{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T18:21:11Z","timestamp":1785349271183,"version":"3.55.0"},"reference-count":141,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T00:00:00Z","timestamp":1765324800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Center of Poland","award":["UMO-2018\/29\/B\/NZ3\/01033"],"award-info":[{"award-number":["UMO-2018\/29\/B\/NZ3\/01033"]}]},{"name":"National Science Center of Poland","award":["UMO-2017\/26\/D\/NZ1\/00833"],"award-info":[{"award-number":["UMO-2017\/26\/D\/NZ1\/00833"]}]},{"name":"National Science Center of Poland","award":["UMO-2016\/21\/D\/NZ3\/12615"],"award-info":[{"award-number":["UMO-2016\/21\/D\/NZ3\/12615"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,4,14]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In all eukaryotic cells, protein prenylation and cytoplasmic isoprenoid biosynthesis pathways leading to sterols, dolichols, and other isoprenoid compounds share a common precursor pool of isopentenyl diphosphate and the isomeric dimethylallyl diphosphate. Despite this, little is known about the interplay between these processes. Here we ask whether perturbation of protein prenylation in plants influences isoprenoid biosynthesis in the endoplasmic reticulum, and in particular if it affects sterol and dolichol biosynthesis. We use an Arabidopsis thaliana mutant with defects in the Rab geranylgeranyl transferase as a viable model of protein hypoprenylation, and we show that sterol and dolichol content is significantly elevated in the mutant plants. Also sterol composition is changed: cholesterol content is increased and some atypical sterol pathway intermediates are accumulating. Our results show that plant sterol biosynthesis involves high levels of crosstalk between pathway branches than previously reported and receives regulatory input from protein prenylation pathways.<\/jats:p>","DOI":"10.1093\/pcp\/pcaf166","type":"journal-article","created":{"date-parts":[[2025,12,10]],"date-time":"2025-12-10T14:24:47Z","timestamp":1765376687000},"page":"346-366","source":"Crossref","is-referenced-by-count":0,"title":["Rab geranylgeranyl transferase activity is required for proper sterol biosynthesis in\n                    <i>Arabidopsis thaliana<\/i>"],"prefix":"10.1093","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6584-7964","authenticated-orcid":false,"given":"Ma\u0142gorzata","family":"Gutkowska","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Microbiology, Institute of Biology, Warsaw University of Life Sciences , ul. Nowoursynowska 159, bldg. 37, 02-776 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Zajbt-\u0141uczniewska","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences , ul. Pawi\u0144skiego 5a, 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Buszewicz","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences , ul. Pawi\u0144skiego 5a, 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Anielska-Mazur","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences , ul. Pawi\u0144skiego 5a, 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agata","family":"Lipko","sequence":"additional","affiliation":[{"name":"Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences , ul. Ks. Trojdena 4, 02-109 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8405-3112","authenticated-orcid":false,"given":"Cezary","family":"P\u0105czkowski","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry, Institute of Biochemistry, Faculty of Biology, University of Warsaw , ul. Miecznikowa 1, 02-096 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"Sp\u00f3lnik","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, Polish Academy of Sciences , ul. Kasprzaka 44\/52, 01-224 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Sojka","sequence":"additional","affiliation":[{"name":"Institute of Organic Chemistry, Polish Academy of Sciences , ul. Kasprzaka 44\/52, 01-224 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Ja\u017awiec","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences , ul. Pawi\u0144skiego 5a, 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilia","family":"Samborowska","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences , ul. Pawi\u0144skiego 5a, 