{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T20:14:13Z","timestamp":1790194453986,"version":"4.1.0"},"reference-count":221,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T00:00:00Z","timestamp":1788220800000},"content-version":"vor","delay-in-days":33,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013365","name":"West China Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","award":["2023HXFH002"],"award-info":[{"award-number":["2023HXFH002"]}],"id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2024YFFK0046"],"award-info":[{"award-number":["2024YFFK0046"]}]},{"name":"Sichuan Science and Technology Program","award":["2026NSFSC1723"],"award-info":[{"award-number":["2026NSFSC1723"]}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2025YFC2424100"],"award-info":[{"award-number":["2025YFC2424100"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,7,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Extensive evidence indicates a strong association between psychological and psychiatric factors and cardiovascular disease (CVD). Psychological and psychiatric factors, including depression, anxiety, and chronic stress, are associated with an increased risk of CVD and adverse cardiovascular outcomes. Furthermore, this association is bidirectional, as patients with CVD have a notably higher risk of developing comorbid mental disorders. We propose the psycho-cardiovascular interaction network (PCIN) to elucidate the multilevel integrated regulatory mechanisms linking psychological status and cardiovascular function. In this review, we synthesize epidemiologic evidence, summarize the major mechanisms through which these factors may influence cardiovascular function, and focus on key signaling pathways within the PCIN, including BDNF, PROK\/PKR, MAPK, 5-HT\/5-HT2A-R, and NLRP3 inflammasome pathways, which may mediate bidirectional brain\u2013heart communication and mental disorder\u2013CVD comorbidity. On the basis of the PCIN framework, we discuss integrated intervention strategies, including nonpharmacological approaches and molecularly targeted therapies for brain\u2013heart axis-informed management. Future research should focus on the translational potential of psycho-cardiovascular regulatory molecules as therapeutic targets and candidate biomarkers, and high-quality studies are urgently needed to elucidate the long-term effects of psychological interventions on cardiovascular health outcomes and their molecular mechanisms. In addition, integrating psychosocial phenotypes with molecular biomarkers may facilitate individualized risk assessment and inform brain\u2013heart axis-based prevention and therapeutic strategies.<\/jats:p>","DOI":"10.1093\/pcmedi\/pbag025","type":"journal-article","created":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:05:04Z","timestamp":1788264304000},"source":"Crossref","is-referenced-by-count":1,"title":["Psycho-cardiovascular interaction network in cardiovascular health and disease: signaling pathways and molecular mechanisms"],"prefix":"10.1093","volume":"9","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5833-4967","authenticated-orcid":false,"given":"Zexi","family":"Li","sequence":"first","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6580-3726","authenticated-orcid":false,"given":"Fanghui","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunyi","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Cardiology, West China Second University Hospital, Sichuan University , Chengdu 610066 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianrui","family":"Xiang","sequence":"additional","affiliation":[{"name":"Public Service and Development Office, West China Second University Hospital, Sichuan University , Chengdu 610066 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6655-6357","authenticated-orcid":false,"given":"Aobo","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0833-1704","authenticated-orcid":false,"given":"Ying","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Mental Health Center and Institute of Psychiatry, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8164-9183","authenticated-orcid":false,"given":"Rui","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, West China Hospital, Sichuan University , Chengdu 610041 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,1]]},"reference":[{"key":"2026091508161545100_bib1","doi-asserted-by":"publisher","first-page":"4156","DOI":"10.1093\/eurheartj\/ehaf191","article-title":"2025 ESC Clinical Consensus Statement on mental health and cardiovascular disease: developed under the auspices of the ESC Clinical Practice Guidelines Committee","volume":"46","author":"Bueno","year":"2025","journal-title":"Eur Heart J"},{"key":"2026091508161545100_bib2","doi-asserted-by":"publisher","first-page":"e763","DOI":"10.1161\/CIR.0000000000000947","article-title":"Psychological health, well-being, and the mind-heart-body connection: a scientific statement from the american heart association","volume":"143","author":"Levine","year":"2021","journal-title":"Circulation"},{"key":"2026091508161545100_bib3","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1038\/s41569-024-01024-y","article-title":"Stress and cardiovascular disease: an update","volume":"21","author":"Vaccarino","year":"2024","journal-title":"Nat Rev Cardiol"},{"key":"2026091508161545100_bib4","doi-asserted-by":"publisher","first-page":"e017706","DOI":"10.1161\/CIRCIMAGING.124.017706","article-title":"Depression and anxiety associate with adverse cardiovascular events via neural, autonomic, and inflammatory pathways","volume":"19","author":"Abohashem","year":"2026","journal-title":"Circ: Cardiovasc Imaging"},{"key":"2026091508161545100_bib5","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1038\/s41583-021-00446-8","article-title":"The self in context: brain systems linking mental and physical health","volume":"22","author":"Koban","year":"2021","journal-title":"Nat Rev Neurosci"},{"key":"2026091508161545100_bib6","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1038\/s41569-020-00463-7","article-title":"Cardiovascular disease in patients with severe mental illness","volume":"18","author":"Nielsen","year":"2021","journal-title":"Nat Rev Cardiol"},{"key":"2026091508161545100_bib7","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1002\/wps.20420","article-title":"Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness: a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls","volume":"16","author":"Correll","year":"2017","journal-title":"World Psychiatry"},{"key":"2026091508161545100_bib8","doi-asserted-by":"publisher","first-page":"537","DOI":"10.1038\/s41569-025-01140-3","article-title":"The brain-heart axis: integrative cooperation of neural, mechanical and biochemical pathways","volume":"22","author":"Valenza","year":"2025","journal-title":"Nat Rev Cardiol"},{"key":"2026091508161545100_bib9","doi-asserted-by":"publisher","first-page":"2372","DOI":"10.1016\/j.jacc.2022.11.001","article-title":"Global burden of cardiovascular diseases and risks collaboration, 1990\u20132021","volume":"80","author":"Lindstrom","year":"2022","journal-title":"J Am Coll Cardiol"},{"key":"2026091508161545100_bib10","doi-asserted-by":"publisher","first-page":"1277","DOI":"10.30773\/pi.2025.0211","article-title":"Global burden of depressive disorders, 1990\u20132021, during the COVID-19 pandemic and projections to 2050: a global burden of disease study 2021","volume":"22","author":"Lee","year":"2025","journal-title":"Psychiatry Investig"},{"key":"2026091508161545100_bib11","doi-asserted-by":"publisher","first-page":"4178541","DOI":"10.1155\/da\/4178541","article-title":"Global, regional, and national trends in the burden of anxiety disorders from 1992 to 2021: an age-period-cohort analysis based on the global burden of disease study 2021","volume":"2025","author":"Zhou","year":"2025","journal-title":"Depress Anxiety"},{"key":"2026091508161545100_bib12","doi-asserted-by":"publisher","first-page":"5319","DOI":"10.1038\/s41380-023-02138-4","article-title":"Incidence, prevalence, and global burden of schizophrenia\u2014data, with critical appraisal, from the Global Burden of Disease (GBD) 2019","volume":"28","author":"Solmi","year":"2023","journal-title":"Mol Psychiatry"},{"key":"2026091508161545100_bib13","doi-asserted-by":"publisher","first-page":"117282","DOI":"10.1016\/j.psychres.2026.117282","article-title":"Global burden of bipolar disorder in 204 countries and territories, 1990\u20132021: a systematic analysis of temporal trends, demographic disparities, and SDI associations for the Global Burden of Disease Study 2021","volume":"364","author":"Wu","year":"2026","journal-title":"Psychiatry Res"},{"key":"2026091508161545100_bib14","doi-asserted-by":"publisher","first-page":"937","DOI":"10.1016\/S0140-6736(04)17018-9","article-title":"Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case-control study","volume":"364","author":"Yusuf","year":"2004","journal-title":"The Lancet"},{"key":"2026091508161545100_bib15","doi-asserted-by":"publisher","first-page":"e67133","DOI":"10.1371\/journal.pone.0067133","article-title":"Life expectancy and death by diseases of the circulatory system in patients with bipolar disorder or schizophrenia in the Nordic countries","volume":"8","author":"Laursen","year":"2013","journal-title":"PLoS One"},{"key":"2026091508161545100_bib16","doi-asserted-by":"publisher","first-page":"1365","DOI":"10.1093\/eurheartj\/eht462","article-title":"Depression and cardiovascular disease: a clinical review","volume":"35","author":"Hare","year":"2014","journal-title":"Eur Heart