{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:33:23Z","timestamp":1790184803610,"version":"4.1.0"},"reference-count":60,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T00:00:00Z","timestamp":1649289600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000076","name":"Directorate for Biological Sciences","doi-asserted-by":"publisher","award":["IOS\u20131734145"],"award-info":[{"award-number":["IOS\u20131734145"]}],"id":[{"id":"10.13039\/100000076","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000076","name":"Directorate for Biological Sciences","doi-asserted-by":"publisher","award":["MCB\u20131818312"],"award-info":[{"award-number":["MCB\u20131818312"]}],"id":[{"id":"10.13039\/100000076","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Iron (Fe) uptake and translocation in plants are fine-tuned by complex mechanisms that are not yet fully understood. In Arabidopsis thaliana, local regulation of Fe homeostasis at the root level has been extensively studied and is better understood than the systemic shoot-to-root regulation. While the root system is solely a sink tissue that depends on photosynthates translocated from source tissues, the shoot system is a more complex tissue, where sink and source tissues occur synchronously. In this study, and to gain better insight into the Fe deficiency responses in leaves, we overexpressed Zinc\/Iron-regulated transporter-like Protein (ZIP5), an Fe\/Zn transporter, in phloem-loading cells (proSUC2::AtZIP5) and determined the timing of Fe deficiency responses in sink (young leaves and roots) and source tissues (leaves). Transgenic lines overexpressing ZIP5 in companion cells displayed increased sensitivity to Fe deficiency in root growth assays. Moreover, young leaves and roots (sink tissues) displayed either delayed or dampened transcriptional responses to Fe deficiency compared to wild-type (WT) plants. We also took advantage of the Arabidopsis mutant nas4x-1 to explore Fe transcriptional responses in the opposite scenario, where Fe is retained in the vasculature but in an unavailable and precipitated form. In contrast to proSUC2::AtZIP5 plants, nas4x-1 young leaves and roots displayed a robust and constitutive Fe deficiency response, while mature leaves showed a delayed and dampened Fe deficiency response compared to WT plants. Altogether, our data provide evidence suggesting that Fe sensing within leaves can also occur locally in a leaf-specific manner.<\/jats:p>","DOI":"10.1093\/pcp\/pcac046","type":"journal-article","created":{"date-parts":[[2022,4,7]],"date-time":"2022-04-07T04:32:10Z","timestamp":1649305930000},"page":"829-841","source":"Crossref","is-referenced-by-count":25,"title":["Iron Availability within the Leaf Vasculature Determines the Magnitude of Iron Deficiency Responses in Source and Sink Tissues in<i>Arabidopsis<\/i>"],"prefix":"10.1093","volume":"63","author":[{"given":"Nga T","family":"Nguyen","sequence":"first","affiliation":[{"name":"Division of Plant Sciences, University of Missouri-Columbia, Bond Life Sciences Center , 1201 Rollins St, Room 271F, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mather A","family":"Khan","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences, University of Missouri-Columbia, Bond Life Sciences Center , 1201 Rollins St, Room 271F, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma A","family":"Castro\u2013Guerrero","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences, University of Missouri-Columbia, Bond Life Sciences Center , 1201 Rollins St, Room 271F, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-5071","authenticated-orcid":false,"given":"Ju-Chen","family":"Chia","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University , 608 Bradfield Hall, 306 Tower Rd., Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olena K","family":"Vatamaniuk","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University , 608 Bradfield Hall, 306 Tower Rd., Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephane","family":"Mari","sequence":"additional","affiliation":[{"name":"IPSiM, Institut des Sciences des Plantes de Montpellier, Universit\u00e9 de Montpellier\/CNRS\/INRAE\/Institut Agro , Place Viala, Montpellier, Cedex 34060, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia S","family":"Jurisson","sequence":"additional","affiliation":[{"name":"Department of Chemistry, University of Missouri-Columbia , Chemistry Building, Room 57, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9616-0791","authenticated-orcid":false,"given":"David G","family":"Mendoza-Cozatl","sequence":"additional","affiliation":[{"name":"Division of Plant Sciences, University of Missouri-Columbia, Bond Life Sciences Center , 1201 Rollins St, Room 271F, Columbia, MO 65211, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2022,4,7]]},"reference":[{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"E450","DOI":"10.1073\/pnas.1100659108","article-title":"Monoubiquitin-dependent endocytosis of the IRON-REGULATED TRANSPORTER 1 (IRT1) transporter controls iron uptake in plants","volume":"108","author":"Barberon","year":"2011","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1104\/pp.15.01589","article-title":"Zinc finger of Arabidopsis thaliana12 (zat12) interacts with Fer-like Iron deficiency-induced Transcription factor (FIT) linking iron deficiency and oxidative stress responses","volume":"170","author":"Brumbarova","year":"2016","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1104\/pp.105.072637","article-title":"An improved grafting technique for mature Arabidopsis plants demonstrates long-distance shoot-to-root transport of phytochelatins in Arabidopsis","volume":"141","author":"Chen","year":"2006","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1104\/pp.110.159103","article-title":"Successful reproduction requires the function of Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 metal-nicotianamine transporters in both vegetative and reproductive structures","volume":"154","author":"Chu","year":"2010","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","article-title":"Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana","volume":"16","author":"Clough","year":"1998","journal-title":"Plant J."