pch\/article-pdf\/31\/6\/647\/68654181\/pxag038.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T16:56:51Z","timestamp":1789577811000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/31\/6\/647\/8722387"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,30]]},"references-count":22,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2026,6,30]]},"published-print":{"date-parts":[[2026,9,16]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/pxag038","relation":{},"ISSN":["1205-7088","1918-1485"],"issn-type":[{"value":"1205-7088","type":"print"},{"value":"1918-1485","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,6,30]]}}}