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Since the 1960s, plant scientists have known that progesterone is an essential precursor of cardenolide formation. Therefore, biosynthesis of plant progesterone was mainly analyzed in species of the cardenolide-containing genus Digitalis during the following decades. Today, Digitalis enzymes catalyzing the main steps of progesterone biosynthesis are known. Most of them are found in a broad range of organisms. This review will summarize the findings of 60\u2009years of research on plant progesterone metabolism with particular focus on the recent results in Digitalis lanata and other plants.<\/jats:p>","DOI":"10.1093\/pcp\/pcae006","type":"journal-article","created":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T10:22:12Z","timestamp":1705400532000},"page":"1500-1514","source":"Crossref","is-referenced-by-count":10,"title":["Progesterone Metabolism in <i>Digitalis<\/i> and Other Plants\u201460 Years of Research and Recent Results"],"prefix":"10.1093","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2676-1505","authenticated-orcid":false,"given":"Jan","family":"Klein","sequence":"first","affiliation":[{"name":"Department of Plant Physiology, Matthias-Schleiden-Institute for Genetics, Bioinformatics and Molecular Botany, Friedrich Schiller University Jena , Dornburger Stra\u00dfe 159, Jena 07743,","place":["Germany"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2024,1,16]]},"reference":[{"key":"2024111312140777200_R1","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/s41586-020-2460-0","article-title":"Extensive signal integration by the phytohormone protein network","volume":"583","author":"Altmann","year":"2020","journal-title":"Nature"},{"key":"2024111312140777200_R2","doi-asserted-by":"crossref","first-page":"111","DOI":"10.14348\/molcells.2016.2188","article-title":"A role for Arabidopsis miR399f in salt, drought, and ABA signaling","volume":"39","author":"Baek","year":"2016","journal-title":"Mol. 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