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"3400","DOI":"10.1105\/tpc.104.024315","article-title":"The essential basic helix-loop-helix protein FIT1 is required for the iron deficiency response","volume":"16","author":"Colangelo","year":"2004","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1126\/science.1153795","article-title":"Cell identity mediates the response of Arabidopsis roots to abiotic stress","volume":"320","author":"Dinneny","year":"2008","journal-title":"Science"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"5624","DOI":"10.1073\/pnas.93.11.5624","article-title":"A novel iron-regulated metal transporter from plants identified by functional expression in yeast","volume":"93","author":"Eide","year":"1996","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00425-007-0596-x","article-title":"Long-distance signals positively regulate the expression of iron uptake genes in tobacco roots","volume":"227","author":"Enomoto","year":"2007","journal-title":"Planta"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1105\/tpc.19.00541","article-title":"The transcription factor bHLH121 interacts with bHLH105 (ILR3) and its closest homologs to regulate iron homeostasis in Arabidopsis","volume":"32","author":"Gao","year":"2020","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00425-012-1757-0","article-title":"Shoot to root communication is necessary to control the expression of iron-acquisition genes in strategy I plants","volume":"237","author":"Garc\u00eda","year":"2013","journal-title":"Planta"},{"key":"2023040700080065300_","doi-asserted-by":"publisher","DOI":"10.3389\/fpls.2015.00716","article-title":"Local and systemic signaling of iron status and its interactions with homeostasis of other essential elements","volume":"6","author":"Gayomba","year":"2015","journal-title":"Front. Plant Sci."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/j.devcel.2019.01.006","article-title":"CIPK11-dependent phosphorylation modulates FIT activity to promote Arabidopsis iron acquisition in response to calcium signaling","volume":"48","author":"Gratz","year":"2019","journal-title":"Dev. Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1038\/s41477-018-0266-y","article-title":"IRON MAN is a ubiquitous family of peptides that control iron transport in plants","volume":"4","author":"Grillet","year":"2018","journal-title":"Nat. Plants"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/S0005-2736(00)00138-3","article-title":"The ZIP family of metal transporters","volume":"1465","author":"Guerinot","year":"2000","journal-title":"Biochim. Biophys. Acta (BBA) Biomembr."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1104\/pp.17.01497","article-title":"A program for iron economy during deficiency targets specific Fe proteins","volume":"176","author":"Hantzis","year":"2018","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1023\/A:1006496308160","article-title":"pGreen: a versatile and flexible binary Ti vector for Agrobacterium-mediated plant transformation","volume":"42","author":"Hellens","year":"2000","journal-title":"Plant Mol. Biol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1023\/A:1019942200164","article-title":"Knock-out of Arabidopsis metal transporter gene IRT1 results in iron deficiency accompanied by cell differentiation defects","volume":"50","author":"Henriques","year":"2002","journal-title":"Plant Mol. Biol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1039\/C7MT00152E","article-title":"BRUTUS and its paralogs, BTS LIKE1 and BTS LIKE2, encode important negative regulators of the iron deficiency response in Arabidopsis thaliana","volume":"9","author":"Hindt","year":"2017","journal-title":"Metallomics"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/pcp\/pcy145","article-title":"The putative peptide gene FEP1 regulates iron deficiency response in Arabidopsis","volume":"59","author":"Hirayama","year":"2018","journal-title":"Plant Cell Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1105\/tpc.113.116244","article-title":"SORTING NEXIN1 is required for modulating the trafficking and stability of the Arabidopsis IRON-REGULATED TRANSPORTER1","volume":"26","author":"Ivanov","year":"2014","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1111\/j.1365-313X.2005.02569.x","article-title":"A loss-of-function mutation in AtYSL1 reveals its role in iron and nicotianamine seed loading","volume":"44","author":"Jean","year":"2005","journal-title":"Plant J."