{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T22:08:43Z","timestamp":1790633323465,"version":"4.1.0"},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100001809","name":"The Natural Science Foundation of China","doi-asserted-by":"crossref","award":["31600248"],"award-info":[{"award-number":["31600248"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Applied Basic Research Program of Shanxi Province","award":["201901D211389"],"award-info":[{"award-number":["201901D211389"]}]},{"name":"Scientific and Technological Innovation Program of Higher Education Institutions in Shanxi Province"},{"name":"Innovation Program of Postgraduate Education in Shanxi Province"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>N-terminal acetylation (Nt-acetylation) is one of the most common protein modifications in eukaryotes. The function of Naa50, the catalytic subunit of the evolutionarily conserved N-terminal acetyltransferase (Nat) E complex, has not been reported in Arabidopsis. In this study, we found that a loss of Naa50 resulted in a pleiotropic phenotype that included dwarfism and sterility, premature leaf senescence and a shortened primary root. Further analysis revealed that root cell patterning and various root cell properties were severely impaired in naa50 mutant plants. Moreover, defects in auxin distribution were observed due to the mislocalization of PIN auxin transporters. In contrast to its homologs in yeast and animals, Naa50 showed no co-immunoprecipitation with any subunit of the Nat A complex. Moreover, plants lacking Naa50 displayed hypersensitivity to abscisic acid and osmotic stress. Therefore, our results suggest that protein N-terminal acetylation catalyzed by Naa50 plays an essential role in Arabidopsis growth and osmotic stress responses.<\/jats:p>","DOI":"10.1093\/pcp\/pcaa081","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T19:10:51Z","timestamp":1591729851000},"page":"1565-1575","source":"Crossref","is-referenced-by-count":21,"title":["The N-Terminal Acetyltransferase Naa50 Regulates Arabidopsis Growth and Osmotic Stress Response"],"prefix":"10.1093","volume":"61","author":[{"given":"Jinlin","family":"Feng","sequence":"first","affiliation":[{"name":"College of Life Sciences, Shanxi Normal University, Linfen, Shanxi 041004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianxin","family":"Hu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Shanxi Normal University, Linfen, Shanxi 041004, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiqi","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9778-8855","authenticated-orcid":false,"given":"Hao","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, National University of Singapore, Singapore 117543, Singapore"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligeng","family":"Ma","sequence":"additional","affiliation":[{"name":"College of Life Sciences, Capital Normal University, Beijing 100048, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,6,16]]},"reference":[{"key":"2020101505445373700_pcaa081-B1","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.cell.2004.09.018","article-title":"The PLETHORA genes mediate patterning of the Arabidopsis root stem cell niche","volume":"119","author":"Aida","year":"2004","journal-title":"Cell"},{"key":"2020101505445373700_pcaa081-B2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.gene.2005.12.008","article-title":"Cloning and characterization of hNAT5\/hSAN: an evolutionarily conserved component of the NatA protein N-\u03b1-acetyltransferase complex","volume":"371","author":"Arnesen","year":"2006","journal-title":"Gene"},{"key":"2020101505445373700_pcaa081-B3","doi-asserted-by":"crossref","first-page":"8157","DOI":"10.1073\/pnas.0901931106","article-title":"Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans","volume":"106","author":"Arnesen","year":"2009","journal-title":"Proc. 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