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3439-8948","authenticated-orcid":false,"given":"Ewa","family":"Swiezewska","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences , ul. Pawi\u0144skiego 5a, 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Hoffman","sequence":"additional","affiliation":[{"name":"Institute of Biochemistry and Biophysics, Polish Academy of Sciences , ul. Pawi\u0144skiego 5a, 02-106 Warsaw ,","place":["Poland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,12,10]]},"reference":[{"key":"2026041410172578100_ref1","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00425-007-0618-8","article-title":"Overexpression of CYP710A1 and CYP710A4 in transgenic Arabidopsis plants increases the level of stigmasterol at the expense of sitosterol","volume":"227","author":"Arnqvist","year":"2008","journal-title":"Planta"},{"key":"2026041410172578100_ref2","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1039\/C3NP70124G","article-title":"Methylerythritol 4-phosphate (MEP) pathway metabolic regulation","volume":"31","author":"Banerjee","year":"2014","journal-title":"Nat. Prod. Rep."},{"key":"2026041410172578100_ref3","doi-asserted-by":"crossref","first-page":"101287","DOI":"10.1016\/j.plipres.2024.101287","article-title":"Plant terpenoid biosynthetic network and its multiple layers of regulation","volume":"95","author":"Bergman","year":"2024","journal-title":"Prog. Lipid Res."},{"key":"2026041410172578100_ref4","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1104\/pp.112.198473","article-title":"Composition and physiological function of the wax layers coating Arabidopsis leaves: beta-amyrin negatively affects the intracuticular water barrier","volume":"160","author":"Buschhaus","year":"2012","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref5","doi-asserted-by":"crossref","first-page":"kiae533","DOI":"10.1093\/plphys\/kiae533","article-title":"Packaging \u201cvegetable oils\u201d: insights into plant lipid droplet proteins","volume":"197","author":"Cai","year":"2025","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref6","first-page":"2163","article-title":"Targeting and topology in the membrane of plant 3-hydroxy-3-methylglutaryl coenzyme a reductase","volume":"7","author":"Campos","year":"1995","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref7","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-1-4939-0606-2_3","article-title":"Determination of 3-Hydroxy-3-methylglutaryl CoA reductase activity in plants","volume":"1153","author":"Campos","year":"2014","journal-title":"Plant Isoprenoids: Methods Protoc. Methods Mol. Biol."},{"key":"2026041410172578100_ref8","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1105\/tpc.003939","article-title":"The identification of CVP1 reveals a role for sterols in vascular patterning","volume":"14","author":"Carland","year":"2002","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref9","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1104\/pp.109.152587","article-title":"The sterol methyltransferases SMT1, SMT2, and SMT3 influence Arabidopsis development through nonbrassinosteroid products","volume":"153","author":"Carland","year":"2010","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref10","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1042\/BCJ20180021","article-title":"Mechanisms of lipid droplet biogenesis","volume":"476","author":"Chapman","year":"2019","journal-title":"Biochem. J."},{"key":"2026041410172578100_ref11","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1104\/pp.109.4.1337","article-title":"Is the reaction catalyzed by 3-Hydroxy-3-Methylglutaryl coenzyme a reductase a rate-limiting step for isoprenoid biosynthesis in plants?","volume":"109","author":"Chappell","year":"1995","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref12","first-page":"1110","article-title":"Methyl-Jasmonate functions as a molecular switch promoting cross-talk between pathways for the biosynthesis of isoprenoid backbones used to modify proteins in plants","volume":"13","author":"Chevalier","year":"2024","journal-title":"Plants (Basel)"},{"key":"2026041410172578100_ref13","doi-asserted-by":"crossref","first-page":"3243","DOI":"10.1093\/jxb\/erx095","article-title":"Arabidopsis dolichol kinase AtDOK1 is involved in flowering time control","volume":"68","author":"Cho","year":"2017","journal-title":"J. Exp. Bot."