J"},{"key":"2026091508161545100_bib17","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.amjmed.2023.04.036","article-title":"Association of depression and cardiovascular disease","volume":"136","author":"Krittanawong","year":"2023","journal-title":"Am J Med"},{"key":"2026091508161545100_bib18","doi-asserted-by":"publisher","first-page":"486","DOI":"10.1177\/02698811261433212","article-title":"Cardiovascular mortality and depression: a systematic review and meta-analysis of the association with antidepressant treatment and co-morbidity","volume":"40","author":"Costa","year":"2026","journal-title":"J Psychopharmacol"},{"key":"2026091508161545100_bib19","doi-asserted-by":"publisher","first-page":"194","DOI":"10.1093\/eurjcn\/zvae113","article-title":"Psychological interventions for depression and anxiety in patients with coronary heart disease, heart failure or atrial fibrillation: Cochrane systematic review and meta-analysis","volume":"24","author":"Ski","year":"2025","journal-title":"Eur J Cardiovasc Nurs"},{"key":"2026091508161545100_bib20","doi-asserted-by":"publisher","first-page":"e1003960","DOI":"10.1371\/journal.pmed.1003960","article-title":"Temporal trends in associations between severe mental illness and risk of cardiovascular disease: a systematic review and meta-analysis","volume":"19","author":"Lambert","year":"2022","journal-title":"PLoS Med"},{"key":"2026091508161545100_bib21","doi-asserted-by":"publisher","first-page":"114233","DOI":"10.1016\/j.psychres.2021.114233","article-title":"Cardiovascular disease and mortality in people with schizophrenia or antipsychotic treatment: a cohort study in primary care","volume":"306","author":"Castillo-S\u00e1nchez","year":"2021","journal-title":"Psychiatry Res"},{"key":"2026091508161545100_bib22","doi-asserted-by":"publisher","first-page":"102632","DOI":"10.1016\/j.cpcardiol.2024.102632","article-title":"Cardiovascular impact of post-traumatic stress disorder: a systematic review and meta-analysis","volume":"49","author":"Padhi","year":"2024","journal-title":"Curr Probl Cardiol"},{"key":"2026091508161545100_bib23","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1016\/j.jpsychires.2020.12.066","article-title":"Risk of specific cardiovascular diseases in obsessive-compulsive disorder","volume":"135","author":"Isomura","year":"2021","journal-title":"J Psychiatr Res"},{"key":"2026091508161545100_bib24","doi-asserted-by":"publisher","first-page":"44","DOI":"10.14423\/SMJ.0000000000001921","article-title":"Cardiovascular consequences of anorexia nervosa: QT prolongation, bradycardia, and structural cardiac changes","volume":"119","author":"Poudel","year":"2026","journal-title":"South Med J"},{"key":"2026091508161545100_bib25","doi-asserted-by":"publisher","first-page":"903","DOI":"10.1016\/0002-9149(76)90117-x","article-title":"Multivariate prediction of coronary heart disease during 8.5 year follow-up in the Western Collaborative Group Study","volume":"37","author":"Rosenman","year":"1976","journal-title":"Am J Cardiol"},{"key":"2026091508161545100_bib26","doi-asserted-by":"publisher","first-page":"872","DOI":"10.1001\/jama.1975.03260080034016","article-title":"Coronary heart disease in Western Collaborative Group Study. Final follow-up experience of 8 1\/2 years","volume":"233","author":"Rosenman","year":"1975","journal-title":"JAMA"},{"key":"2026091508161545100_bib27","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/PSY.0000000000001164","article-title":"Type D personality as a risk factor for adverse outcome in patients with cardiovascular disease: an individual patient-data meta-analysis","volume":"85","author":"Lodder","year":"2023","journal-title":"Psychosom Med"},{"key":"2026091508161545100_bib28","doi-asserted-by":"publisher","first-page":"2940","DOI":"10.3390\/ijms26072940","article-title":"Chronic stress-associated depressive disorders: the impact of HPA axis dysregulation and neuroinflammation on the hippocampus-a mini review","volume":"26","author":"Lei","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib29","doi-asserted-by":"publisher","first-page":"200305","DOI":"10.1016\/j.ijcrp.2024.200305","article-title":"Association of stress hormones and the risk of cardiovascular diseases systematic review and meta-analysis","volume":"23","author":"Tsai","year":"2024","journal-title":"Int J Cardiol Cardiovasc Risk Prev"},{"key":"2026091508161545100_bib30","doi-asserted-by":"publisher","first-page":"1241","DOI":"10.3390\/medicina60081241","article-title":"An overview of cardiovascular risk in pituitary disorders","volume":"60","author":"Ntali","year":"2024","journal-title":"Medicina"},{"key":"2026091508161545100_bib31","doi-asserted-by":"publisher","first-page":"548","DOI":"10.1007\/s12020-023-03623-0","article-title":"Cardiac disease in Cushing\u2019s syndrome. Emphasis on the role of cardiovascular magnetic resonance imaging","volume":"83","author":"Moustaki","year":"2024","journal-title":"Endocrine"},{"key":"2026091508161545100_bib32","doi-asserted-by":"publisher","first-page":"1909","DOI":"10.1007\/s40618-024-02453-9","article-title":"Hypertension and cushing\u2019s syndrome: hunt for the red flag","volume":"48","author":"De\u00a0Martino","year":"2025","journal-title":"J Endocrinol Invest"},{"key":"2026091508161545100_bib33","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1530\/EJE-21-1157","article-title":"Autonomous cortisol secretion is associated with worse arterial stiffness and vascular fibrosis in primary aldosteronism: a cross-sectional study with follow-up data","volume":"187","author":"Tsai","year":"2022","journal-title":"Eur J Endocrinol"},{"key":"2026091508161545100_bib34","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1503\/jpn.140217","article-title":"Autonomic nervous system dysfunction in psychiatric disorders and the impact of psychotropic medications: a systematic review and meta-analysis","volume":"41","author":"Alvares","year":"2016","journal-title":"J Psychiatry Neurosci"},{"key":"2026091508161545100_bib35","doi-asserted-by":"publisher","first-page":"270","DOI":"10.1161\/HYPERTENSIONAHA.109.142042","article-title":"Sympathetic nervous system modulation of inflammation and remodeling in the hypertensive heart","volume":"55","author":"Levick","year":"2010","journal-title":"Hypertension"},{"key":"2026091508161545100_bib36","doi-asserted-by":"publisher","first-page":"2597","DOI":"10.3390\/jcm13092597","article-title":"Stress and heart in remodeling process: multiple stressors at the same time kill","volume":"13","author":"Yal\u00e7in","year":"2024","journal-title":"JCM"},{"key":"2026091508161545100_bib37","doi-asserted-by":"publisher","first-page":"259","DOI":"10.1016\/j.jad.2023.03.018","article-title":"Heart rate variability in generalized anxiety disorder, major depressive disorder and panic disorder: a network meta-analysis and systematic review","volume":"330","author":"Wang","year":"2023","journal-title":"J Affect Disord"},{"key":"2026091508161545100_bib38","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1017\/S003329172000207X","article-title":"Autonomic dysfunction in posttraumatic stress disorder indexed by heart rate variability: a meta-analysis","volume":"50","author":"Schneider","year":"2020","journal-title":"Psychol Med"},{"key":"2026091508161545100_bib39","doi-asserted-by":"publisher","first-page":"104907","DOI":"10.1016\/j.neubiorev.2022.104907","article-title":"Heart rate variability in the prediction of mortality: a systematic review and meta-analysis of healthy and patient populations","volume":"143","author":"Jarczok","year":"2022","journal-title":"Neurosci Biobehav Rev"},{"key":"2026091508161545100_bib40","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/j.biopsych.2022.11.003","article-title":"Inflammation-related functional and structural dysconnectivity as a pathway to psychopathology","volume":"93","author":"Goldsmith","year":"2023","journal-title":"Biol Psychiatry"},{"key":"2026091508161545100_bib41","doi-asserted-by":"publisher","first-page":"12906","DOI":"10.3390\/ijms232112906","article-title":"The role of inflammation in cardiovascular disease","volume":"23","author":"Henein","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib42","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1038\/sj.bjp.0707569","article-title":"CB2 cannabinoid receptor agonists attenuate TNF-alpha-induced human vascular smooth muscle cell proliferation and migration","volume":"153","author":"Rajesh","year":"2008","journal-title":"British J Pharmacology"},{"key":"2026091508161545100_bib43","doi-asserted-by":"publisher","first-page":"387","DOI":"10.1159\/000079706","article-title":"Role of JAK\/STAT pathway in IL-6-induced activation of vascular smooth muscle cells","volume":"24","author":"Watanabe","year":"2004","journal-title":"Am J Nephrol"},{"key":"2026091508161545100_bib44","doi-asserted-by":"publisher","first-page":"7813","DOI":"10.3390\/ijms25147813","article-title":"STAT4 mediates IL-6 trans-signaling arrhythmias in high fat diet guinea pig heart","volume":"25","author":"Corbin","year":"2024","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib45","doi-asserted-by":"publisher","first-page":"378","DOI":"10.1016\/j.ceca.2010.02.002","article-title":"TNF-alpha and IL-1beta increase Ca2+ leak from the sarcoplasmic reticulum and susceptibility to arrhythmia in rat ventricular myocytes","volume":"47","author":"Duncan","year":"2010","journal-title":"Cell Calcium"},{"key":"2026091508161545100_bib46","doi-asserted-by":"publisher","first-page":"186","DOI":"10.3109\/10253890.2014.888548","article-title":"Effects of acute and chronic psychological stress on platelet aggregation in