{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T02:58:20Z","timestamp":1776481100879,"version":"3.51.2"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T00:00:00Z","timestamp":1665532800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2015\/17\/B\/NZ1\/00871"],"award-info":[{"award-number":["2015\/17\/B\/NZ1\/00871"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Glucosinolates are specialized defensive metabolites characteristic of the Brassicales order. Among them, aliphatic and indolic glucosinolates (IGs) are usually highly abundant in species from the Brassicaceae family. The exceptions this trend are species representing a subclade of the Camelineae tribe, including Capsella and Camelina genera, which have reduced capacity to produce and metabolize IGs. Our study addresses the contribution of specific glucosinolate-related myeloblastosis (MYB) transcription factors to this unprecedented backward evolution of IG biosynthesis. To this end, we performed phylogenomic and functional studies of respective MYB proteins. The obtained results revealed weakened conservation of glucosinolate-related MYB transcription factors, including loss of functional MYB34 protein, in the investigated species. We showed that the introduction of functional MYB34 from Arabidopsis thaliana partially restores IG biosynthesis in Capsella rubella, indicating that the loss of this transcription factor contributes to the backward evolution of this metabolic pathway. Finally, we performed an analysis of the impact of particular myb mutations on the feedback loop in IG biosynthesis, which drives auxin overproduction, metabolic dysregulation and strong growth retardation caused by mutations in IG biosynthetic genes. This uncovered the unique function of MYB34 among IG-related MYBs in this feedback regulation and consequently in IG conservation in Brassicaceae plants.<\/jats:p>","DOI":"10.1093\/pcp\/pcac142","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T11:27:59Z","timestamp":1665574079000},"page":"80-93","source":"Crossref","is-referenced-by-count":12,"title":["Loss of MYB34 Transcription Factor Supports the Backward Evolution of Indole Glucosinolate Biosynthesis in a Subclade of the Camelineae Tribe and Releases the Feedback Loop in This Pathway in Arabidopsis"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4897-0941","authenticated-orcid":false,"given":"Pawe\u0142","family":"Czerniawski","sequence":"first","affiliation":[{"name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego 12\/14, Pozna\u0144 61-704, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9241-3328","authenticated-orcid":false,"given":"Mariola","family":"Pi\u015blewska-Bednarek","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego 12\/14, Pozna\u0144 61-704, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0983-7507","authenticated-orcid":false,"given":"Anna","family":"Piasecka","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego 12\/14, Pozna\u0144 61-704, Poland"},{"name":"Institute of Plant Genetics, Polish Academy of Sciences , Strzeszy\u0144ska 34, Pozna\u0144 60-479, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8398-7749","authenticated-orcid":false,"given":"Karolina","family":"Ku\u0142ak","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego 12\/14, Pozna\u0144 61-704, Poland"},{"name":"Department of General Botany, Institute of Experimental Biology, Adam Mickiewicz University , Uniwersytetu Pozna\u0144skiego 6, Pozna\u0144 61-614, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3064-7775","authenticated-orcid":false,"given":"Pawe\u0142","family":"Bednarek","sequence":"additional","affiliation":[{"name":"Institute of Bioorganic Chemistry, Polish Academy of Sciences , Noskowskiego 12\/14, Pozna\u0144 61-704, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2022,10,12]]},"reference":[{"key":"2024010313390270000_R1","doi-asserted-by":"publisher","first-page":"108","DOI":"10.1104\/pp.127.1.108","article-title":"The involvement of two P450 enzymes, CYP83B1 and CYP83A1, in auxin homeostasis and glucosinolate biosynthesis","volume":"127","author":"Bak","year":"2001","journal-title":"Plant Physiol."},{"key":"2024010313390270000_R2","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1105\/tpc.13.1.101","article-title":"CYP83B1, a cytochrome P450 at the metabolic branch point in auxin and indole glucosinolate biosynthesis in Arabidopsis","volume":"13","author":"Bak","year":"2001","journal-title":"Plant Cell"},{"key":"2024010313390270000_R3","doi-asserted-by":"publisher","first-page":"585","DOI":"10.1146\/annurev-arplant-050718-100152","article-title":"Evolution of glucosinolate diversity via whole-genome duplications, gene rearrangements, and substrate promiscuity","volume":"70","author":"Barco","year":"2019","journal-title":"Annu. 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