},{"key":"2026041410172578100_ref14","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1038\/s41467-022-28150-w","article-title":"Activation of the plant mevalonate pathway by extracellular ATP","volume":"13","author":"Cho","year":"2022","journal-title":"Nat. Commun."},{"key":"2026041410172578100_ref15","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1104\/pp.119.3.897","article-title":"The Arabidopsis dwarf1 mutant is defective in the conversion of 24-methylenecholesterol to campesterol in brassinosteroid biosynthesis","volume":"119","author":"Choe","year":"1999","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref16","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1111\/j.1365-313X.2010.04253.x","article-title":"The Arabidopsis thaliana FPP synthase isozymes have overlapping and specific functions in isoprenoid biosynthesis, and complete loss of FPP synthase activity causes early developmental arrest","volume":"63","author":"Closa","year":"2010","journal-title":"Plant J."},{"key":"2026041410172578100_ref17","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1194\/jlr.M050229","article-title":"High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation","volume":"55","author":"Currie","year":"2014","journal-title":"J. Lipid Res."},{"key":"2026041410172578100_ref18","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1042\/bj20031572","article-title":"Plant sterol biosynthesis: identification of two distinct families of sterol 4alpha-methyl oxidases","volume":"378","author":"Darnet","year":"2004","journal-title":"Biochem. J."},{"key":"2026041410172578100_ref19","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.3390\/molecules25051111","article-title":"Inhibition of phytosterol biosynthesis by azasterols","volume":"25","author":"Darnet","year":"2020","journal-title":"Molecules"},{"key":"2026041410172578100_ref20","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1105\/tpc.12.6.853","article-title":"Sterol methyltransferase 1 controls the level of cholesterol in plants","volume":"12","author":"Diener","year":"2000","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref21","doi-asserted-by":"crossref","first-page":"108214","DOI":"10.1016\/j.biotechadv.2023.108214","article-title":"Recent advances in triterpenoid pathway elucidation and engineering","volume":"68","author":"Dinday","year":"2023","journal-title":"Biotechnol. Adv."},{"key":"2026041410172578100_ref22","doi-asserted-by":"crossref","first-page":"e64688","DOI":"10.7554\/eLife.64688","article-title":"Type 1 polyisoprenoid diphosphate phosphatase modulates geranylgeranyl-mediated control of HMG CoA reductase and UBIAD1","volume":"10","author":"Elsabrouty","year":"2021","journal-title":"Elife"},{"key":"2026041410172578100_ref23","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1073\/pnas.91.3.927","article-title":"Arabidopsis thaliana contains two differentially expressed 3-hydroxy-3-methylglutaryl-CoA reductase genes, which encode microsomal forms of the enzyme","volume":"91","author":"Enjuto","year":"1994","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041410172578100_ref24","doi-asserted-by":"crossref","first-page":"108111","DOI":"10.1016\/j.abb.2019.108111","article-title":"Investigation of the conserved reentrant membrane helix in the monotopic phosphoglycosyl transferase superfamily supports key molecular interactions with polyprenol phosphate substrates","volume":"675","author":"Entova","year":"2019","journal-title":"Arch. Biochem. Biophys."},{"key":"2026041410172578100_ref25","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1055\/a-0635-8369","article-title":"Review: endoplasmic reticulum-associated degradation (ERAD)-dependent control of (tri)terpenoid metabolism in plants","volume":"84","author":"Erffelinck","year":"2018","journal-title":"Planta Med."},{"key":"2026041410172578100_ref26","doi-asserted-by":"crossref","first-page":"1006822","DOI":"10.3389\/fmolb.2022.1006822","article-title":"Synthesis, function, and regulation of sterol and nonsterol isoprenoids","volume":"9","author":"Faulkner","year":"2022","journal-title":"Front. Mol. Biosci."