mice","volume":"17","author":"Matsuhisa","year":"2014","journal-title":"Stress"},{"key":"2026091508161545100_bib47","doi-asserted-by":"publisher","first-page":"7560","DOI":"10.3390\/ijms21207560","article-title":"Depression and cardiovascular disease: the viewpoint of platelets","volume":"21","author":"Amadio","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib48","doi-asserted-by":"publisher","first-page":"143","DOI":"10.1097\/00006842-199603000-00008","article-title":"Effects of hostility on platelet reactivity to psychological stress in coronary heart disease patients and in healthy controls","volume":"58","author":"Markovitz","year":"1996","journal-title":"Psychosom Med"},{"key":"2026091508161545100_bib49","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1007\/s11481-020-09945-4","article-title":"Stress enhances proinflammatory platelet activity: the impact of acute and chronic mental stress","volume":"16","author":"Koudouovoh-Tripp","year":"2021","journal-title":"J Neuroimmune Pharmacol"},{"key":"2026091508161545100_bib50","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1016\/s0165-1781(02)00017-3","article-title":"Beta-thromboglobulin and platelet factor 4 levels in post-myocardial infarction patients with major depression","volume":"109","author":"Kuijpers","year":"2002","journal-title":"Psychiatry Res"},{"key":"2026091508161545100_bib51","doi-asserted-by":"publisher","first-page":"102585","DOI":"10.1016\/j.cpr.2025.102585","article-title":"Clusters of healthy lifestyle behaviours are associated with symptoms of depression, anxiety, and psychological distress: a systematic review and meta-analysis of observational studies","volume":"118","author":"Bourke","year":"2025","journal-title":"Clin Psychol Rev"},{"key":"2026091508161545100_bib52","doi-asserted-by":"publisher","first-page":"284","DOI":"10.1016\/j.jad.2024.04.027","article-title":"Overall diet quality, food groups and mental health disorders among Brazilians older than 15 years old: Brazilian National Health Survey\u20132019","volume":"356","author":"Leme","year":"2024","journal-title":"J Affect Disord"},{"key":"2026091508161545100_bib53","doi-asserted-by":"publisher","first-page":"3456","DOI":"10.1093\/eurheartj\/ehag226","article-title":"Ultra-processed foods, lifestyle management, and cardiovascular diseases: a clinical consensus statement of the European Society of Cardiology Council for Cardiology Practice and the European Association of Preventive Cardiology of the European Society of Cardiology","volume":"47","author":"Guasti","year":"2026","journal-title":"Eur Heart J"},{"key":"2026091508161545100_bib54","doi-asserted-by":"publisher","first-page":"zsac149","DOI":"10.1093\/sleep\/zsac149","article-title":"The natural history of insomnia: high sleep reactivity interacts with greater life stress to predict the onset of acute insomnia","volume":"45","author":"Walker","year":"2022","journal-title":"Sleep"},{"key":"2026091508161545100_bib55","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1007\/s00213-021-05982-w","article-title":"Chronic mild stress paradigm as a rat model of depression: facts, artifacts, and future perspectives","volume":"239","author":"Strekalova","year":"2022","journal-title":"Psychopharmacology"},{"key":"2026091508161545100_bib56","doi-asserted-by":"publisher","first-page":"101965","DOI":"10.1016\/j.smrv.2024.101965","article-title":"Associations of sleep with cardiometabolic risk factors and cardiovascular diseases: an umbrella review of observational and mendelian randomization studies","volume":"77","author":"Yang","year":"2024","journal-title":"Sleep Med Rev"},{"key":"2026091508161545100_bib57","doi-asserted-by":"publisher","first-page":"1975","DOI":"10.5664\/jcsm.11326","article-title":"Associations between insomnia and cardiovascular diseases: a meta-review and meta-analysis of observational and Mendelian randomization studies","volume":"20","author":"Zhang","year":"2024","journal-title":"J Clin Sleep Med"},{"key":"2026091508161545100_bib58","doi-asserted-by":"publisher","first-page":"107114","DOI":"10.1016\/j.psyneuen.2024.107114","article-title":"The effect of total sleep deprivation on autonomic nervous system and cortisol responses to acute stressors in healthy individuals: a systematic review","volume":"168","author":"Messa","year":"2024","journal-title":"Psychoneuroendocrinology"},{"key":"2026091508161545100_bib59","doi-asserted-by":"publisher","first-page":"7777","DOI":"10.3390\/ijms21207777","article-title":"Neurotrophic factor BDNF, physiological functions and therapeutic potential in depression, neurodegeneration and brain cancer","volume":"21","author":"Colucci-D\u2019Amato","year":"2020","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib60","doi-asserted-by":"publisher","first-page":"3568","DOI":"10.1182\/bloodadvances.2020004098","article-title":"The brain-derived neurotrophic factor prompts platelet aggregation and secretion","volume":"5","author":"Boukhatem","year":"2021","journal-title":"Blood Adv"},{"key":"2026091508161545100_bib61","doi-asserted-by":"publisher","first-page":"15","DOI":"10.1016\/j.cytogfr.2012.01.002","article-title":"Truncated trkB: beyond a dominant negative receptor","volume":"23","author":"Fenner","year":"2012","journal-title":"Cytokine Growth Factor Rev"},{"key":"2026091508161545100_bib62","doi-asserted-by":"publisher","first-page":"455","DOI":"10.3389\/fphys.2019.00455","article-title":"BDNF actions in the cardiovascular system: roles in development, adulthood and response to injury","volume":"10","author":"Kermani","year":"2019","journal-title":"Front. Physiol."},{"key":"2026091508161545100_bib63","doi-asserted-by":"publisher","first-page":"105611","DOI":"10.1016\/j.nbd.2022.105611","article-title":"MED1\/BDNF\/TrkB pathway is involved in thalamic hemorrhage-induced pain and depression by regulating microglia","volume":"164","author":"Infantino","year":"2022","journal-title":"Neurobiol Dis"},{"key":"2026091508161545100_bib64","doi-asserted-by":"publisher","first-page":"3091424","DOI":"10.1155\/2018\/3091424","article-title":"Pro-BDNF contributes to hypoxia\/reoxygenation injury in myocardial microvascular endothelial cells: roles of receptors p75NTR and sortilin and activation of JNK and caspase 3","volume":"2018","author":"Yu","year":"2018","journal-title":"Oxid Med Cell Long"},{"key":"2026091508161545100_bib65","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1038\/s41583-022-00624-2","article-title":"CaMKII: a central molecular organizer of synaptic plasticity, learning and memory","volume":"23","author":"Yasuda","year":"2022","journal-title":"Nat Rev Neurosci"},{"key":"2026091508161545100_bib66","doi-asserted-by":"publisher","first-page":"135","DOI":"10.1007\/s00406-025-02016-w","article-title":"BDNF mediates the heart-brain axis: implications for cardiovascular diseases and mental disorders","volume":"276","author":"Huang","year":"2026","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"2026091508161545100_bib67","doi-asserted-by":"publisher","first-page":"2881","DOI":"10.1039\/d2fo03874a","article-title":"Dietary choline metabolite TMAO impairs cognitive function and induces hippocampal synaptic plasticity declining through the mTOR\/P70S6K\/4EBP1 pathway","volume":"14","author":"Zhou","year":"2023","journal-title":"Food Funct"},{"key":"2026091508161545100_bib68","doi-asserted-by":"publisher","first-page":"1555","DOI":"10.3390\/biom13101555","article-title":"Navigating the ERK1\/2 MAPK cascade","volume":"13","author":"Martin-Vega","year":"2023","journal-title":"Biomolecules"},{"key":"2026091508161545100_bib69","doi-asserted-by":"publisher","first-page":"2667","DOI":"10.3390\/ijms26062667","article-title":"The role of the MAPK signaling pathway in cardiovascular disease: pathophysiological mechanisms and clinical therapy","volume":"26","author":"Wang","year":"2025","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib70","doi-asserted-by":"publisher","first-page":"1464","DOI":"10.3390\/ijms23031464","article-title":"MAPK\/ERK Pathway as a central regulator in vertebrate organ regeneration","volume":"23","author":"Wen","year":"2022","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib71","doi-asserted-by":"publisher","first-page":"8021","DOI":"10.1038\/s41467-023-43728-8","article-title":"JUN upregulation drives aberrant transposable element mobilization, associated innate immune response, and impaired neurogenesis in Alzheimer\u2019s disease","volume":"14","author":"Scopa","year":"2023","journal-title":"Nat Commun"},{"key":"2026091508161545100_bib72","doi-asserted-by":"publisher","first-page":"1405","DOI":"10.1016\/j.ijcard.2014.08.019","article-title":"BDNF expression of macrophages and angiogenesis after myocardial infarction","volume":"176","author":"Hong","year":"2014","journal-title":"Int J Cardiol"},{"key":"2026091508161545100_bib73","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1186\/s12872-018-0762-z","article-title":"Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease","volume":"18","author":"Jin","year":"2018","journal-title":"BMC Cardiovasc Disord"},{"key":"2026091508161545100_bib74","doi-asserted-by":"publisher","first-page":"1880","DOI":"10.1073\/pnas.1417949112","article-title":"Constitutive BDNF\/TrkB signaling is required for normal cardiac contraction and relaxation","volume":"112","author":"Feng","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2026091508161545100_bib75","doi-asserted-by":"publisher","first-page":"H1821","DOI":"10.1152\/ajpheart.00245.2018","article-title":"Effects of exercise training and TrkB blockade on cardiac function and BDNF-TrkB signaling postmyocardial infarction in