{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T03:50:30Z","timestamp":1775706630121,"version":"3.50.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T00:00:00Z","timestamp":1693440000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"publisher","award":["17J06965 19H05637 21H02087"],"award-info":[{"award-number":["17J06965 19H05637 21H02087"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Grants-in-Aid for Scientific Research","doi-asserted-by":"publisher","award":["17J06965 19H05637 21H02087"],"award-info":[{"award-number":["17J06965 19H05637 21H02087"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,12,21]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Under low-Ca conditions, plants accumulate salicylic acid (SA) and induce SA-responsive genes. However, the relationship between SA and low-Ca tolerance remains unclear. Here, we demonstrated that the inhibition or suppression of nonexpressor of pathogenesis-related 1 (NPR1) activity, a major regulator of the SA signaling pathway in the defense response, improves shoot growth under low-Ca conditions. Furthermore, mutations in phytoalexin-deficient 4 (PAD4) or enhanced disease susceptibility 1 (EDS1), which are upstream regulators of NPR1, improved shoot growth under low-Ca conditions, suggesting that NPR1 suppressed growth under low-Ca conditions. In contrast, growth of SA induction\u2013deficient 2-2 (sid2-2), which is an SA-deficient mutant, was sensitive to low Ca levels, suggesting that SA accumulation by SID2 was not related to growth inhibition under low-Ca conditions. Additionally, npr1-1 showed low-Ca tolerance, and the application of tenoxicam\u2014an inhibitor of the NPR1-mediated activation of gene expression\u2014also improved shoot growth under low Ca conditions. The low-Ca tolerance of double mutants pad4-1, npr1-1 and eds1-22 npr1-1 was similar to that of the single mutants, suggesting that PAD4 and EDS1 are involved in the same genetic pathway in suppressing growth under low-Ca conditions as NPR1. Cell death and low-Ca tolerance did not correlate among the mutants, suggesting that growth improvement in the mutants was not due to cell death inhibition. In conclusion, we revealed that NPR1 suppresses plant growth under low-Ca conditions and that the other SA-related genes influence plant growth and cell death.<\/jats:p>","DOI":"10.1093\/pcp\/pcad096","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T13:34:41Z","timestamp":1693488881000},"page":"1579-1589","source":"Crossref","is-referenced-by-count":5,"title":["Inhibition of\u00a0NPR1 Leads to Shoot Growth Improvement under Low-Calcium Conditions in\u00a0<i>Arabidopsis<\/i>"],"prefix":"10.1093","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2445-9743","authenticated-orcid":false,"given":"Shuichi","family":"Hashimoto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8429-3389","authenticated-orcid":false,"given":"Yusuke","family":"Shikanai","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657 Japan"},{"name":"Department of Agricultural Chemistry, Tokyo University of Agriculture , Setagaya-ku, Tokyo, 156-8502 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4151-6698","authenticated-orcid":false,"given":"Miyuki","family":"Kusajima","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1410-2986","authenticated-orcid":false,"given":"Hidemitsu","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5363-6040","authenticated-orcid":false,"given":"Toru","family":"Fujiwara","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3790-7119","authenticated-orcid":false,"given":"Takehiro","family":"Kamiya","sequence":"additional","affiliation":[{"name":"Department of Applied Biological Chemistry, Graduate School of Agricultural and Life Sciences, The University of Tokyo , Bunkyo-ku, Tokyo, 113-8657 Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2023,8,31]]},"reference":[{"key":"2023122117543346200_R1","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1105\/tpc.105.039982","article-title":"Salicylic acid\u2013independent ENHANCED DISEASE SUSCEPTIBILITY1 signaling in\u00a0Arabidopsis immunity and\u00a0cell death is regulated by the monooxygenase FMO1 and\u00a0the nudix hydrolase NUDT7","volume":"18","author":"Bartsch","year":"2006","journal-title":"Plant Cell"},{"key":"2023122117543346200_R2","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1111\/j.1469-8137.2005.01408.x","article-title":"Mutations in\u00a0CAX1 produce phenotypes characteristic of\u00a0plants tolerant to serpentine soils","volume":"167","author":"Bradshaw","year":"2005","journal-title":"New Phytol."},{"key":"2023122117543346200_R3","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/S0092-8674(00)81858-9","article-title":"The Arabidopsis NPR1 gene that controls systemic acquired resistance encodes a novel protein containing ankyrin repeats","volume":"88","author":"Cao","year":"1997","journal-title":"Cell"},{"key":"2023122117543346200_R4","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abl7173","article-title":"Two interacting transcriptional coactivators cooperatively control plant immune responses","volume":"7","author":"Chen","year":"2021","journal-title":"Sci. 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