},{"key":"2026041410172578100_ref27","doi-asserted-by":"crossref","first-page":"e2318822121","DOI":"10.1073\/pnas.2318822121","article-title":"Direct binding to sterols accelerates endoplasmic reticulum-associated degradation of HMG CoA reductase","volume":"121","author":"Faulkner","year":"2024","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041410172578100_ref28","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.plipres.2017.06.002","article-title":"Emerging roles for conjugated sterols in plants","volume":"67","author":"Ferrer","year":"2017","journal-title":"Prog. Lipid Res."},{"key":"2026041410172578100_ref29","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1104\/pp.15.00597","article-title":"Proliferation and morphogenesis of the endoplasmic reticulum driven by the membrane domain of 3-hydroxy-3-methylglutaryl coenzyme a reductase in plant cells","volume":"168","author":"Ferrero","year":"2015","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref31","doi-asserted-by":"crossref","first-page":"59","DOI":"10.2174\/1570159X15666170703101816","article-title":"Statins and the brain: more than lipid lowering agents?","volume":"17","author":"Fracassi","year":"2019","journal-title":"Curr. Neuropharmacol."},{"key":"2026041410172578100_ref32","doi-asserted-by":"crossref","first-page":"1605","DOI":"10.1038\/s41467-022-29272-x","article-title":"Membrane thickness, lipid phase and sterol type are determining factors in the permeability of membranes to small solutes","volume":"13","author":"Frallicciardi","year":"2022","journal-title":"Nat. Commun."},{"key":"2026041410172578100_ref33","doi-asserted-by":"crossref","first-page":"113800","DOI":"10.1016\/j.phytochem.2023.113800","article-title":"Sterol composition in plants is specific to pollen, leaf, pollination and pollinator","volume":"214","author":"Furse","year":"2023","journal-title":"Phytochemistry"},{"key":"2026041410172578100_ref34","doi-asserted-by":"crossref","first-page":"35368","DOI":"10.1074\/jbc.M109.023994","article-title":"Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-hydroxy-3-methylglutaryl-CoA reductase degradation in yeast","volume":"284","author":"Garza","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref35","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/pce.14223","article-title":"cis-prenyltransferase 3 and alpha\/beta-hydrolase are new determinants of dolichol accumulation in Arabidopsis","volume":"45","author":"Gawarecka","year":"2022","journal-title":"Plant Cell Environ."},{"key":"2026041410172578100_ref36","doi-asserted-by":"crossref","first-page":"4274","DOI":"10.1093\/plcell\/koac239","article-title":"The Arabidopsis Rab protein RABC1 affects stomatal development by regulating lipid droplet dynamics","volume":"34","author":"Ge","year":"2022","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref37","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1105\/tpc.108.063248","article-title":"The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells","volume":"21","author":"Gerber","year":"2009","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref38","doi-asserted-by":"crossref","first-page":"5810","DOI":"10.1074\/jbc.M114.598805","article-title":"Differential effect of plant lipids on membrane organization: specificities of phytosphingolipids and phytosterols","volume":"290","author":"Grosjean","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref39","doi-asserted-by":"crossref","first-page":"998","DOI":"10.1016\/j.bbrc.2004.08.025","article-title":"Proteins are polyisoprenylated in Arabidopsis thaliana","volume":"322","author":"Gutkowska","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026041410172578100_ref40","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1093\/jxb\/eru412","article-title":"Rab geranylgeranyl transferase beta subunit is essential for male fertility and tip growth in Arabidopsis","volume":"66","author":"Gutkowska","year":"2015","journal-title":"J. Exp. Bot."},{"key":"2026041410172578100_ref41","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1111\/tpj.15519","article-title":"Impact of C-terminal truncations in the Arabidopsis Rab escort protein (REP) on REP-Rab interaction and plant fertility","volume":"108","author":"Gutkowska","year":"2021","journal-title":"Plant J."},{"key":"2026041410172578100_ref42","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1146\/annurev-arplant-070122-021752","article-title":"Lipid droplets: packing hydrophobic molecules within the aqueous cytoplasm","volume":"74","author":"Guzha","year":"2023","journal-title":"Annu. Rev. Plant Biol."