rats","volume":"315","author":"Lee","year":"2018","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"2026091508161545100_bib76","doi-asserted-by":"publisher","first-page":"2921","DOI":"10.1007\/s12035-023-03758-1","article-title":"Role of brain-derived neurotrophic factor in anxiety or depression after percutaneous coronary intervention","volume":"61","author":"Ning","year":"2024","journal-title":"Mol Neurobiol"},{"key":"2026091508161545100_bib77","doi-asserted-by":"publisher","first-page":"4926","DOI":"10.1007\/s12035-022-02889-1","article-title":"Interactions among brain-derived neurotrophic factor and neuroimmune pathways are key components of the major psychiatric disorders","volume":"59","author":"Mehterov","year":"2022","journal-title":"Mol Neurobiol"},{"key":"2026091508161545100_bib78","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1161\/CIRCRESAHA.122.321583","article-title":"\u03b23AR-dependent brain-derived neurotrophic factor (BDNF) generation limits chronic postischemic heart failure","volume":"132","author":"Cannavo","year":"2023","journal-title":"Circ Res"},{"key":"2026091508161545100_bib79","doi-asserted-by":"publisher","first-page":"7483","DOI":"10.3390\/ijms22147483","article-title":"Escitalopram targets oxidative stress, caspase-3, BDNF and MeCP2 in the hippocampus and frontal cortex of a rat model of depression induced by chronic unpredictable mild stress","volume":"22","author":"Dionisie","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib80","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.7150\/thno.81067","article-title":"Hyperactive neuronal autophagy depletes BDNF and impairs adult hippocampal neurogenesis in a corticosterone-induced mouse model of depression","volume":"13","author":"Zhang","year":"2023","journal-title":"Theranostics"},{"key":"2026091508161545100_bib81","doi-asserted-by":"publisher","first-page":"850","DOI":"10.1111\/jne.12324","article-title":"Involvement of endogenous brain-derived neurotrophic factor in hypothalamic-pituitary-adrenal axis activity","volume":"27","author":"Naert","year":"2015","journal-title":"J Neuroendocrinol"},{"key":"2026091508161545100_bib82","doi-asserted-by":"publisher","first-page":"15421","DOI":"10.1038\/s41598-019-51776-8","article-title":"Brain-derived neurotrophic factor is related with adverse cardiac remodeling and high NTproBNP","volume":"9","author":"Bahls","year":"2019","journal-title":"Sci Rep"},{"key":"2026091508161545100_bib83","doi-asserted-by":"publisher","first-page":"244","DOI":"10.18502\/jthc.v18i4.14823","article-title":"Peripheral levels of the brain-derived neurotrophic factor in coronary artery disease: a systematic review and meta-analysis","volume":"18","author":"Shobeiri","year":"2023","journal-title":"J Tehran Heart Cent"},{"key":"2026091508161545100_bib84","doi-asserted-by":"publisher","first-page":"19108","DOI":"10.1038\/s41598-021-98663-9","article-title":"Interaction between dietary total antioxidant capacity and BDNF Val66Met polymorphism on lipid profiles and atherogenic indices among diabetic patients","volume":"11","author":"Abaj","year":"2021","journal-title":"Sci Rep"},{"key":"2026091508161545100_bib85","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1038\/417405a","article-title":"Prokineticin 2 transmits the behavioural circadian rhythm of the suprachiasmatic nucleus","volume":"417","author":"Cheng","year":"2002","journal-title":"Nature"},{"key":"2026091508161545100_bib86","doi-asserted-by":"publisher","first-page":"19276","DOI":"10.1074\/jbc.M202139200","article-title":"Identification and molecular characterization of two closely related G protein-coupled receptors activated by prokineticins\/endocrine gland vascular endothelial growth factor","volume":"277","author":"Lin","year":"2002","journal-title":"J Biol Chem"},{"key":"2026091508161545100_bib87","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1016\/s0167-4781(00)00023-3","article-title":"Y-receptor-like genes GPR72 and GPR73: molecular cloning, genomic organisation and assignment to human chromosome 11q21.1 and 2p14 and mouse chromosome 9 and 6","volume":"1491","author":"Parker","year":"2000","journal-title":"Biochim Biophys Acta (BBA)\u2014Gene Struct Expr"},{"key":"2026091508161545100_bib88","doi-asserted-by":"publisher","first-page":"1055","DOI":"10.1152\/physrev.00012.2017","article-title":"The prokineticins: neuromodulators and mediators of inflammation and myeloid cell-dependent angiogenesis","volume":"98","author":"Negri","year":"2018","journal-title":"Physiol Rev"},{"key":"2026091508161545100_bib89","doi-asserted-by":"publisher","first-page":"110000","DOI":"10.1016\/j.cellsig.2021.110000","article-title":"Prokineticin receptors interact unselectively with several G protein subtypes but bind selectively to \u03b2-arrestin 2","volume":"83","author":"Casella","year":"2021","journal-title":"Cell Signal"},{"key":"2026091508161545100_bib90","doi-asserted-by":"publisher","first-page":"5109","DOI":"10.1523\/JNEUROSCI.3870-05.2006","article-title":"Sensitization of transient receptor potential vanilloid 1 by the prokineticin receptor agonist Bv8","volume":"26","author":"Vellani","year":"2006","journal-title":"J Neurosci"},{"key":"2026091508161545100_bib91","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.neuroscience.2019.12.003","article-title":"Abnormal pain sensation in mice lacking the prokineticin receptor PKR2: interaction of PKR2 with transient receptor potential TRPV1 and TRPA1","volume":"427","author":"Maftei","year":"2020","journal-title":"Neuroscience"},{"key":"2026091508161545100_bib92","doi-asserted-by":"publisher","first-page":"2980","DOI":"10.1096\/fj.07-8116com","article-title":"The prokineticin receptor-1 (GPR73) promotes cardiomyocyte survival and angiogenesis","volume":"21","author":"Urayama","year":"2007","journal-title":"FASEB J"},{"key":"2026091508161545100_bib93","doi-asserted-by":"publisher","first-page":"8724","DOI":"10.1074\/jbc.M110594200","article-title":"Characterization of endocrine gland-derived vascular endothelial growth factor signaling in adrenal cortex capillary endothelial cells","volume":"277","author":"Lin","year":"2002","journal-title":"J Biol Chem"},{"key":"2026091508161545100_bib94","doi-asserted-by":"publisher","first-page":"2070","DOI":"10.1124\/mol.105.0116199","article-title":"Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1","volume":"67","author":"Chen","year":"2005","journal-title":"Mol Pharmacol"},{"key":"2026091508161545100_bib95","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1093\/cvr\/cvr228","article-title":"Prokineticin receptor 1 (PKR1) signalling in cardiovascular and kidney functions","volume":"92","author":"Boulberdaa","year":"2011","journal-title":"Cardiovasc Res"},{"key":"2026091508161545100_bib96","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1080\/21691401.2019.1709850","article-title":"Prokineticin 2 relieves hypoxia\/reoxygenation-induced injury through activation of Akt\/mTOR pathway in H9c2 cardiomyocytes","volume":"48","author":"Su","year":"2020","journal-title":"Artificial Cells, Nanomedicine, and Biotechnology"},{"key":"2026091508161545100_bib97","doi-asserted-by":"publisher","first-page":"841","DOI":"10.1161\/ATVBAHA.108.162404","article-title":"Prokineticin receptor-1 induces neovascularization and epicardial-derived progenitor cell differentiation","volume":"28","author":"Urayama","year":"2008","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"2026091508161545100_bib98","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1093\/cvr\/cvn251","article-title":"Transgenic myocardial overexpression of prokineticin receptor-2 (GPR73b) induces hypertrophy and capillary vessel leakage","volume":"81","author":"Urayama","year":"2009","journal-title":"Cardiovasc Res"},{"key":"2026091508161545100_bib99","doi-asserted-by":"publisher","first-page":"H844","DOI":"10.1152\/ajpheart.00898.2009","article-title":"Divergent roles of prokineticin receptors in the endothelial cells: angiogenesis and fenestration","volume":"298","author":"Guilini","year":"2010","journal-title":"Am J Physiol-Heart Circ Physiol"},{"key":"2026091508161545100_bib100","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1161\/HYPERTENSIONAHA.116.08037","article-title":"Updates on endothelial functions of proangiogenic prokineticin","volume":"68","author":"Nebigil","year":"2016","journal-title":"Hypertension"},{"key":"2026091508161545100_bib101","doi-asserted-by":"publisher","first-page":"2832","DOI":"10.1091\/mbc.E10-01-0059","article-title":"Molecular characterization of EG-VEGF-mediated angiogenesis: differential effects on microvascular and macrovascular endothelial cells","volume":"21","author":"Brouillet","year":"2010","journal-title":"MBoC"},{"key":"2026091508161545100_bib102","doi-asserted-by":"publisher","first-page":"25541","DOI":"10.1038\/srep25541","article-title":"Prokineticin receptor-1 signaling promotes Eepicardial to mesenchymal transition during heart development","volume":"6","author":"Arora","year":"2016","journal-title":"Sci Rep"},{"key":"2026091508161545100_bib103","doi-asserted-by":"publisher","first-page":"1589","DOI":"10.1002\/stem.2866","article-title":"A prokineticin-driven epigenetic switch regulates human epicardial cell stemness and fate","volume":"36","author":"Qureshi","year":"2018","journal-title":"Stem Cells"},{"key":"2026091508161545100_bib104","doi-asserted-by":"publisher","first-page":"1923","DOI":"10.1126\/science.1112103","article-title":"Dependence of olfactory bulb neurogenesis on prokineticin 2 signaling","volume":"308","author":"Ng","year":"2005","journal-title":"Science"},{"key":"2026091508161545100_bib105","doi-asserted-by":"publisher","first-page":"2931","DOI":"10.1002\/cne.24719","article-title":"The