{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:52:30Z","timestamp":1781081550352,"version":"3.54.1"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T00:00:00Z","timestamp":1554854400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,4,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This case report illustrates the unexpected identification of intrafamilial sexual abuse of a young mother through genetic testing of her child. The child\u2019s genome was found to have a relatively common chromosomal condition with congruent clinical manifestations, but the microarray also suggested a close biological relationship between the parents because of a high degree of homozygosity. This prompted a child protection investigation as the mother had been a minor at the time of conception, and intrafamilial sexual abuse was confirmed. Both the intended and unintended results of microarray should be considered with respect to the health and social context of the child and their biological parents. This becomes particularly important for young mothers and raises protection concerns when significant amounts of homozygosity (consanguinity) are detected.<\/jats:p>","DOI":"10.1093\/pch\/pxz034","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T12:33:53Z","timestamp":1554899633000},"page":"134-135","source":"Crossref","is-referenced-by-count":1,"title":["Microarray results as an indicator of sexual abuse"],"prefix":"10.1093","volume":"25","author":[{"given":"Vanessa","family":"Russell","sequence":"first","affiliation":[{"name":"Faculty of Medicine, University of Ottawa, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah M","family":"Nikkel","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle G K","family":"Ward","sequence":"first","affiliation":[{"name":"Division of Child and Youth Protection, Department of Pediatrics, University of Ottawa, Ottawa, Ontario"},{"name":"CHEO Research Institute, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,4,10]]},"reference":[{"issue":"1","key":"2020041012252605900_CIT0001","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pediatrneurol.2013.03.008","article-title":"The perils of SNP microarray testing: Uncovering unexpected consanguinity","volume":"49","author":"Tarini","year":"2013","journal-title":"Pediatr Neurol"},{"issue":"1","key":"2020041012252605900_CIT0002","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ajhg.2015.05.022","article-title":"Points to consider: Ethical, legal, and psychosocial implications of genetic testing in children and adolescents","volume":"97","author":"Botkin","year":"2015","journal-title":"Am J Hum Genet"},{"issue":"9","key":"2020041012252605900_CIT0003","doi-asserted-by":"crossref","first-page":"E324","DOI":"10.1503\/cmaj.131792","article-title":"Child abuse and mental disorders in Canada","volume":"186","author":"Afifi","year":"2014","journal-title":"CMAJ"},{"issue":"3","key":"2020041012252605900_CIT0004","doi-asserted-by":"crossref","first-page":"e736","DOI":"10.1542\/peds.2014-2593","article-title":"Institutional protocol to manage consanguinity detected by genetic testing in pregnancy in a minor","volume":"135","author":"Chen","year":"2015","journal-title":"Pediatrics"},{"issue":"2","key":"2020041012252605900_CIT0005","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/gim.2012.169","article-title":"American College of Medical Genetics and Genomics: Standards and guidelines for documenting suspected consanguinity as an incidental finding of genomic testing","volume":"15","author":"Rehder","year":"2013","journal-title":"Genet Med"},{"issue":"9765","key":"2020041012252605900_CIT0006","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0140-6736(11)60201-8","article-title":"Identification of incestuous parental relationships by SNP-based DNA microarrays","volume":"377","author":"Schaaf","year":"2011","journal-title":"Lancet"},{"issue":"1","key":"2020041012252605900_CIT0007","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1186\/1755-8166-6-38","article-title":"Frequent detection of parental consanguinity in children with developmental disorders by a combined CGH and SNP microarray","volume":"6","author":"Fan","year":"2013","journal-title":"Mol Cytogenet"},{"key":"2020041012252605900_CIT0008","author":"Stavropoulos","year":"2016"},{"issue":"4","key":"2020041012252605900_CIT0009","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1136\/jmedgenet-2017-105013","article-title":"Practice guideline: Joint CCMG-SOGC recommendations for the use of chromosomal microarray analysis for prenatal diagnosis and assessment of fetal loss in Canada","volume":"55","author":"Armour","year":"2018","journal-title":"J Med Genet"},{"issue":"4","key":"2020041012252605900_CIT0010","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1111\/j.1748-720X.2012.00731.x","article-title":"Currents in contemporary bioethics. Identifying consanguinity through routine genomic analysis: reporting requirements","volume":"40","author":"McGuire","year":"2012","journal-title":"J Law Med Ethics"}],"container-title":["Paediatrics &amp; Child Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/pch\/article-pdf\/25\/3\/134\/33033527\/pxz034.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/pch\/article-pdf\/25\/3\/134\/33033527\/pxz034.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,4,10]],"date-time":"2020-04-10T18:01:35Z","timestamp":1586541695000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/25\/3\/134\/5437608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4,10]]},"references-count":10,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,4,10]]},"published-print":{"date-parts":[[2020,4,10]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/pxz034","relation":{},"ISSN":["1205-7088","1918-1485"],"issn-type":[{"value":"1205-7088","type":"print"},{"value":"1918-1485","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2019,4,10]]}}}