},{"key":"2026041410172578100_ref43","doi-asserted-by":"crossref","first-page":"3906","DOI":"10.3390\/molecules24213906","article-title":"Protein prenylation in plant stress responses","volume":"24","author":"Hala","year":"2019","journal-title":"Molecules"},{"key":"2026041410172578100_ref44","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1111\/j.1365-313X.2010.04172.x","article-title":"Arabidopsis RAB geranylgeranyl transferase beta-subunit mutant is constitutively photomorphogenic, and has shoot growth and gravitropic defects","volume":"62","author":"Hala","year":"2010","journal-title":"Plant J."},{"key":"2026041410172578100_ref45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1046\/j.1467-7652.2003.00011.x","article-title":"Enhancement of seed phytosterol levels by expression of an N-terminal truncated Hevea brasiliensis (rubber tree) 3-hydroxy-3-methylglutaryl-CoA reductase","volume":"1","author":"Harker","year":"2003","journal-title":"Plant Biotechnol. J."},{"key":"2026041410172578100_ref46","doi-asserted-by":"crossref","first-page":"3523","DOI":"10.1093\/jxb\/ern202","article-title":"An isoform of Arabidopsis myosin XI interacts with small GTPases in its C-terminal tail region","volume":"59","author":"Hashimoto","year":"2008","journal-title":"J. Exp. Bot."},{"key":"2026041410172578100_ref47","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1104\/pp.123.4.1257","article-title":"Farnesol-induced cell death and stimulation of 3-hydroxy-3-methylglutaryl-coenzyme a reductase activity in tobacco cv bright yellow-2 cells","volume":"123","author":"Hemmerlin","year":"2000","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref48","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.plipres.2011.12.001","article-title":"A raison d'etre for two distinct pathways in the early steps of plant isoprenoid biosynthesis?","volume":"51","author":"Hemmerlin","year":"2012","journal-title":"Prog. Lipid Res."},{"key":"2026041410172578100_ref49","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1534\/genetics.117.300322","article-title":"Long-chain polyprenols promote spore wall formation in Saccharomyces cerevisiae","volume":"207","author":"Hoffmann","year":"2017","journal-title":"Genetics"},{"key":"2026041410172578100_ref50","doi-asserted-by":"crossref","first-page":"kiaf042","DOI":"10.1093\/plphys\/kiaf042","article-title":"The TRAPPC8\/TRS85 subunit of the Arabidopsis TRAPPIII tethering complex regulates endoplasmic reticulum function and autophagy","volume":"197","author":"Hoffman-Sommer","year":"2025","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref51","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1046\/j.1365-313X.2003.01851.x","article-title":"Co-expression of N-terminal truncated 3-hydroxy-3-methylglutaryl CoA reductase and C24-sterol methyltransferase type 1 in transgenic tobacco enhances carbon flux towards end-product sterols","volume":"36","author":"Holmberg","year":"2003","journal-title":"Plant J."},{"key":"2026041410172578100_ref52","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1023\/A:1006476123930","article-title":"Molecular cloning and expression in yeast of 2,3-oxidosqualene-triterpenoid cyclases from Arabidopsis thaliana","volume":"45","author":"Husselstein-Muller","year":"2001","journal-title":"Plant Mol. Biol."},{"key":"2026041410172578100_ref53","doi-asserted-by":"crossref","first-page":"1315","DOI":"10.1016\/j.bbalip.2016.03.023","article-title":"Lipids in pollen - they are different","volume":"1861","author":"Ischebeck","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"key":"2026041410172578100_ref54","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1139\/o92-071","article-title":"Changes of dolichol and dolichyl fatty acyl esters during the germination and development of soybeans","volume":"70","author":"Ishinaga","year":"1992","journal-title":"Biochem. Cell Biol."