PROK2\/PROKR2 signaling pathway is required for the migration of most olfactory bulb interneurons","volume":"527","author":"Wen","year":"2019","journal-title":"J Comp Neurol"},{"key":"2026091508161545100_bib106","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1111\/j.1460-9568.2007.05958.x","article-title":"Olfactory bulb hypoplasia in Prokr2 null mice stems from defective neuronal progenitor migration and differentiation","volume":"26","author":"Prosser","year":"2007","journal-title":"Eur J of Neuroscience"},{"key":"2026091508161545100_bib107","doi-asserted-by":"publisher","first-page":"4140","DOI":"10.1073\/pnas.0508881103","article-title":"Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2","volume":"103","author":"Matsumoto","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"2026091508161545100_bib108","doi-asserted-by":"publisher","first-page":"e175","DOI":"10.1371\/journal.pgen.0020175","article-title":"Kallmann syndrome: mutations in the genes encoding prokineticin-2 and prokineticin receptor-2","volume":"2","author":"Dod\u00e9","year":"2006","journal-title":"PLoS Genet"},{"key":"2026091508161545100_bib109","doi-asserted-by":"publisher","first-page":"19","DOI":"10.3389\/fendo.2013.00019","article-title":"PROK2\/PROKR2 signaling and Kallmann syndrome","volume":"4","author":"Dod\u00e9","year":"2013","journal-title":"Front Endocrinol"},{"key":"2026091508161545100_bib110","doi-asserted-by":"publisher","first-page":"1160","DOI":"10.1523\/JNEUROSCI.1412-17.2017","article-title":"Loss of intercalated cells (ITCs) in the mouse amygdala of Tshz1 mutants correlates with fear, depression, and social interaction phenotypes","volume":"38","author":"Kuerbitz","year":"2018","journal-title":"J. Neurosci."},{"key":"2026091508161545100_bib111","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.neuropharm.2010.08.014","article-title":"Prokineticin 2 suppresses GABA-activated current in rat primary sensory neurons","volume":"59","author":"Xiong","year":"2010","journal-title":"Neuropharmacology"},{"key":"2026091508161545100_bib112","doi-asserted-by":"publisher","first-page":"114","DOI":"10.1007\/s12017-009-8067-0","article-title":"Possible association of prokineticin 2 receptor gene (PROKR2) with mood disorders in the Japanese population","volume":"11","author":"Kishi","year":"2009","journal-title":"Neuromol Med"},{"key":"2026091508161545100_bib113","doi-asserted-by":"publisher","first-page":"1033","DOI":"10.1016\/j.pnpbp.2010.05.018","article-title":"PROKR2 is associated with methamphetamine dependence in the Japanese population","volume":"34","author":"Kishi","year":"2010","journal-title":"Prog Neuropsychopharmacol Biol Psychiatry"},{"key":"2026091508161545100_bib114","doi-asserted-by":"publisher","first-page":"1167","DOI":"10.1124\/pharmrev.122.000801","article-title":"Therapeutic potential of targeting prokineticin receptors in diseases","volume":"75","author":"Vincenzi","year":"2023","journal-title":"Pharmacol Rev"},{"key":"2026091508161545100_bib115","doi-asserted-by":"publisher","first-page":"188736","DOI":"10.1016\/j.bbcan.2022.188736","article-title":"E3 ligases and deubiquitinating enzymes regulating the MAPK signaling pathway in cancers","volume":"1877","author":"Park","year":"2022","journal-title":"Biochim Biophys Acta (BBA)\u2014Rev Cancer"},{"key":"2026091508161545100_bib116","doi-asserted-by":"publisher","first-page":"451","DOI":"10.1385\/CBB:43:3:451","article-title":"Mitogen-activated protein kinases in cell-cycle control","volume":"43","author":"MacCorkle","year":"2005","journal-title":"Cell Biochem Biophys"},{"key":"2026091508161545100_bib117","doi-asserted-by":"publisher","first-page":"1346","DOI":"10.3390\/ijms20061346","article-title":"Roles of cyclic AMP response element binding activation in the ERK1\/2 and p38 MAPK signalling pathway in central nervous system, cardiovascular system, osteoclast differentiation and mucin and cytokine production","volume":"20","author":"Koga","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib118","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1016\/j.brainresbull.2013.09.007","article-title":"The MAP(K) of fear: from memory consolidation to memory extinction","volume":"105","author":"Cestari","year":"2014","journal-title":"Brain Res Bull"},{"key":"2026091508161545100_bib119","doi-asserted-by":"publisher","first-page":"867","DOI":"10.1007\/s00204-015-1472-2","article-title":"Compromised MAPK signaling in human diseases: an update","volume":"89","author":"Kim","year":"2015","journal-title":"Arch Toxicol"},{"key":"2026091508161545100_bib120","doi-asserted-by":"publisher","first-page":"362","DOI":"10.1038\/mp.2016.203","article-title":"JNK1 controls adult hippocampal neurogenesis and imposes cell-autonomous control of anxiety behaviour from the neurogenic niche","volume":"23","author":"Mohammad","year":"2018","journal-title":"Mol Psychiatry"},{"key":"2026091508161545100_bib121","doi-asserted-by":"publisher","first-page":"104580","DOI":"10.1016\/j.psyneuen.2019.104580","article-title":"Inhibition of JNK ameliorates depressive-like behaviors and reduces the activation of pro-inflammatory cytokines and the phosphorylation of glucocorticoid receptors at serine 246 induced by neuroinflammation","volume":"113","author":"Zhang","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"2026091508161545100_bib122","doi-asserted-by":"publisher","first-page":"e671","DOI":"10.1038\/tp.2015.168","article-title":"A requirement of serotonergic p38\u03b1 mitogen-activated protein kinase for peripheral immune system activation of CNS serotonin uptake and serotonin-linked behaviors","volume":"5","author":"Baganz","year":"2015","journal-title":"Transl Psychiatry"},{"key":"2026091508161545100_bib123","doi-asserted-by":"publisher","first-page":"498","DOI":"10.1016\/j.neuron.2011.06.011","article-title":"Selective p38\u03b1 MAPK deletion in serotonergic neurons produces stress resilience in models of depression and addiction","volume":"71","author":"Bruchas","year":"2011","journal-title":"Neuron"},{"key":"2026091508161545100_bib124","doi-asserted-by":"publisher","first-page":"98","DOI":"10.1186\/s12974-019-1493-5","article-title":"Deletion of p38\u03b1 MAPK in microglia blunts trauma-induced inflammatory responses in mice","volume":"16","author":"Morganti","year":"2019","journal-title":"J Neuroinflammation"},{"key":"2026091508161545100_bib125","doi-asserted-by":"publisher","first-page":"313","DOI":"10.1038\/s41398-022-02094-7","article-title":"The role of the immune system in posttraumatic stress disorder","volume":"12","author":"Katrinli","year":"2022","journal-title":"Transl Psychiatry"},{"key":"2026091508161545100_bib126","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1042\/CS20070430","article-title":"MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets","volume":"115","author":"Muslin","year":"2008","journal-title":"Clin Sci"},{"key":"2026091508161545100_bib127","doi-asserted-by":"publisher","first-page":"319","DOI":"10.1016\/j.ejphar.2016.07.053","article-title":"Activin A stimulates the proliferation and differentiation of cardiac fibroblasts via the ERK1\/2 and p38-MAPK pathways","volume":"789","author":"Hu","year":"2016","journal-title":"Eur J Pharmacol"},{"key":"2026091508161545100_bib128","doi-asserted-by":"publisher","first-page":"116413","DOI":"10.1016\/j.biopha.2024.116413","article-title":"Targeting MAPK-ERK\/JNK pathway: A potential intervention mechanism of myocardial fibrosis in heart failure","volume":"173","author":"Zhang","year":"2024","journal-title":"Biomed Pharmacother"},{"key":"2026091508161545100_bib129","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1016\/j.bcp.2009.04.029","article-title":"Inflammatory cytokines in vascular dysfunction and vascular disease","volume":"78","author":"Sprague","year":"2009","journal-title":"Biochem Pharmacol"},{"key":"2026091508161545100_bib130","doi-asserted-by":"publisher","first-page":"1366","DOI":"10.1038\/s41401-023-01057-y","article-title":"Notoginsenoside R1 protects against myocardial ischemia\/reperfusion injury in mice via suppressing TAK1-JNK\/p38 signaling","volume":"44","author":"Zeng","year":"2023","journal-title":"Acta Pharmacol Sin"},{"key":"2026091508161545100_bib131","doi-asserted-by":"publisher","first-page":"3515","DOI":"10.1242\/jcs.091140","article-title":"ERK1\/2 activation in heart is controlled by melusin, focal adhesion kinase and the scaffold protein IQGAP1","volume":"124","author":"Sbroggi\u00f2","year":"2011","journal-title":"J Cell Sci"},{"key":"2026091508161545100_bib132","doi-asserted-by":"publisher","first-page":"346","DOI":"10.3390\/biology10040346","article-title":"ERK1\/2: an integrator of signals that alters cardiac homeostasis and growth","volume":"10","author":"Gilbert","year":"2021","journal-title":"Biology"},{"key":"2026091508161545100_bib133","doi-asserted-by":"publisher","first-page":"1927","DOI":"10.1016\/s0024-3205(01)01283-8","article-title":"Emotional stress activates MAP kinase in the rat heart","volume":"69","author":"Ueyama","year":"2001","journal-title":"Life Sci"},{"key":"2026091508161545100_bib134","doi-asserted-by":"publisher","first-page":"464","DOI":"10.3389\/fphar.2017.00464","article-title":"Attenuation of TNF-\u03b1-induced inflammatory injury in endothelial cells by ginsenoside Rb1 via inhibiting NF-\u03baB, JNK and p38 signaling pathways","volume":"8","author":"Zhou","year":"2017","journal-title":"Front Pharmacol"},{"key":"2026091508161545100_bib135","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.1016\/j.biopha.2016.10.036","article-title":"The protective role of liquiritin in high