{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:35:48Z","timestamp":1791588948534,"version":"4.3.4"},"reference-count":46,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":64,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Natural Science Foundation of Changsha","award":["KQ2208389"],"award-info":[{"award-number":["KQ2208389"]}]},{"name":"Youth Science Foundation of Xiangya Hospital","award":["2022Q12"],"award-info":[{"award-number":["2022Q12"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,7,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Numerous investigations have revealed the interplay between gut microbiota (GM) and psoriasis (Ps) and psoriatic arthritis (PsA). However, the causal relationship between them remains unknown.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>We curated a collection of genetic variants (P\u00a0&amp;lt;\u00a01\u00a0\u00d7\u00a010\u22125) associated with GM (n\u00a0=\u00a018\u00a0340) derived from the MiBioGen study. To explore the intricate relationship between GM and Ps as well as PsA, we harnessed the comprehensive resources of the FinnGen database, encompassing a vast cohort of individuals, including 4510 Ps cases and 212\u00a0242 controls and 1637 PsA cases and 212\u00a0242 controls. Mendelian randomization (MR) was used, including an inverse variance weighting method, followed by a sensitivity analysis to verify the robustness of the results.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>For Ps, some bacterial taxa, including Lactococcus, Ruminiclostridium 5, and Eubacterium fissicatena, were identified as risk factors; but Odoribacter demonstrated a protective effect against Ps. In the case of PsA, Lactococcus, Verrucomicrobiales, Akkermansia, Coprococcus 1, and Verrucomicrobiaceae were identified as risk factors; Odoribacter and Rikenellaceae exhibited a protective effect against the development of PsA.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Our study establishes a causal link between the GM and Ps and PsA. These findings provide insights into the underlying mechanisms and suggest potential therapeutic targets.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pcmedi\/pbad023","type":"journal-article","created":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T07:28:30Z","timestamp":1694849310000},"source":"Crossref","is-referenced-by-count":20,"title":["Investigating the gut microbiota's influence on psoriasis and psoriatic arthritis risk: a Mendelian randomization analysis"],"prefix":"10.1093","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6995-9840","authenticated-orcid":false,"given":"Nianzhou","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University , Changsha 410008 , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayi","family":"Wang","sequence":"additional","affiliation":[{"name":"Xiangya School of Medicine, Central South University , Changsha 410083 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuancheng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University , Changsha 410008 , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeye","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Hunan Engineering Research Center of Skin Health and Disease, Hunan Key Laboratory of Skin Cancer and Psoriasis, Xiangya Hospital, Central South University , Changsha 410008 , China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University , Changsha 410008 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2023,9,15]]},"reference":[{"key":"2023092917225996100_bib1","doi-asserted-by":"publisher","first-page":"485","DOI":"10.1002\/JLB.5MR0120-439R","article-title":"Keratinocyte: A trigger or an executor of psoriasis?","volume":"108","author":"Ni","year":"2020","journal-title":"J Leukoc Biol"},{"key":"2023092917225996100_bib2","doi-asserted-by":"publisher","first-page":"1301","DOI":"10.1016\/S0140-6736(20)32549-6","article-title":"Psoriasis","volume":"397","author":"Griffiths","year":"2021","journal-title":"Lancet"},{"key":"2023092917225996100_bib3","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1684\/ejd.2022.4245","article-title":"Global trends in the incidence of psoriasis from 1990 to 2019","volume":"32","author":"Mou","year":"2022","journal-title":"Eur J Dermatol"},{"key":"2023092917225996100_bib4","doi-asserted-by":"publisher","first-page":"465","DOI":"10.1038\/s41584-022-00798-0","article-title":"Group for Research and Assessment of Psoriasis and Psoriatic Arthritis (GRAPPA): updated treatment recommendations for psoriatic arthritis 2021","volume":"18","author":"Coates","year":"2022","journal-title":"Nat Rev