{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T10:13:57Z","timestamp":1792059237443,"version":"4.4.0"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470022"],"award-info":[{"award-number":["32470022"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82020108021"],"award-info":[{"award-number":["82020108021"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["SWU-KR22013"],"award-info":[{"award-number":["SWU-KR22013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,10,13]]},"DOI":"10.1093\/pcmedi\/pbaf024","type":"journal-article","created":{"date-parts":[[2025,9,30]],"date-time":"2025-09-30T12:22:30Z","timestamp":1759234950000},"source":"Crossref","is-referenced-by-count":2,"title":["CRISPR-based prime editing improves therapeutic outcomes for childhood alternating hemiplegia"],"prefix":"10.1093","volume":"8","author":[{"given":"Guanwang","family":"Shen","sequence":"first","affiliation":[{"name":"Biological Science Research Center, Academy for Advanced Interdisciplinary Studies, Southwest University , Chongqing 400716 ,","place":["China"]},{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Chongqing Technology Innovation Center of Breeding , Chongqing 400716 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Liao","sequence":"additional","affiliation":[{"name":"Biological Science Research Center, Academy for Advanced Interdisciplinary Studies, Southwest University , Chongqing 400716 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Lin","sequence":"additional","affiliation":[{"name":"Biological Science Research Center, Academy for Advanced Interdisciplinary Studies, Southwest University , Chongqing 400716 ,","place":["China"]},{"name":"Integrative Science Center of Germplasm Creation in Western China (Chongqing) Science City, Chongqing Technology Innovation Center of Breeding , Chongqing 400716 ,","place":["China"]},{"name":"Wound Trauma Medical Center, State Key Laboratory of Trauma, Burns and Combined Injury, Daping Hospital, Army Medical University , Chongqing 400042 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,10,1]]},"reference":[{"key":"2025110510031411600_bib1","doi-asserted-by":"publisher","first-page":"1030","DOI":"10.1038\/ng.2358","article-title":"De novo mutations in ATP1A3 cause alternating hemiplegia of childhood","volume":"44","author":"Heinzen","year":"2012","journal-title":"Nat Genet"},{"key":"2025110510031411600_bib2","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1007\/s11940-017-0444-7","article-title":"Diagnosis and treatment of alternating hemiplegia of childhood","volume":"19","author":"Masoud","year":"2017","journal-title":"Curr Treat Options Neurol"},{"key":"2025110510031411600_bib3","doi-asserted-by":"publisher","first-page":"4275","DOI":"10.1016\/j.cell.2025.06.038","article-title":"In vivo prime editing rescues alternating hemiplegia of childhood in mice","volume":"188","author":"Sousa","year":"2025","journal-title":"Cell"},{"key":"2025110510031411600_bib4","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1016\/B978-0-12-823356-6.00005-6","article-title":"Alternating hemiplegia of childhood","volume":"198","author":"Ananthavarathan","year":"2023","journal-title":"Handb Clin Neurol"},{"key":"2025110510031411600_bib5","doi-asserted-by":"publisher","first-page":"14085","DOI":"10.1073\/pnas.0904817106","article-title":"Mutation I810N in the alpha3 isoform of Na+,K+-ATPase causes impairments in the sodium pump and hyperexcitability in the CNS","volume":"106","author":"Clapcote","year":"2009","journal-title":"Proc Natl Acad Sci USA"},{"key":"2025110510031411600_bib6","doi-asserted-by":"publisher","first-page":"eadd8643","DOI":"10.1126\/science.add8643","article-title":"CRISPR technology: A decade of genome editing is only the beginning","volume":"379","author":"Wang","year":"2023","journal-title":"Science"},{"key":"2025110510031411600_bib7","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1038\/s41586-019-1711-4","article-title":"Search-and-replace genome editing without double-strand breaks or donor DNA","volume":"576","author":"Anzalone","year":"2019","journal-title":"Nature"},{"key":"2025110510031411600_bib8","doi-asserted-by":"publisher","first-page":"402","DOI":"10.1038\/s41587-021-01039-7","article-title":"Engineered pegRNAs improve prime editing efficiency","volume":"40","author":"Nelson","year":"2022","journal-title":"Nat Biotechnol"},{"key":"2025110510031411600_bib9","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1089\/hum.2020.191","article-title":"Adeno-associated virus-mediated gene therapy in the Mashlool, Atp1a3Mashl\/+, mouse model of alternating hemiplegia of childhood","volume":"32","author":"Hunanyan","year":"2021","journal-title":"Hum Gene Ther"},{"key":"2025110510031411600_bib10","doi-asserted-by":"publisher","first-page":"1220","DOI":"10.1126\/science.adm8386","article-title":"An AAV capsid reprogrammed to bind human transferrin receptor mediates brain-wide gene delivery","volume":"384","author":"Huang","year":"2024","journal-title":"Science"}],"container-title":["Precision Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pcm\/advance-article-pdf\/doi\/10.1093\/pcmedi\/pbaf024\/64464476\/pbaf024.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcm\/article-pdf\/8\/4\/pbaf024\/64464476\/pbaf024.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcm\/article-pdf\/8\/4\/pbaf024\/64464476\/pbaf024.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T15:03:16Z","timestamp":1762354996000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pcm\/article\/doi\/10.1093\/pcmedi\/pbaf024\/8270675"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,13]]}},"URL":"https:\/\/doi.org\/10.1093\/pcmedi\/pbaf024","relation":{},"ISSN":["2096-5303","2516-1571"],"issn-type":[{"value":"2096-5303","type":"print"},{"value":"2516-1571","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,12]]},"published":{"date-parts":[[2025,10,1]]},"article-number":"pbaf024"}}