{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T09:25:23Z","timestamp":1784193923978,"version":"3.55.0"},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T00:00:00Z","timestamp":1552694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,13]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A term, growth-restricted newborn presented with a sepsis-like picture, persistent pulmonary hypertension and bilateral cataracts. Initial review of prenatal and family history, as well as microbiological investigations were noncontributory. Following lenticular extraction, viral examination of the lenses confirmed the presence of rubella. Congenital rubella syndrome (CRS) presents with a constellation of signs and symptoms that overlap with many other conditions. The presence of bilateral cataracts in a newborn is a rare finding and this case is used to review the broad etiology of congenital cataracts. We propose a structured diagnostic approach for clinicians, remembering that CRS is a rare but possible etiology. The early diagnosis of CRS in this case, allowed us to initiate appropriate management and preventive measurements.<\/jats:p>","DOI":"10.1093\/pch\/pxz005","type":"journal-article","created":{"date-parts":[[2019,3,16]],"date-time":"2019-03-16T10:26:31Z","timestamp":1552731991000},"page":"72-76","source":"Crossref","is-referenced-by-count":4,"title":["Newborn with bilateral congenital cataracts: Never forget congenital rubella syndrome"],"prefix":"10.1093","volume":"25","author":[{"given":"Inara","family":"Chacon Fonseca","sequence":"first","affiliation":[{"name":"Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacqueline","family":"Wong","sequence":"additional","affiliation":[{"name":"Division of Infectious diseases, Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Ontario"},{"name":"Department of Pediatrics, North York General Hospital, Toronto, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamiar","family":"Mireskandari","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Vision Sciences, The Hospital for Sick Children and University of Toronto, Toronto, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Chitayat","sequence":"additional","affiliation":[{"name":"Division of Clinical and Metabolic Genetics, Department of Pediatrics, The Hospital for Sick Children and University of Toronto, Toronto, Ontario"},{"name":"The Prenatal Diagnosis and Medical Genetics Program, Department of Obstetrics and Gynecology, Mount Sinai Hospital, Toronto, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,3,16]]},"reference":[{"key":"2020120806432989500_CIT0001","doi-asserted-by":"crossref","first-page":"28564","DOI":"10.1038\/srep28564","article-title":"Prevalence and epidemiological characteristics of congenital cataract: A systematic review and meta-analysis","volume":"6","author":"Wu","year":"2016","journal-title":"Sci Rep"},{"issue":"4","key":"2020120806432989500_CIT0002","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1007\/s00431-012-1700-1","article-title":"Congenital and infantile cataract: Aetiology and management","volume":"171","author":"Chan","year":"2012","journal-title":"Eur J Pediatr"},{"issue":"4","key":"2020120806432989500_CIT0003","first-page":"422","article-title":"Epidemiology and molecular genetics of congenital cataracts","volume":"4","author":"Yi","year":"2011","journal-title":"Int J Ophthalmol"},{"key":"2020120806432989500_CIT0004"},{"issue":"11","key":"2020120806432989500_CIT0005","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1016\/j.ophtha.2014.06.006","article-title":"Personalized diagnosis and management of congenital cataract by next-generation sequencing","volume":"121","author":"Gillespie","year":"2014","journal-title":"Ophthalmology"},{"issue":"8","key":"2020120806432989500_CIT0006","first-page":"2108","article-title":"Congenital and infantile cataract in the United Kingdom: Underlying or associated factors. 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