{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T18:33:19Z","timestamp":1789669999590,"version":"4.0.1"},"reference-count":29,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T00:00:00Z","timestamp":1728950400000},"content-version":"vor","delay-in-days":4,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270562"],"award-info":[{"award-number":["82270562"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82302800"],"award-info":[{"award-number":["82302800"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2024,10,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Both intestinal and pulmonary systems are parts of the mucosal immune system, comprising \u223c80% of all immune cells. These immune cells migrate or are transported between various mucosal tissues to maintain tissue homeostasis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>In this study, we isolated neutrophils from the peripheral blood of patients and utilized immunofluorescence, flow cytometry, and Western blotting to confirm the incidence of \u201cnucleus-directed degranulation\u201d in vitro. Subsequently, we conducted a precise analysis using arivis software. Furthermore, using the DSS mouse model of colitis and tissue clearing technologies, we validated the \u201ctargeted nuclear degranulation\u201d of neutrophils and their migration to the lungs in an inflammatory intestinal environment.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Result<\/jats:title>\n                  <jats:p>In this study, we found that among patients with ulcerative colitis, the migration of neutrophils with \u201ctargeted nuclear degranulation\u201d from the intestinal mucosa to the lungs significantly exacerbates lung inflammation during pulmonary infections. Notably, patients with ulcerative colitis exhibited a higher abundance of neutrophils with targeted nuclear degranulation. Using DSS mice, we observed that neutrophils with targeted nuclear degranulation from the intestinal mucosa migrated to the lung and underwent activation during pulmonary infections. These neutrophils rapidly released a high amount of neutrophil extracellular traps to mediate the progression of lung inflammation. Alterations in the neutrophil cytoskeleton and its interaction with the nuclear membrane represent the primary mechanisms underlying targeted nuclear degranulation.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>This study revealed that neutrophils accelerate lung inflammation progression in colitis, offering new insights and potential treatment targets for lung infections for patients with colitis.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1093\/pcmedi\/pbae028","type":"journal-article","created":{"date-parts":[[2024,10,15]],"date-time":"2024-10-15T02:50:24Z","timestamp":1728960624000},"source":"Crossref","is-referenced-by-count":6,"title":["Targeted nuclear degranulation of neutrophils promotes the progression of pneumonia in ulcerative colitis"],"prefix":"10.1093","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3999-7242","authenticated-orcid":false,"given":"Yiming","family":"Shao","sequence":"first","affiliation":[{"name":"Taishan Scholars Laboratory, Affiliated Hospital of Jining Medical University , Jining 272000 ,","place":["China"]},{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Jining Medical University , Jining 272000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qibing","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, Affiliated Hospital of Jining Medical University , Jining 272000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaobei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Taishan Scholars Laboratory, Affiliated Hospital of Jining Medical University , Jining 272000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Research Center for Neutrophil Engineering Technology, Affiliated Suzhou Hospital of Nanjing Medical University , Suzhou 215002 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingxin","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, First Affiliated Hospital of Guangxi Medical University , Nanning 530000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Burns and Plastic Surgery, First Affiliated Hospital of Guangxi Medical University , Nanning 530000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahong","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Burns 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