{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T03:16:56Z","timestamp":1778815016627,"version":"3.51.4"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2019,8,9]],"date-time":"2019-08-09T00:00:00Z","timestamp":1565308800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Canadian Neonatal Network"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,11,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To evaluate trends in organisms causing early-onset neonatal sepsis (EONS). Congruent with recent reports, we hypothesized there would be an increase in EONS caused by Escherichia coli.<\/jats:p><\/jats:sec><jats:sec><jats:title>Study Design<\/jats:title><jats:p>National data on infants admitted to neonatal intensive care units from 2009 to 2014 were compared to previously reported data from 2003 to 2008. We report 430 cases of EONS from 2009 to 2014. Bivariate analyses were used to analyze the distribution of causative organisms over time and differences by gestational age. Linear regression was used to estimate trends in causative organisms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Since 2003, there has been a trend of increasing numbers of cases caused by E coli (P&amp;lt;0.01). The predominant organism was E coli in preterm infants and Group B Streptococcus in term infants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>With the majority of EONS cases now caused by E coli, our findings emphasize the importance of continued surveillance of causative organism patterns and developing approaches to reduce cases caused by E coli.<\/jats:p><\/jats:sec>","DOI":"10.1093\/pch\/pxz073","type":"journal-article","created":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T03:21:08Z","timestamp":1604373668000},"page":"425-431","source":"Crossref","is-referenced-by-count":13,"title":["Early-onset neonatal sepsis: Organism patterns between 2009 and 2014"],"prefix":"10.1093","volume":"25","author":[{"given":"Michael","family":"Sgro","sequence":"first","affiliation":[{"name":"Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, Ontario"},{"name":"Department of Pediatrics, St. Michael\u2019s Hospital, Toronto, Ontario"},{"name":"Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael\u2019s Hospital, Toronto, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Douglas M","family":"Campbell","sequence":"additional","affiliation":[{"name":"Keenan Research Centre of the Li Ka Shing Knowledge Institute, St Michael\u2019s Hospital, Toronto, Ontario"},{"name":"Department of Pediatrics, St. Michael\u2019s Hospital, Toronto, Ontario"},{"name":"Division of Neonatology, Department of Pediatrics, University of Toronto, Toronto, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaitlyn L","family":"Mellor","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, University of Toronto, Toronto, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Hollamby","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, St. Michael\u2019s Hospital, Toronto, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaya","family":"Bodani","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Regina Qu\u2019Appelle Health Region, Regina, Saskatchewan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prakesh S","family":"Shah","sequence":"additional","affiliation":[{"name":"Division of Neonatology, Department of Pediatrics, University of Toronto, Toronto, Ontario"},{"name":"Department of Pediatrics, Mount Sinai Hospital, Toronto, Ontario"},{"name":"Maternal-Infant Care Research Center, Mount Sinai Hospital, Toronto, Ontario"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2019,8,9]]},"reference":[{"key":"2020110222210307700_CIT0001","doi-asserted-by":"crossref","first-page":"S24","DOI":"10.1016\/j.jinf.2013.09.011","article-title":"Neonatal sepsis: Progress towards improved 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