{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T13:12:04Z","timestamp":1785503524079,"version":"3.56.0"},"reference-count":49,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T00:00:00Z","timestamp":1783296000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004829","name":"Department of Science and Technology of Sichuan Province","doi-asserted-by":"publisher","award":["2024YFFK0332"],"award-info":[{"award-number":["2024YFFK0332"]}],"id":[{"id":"10.13039\/501100004829","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2682023ZTPY071"],"award-info":[{"award-number":["2682023ZTPY071"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012542","name":"Sichuan Province Science and Technology Support Program","doi-asserted-by":"publisher","award":["2022NSFSC0779"],"award-info":[{"award-number":["2022NSFSC0779"]}],"id":[{"id":"10.13039\/100012542","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004536","name":"Southwest Jiaotong University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004536","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Extrachromosomal circular DNA (eccDNA) contributes to tumorigenesis, but its role in tumor recurrence remains unclear. This study aimed to systematically characterize eccDNA profiles in recurrent and non-recurrent early-stage lung adenocarcinoma (LUAD) patients and evaluate their potential as prognostic biomarkers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Tumor tissues, matched adjacent non-tumor tissues, and plasma were collected from patients with early-stage LUAD. All patients underwent a 2-year postoperative follow-up to identify recurrence. Circle-seq and multi-omics analyses were applied to profile eccDNA landscapes in recurrent and non-recurrent patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>eccDNAs in recurrent LUAD patients exhibited significantly distinct features, including higher GC content, enhanced structural stability, increased expression levels, and enrichment in transcriptionally active regions. Recurrence-associated eccDNAs carry oncogenes and regulate pathways involved in tumor migration, invasion, and immune evasion via suppression of immune factor receptors. A recurrence risk model based on seven plasma eccDNA marker genes effectively stratified patients, with high-risk patients exhibiting significantly poorer disease-free survival.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These findings highlight the characteristics of eccDNAs in LUAD recurrence and their potential as prognostic biomarkers, providing preliminary multi-omics evidence for understanding the role of eccDNA in LUAD recurrence and laying the groundwork for future mechanistic studies and clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1093\/pcmedi\/pbag017","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:52:35Z","timestamp":1783353155000},"source":"Crossref","is-referenced-by-count":0,"title":["Multi-omics profiling of recurrence-associated extrachromosomal circular DNA characteristics and its prognostic potential in lung adenocarcinoma"],"prefix":"10.1093","volume":"9","author":[{"given":"Xinyu","family":"Zhao","sequence":"first","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xingyi","family":"Du","sequence":"additional","affiliation":[{"name":"School of Life Sciences and Engineering, Southwest Jiaotong University , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenqiao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Health and Rehabilitation, Chengdu University of Traditional Chinese Medicine , Chengdu 611137 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Su","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunlan","family":"Pu","sequence":"additional","affiliation":[{"name":"Medical Research Center, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hengrui","family":"Fan","sequence":"additional","affiliation":[{"name":"Medical Research Center, Affiliated Hospital of Southwest Jiaotong University, The Third People\u2019s Hospital of Chengdu , Chengdu 610031 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingbiao","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Pathology, Deyang People\u2019s Hospital , Deyang 618000 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