{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T12:38:29Z","timestamp":1789907909308,"version":"4.0.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,2,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Beta-lactam allergy is commonly diagnosed in paediatric patients, but over 90% of individuals reporting this allergy are able to tolerate the medications prescribed after evaluation by an allergist. Beta-lactam allergy labels are associated with negative clinical and administrative outcomes, including use of less desirable alternative antibiotics, longer hospitalizations, increasing antibiotic-resistant infections, and greater medical costs. Also, children with true IgE-mediated allergy to penicillin medications are often advised to avoid all beta-lactam antibiotics, including cephalosporins, which is likely unnecessary in greater than 97% of those reporting penicillin allergies. Most patients can be safely treated with penicillin or amoxicillin if they do not have a history compatible with IgE-mediated or systemic, delayed reactions such as Stevens-Johnson syndrome (SJS), serum sickness-like reactions, drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, or acute generalized exanthematous pustulosis (AGEP). Guidance is provided on how to stratify risk of beta-lactam allergy, and on test dosing and monitoring in the outpatient setting for patients deemed low risk. Guidance for patients at higher risk of beta-lactam allergy includes criteria for appropriate referral to allergists and the use of alternative antimicrobials, such as cephalosporins, while awaiting specialist assessment.<\/jats:p>","DOI":"10.1093\/pch\/pxz179","type":"journal-article","created":{"date-parts":[[2020,2,6]],"date-time":"2020-02-06T05:23:47Z","timestamp":1580966627000},"page":"62-62","source":"Crossref","is-referenced-by-count":16,"title":["Beta-lactam allergy in the paediatric population"],"prefix":"10.1093","volume":"25","author":[{"given":"Tiffany","family":"Wong","sequence":"first","affiliation":[{"name":"Canadian Paediatric Society, Allergy Section, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelle","family":"Atkinson","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Allergy Section, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Geert","family":"t\u2019Jong","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Allergy Section, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J","family":"Rieder","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Allergy Section, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmond S","family":"Chan","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Allergy Section, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissa M","family":"Abrams","sequence":"additional","affiliation":[{"name":"Canadian Paediatric Society, Allergy Section, Ottawa, Ontario"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,2,6]]},"container-title":["Paediatrics &amp; Child Health"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/pch\/article-pdf\/25\/1\/62\/34783843\/pxz179.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"http:\/\/academic.oup.com\/pch\/article-pdf\/25\/1\/62\/34783843\/pxz179.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T22:03:34Z","timestamp":1607551414000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pch\/article\/25\/1\/62\/5728424"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":0,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2020,2,6]]},"published-print":{"date-parts":[[2020,2,6]]}},"URL":"https:\/\/doi.org\/10.1093\/pch\/pxz179","relation":{},"ISSN":["1205-7088","1918-1485"],"issn-type":[{"value":"1205-7088","type":"print"},{"value":"1918-1485","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2020,2]]}}}