{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T18:53:45Z","timestamp":1790880825398,"version":"4.1.0"},"reference-count":44,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T00:00:00Z","timestamp":1660694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772075"],"award-info":[{"award-number":["81772075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81772076"],"award-info":[{"award-number":["81772076"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071186"],"award-info":[{"award-number":["32071186"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,9,19]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The dermal papilla cells in hair follicles function as critical regulators of hair growth. In particular, alopecia areata (AA) is closely related to the malfunctioning of the human dermal papilla cells (hDPCs). Thus, identifying the regulatory mechanism of hDPCs is important in inducing hair follicle (HF) regeneration in AA patients. Recently, growing evidence has indicated that 3\u2032 untranslated regions (3\u2032 UTR) of key genes may participate in the regulatory circuitry underlying cell differentiation and diseases through a so-called competing endogenous mechanism, but none have been reported in HF regeneration. Here, we demonstrate that the 3\u2032 UTR of junctional adhesion molecule A (JAM-A) could act as an essential competing endogenous RNA to maintain hDPCs function and promote HF regeneration in AA. We showed that the 3\u2032 UTR of JAM-A shares many microRNA (miRNA) response elements, especially miR-221\u20133p, with versican (VCAN) mRNA, and JAM-A 3\u2032 UTR could directly modulate the miRNA-mediated suppression of VCAN in self-renewing hDPCs. Furthermore, upregulated VCAN can in turn promote the expression level of JAM-A. Overall, we propose that JAM-A 3\u2032 UTR forms a feedback loop with VCAN and miR-221\u20133p to regulate hDPC maintenance, proliferation, and differentiation, which may lead to developing new therapies for hair loss.<\/jats:p>","DOI":"10.1093\/pcmedi\/pbac020","type":"journal-article","created":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T21:17:40Z","timestamp":1660771060000},"source":"Crossref","is-referenced-by-count":12,"title":["JAM-A facilitates hair follicle regeneration in alopecia areata through functioning as ceRNA to protect VCAN expression in dermal papilla cells"],"prefix":"10.1093","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6734-5618","authenticated-orcid":false,"given":"Minjuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Histology and Embryology, Naval Medical University , Shanghai 200433, China"},{"name":"Burns Institute of People's Liberation Army, Changhai Hospital, Naval Medical University , Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Naval Medical University , Shanghai 200433, China"},{"name":"Spine Center, Department of Orthopedics, Changzheng Hospital, Naval Medical University , Shanghai 200003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Naval Medical University , Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sha","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Naval Medical University , Shanghai 200433, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology, Naval Medical 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