{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,29]],"date-time":"2025-11-29T08:04:20Z","timestamp":1764403460879,"version":"3.43.0"},"reference-count":58,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T00:00:00Z","timestamp":1748304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24380039","16K14872"],"award-info":[{"award-number":["24380039","16K14872"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,8,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Responses to aluminum (Al) were investigated in tobacco cells (cell line SL) in a calcium-sucrose solution for up to 24\u00a0h under shaking (aerobic) condition. Microarray analysis of upregulated and downregulated genes under Al exposure and following Gene Ontology (GO) enrichment analysis of biological process category revealed only one GO term to be enriched for the upregulated genes, \u201cresponse to chitin,\u201d annotated with genes encoding transcription factors (NtERF1 and NtMYB3) and MAP kinase (WIPK), and nine GO terms for the downregulated genes, including \u201ccell wall loosening\u201d and \u201clipid transport,\u201d annotated with genes encoding expansin (NtEXPA4) and lipid transfer protein (LTP)\/LTP-like (NtLTP3 and NtEIG-C29), respectively. Al triggered the production of nitric oxide (NO) then reactive oxygen species (ROS). Addition of NO scavenger 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide decreased the levels of NO and a part of the transcriptional changes described above, but increased the levels of ROS and a loss of growth capacity, suggesting a role of the NO to induce the transcriptional changes partly and to repress these toxic responses under Al exposure. Under non-shaking (anaerobic) condition, the cells exhibited upregulation of several hypoxia-responsive genes. The cells exposed to Al exhibited the same level of Al accumulation but much lower levels of the Al responses including NO production, ROS production, a loss of growth capacity, citrate secretion, and a part of the transcriptional changes described above, compared with the cells under shaking condition. These results suggest that coexistence of oxygen with Al is necessary to trigger the Al responses related to toxicity and tolerance.<\/jats:p>","DOI":"10.1093\/pcp\/pcaf055","type":"journal-article","created":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T07:22:50Z","timestamp":1748244170000},"page":"1044-1060","source":"Crossref","is-referenced-by-count":1,"title":["Oxygen supply is a prerequisite for response to aluminum in cultured cells of tobacco (<i>Nicotiana tabacum<\/i>)"],"prefix":"10.1093","volume":"66","author":[{"given":"Yoshiyuki","family":"Tsuchiya","sequence":"first","affiliation":[{"name":"Institute of Plant Science and Resources, Okayama University , Chuo 2-20-1, Kurashiki 710-0046 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maki","family":"Katsuhara","sequence":"additional","affiliation":[{"name":"Institute of Plant Science and Resources, Okayama University , Chuo 2-20-1, Kurashiki 710-0046 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Institute of Plant Science and Resources, Okayama University , Chuo 2-20-1, Kurashiki 710-0046 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoko","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"Institute of Plant Science and Resources, Okayama University , Chuo 2-20-1, Kurashiki 710-0046 ,","place":["Japan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2025,5,27]]},"reference":[{"key":"2025081302221374800_ref1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1093\/jxb\/erq027","article-title":"Aluminium reduces sugar uptake in tobacco cell cultures: a potential cause of inhibited elongation but not of toxicity","volume":"61","author":"Abdel-Basset","year":"2010","journal-title":"J. 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