Rheumatol"},{"key":"2023092917225996100_bib5","doi-asserted-by":"publisher","first-page":"101494","DOI":"10.1016\/j.berh.2020.101494","article-title":"The gut microbiome in psoriasis and psoriatic arthritis","volume":"33","author":"Myers","year":"2019","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"2023092917225996100_bib6","doi-asserted-by":"publisher","first-page":"3998","DOI":"10.3390\/ijms22083998","article-title":"Alterations of the skin and gut microbiome in psoriasis and psoriatic arthritis","volume":"22","author":"Olejniczak-Staruch","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2023092917225996100_bib7","doi-asserted-by":"publisher","first-page":"463","DOI":"10.3390\/pathogens9060463","article-title":"Gut microbiome in psoriasis: an updated review","volume":"9","author":"Sikora","year":"2020","journal-title":"Pathogens"},{"key":"2023092917225996100_bib8","doi-asserted-by":"publisher","first-page":"236","DOI":"10.3389\/fmicb.2019.00236","article-title":"Crucial role of microbiota in experimental psoriasis revealed by a gnotobiotic mouse model","volume":"10","author":"Stehlikova","year":"2019","journal-title":"Front Microbiol"},{"key":"2023092917225996100_bib9","doi-asserted-by":"publisher","first-page":"767","DOI":"10.1016\/j.ajhg.2022.04.001","article-title":"Combining evidence from mendelian randomization and colocalization: review and comparison of approaches","volume":"109","author":"Zuber","year":"2022","journal-title":"Am J Hum Genet"},{"key":"2023092917225996100_bib10","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1038\/s41588-020-00763-1","article-title":"Large-scale association analyses identify host factors influencing human gut microbiome composition","volume":"53","author":"Kurilshikov","year":"2021","journal-title":"Nat Genet"},{"key":"2023092917225996100_bib11","doi-asserted-by":"publisher","first-page":"508","DOI":"10.1038\/s41586-022-05473-8","article-title":"FinnGen provides genetic insights from a well-phenotyped isolated population","volume":"613","author":"Kurki","year":"2023","journal-title":"Nature"},{"key":"2023092917225996100_bib12","doi-asserted-by":"publisher","first-page":"1334","DOI":"10.1093\/bioinformatics\/btu779","article-title":"SNiPA: an interactive, genetic variant-centered annotation browser","volume":"31","author":"Arnold","year":"2015","journal-title":"Bioinformatics"},{"key":"2023092917225996100_bib13","doi-asserted-by":"publisher","first-page":"1167346","DOI":"10.3389\/fcvm.2023.1167346","article-title":"Causality of gut microbiome and hypertension: A bidirectional mendelian randomization study","volume":"10","author":"Li","year":"2023","journal-title":"Front Cardiovasc Med"},{"key":"2023092917225996100_bib14","doi-asserted-by":"publisher","first-page":"780133","DOI":"10.3389\/fendo.2022.780133","article-title":"Genetically predicted causality of 28 gut microbiome families and type 2 diabetes mellitus risk","volume":"13","author":"Xiang","year":"2022","journal-title":"Front Endocrinol (Lausanne)"},{"key":"2023092917225996100_bib15","doi-asserted-by":"publisher","first-page":"4851","DOI":"10.1093\/bioinformatics\/btz469","article-title":"PhenoScanner V2: an expanded tool for searching human genotype-phenotype associations","volume":"35","author":"Kamat","year":"2019","journal-title":"Bioinformatics"},{"key":"2023092917225996100_bib16","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1111\/jdv.16926","article-title":"EuroGuiDerm Guideline on the systemic treatment of Psoriasis vulgaris - Part 2: specific clinical and comorbid situations","volume":"35","author":"Nast","year":"2021","journal-title":"J Eur Acad Dermatol Venereol"},{"key":"2023092917225996100_bib17","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1093\/ije\/dyv080","article-title":"Mendelian randomization with invalid instruments: effect estimation and bias detection through Egger regression","volume":"44","author":"Bowden","year":"2015","journal-title":"Int J Epidemiol"},{"key":"2023092917225996100_bib18","doi-asserted-by":"publisher","first-page":"e1001841","DOI":"10.1371\/journal.pmed.1001841","article-title":"Associations between potentially modifiable risk factors and Alzheimer disease: A mendelian randomization study","volume":"12","author":"\u00d8stergaard","year":"2015","journal-title":"PLoS Med"},{"key":"2023092917225996100_bib19","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1093\/ije\/dyr036","article-title":"Avoiding bias from weak instruments in mendelian randomization studies","volume":"40","author":"Burgess","year":"2011","journal-title":"Int J