},{"key":"2026041410172578100_ref55","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1105\/tpc.114.124446","article-title":"Plasma membranes are subcompartmentalized into a plethora of coexisting and diverse microdomains in Arabidopsis and Nicotiana benthamiana","volume":"26","author":"Jarsch","year":"2014","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref56","doi-asserted-by":"crossref","first-page":"3336","DOI":"10.1105\/tpc.15.00463","article-title":"Polyprenol reductase2 deficiency is lethal in Arabidopsis due to male sterility","volume":"27","author":"Jozwiak","year":"2015","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref57","doi-asserted-by":"crossref","first-page":"e2426532122","DOI":"10.1073\/pnas.2426532122","article-title":"Allosteric regulation of UBIAD1 trafficking from ER to Golgi revealed by chemical genetic screening","volume":"122","author":"Jun","year":"2025","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041410172578100_ref58","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1111\/tpj.12727","article-title":"Arabidopsis DOK1 encodes a functional dolichol kinase involved in reproduction","volume":"81","author":"Kanehara","year":"2015","journal-title":"Plant J."},{"key":"2026041410172578100_ref59","doi-asserted-by":"crossref","first-page":"e49109","DOI":"10.1371\/journal.pone.0049109","article-title":"Characterization of Arabidopsis FPS isozymes and FPS gene expression analysis provide insight into the biosynthesis of isoprenoid precursors in seeds","volume":"7","author":"Keim","year":"2012","journal-title":"PLoS One"},{"key":"2026041410172578100_ref60","doi-asserted-by":"crossref","first-page":"4556","DOI":"10.3390\/molecules24244556","article-title":"Functional gene network of prenyltransferases in Arabidopsis thaliana","volume":"24","author":"Kopcsayova","year":"2019","journal-title":"Molecules"},{"key":"2026041410172578100_ref61","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1016\/j.molp.2015.02.007","article-title":"Arabidopsis squalene epoxidase 3 (SQE3) complements SQE1 and is important for embryo development and bulk squalene epoxidase activity","volume":"8","author":"Laranjeira","year":"2015","journal-title":"Mol. Plant"},{"key":"2026041410172578100_ref62","doi-asserted-by":"crossref","first-page":"32150","DOI":"10.1074\/jbc.M111.278036","article-title":"Metabolically regulated endoplasmic reticulum-associated degradation of 3-hydroxy-3-methylglutaryl-CoA reductase: evidence for requirement of a geranylgeranylated protein","volume":"286","author":"Leichner","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref63","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1104\/pp.104.050245","article-title":"Subcellular localization of Arabidopsis 3-hydroxy-3-methylglutaryl-coenzyme a reductase","volume":"137","author":"Leivar","year":"2005","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref64","doi-asserted-by":"crossref","first-page":"2367","DOI":"10.1021\/acs.jafc.1c00350","article-title":"Advanced strategies for the synthesis of terpenoids in Yarrowia lipolytica","volume":"69","author":"Li","year":"2021","journal-title":"J. Agric. Food Chem."},{"key":"2026041410172578100_ref65","doi-asserted-by":"crossref","first-page":"e1002139","DOI":"10.1371\/journal.pbio.1002139","article-title":"TURAN and EVAN mediate pollen tube reception in Arabidopsis synergids through protein glycosylation","volume":"13","author":"Lindner","year":"2015","journal-title":"PLoS Biol."},{"key":"2026041410172578100_ref66","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1042\/BCJ20220578","article-title":"Divergent contribution of the MVA and MEP pathways to the formation of polyprenols and dolichols in Arabidopsis","volume":"480","author":"Lipko","year":"2023","journal-title":"Biochem. J."},{"key":"2026041410172578100_ref67","doi-asserted-by":"crossref","first-page":"11213","DOI":"10.1021\/ja073133u","article-title":"An oxidosqualene cyclase makes numerous products by diverse mechanisms: a challenge to prevailing concepts of triterpene biosynthesis","volume":"129","author":"Lodeiro","year":"2007","journal-title":"J. Am. Chem. Soc."},{"key":"2026041410172578100_ref68","doi-asserted-by":"crossref","first-page":"e70022","DOI":"10.1111\/ppl.70022","article-title":"Differential impact of impaired steryl ester biosynthesis on the metabolome of tomato fruits and seeds","volume":"177","author":"Lopez-Tubau","year":"2025","journal-title":"Physiol. Plant."