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"2263","DOI":"10.1111\/pce.13192","article-title":"Changes in iron availability in Arabidopsis are rapidly sensed in the leaf vasculature and impaired sensing leads to opposite transcriptional programs in leaves and roots","volume":"41","author":"Khan","year":"2018","journal-title":"Plant Cell Environ."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"24933","DOI":"10.1073\/pnas.1916892116","article-title":"The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI","volume":"116","author":"Kim","year":"2019","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1104\/pp.109.136374","article-title":"The analysis of Arabidopsis nicotianamine synthase mutants reveals functions for nicotianamine in seed iron loading and iron deficiency responses","volume":"150","author":"Klatte","year":"2009","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.1101\/gad.1331305","article-title":"Transcription switches for protoxylem and metaxylem vessel formation","volume":"19","author":"Kubo","year":"2005","journal-title":"Genes Dev."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.1104\/pp.17.00821","article-title":"Iron-nicotianamine transporters are required for proper long distance iron signaling","volume":"175","author":"Kumar","year":"2017","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1093\/jxb\/erab483","article-title":"Metal crossroads in plants: modulation of nutrient acquisition and root development by essential trace metals","volume":"73","author":"Le\u0161kov\u00e1","year":"2022","journal-title":"J. Exp. Bot."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"2478","DOI":"10.1104\/pp.15.01827","article-title":"Two bHLH transcription factors, bHLH34 and bHLH104, regulate iron homeostasis in Arabidopsis thaliana","volume":"170","author":"Li","year":"2016","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","article-title":"IRON MAN interacts with BRUTUS to maintain iron homeostasis in Arabidopsis","volume":"118","author":"Li","year":"2021","journal-title":"Proc. Natl. Acad. Sci."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1105\/tpc.110.074096","article-title":"The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots","volume":"22","author":"Long","year":"2010","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2016.00178","article-title":"Chloroplast iron transport proteins \u2013 function and impact on plant physiology","volume":"7","author":"L\u00f3pez-Mill\u00e1n","year":"2016","journal-title":"Front. Plant Sci."},{"key":"2023040700080065300_","doi-asserted-by":"publisher","DOI":"10.1093\/jxb\/erab393","article-title":"Cadmium interference with iron sensing reveals transcriptional programs sensitive and insensitive to reactive oxygen species","volume":"73","author":"McInturf","year":"2022","journal-title":"J. Exp. Bot."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"4197","DOI":"10.1093\/jxb\/erz290","article-title":"Keep talking: crosstalk between iron and sulfur networks fine-tunes growth and development to promote survival under iron limitation","volume":"70","author":"Mendoza-C\u00f3zatl","year":"2019","journal-title":"J. Exp. Bot."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.1093\/mp\/ssu067","article-title":"OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds","volume":"7","author":"Mendoza-C\u00f3zatl","year":"2014","journal-title":"Mol. Plant"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"18843","DOI":"10.1073\/pnas.0906131106","article-title":"Profiling translatomes of discrete cell populations resolves altered cellular priorities during hypoxia in Arabidopsis","volume":"106","author":"Mustroph","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1111\/j.1365-313X.2007.03212.x","article-title":"A multicolored set of in\u2003vivo organelle markers for co-localization studies in Arabidopsis and other plants","volume":"51","author":"Nelson","year":"2007","journal-title":"Plant J."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.3791\/54317-v","article-title":"Hydroponics: a versatile system to study nutrient allocation and plant responses to nutrient availability and exposure to toxic elements","author":"Nguyen","year":"2016","journal-title":"JoVE"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1111\/nph.17090","article-title":"Coumarin accumulation and trafficking in Arabidopsis thaliana: a complex and dynamic process","volume":"229","author":"Robe","year":"2021","journal-title":"New Phytol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1038\/17800","article-title":"A ferric-chelate reductase for iron uptake from soils","volume":"397","author":"Robinson","year":"1999","journal-title":"Nature"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.3389\/fpls.2019.00098","article-title":"Hemerythrin E3 Ubiquitin ligases as negative regulators of iron homeostasis in plants","volume":"10","author":"Rodr\u00edguez-celma","year":"2019","journal-title":"Front. Plant Sci."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/j.1399-3054.1992.tb04716.x","article-title":"Role of roots and shoots in the regulation of the Fe efficiency responses in sunflower and cucumber","volume":"85","author":"Romera","year":"1992","journal-title":"Physiol. Plant."