Epidemiol"},{"key":"2023092917225996100_bib20","doi-asserted-by":"publisher","first-page":"377","DOI":"10.1007\/s10654-017-0255-x","article-title":"Interpreting findings from mendelian randomization using the MR-Egger method","volume":"32","author":"Burgess","year":"2017","journal-title":"Eur J Epidemiol"},{"key":"2023092917225996100_bib21","doi-asserted-by":"publisher","first-page":"693","DOI":"10.1038\/s41588-018-0099-7","article-title":"Detection of widespread horizontal pleiotropy in causal relationships inferred from mendelian randomization between complex traits and diseases","volume":"50","author":"Verbanck","year":"2018","journal-title":"Nat Genet"},{"key":"2023092917225996100_bib22","doi-asserted-by":"publisher","first-page":"248","DOI":"10.1111\/dom.14869","article-title":"Mendelian randomization identifies age at menarche as an independent causal effect factor for gestational diabetes mellitus","volume":"25","author":"Lu","year":"2023","journal-title":"Diabetes Obes Metab"},{"key":"2023092917225996100_bib23","doi-asserted-by":"publisher","first-page":"545","DOI":"10.1016\/j.rdc.2015.07.001","article-title":"The epidemiology of psoriatic arthritis","volume":"41","author":"Ogdie","year":"2015","journal-title":"Rheum Dis Clin North Am"},{"key":"2023092917225996100_bib24","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1007\/s11427-018-9376-6","article-title":"Dysbiosis of gut microbiota was closely associated with psoriasis","volume":"62","author":"Huang","year":"2019","journal-title":"Sci China Life Sci"},{"key":"2023092917225996100_bib25","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1111\/1346-8138.14933","article-title":"Psoriatic patients have a distinct structural and functional fecal microbiota compared with controls","volume":"46","author":"Shapiro","year":"2019","journal-title":"J Dermatol"},{"key":"2023092917225996100_bib26","doi-asserted-by":"publisher","first-page":"1952","DOI":"10.3390\/nu15081952","article-title":"Dose-response efficacy and mechanisms of orally administered bifidobacterium breve CCFM683 on IMQ-induced psoriasis in mice","volume":"15","author":"Chen","year":"2023","journal-title":"Nutrients"},{"key":"2023092917225996100_bib27","doi-asserted-by":"publisher","first-page":"605825","DOI":"10.3389\/fcimb.2021.605825","article-title":"Deciphering gut microbiota dysbiosis and corresponding genetic and metabolic dysregulation in psoriasis patients using metagenomics sequencing","volume":"11","author":"Xiao","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"2023092917225996100_bib28","doi-asserted-by":"publisher","first-page":"1249","DOI":"10.3389\/fphar.2020.01249","article-title":"Resveratrol modulates the gut microbiota and inflammation to protect against diabetic nephropathy in mice","volume":"11","author":"Cai","year":"2020","journal-title":"Front Pharmacol"},{"key":"2023092917225996100_bib29","doi-asserted-by":"publisher","first-page":"e0126599","DOI":"10.1371\/journal.pone.0126599","article-title":"Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice","volume":"10","author":"Kjaer","year":"2015","journal-title":"PLoS One"},{"key":"2023092917225996100_bib30","doi-asserted-by":"publisher","first-page":"417","DOI":"10.1016\/j.xphs.2021.08.023","article-title":"Resveratrol-loaded vesicular elastic nanocarriers gel in imiquimod-induced psoriasis treatment: in vitro and in vivo evaluation","volume":"111","author":"Elgewelly","year":"2022","journal-title":"J Pharm Sci"},{"key":"2023092917225996100_bib31","doi-asserted-by":"publisher","first-page":"111191","DOI":"10.1016\/j.celrep.2022.111191","article-title":"Dysbiosis in imiquimod-induced psoriasis alters gut immunity and exacerbates colitis development","volume":"40","author":"Pinget","year":"2022","journal-title":"Cell Rep"},{"key":"2023092917225996100_bib32","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1111\/exd.13463","article-title":"The Akkermansia muciniphila is a gut microbiota signature in psoriasis","volume":"27","author":"Tan","year":"2018","journal-title":"Exp Dermatol"},{"key":"2023092917225996100_bib33","doi-asserted-by":"publisher","first-page":"957","DOI":"10.1056\/NEJMra1505557","article-title":"Psoriatic arthritis","volume":"376","author":"Ritchlin","year":"2017","journal-title":"N Engl J Med"},{"key":"2023092917225996100_bib34","doi-asserted-by":"publisher","first-page":"1336","DOI":"10.1111\/exd.13786","article-title":"Intestinal microbiota profiling and predicted metabolic dysregulation in psoriasis patients","volume":"27","author":"Chen","year":"2018","journal-title":"Exp Dermatol"},{"key":"2023092917225996100_bib35","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1002\/art.38892","article-title":"Decreased