{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:37:24Z","timestamp":1787499444032,"version":"build-2736575974"},"reference-count":67,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T00:00:00Z","timestamp":1770940800000},"content-version":"vor","delay-in-days":14,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["92478101"],"award-info":[{"award-number":["92478101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key R&D Program of China","doi-asserted-by":"publisher","award":["2022YFF0608401"],"award-info":[{"award-number":["2022YFF0608401"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2024NSFSC0587"],"award-info":[{"award-number":["2024NSFSC0587"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2025YFHZ0213"],"award-info":[{"award-number":["2025YFHZ0213"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,1,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Minor glomerular abnormalities (MGAs) are histopathologically heterogeneous renal lesions with subtle structural changes and latent clinical manifestations, yet their molecular mechanisms remain poorly characterized and underexplored.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we employed pressure cycling technology-assisted sample preparation combined with data-independent acquisition mass spectrometry to systematically compare the proteomic profiles of distant non-neoplastic tissues (n\u00a0=\u00a024) and MGA tissues (n\u00a0=\u00a027).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 9\u2009529 protein groups were quantified with a false discovery rate\u00a0&amp;lt;\u00a01%, and 1\u2009338 differentially expressed protein groups were identified (fold-change\u00a0&amp;gt;\u00a02 or\u00a0&amp;lt;\u00a00.5, P\u00a0&amp;lt;\u00a00.05), including 190 downregulated and 1\u2009148 upregulated protein groups in MGA tissues. Gene ontology analysis revealed that the downregulated proteins were enriched in cell adhesion, ion binding, and molecular transport, whereas the upregulated proteins were enriched in transcriptional regulation, DNA replication\/repair, and nucleic acid binding. Kyoto Encyclopedia of Genes and Genomes pathway analysis indicated inhibition of metabolic pathways and the peroxisome proliferator-activated receptor signaling pathway, as well as the activation of basal transcription factors and nucleotide excision repair in MGAs. Further screening revealed 13 core upregulated nuclear proteins (e.g. YY1, TAF9, RFC1, and POLR1D) with a &amp;gt;90% detection rate in MGA tissues; these proteins are functionally associated with renal inflammation, cell proliferation, and the DNA damage response.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our study establishes a high-resolution proteomic landscape of MGAs, provides novel insights into their molecular pathogenesis, and identifies potential tissue biomarkers and therapeutic targets. The pressure cycling technology-assisted data-independent acquisition workflow also offers a robust technical framework for proteomic analysis of microscale renal biopsy samples.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pcmedi\/pbag006","type":"journal-article","created":{"date-parts":[[2026,2,12]],"date-time":"2026-02-12T12:43:30Z","timestamp":1770900210000},"source":"Crossref","is-referenced-by-count":4,"title":["Pressure cycling technology-assisteddata-independent acquisition proteomics reveals molecular alterations and potential therapeutic targets in minor glomerular abnormalities"],"prefix":"10.1093","volume":"9","author":[{"given":"Ling","family":"Li","sequence":"first","affiliation":[{"name":"Kidney Research Institute, West China Hospital, Sichuan University Department of Nephrology, , Chengdu 610041 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610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2214-9474","authenticated-orcid":false,"given":"Hao","family":"Yang","sequence":"additional","affiliation":[{"name":"Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University Department of Nephrology, , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Liu","sequence":"additional","affiliation":[{"name":"Kidney Research Institute, West China Hospital, Sichuan University Department of Nephrology, , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guisen","family":"Li","sequence":"additional","affiliation":[{"name":"University of Electronic Science and Technology of China, Sichuan Clinical Research Center for Kidney Diseases Renal Department and Institute of Nephrology, Sichuan Provincial People\u2019s Hospital, , Chengdu 611731 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinfang","family":"Xie","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Xi\u2019an Jiaotong University Department of Nephrology, , Xi\u2019an 710061 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajeev K","family":"Singla","sequence":"additional","affiliation":[{"name":"Center for High Altitude Medicine, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University Department of Pharmacy and Institutes for Systems Genetics, , Chengdu 610041 ,","place":["China"]},{"name":"School of Pharmaceutical Sciences, Lovely Professional University , Phagwara, Punjab 144411 ,","place":["India"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengyan","family":"Ma","sequence":"additional","affiliation":[{"name":"Kidney Research 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