fructose-induced myocardial fibrosis via inhibiting NF-\u03baB and MAPK signaling pathway","volume":"84","author":"Zhang","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"2026091508161545100_bib136","doi-asserted-by":"publisher","first-page":"112545","DOI":"10.1016\/j.biopha.2021.112545","article-title":"Polyphenols inhibiting MAPK signalling pathway mediated oxidative stress and inflammation in depression","volume":"146","author":"Behl","year":"2022","journal-title":"Biomed Pharmacother"},{"key":"2026091508161545100_bib137","doi-asserted-by":"publisher","first-page":"1049","DOI":"10.1210\/en.2016-1839","article-title":"The diverse metabolic roles of peripheral serotonin","volume":"158","author":"Martin","year":"2017","journal-title":"Endocrinology"},{"key":"2026091508161545100_bib138","doi-asserted-by":"publisher","first-page":"1128","DOI":"10.1016\/s0006-3223(98)00132-2","article-title":"The molecular biology of serotonin receptors: therapeutic implications for the interface of mood and psychosis","volume":"44","author":"Kroeze","year":"1998","journal-title":"Biol Psychiatry"},{"key":"2026091508161545100_bib139","doi-asserted-by":"publisher","first-page":"472","DOI":"10.1016\/j.tips.2008.06.009","article-title":"5-hydroxytryptamine and cardiovascular regulation","volume":"29","author":"Ramage","year":"2008","journal-title":"Trends Pharmacol Sci"},{"key":"2026091508161545100_bib140","doi-asserted-by":"publisher","first-page":"108155","DOI":"10.1016\/j.neuropharm.2020.108155","article-title":"Central 5-HT receptors and their function; present and future","volume":"177","author":"Sharp","year":"2020","journal-title":"Neuropharmacology"},{"key":"2026091508161545100_bib141","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1002\/jnr.23180","article-title":"HTR2A-1438A\/G polymorphism influences the risk of schizophrenia but not bipolar disorder or major depressive disorder: a meta-analysis","volume":"91","author":"Gu","year":"2013","journal-title":"J Neurosc Res"},{"key":"2026091508161545100_bib142","doi-asserted-by":"publisher","first-page":"811","DOI":"10.1017\/s146114570800847x","article-title":"The role of 5-HT2A and 5-HT2C receptors in the signal attenuation rat model of obsessive-compulsive disorder","volume":"11","author":"Flaisher-Grinberg","year":"2008","journal-title":"Int J Neuropsychopharm"},{"key":"2026091508161545100_bib143","doi-asserted-by":"publisher","first-page":"357","DOI":"10.1016\/s0022-3956(03)00050-5","article-title":"Involvement of serotonin in depression: evidence from postmortem and imaging studies of serotonin receptors and the serotonin transporter","volume":"37","author":"Stockmeier","year":"2003","journal-title":"J Psychiatr Res"},{"key":"2026091508161545100_bib144","doi-asserted-by":"publisher","first-page":"1487","DOI":"10.2217\/14622416.9.10.1487","article-title":"Genetic susceptibility to eating disorders: associated polymorphisms and pharmacogenetic suggestions","volume":"9","author":"Monteleone","year":"2008","journal-title":"Pharmacogenomics"},{"key":"2026091508161545100_bib145","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1038\/sj.mp.4002100","article-title":"Exploration of 19 serotoninergic candidate genes in adults and children with attention-deficit\/hyperactivity disorder identifies association for 5HT2A, DDC and MAOB","volume":"14","author":"Ribas\u00e9s","year":"2009","journal-title":"Mol Psychiatry"},{"key":"2026091508161545100_bib146","doi-asserted-by":"publisher","first-page":"505","DOI":"10.1080\/15622975.2020.1839967","article-title":"5-HT2A receptor-mediated G\u03b1q\/11 activation in psychiatric disorders: a postmortem study","volume":"22","author":"Odagaki","year":"2021","journal-title":"World J Biol Psychiatry"},{"key":"2026091508161545100_bib147","doi-asserted-by":"publisher","first-page":"2490","DOI":"10.1152\/jn.00843.2001","article-title":"Stimulation of 5-HT2 receptors in prefrontal pyramidal neurons inhibits Cav1.2 L type Ca2+ currents via a PLC\u03b2\/IP3\/calcineurin signaling cascade","volume":"87","author":"Day","year":"2002","journal-title":"J Neurophysiol"},{"key":"2026091508161545100_bib148","doi-asserted-by":"publisher","first-page":"26","DOI":"10.1111\/j.1749-6632.1991.tb36478.x","article-title":"Enzymatic gating of voltage-activated calcium channels","volume":"635","author":"Armstrong","year":"1991","journal-title":"Ann NY Acad Sci"},{"key":"2026091508161545100_bib149","doi-asserted-by":"publisher","first-page":"12138","DOI":"10.1523\/jneurosci.3245-10.2010","article-title":"Enhanced function of prefrontal serotonin 5-HT2 receptors in a rat model of psychiatric vulnerability","volume":"30","author":"Benekareddy","year":"2010","journal-title":"J Neurosci"},{"key":"2026091508161545100_bib150","doi-asserted-by":"publisher","first-page":"1145","DOI":"10.1046\/j.1471-4159.1996.67031145.x","article-title":"Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects","volume":"67","author":"Friedman","year":"1996","journal-title":"J Neurochem"},{"key":"2026091508161545100_bib151","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1177\/0269881109106911","article-title":"5-HT2A receptor antagonism by MDL 11,939 during inescapable stress prevents subsequent exaggeration of acoustic startle response and reduced body weight in rats","volume":"25","author":"Jiang","year":"2011","journal-title":"J Psychopharmacol"},{"key":"2026091508161545100_bib152","doi-asserted-by":"publisher","first-page":"1325","DOI":"10.1152\/physrev.00023.2003","article-title":"Ca2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase","volume":"83","author":"Somlyo","year":"2003","journal-title":"Physiol Rev"},{"key":"2026091508161545100_bib153","doi-asserted-by":"publisher","first-page":"115317","DOI":"10.1016\/j.bcp.2022.115317","article-title":"The Ca2+\/CaM, Src kinase and\/or PI3K-dependent EGFR transactivation via 5-HT2A and 5-HT1B receptor subtypes mediates 5-HT-induced vasoconstriction","volume":"206","author":"Guner","year":"2022","journal-title":"Biochem Pharmacol"},{"key":"2026091508161545100_bib154","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1182\/blood-2008-06-162032","article-title":"Group IVA cytosolic phospholipase A2 (cPLA2\u03b1) and integrin \u03b1IIb\u03b23 reinforce each other\u2019s functions during \u03b1IIb\u03b23 signaling in platelets","volume":"113","author":"Pr\u00e9vost","year":"2009","journal-title":"Blood"},{"key":"2026091508161545100_bib155","doi-asserted-by":"publisher","first-page":"B11","DOI":"10.1016\/0002-9149(91)90379-y","article-title":"Mechanisms of platelet activation: thromboxane A2 as an amplifying signal for other agonists","volume":"68","author":"FitzGerald","year":"1991","journal-title":"Am J Cardiol"},{"key":"2026091508161545100_bib156","doi-asserted-by":"publisher","first-page":"322","DOI":"10.5551\/jat.58305","article-title":"5-HT2A Receptor and 5-HT degradation play a crucial role in atherosclerosis by modulating macrophage foam cell formation, vascular endothelial cell inflammation, and hepatic steatosis","volume":"29","author":"Ma","year":"2022","journal-title":"JAT"},{"key":"2026091508161545100_bib157","doi-asserted-by":"publisher","first-page":"729","DOI":"10.1097\/01.psy.0000088596.42029.10","article-title":"Increased coronary events in depressed cardiovascular patients: 5-HT2A receptor as missing link?","volume":"65","author":"Schins","year":"2003","journal-title":"Psychosom Med"},{"key":"2026091508161545100_bib158","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2009\/475108","article-title":"Serotonin 5-HT2A receptor function as a contributing factor to both neuropsychiatric and cardiovascular diseases","volume":"2009","author":"Nichols","year":"2009","journal-title":"Cardiovasc Psychiatry Neurol"},{"key":"2026091508161545100_bib159","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1016\/j.psyneuen.2016.11.015","article-title":"Serotonin 2A receptor (5-HT2A) gene promoter variant interacts with chronic perceived stress to modulate resting parasympathetic activity in humans","volume":"76","author":"Chang","year":"2017","journal-title":"Psychoneuroendocrinology"},{"key":"2026091508161545100_bib160","doi-asserted-by":"publisher","first-page":"1619","DOI":"10.1021\/acschemneuro.4c00031","article-title":"Serotonin receptors in myocardial infarction: friend or foe?","volume":"15","author":"Bahr","year":"2024","journal-title":"ACS Chem Neurosci"},{"key":"2026091508161545100_bib161","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1016\/j.autneu.2009.01.004","article-title":"5-HT2A receptors are concentrated in regions of the human infant medulla involved in respiratory and autonomic control","volume":"147","author":"Paterson","year":"2009","journal-title":"Auton Neurosci"},{"key":"2026091508161545100_bib162","doi-asserted-by":"publisher","first-page":"e75426","DOI":"10.1371\/journal.pone.0075426","article-title":"Serotonin 5-HT2A receptor activation blocks TNF-\u03b1 mediated inflammation in vivo.","volume":"8","author":"Nau","year":"2013","journal-title":"PLoS One"},{"key":"2026091508161545100_bib163","doi-asserted-by":"publisher","first-page":"927","DOI":"10.1007\/s00702-013-1011-3","article-title":"Role of serotonin 5-HT2A receptors in the development of cardiac hypertrophy in response to aortic constriction in mice","volume":"120","author":"Lairez","year":"2013","journal-title":"J Neural Transm"},{"key":"2026091508161545100_bib164","doi-asserted-by":"publisher","first-page":"2068","DOI":"10.3390\/diagnostics16132068","article-title":"Serotonin in cardiovascular disease: from pathophysiological insights to clinical