bacterial diversity characterizes the altered gut microbiota in patients with psoriatic arthritis, resembling dysbiosis in inflammatory bowel disease","volume":"67","author":"Scher","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"2023092917225996100_bib36","doi-asserted-by":"publisher","first-page":"643","DOI":"10.1016\/j.rdc.2015.07.006","article-title":"Etiology and pathogenesis of psoriatic arthritis","volume":"41","author":"Barnas","year":"2015","journal-title":"Rheum Dis Clin North Am"},{"key":"2023092917225996100_bib37","doi-asserted-by":"publisher","first-page":"F1000 Faculty Rev","DOI":"10.12688\/f1000research.19144.1","article-title":"Psoriatic arthritis","volume":"8","author":"Ocampo","year":"2019","journal-title":"F1000Res"},{"key":"2023092917225996100_bib38","doi-asserted-by":"publisher","first-page":"1922","DOI":"10.1002\/art.39649","article-title":"Interleukin-9 overexpression and Th9 polarization characterize the inflamed gut, the synovial tissue, and the peripheral blood of patients with psoriatic arthritis","volume":"68","author":"Ciccia","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2023092917225996100_bib39","first-page":"2273","article-title":"The evolution of spondyloarthropathies in relation to gut histology. II. Histological aspects","volume":"22","author":"Mielants","year":"1995","journal-title":"J Rheumatol"},{"key":"2023092917225996100_bib40","first-page":"1241","article-title":"Microscopic inflammatory changes in colon of patients with both active psoriasis and psoriatic arthritis without bowel symptoms","volume":"27","author":"Scarpa","year":"2000","journal-title":"J Rheumatol"},{"key":"2023092917225996100_bib41","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1172\/JCI16069","article-title":"Mechanisms of TNF-alpha- and RANKL-mediated osteoclastogenesis and bone resorption in psoriatic arthritis","volume":"111","author":"Ritchlin","year":"2003","journal-title":"J Clin Invest"},{"key":"2023092917225996100_bib42","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1016\/j.reuma.2014.01.004","article-title":"A report of 4 years of experience of a multidisciplinary unit of psoriasis and psoriatic arthritis","volume":"10","author":"Luelmo","year":"2014","journal-title":"Reumatol Clin"},{"key":"2023092917225996100_bib43","doi-asserted-by":"publisher","first-page":"2911","DOI":"10.1002\/art.39800","article-title":"Brief report: CXCL10 is a possible biomarker for the development of psoriatic arthritis among patients with psoriasis","volume":"68","author":"Abji","year":"2016","journal-title":"Arthritis Rheumatol"},{"key":"2023092917225996100_bib44","doi-asserted-by":"publisher","first-page":"454","DOI":"10.1002\/acr.23298","article-title":"Differentiating psoriatic arthritis from psoriasis without psoriatic arthritis using novel serum biomarkers","volume":"70","author":"Cretu","year":"2018","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"2023092917225996100_bib45","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1186\/1559-0275-12-1","article-title":"Quantitative tandem mass-spectrometry of skin tissue reveals putative psoriatic arthritis biomarkers","volume":"12","author":"Cretu","year":"2015","journal-title":"Clin Proteomics"},{"key":"2023092917225996100_bib46","doi-asserted-by":"publisher","first-page":"186","DOI":"10.12688\/wellcomeopenres.15555.3","article-title":"Guidelines for performing mendelian randomization investigations: update for summer 2023","volume":"4","author":"Burgess","year":"2019","journal-title":"Wellcome Open Res"}],"container-title":["Precision Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pcm\/advance-article-pdf\/doi\/10.1093\/pcmedi\/pbad023\/51608903\/pbad023.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcm\/article-pdf\/6\/3\/pbad023\/51799130\/pbad023.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcm\/article-pdf\/6\/3\/pbad023\/51799130\/pbad023.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T17:23:32Z","timestamp":1696008212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pcm\/article\/doi\/10.1093\/pcmedi\/pbad023\/7275105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7,14]]},"references-count":46,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,7,14]]}},"URL":"https:\/\/doi.org\/10.1093\/pcmedi\/pbad023","relation":{},"ISSN":["2096-5303","2516-1571"],"issn-type":[{"value":"2096-5303","type":"print"},{"value":"2516-1571","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2023,9]]},"published":{"date-parts":[[2023,7,14]]},"article-number":"pbad023"}}