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.1016\/j.rhisph.2020.100296","article-title":"Root exudation of coumarins from soil-grown Arabidopsis thaliana in response to iron deficiency","volume":"17","author":"Rosenkranz","year":"2021","journal-title":"Rhizosphere"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1111\/j.1469-8137.2009.02908.x","article-title":"Dissecting iron deficiency-induced proton extrusion in Arabidopsis roots","volume":"183","author":"Santi","year":"2009","journal-title":"New Phytol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/BF00340712","article-title":"High efficiency transformation of intact yeast cells using single stranded nucleic acids as a carrier","volume":"16","author":"Schiestl","year":"1989","journal-title":"Curr. Genet."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.1186\/1471-2229-11-87","article-title":"Transcriptome analysis by GeneTrail revealed regulation of functional categories in response to alterations of iron homeostasis in Arabidopsis thaliana","volume":"11","author":"Schuler","year":"2011","journal-title":"BMC Plant Biol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1105\/tpc.112.099077","article-title":"Nicotianamine functions in the Phloem-based transport of iron to sink organs, in pollen development and pollen tube growth in Arabidopsis","volume":"24","author":"Schuler","year":"2012","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1104\/pp.114.250837","article-title":"Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors","volume":"167","author":"Selote","year":"2015","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044843","article-title":"Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway","volume":"7","author":"Sivitz","year":"2012","journal-title":"PLoS One"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1046\/j.1365-313X.2002.01381.x","article-title":"The metal ion transporter IRT1 is necessary for iron homeostasis and efficient photosynthesis in Arabidopsis thaliana","volume":"31","author":"Varotto","year":"2002","journal-title":"Plant J."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1105\/tpc.001388","article-title":"IRT1, an Arabidopsis transporter essential for iron uptake from the soil and for plant growth","volume":"14","author":"Vert","year":"2002","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1104\/pp.102.016089","article-title":"Dual regulation of the Arabidopsis high-affinity root iron uptake system by local and long-distance signals","volume":"132","author":"Vert","year":"2003","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1104\/pp.106.082586","article-title":"Mutations in Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 reveal their roles in metal ion homeostasis and loading of metal ions in seeds","volume":"141","author":"Waters","year":"2006","journal-title":"Plant Physiol."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"47644","DOI":"10.1074\/jbc.M309338200","article-title":"Expression profiles of Arabidopsis thaliana in mineral deficiencies reveal novel transporters involved in metal homeostasis","volume":"278","author":"Wintz","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.18388\/abp.2006_3341","article-title":"Optimization of transient Agrobacterium-mediated gene expression system in leaves of Nicotiana benthamiana","author":"Wydro","year":"2006"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/cr.2008.26","article-title":"FIT interacts with AtbHLH38 and AtbHLH39 in regulating iron uptake gene expression for iron homeostasis in Arabidopsis","volume":"18","author":"Yuan","year":"2008","journal-title":"Cell Res."},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1105\/tpc.114.123737","article-title":"OPT3 is a phloem-specific iron transporter that is essential for systemic iron signaling and redistribution of iron and cadmium in Arabidopsis","volume":"26","author":"Zhai","year":"2014","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1007\/s13238-014-0083-7","article-title":"Essential functions of iron-requiring proteins in DNA replication, repair and cell cycle control","volume":"5","author":"Zhang","year":"2014","journal-title":"Protein Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1105\/tpc.114.132704","article-title":"The bHLH transcription factor bHLH104 interacts with IAA-LEUCINE RESISTANT3 and modulates iron homeostasis in Arabidopsis","volume":"27","author":"Zhang","year":"2015","journal-title":"Plant Cell"},{"key":"2023040700080065300_","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-03250-6","article-title":"Arabidopsis Transporter ABCG37\/PDR9 contributes primarily highly oxygenated coumarins to root exudation","volume":"7","author":"Ziegler","year":"2017","journal-title":"Sci. Rep."}],"container-title":["Plant and Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pcp\/advance-article-pdf\/doi\/10.1093\/pcp\/pcac046\/43704734\/pcac046.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcp\/article-pdf\/63\/6\/829\/44071688\/pcac046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcp\/article-pdf\/63\/6\/829\/44071688\/pcac046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,19]],"date-time":"2023-11-19T19:03:38Z","timestamp":1700420618000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pcp\/article\/63\/6\/829\/6564417"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,4,7]]},"references-count":60,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2022,4,7]]},"published-print":{"date-parts":[[2022,6,15]]}},"URL":"https:\/\/doi.org\/10.1093\/pcp\/pcac046","relation":{},"ISSN":["0032-0781","1471-9053"],"issn-type":[{"value":"0032-0781","type":"print"},{"value":"1471-9053","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2022,6,1]]},"published":{"date-parts":[[2022,4,7]]}}}