utility","volume":"16","author":"Veliz\u00a0Perez","year":"2026","journal-title":"Diagnostics"},{"key":"2026091508161545100_bib165","doi-asserted-by":"publisher","first-page":"367","DOI":"10.1016\/j.bbi.2017.03.002","article-title":"NLRP3 inflammasome-driven pathways in depression: clinical and preclinical findings","volume":"64","author":"Kaufmann","year":"2017","journal-title":"Brain Behav Immun"},{"key":"2026091508161545100_bib166","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1038\/nri.2016.58","article-title":"Inflammasomes: mechanism of assembly, regulation and signalling","volume":"16","author":"Broz","year":"2016","journal-title":"Nat Rev Immunol"},{"key":"2026091508161545100_bib167","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1016\/j.tibs.2022.10.002","article-title":"The NLRP3 inflammasome: activation and regulation","volume":"48","author":"Xu","year":"2023","journal-title":"Trends Biochem Sci"},{"key":"2026091508161545100_bib168","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/s41586-022-05570-8","article-title":"Cryo-EM structures of the active NLRP3 inflammasome disc","volume":"613","author":"Xiao","year":"2023","journal-title":"Nature"},{"key":"2026091508161545100_bib169","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1038\/s41586-019-1295-z","article-title":"Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome","volume":"570","author":"Sharif","year":"2019","journal-title":"Nature"},{"key":"2026091508161545100_bib170","doi-asserted-by":"publisher","first-page":"588","DOI":"10.1038\/nrd.2018.97","article-title":"Targeting the NLRP3 inflammasome in inflammatory diseases","volume":"17","author":"Mangan","year":"2018","journal-title":"Nat Rev Drug Discov"},{"key":"2026091508161545100_bib171","doi-asserted-by":"publisher","first-page":"105","DOI":"10.1016\/j.bbi.2012.12.008","article-title":"The inflammasome: pathways linking psychological stress, depression, and systemic illnesses","volume":"31","author":"Iwata","year":"2013","journal-title":"Brain Behav Immun"},{"key":"2026091508161545100_bib172","doi-asserted-by":"publisher","first-page":"pyv006","DOI":"10.1093\/ijnp\/pyv006","article-title":"NLRP3 Inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation","volume":"18","author":"Zhang","year":"2015","journal-title":"Int J Neuropsychopharmacolog"},{"key":"2026091508161545100_bib173","doi-asserted-by":"publisher","first-page":"210","DOI":"10.3389\/fnmol.2019.00210","article-title":"Glucocorticoid-driven NLRP3 inflammasome activation in hippocampal microglia mediates chronic stress-induced depressive-like behaviors","volume":"12","author":"Feng","year":"2019","journal-title":"Front Mol Neurosci"},{"key":"2026091508161545100_bib174","doi-asserted-by":"publisher","first-page":"717","DOI":"10.1038\/sj.mp.4002055","article-title":"Brain interleukin-1 mediates chronic stress-induced depression in mice via adrenocortical activation and hippocampal neurogenesis suppression","volume":"13","author":"Goshen","year":"2008","journal-title":"Mol Psychiatry"},{"key":"2026091508161545100_bib175","doi-asserted-by":"publisher","first-page":"257","DOI":"10.2174\/1568010023344599","article-title":"The mechanisms of immune-to-brain communication in inflammation as a drug target","volume":"1","author":"Hosoi","year":"2002","journal-title":"Curr Drug Targets Inflamm Allergy"},{"key":"2026091508161545100_bib176","doi-asserted-by":"publisher","first-page":"206","DOI":"10.3390\/jcdd11070206","article-title":"Systematic review on the role of IL-6 and IL-1\u03b2 in cardiovascular diseases","volume":"11","author":"Katkenov","year":"2024","journal-title":"J Cardiovasc Dev Dis"},{"key":"2026091508161545100_bib177","doi-asserted-by":"publisher","first-page":"188","DOI":"10.1097\/fjc.0000000000000709","article-title":"Cell-specific roles of NLRP3 inflammasome in myocardial infarction","volume":"74","author":"Takahashi","year":"2019","journal-title":"J Cardiovasc Pharmacol"},{"key":"2026091508161545100_bib178","doi-asserted-by":"publisher","first-page":"338","DOI":"10.1161\/circulationaha.122.060860","article-title":"NLRP3 inflammasome activation through heart-brain interaction initiates cardiac inflammation and hypertrophy during pressure overload","volume":"147","author":"Higashikuni","year":"2023","journal-title":"Circulation"},{"key":"2026091508161545100_bib179","doi-asserted-by":"publisher","first-page":"107511","DOI":"10.1016\/j.pharmthera.2020.107511","article-title":"Targeting the NLRP3 inflammasome to treat cardiovascular fibrosis","volume":"209","author":"Pinar","year":"2020","journal-title":"Pharmacol Ther"},{"key":"2026091508161545100_bib180","doi-asserted-by":"publisher","first-page":"15","DOI":"10.5152\/AnatolJCardiol.2021.580","article-title":"NLRP3 inflammasome as a novel therapeutic target for heart failure","volume":"26","author":"Wang","year":"2022","journal-title":"Anatol J Cardiol"},{"key":"2026091508161545100_bib181","doi-asserted-by":"publisher","first-page":"91","DOI":"10.1002\/ctm2.13","article-title":"NLRP3 inflammasome, an immune-inflammatory target in pathogenesis and treatment of cardiovascular diseases","volume":"10","author":"Wang","year":"2020","journal-title":"Clin Transl Med"},{"key":"2026091508161545100_bib182","doi-asserted-by":"publisher","first-page":"4330574","DOI":"10.1155\/mi\/4330574","article-title":"NLRP3 inflammasome: a new target for the treatment of CVD and depression comorbidity","volume":"2025","author":"Chen","year":"2025","journal-title":"Mediators Inflamm"},{"key":"2026091508161545100_bib183","doi-asserted-by":"publisher","first-page":"117003","DOI":"10.1016\/j.psychres.2026.117003","article-title":"NLRP3 inflammasome priming and activation is involved in depression: a systematic review and meta-analysis","volume":"359","author":"McColgan","year":"2026","journal-title":"Psychiatry Res"},{"key":"2026091508161545100_bib184","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1186\/s12974-020-01879-1","article-title":"NLRP3 inflammasome-mediated microglial pyroptosis is critically involved in the development of post-cardiac arrest brain injury","volume":"17","author":"Chang","year":"2020","journal-title":"J Neuroinflammation"},{"key":"2026091508161545100_bib185","doi-asserted-by":"publisher","first-page":"pyw037","DOI":"10.1093\/ijnp\/pyw037","article-title":"Fluoxetine inhibits NLRP3 inflammasome activation: implication in depression","volume":"19","author":"Du","year":"2016","journal-title":"Int J Neuropsychopharmacol"},{"key":"2026091508161545100_bib186","doi-asserted-by":"publisher","first-page":"863426","DOI":"10.3389\/fncel.2022.863426","article-title":"NLRP3-dependent pyroptosis: a candidate therapeutic target for depression","volume":"16","author":"Wan","year":"2022","journal-title":"Front Cell Neurosci"},{"key":"2026091508161545100_bib187","doi-asserted-by":"publisher","first-page":"106625","DOI":"10.1016\/j.phrs.2022.106625","article-title":"The NLRP3 inflammasome in depression: potential mechanisms and therapies","volume":"187","author":"Xia","year":"2023","journal-title":"Pharmacol Res"},{"key":"2026091508161545100_bib188","doi-asserted-by":"publisher","first-page":"105575","DOI":"10.1016\/j.intimp.2019.04.022","article-title":"The selective NLRP3-inflammasome inhibitor MCC950 reduces myocardial fibrosis and improves cardiac remodeling in a mouse model of myocardial infarction","volume":"74","author":"Gao","year":"2019","journal-title":"Int Immunopharmacol"},{"key":"2026091508161545100_bib189","doi-asserted-by":"publisher","first-page":"589654","DOI":"10.3389\/fimmu.2020.589654","article-title":"Targeting IL-1\u03b2 in the treatment of atherosclerosis","volume":"11","author":"Mai","year":"2020","journal-title":"Front Immunol"},{"key":"2026091508161545100_bib190","doi-asserted-by":"publisher","first-page":"136290","DOI":"10.1016\/j.neulet.2021.136290","article-title":"Inhibition of the NLRP3 inflammasome with MCC950 prevents chronic social isolation-induced depression-like behavior in male mice","volume":"765","author":"Li","year":"2021","journal-title":"Neurosci Lett"},{"key":"2026091508161545100_bib191","doi-asserted-by":"publisher","first-page":"109","DOI":"10.1007\/s12529-012-9282-x","article-title":"Psychological interventions for coronary heart disease: cochrane systematic review and meta-analysis","volume":"21","author":"Whalley","year":"2014","journal-title":"Int J Behav Med"},{"key":"2026091508161545100_bib192","doi-asserted-by":"publisher","first-page":"e031117","DOI":"10.1161\/jaha.123.031117","article-title":"Impact of mental health treatment on outcomes in patients with heart failure and ischemic heart disease","volume":"13","author":"Carmin","year":"2024","journal-title":"J Am Heart Assoc"},{"key":"2026091508161545100_bib193","doi-asserted-by":"publisher","first-page":"831359","DOI":"10.3389\/fpsyt.2022.831359","article-title":"Psychological and psychopharmacological interventions in psychocardiology","volume":"13","author":"Kahl","year":"2022","journal-title":"Front Psychiatry"},{"key":"2026091508161545100_bib194","doi-asserted-by":"publisher","first-page":"100116","DOI":"10.1016\/j.bionps.2024.100116","article-title":"HPA system in anxiety disorder patients treated with cognitive behavioural therapy: a review","volume":"12","author":"Lange","year":"2025","journal-title":"Biomark Neuropsychiatry"},{"key":"2026091508161545100_bib195","doi-asserted-by":"publisher","first-page":"1552","DOI":"10.3390\/neurolint16060115","article-title":"Mindfulness-based interventions and the hypothalamic-pituitary-adrenal axis: a systematic review","volume":"16","author":"Vargas-Uricoechea","year":"2024","journal-title":"Neurol Int"},{"key":"2026091508161545100_bib196","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.psyneuen.2019.03.009","article-title":"Cognitive behavioral therapy, mindfulness, and cortisol habituation: a randomized controlled trial","volume":"104","author":"Manigault","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"2026091508161545100_bib197","doi-asserted-by":"publisher","first-page":"418","DOI":"10.3389\/fpsyt.2018.00418","article-title":"Methylation of FKBP5 and SLC6A4 in relation to treatment response to mindfulness based stress reduction for posttraumatic stress disorder","volume":"9","author":"Bishop","year":"2018","journal-title":"Front Psychiatry"},{"key":"2026091508161545100_bib198","doi-asserted-by":"publisher","first-page":"512","DOI":"10.1007\/s12671-017-0793-z","article-title":"Mindfulness training, yoga, or both? Dismantling the active components of a mindfulness-based stress reduction intervention","volume":"9","author":"Hunt","year":"2018","journal-title":"Mindfulness"},{"key":"2026091508161545100_bib199","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1016\/j.janxdis.2019.03.001","article-title":"Heart rate variability in patients with agoraphobia with or without panic disorder remains stable during CBT but increases following in-vivo exposure","volume":"64","author":"Mumm","year":"2019","journal-title":"J Anxiety Disord"},{"key":"2026091508161545100_bib200","doi-asserted-by":"publisher","first-page":"4445","DOI":"10.3390\/ijms24054445","article-title":"Only small effects of mindfulness-based interventions on biomarker levels of inflammation and stress: a preregistered systematic review and two three-level meta-analyses","volume":"24","author":"Grasmann","year":"2023","journal-title":"Int J Mol Sci"},{"key":"2026091508161545100_bib201","doi-asserted-by":"publisher","first-page":"1095","DOI":"10.1016\/j.bbi.2012.07.006","article-title":"Mindfulness-based stress reduction training reduces loneliness and pro-inflammatory gene expression in older adults: a small randomized controlled trial","volume":"26","author":"Creswell","year":"2012","journal-title":"Brain Behav Immun"},{"key":"2026091508161545100_bib202","doi-asserted-by":"publisher","first-page":"e2576","DOI":"10.1371\/journal.pone.0002576","article-title":"Genomic counter-stress changes induced by the relaxation response","volume":"3","author":"Dusek","year":"2008","journal-title":"PLoS One"},{"key":"2026091508161545100_bib203","doi-asserted-by":"publisher","first-page":"366","DOI":"10.1016\/j.biopsych.2011.10.007","article-title":"Cognitive-behavioral stress management reverses anxiety-related leukocyte transcriptional dynamics","volume":"71","author":"Antoni","year":"2012","journal-title":"Biol Psychiatry"},{"key":"2026091508161545100_bib204","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1007\/s00392-020-01697-8","article-title":"The impact of SSRIs on mortality and cardiovascular events in patients with coronary artery disease and depression: systematic review and meta-analysis","volume":"110","author":"Fernandes","year":"2021","journal-title":"Clin Res Cardiol"},{"key":"2026091508161545100_bib205","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.ejphar.2018.07.033","article-title":"Platelet serotonin and serotonin transporter as peripheral surrogates in depression and anxiety patients","volume":"834","author":"Zhuang","year":"2018","journal-title":"Eur J Pharmacol"},{"key":"2026091508161545100_bib206","doi-asserted-by":"publisher","first-page":"16677","DOI":"10.1038\/s41598-018-34389-5","article-title":"Two novel, putative mechanisms of action for citalopram-induced platelet inhibition","volume":"8","author":"Roweth","year":"2018","journal-title":"Sci Rep"},{"key":"2026091508161545100_bib207","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.thromres.2013.02.007","article-title":"Selective serotonin reuptake inhibitors reduce P2Y12 receptor-mediated amplification of platelet aggregation","volume":"131","author":"Tseng","year":"2013","journal-title":"Thromb Res"},{"key":"2026091508161545100_bib208","doi-asserted-by":"publisher","first-page":"E19","DOI":"10.1161\/01.Cir.0000113707.06004.3b","article-title":"Selective serotonin reuptake inhibitors and myocardial infarction","volume":"109","author":"Le\u00a0Mell\u00e9do","year":"2004","journal-title":"Circulation"},{"key":"2026091508161545100_bib209","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1177\/02698811231152748","article-title":"Associations of antidepressants and antipsychotics with lipid parameters: Do CYP2C19\/CYP2D6 genes play a role? A UK population-based study","volume":"37","author":"Richards-Belle","year":"2023","journal-title":"J Psychopharmacol"},{"key":"2026091508161545100_bib210","doi-asserted-by":"publisher","first-page":"115300","DOI":"10.1016\/j.psychres.2023.115300","article-title":"Cardiovascular toxicity induced by SSRIs: analysis of spontaneous reports submitted to FAERS","volume":"326","author":"Chen","year":"2023","journal-title":"Psychiatry Res"},{"key":"2026091508161545100_bib211","doi-asserted-by":"publisher","first-page":"813","DOI":"10.1124\/jpet.123.002013","article-title":"Reversal of high fat diet-induced obesity, systemic inflammation, and astrogliosis by the NLRP3 inflammasome inhibitors NT-0249 and NT-0796","volume":"388","author":"Thornton","year":"2024","journal-title":"J Pharmacol Exp Ther"},{"key":"2026091508161545100_bib212","doi-asserted-by":"publisher","first-page":"14897","DOI":"10.1021\/acs.jmedchem.3c01398","article-title":"Discovery of clinical candidate NT-0796, a brain-penetrant and highly potent NLRP3 inflammasome inhibitor for neuroinflammatory disorders","volume":"66","author":"Harrison","year":"2023","journal-title":"J Med Chem"},{"key":"2026091508161545100_bib213","doi-asserted-by":"publisher","first-page":"1479","DOI":"10.2174\/1570159X19666210915122820","article-title":"7,8-Dihydroxyflavone and neuropsychiatric disorders: a translational perspective from the mechanism to drug development","volume":"20","author":"Yang","year":"2022","journal-title":"Curr Neuropharmacol"},{"key":"2026091508161545100_bib214","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.freeradbiomed.2018.11.024","article-title":"Activation of cardiac TrkB receptor by its small molecular agonist 7,8-dihydroxyflavone inhibits doxorubicin-induced cardiotoxicity via enhancing mitochondrial oxidative phosphorylation","volume":"130","author":"Zhao","year":"2019","journal-title":"Free Radical Biol Med"},{"key":"2026091508161545100_bib215","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1016\/j.freeradbiomed.2019.09.033","article-title":"Brain-derived neurotrophic factor mimetic, 7,8-dihydroxyflavone, protects against myocardial ischemia by rebalancing optic atrophy 1 processing","volume":"145","author":"Wang","year":"2019","journal-title":"Free Radical Biol Med"},{"key":"2026091508161545100_bib216","doi-asserted-by":"publisher","first-page":"175420","DOI":"10.1016\/j.ejphar.2022.175420","article-title":"7,8-Dihydroxyflavone alleviates cardiac fibrosis by restoring circadian signals via downregulating Bmal1\/Akt pathway","volume":"938","author":"Hang","year":"2023","journal-title":"Eur J Pharmacol"},{"key":"2026091508161545100_bib217","doi-asserted-by":"publisher","first-page":"S32.e11","DOI":"10.1016\/j.wneu.2012.12.028","article-title":"Gene therapy for psychiatric disorders","volume":"80","author":"Gelfand","year":"2013","journal-title":"World Neurosurg"},{"key":"2026091508161545100_bib218","doi-asserted-by":"publisher","first-page":"360","DOI":"10.1038\/s41434-020-0148-6","article-title":"Gene therapy for cardiovascular diseases in China: basic research","volume":"27","author":"Deng","year":"2020","journal-title":"Gene Ther"},{"key":"2026091508161545100_bib219","doi-asserted-by":"publisher","first-page":"1285","DOI":"10.1016\/j.hlc.2018.03.005","article-title":"Adeno-associated virus gene therapy: translational progress and future prospects in the treatment of heart failure","volume":"27","author":"Bass-Stringer","year":"2018","journal-title":"Heart, Lung Circ"},{"key":"2026091508161545100_bib220","doi-asserted-by":"publisher","first-page":"22404","DOI":"10.1038\/srep22404","article-title":"Intranasal delivery of recombinant AAV containing BDNF fused with HA2TAT: a potential promising therapy strategy for major depressive disorder","volume":"6","author":"Ma","year":"2016","journal-title":"Sci Rep"},{"key":"2026091508161545100_bib221","doi-asserted-by":"publisher","first-page":"203","DOI":"10.1038\/s41434-025-00553-6","article-title":"High-throughput evaluation of cardiac-specific promoters for adeno-associated virus mediated cardiac gene therapy","volume":"33","author":"Ravindran","year":"2026","journal-title":"Gene Ther"}],"container-title":["Precision Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pcm\/advance-article-pdf\/doi\/10.1093\/pcmedi\/pbag025\/70893422\/pbag025.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcm\/article-pdf\/9\/3\/pbag025\/70893422\/pbag025.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcm\/article-pdf\/9\/3\/pbag025\/70893422\/pbag025.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:16:24Z","timestamp":1789474584000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pcm\/article\/doi\/10.1093\/pcmedi\/pbag025\/8778470"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,30]]},"references-count":221,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7,30]]}},"URL":"https:\/\/doi.org\/10.1093\/pcmedi\/pbag025","relation":{},"ISSN":["2096-5303","2516-1571"],"issn-type":[{"value":"2096-5303","type":"print"},{"value":"2516-1571","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,9]]},"published":{"date-parts":[[2026,7,30]]},"article-number":"pbag025"}}