},{"key":"2026041410172578100_ref69","doi-asserted-by":"crossref","first-page":"13394","DOI":"10.1074\/jbc.275.18.13394","article-title":"Functional cloning of an Arabidopsis thaliana cDNA encoding cycloeucalenol cycloisomerase","volume":"275","author":"Lovato","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref70","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1104\/pp.17.00412","article-title":"Acyl-CoA-binding protein ACBP1 modulates sterol synthesis during embryogenesis","volume":"174","author":"Lung","year":"2017","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref71","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1194\/jlr.M056986","article-title":"The terminal enzymes of cholesterol synthesis, DHCR24 and DHCR7, interact physically and functionally","volume":"56","author":"Luu","year":"2015","journal-title":"J. Lipid Res."},{"key":"2026041410172578100_ref72","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1104\/pp.16.00431","article-title":"Suppressing farnesyl diphosphate synthase alters chloroplast development and triggers sterol-dependent induction of Jasmonate- and Fe-related responses","volume":"172","author":"Manzano","year":"2016","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref73","doi-asserted-by":"crossref","first-page":"5424","DOI":"10.3390\/ijms23105424","article-title":"Protein prenyltransferases and their inhibitors: structural and functional characterization","volume":"23","author":"Marchwicka","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"2026041410172578100_ref75","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bcp.2013.03.021","article-title":"A comprehensive machine-readable view of the mammalian cholesterol biosynthesis pathway","volume":"86","author":"Mazein","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"2026041410172578100_ref76","first-page":"765","article-title":"Brain of the blind: transcriptomics of the golden-line cavefish brain","volume":"64","author":"Meng","year":"2018","journal-title":"Curr. Zool."},{"key":"2026041410172578100_ref77","doi-asserted-by":"crossref","first-page":"4879","DOI":"10.1105\/tpc.113.115576","article-title":"Arabidopsis ERG28 tethers the sterol C4-demethylation complex to prevent accumulation of a biosynthetic intermediate that interferes with polar auxin transport","volume":"25","author":"Mialoundama","year":"2013","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref78","doi-asserted-by":"crossref","first-page":"e07999","DOI":"10.7554\/eLife.07999","article-title":"Flux analysis of cholesterol biosynthesis in vivo reveals multiple tissue and cell-type specific pathways","volume":"4","author":"Mitsche","year":"2015","journal-title":"Elife"},{"key":"2026041410172578100_ref79","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.bbalip.2005.11.002","article-title":"A systematic study of yeast sterol biosynthetic protein-protein interactions using the split-ubiquitin system","volume":"1737","author":"Mo","year":"2005","journal-title":"Biochim. Biophys. Acta"},{"key":"2026041410172578100_ref80","doi-asserted-by":"crossref","first-page":"9739","DOI":"10.1073\/pnas.112202799","article-title":"Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis","volume":"99","author":"Mo","year":"2002","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041410172578100_ref81","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/S1388-1981(03)00088-X","article-title":"In yeast sterol biosynthesis the 3-keto reductase protein (Erg27p) is required for oxidosqualene cyclase (Erg7p) activity","volume":"1633","author":"Mo","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"2026041410172578100_ref82","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbalip.2004.08.001","article-title":"The ERG28-encoded protein, Erg28p, interacts with both the sterol C-4 demethylation enzyme complex as well as the late biosynthetic protein, the C-24 sterol methyltransferase (Erg6p)","volume":"1686","author":"Mo","year":"2004","journal-title":"Biochim. Biophys. Acta"},{"key":"2026041410172578100_ref83","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.tplants.2010.09.003","article-title":"Membrane rafts in plant cells","volume":"15","author":"Mongrand","year":"2010","journal-title":"Trends Plant Sci."},{"key":"2026041410172578100_ref84","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1105\/tpc.105.036012","article-title":"Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato","volume":"18","author":"Morikawa","year":"2006","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref85","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1111\/tpj.13043","article-title":"Diversification of sterol methyltransferase enzymes in plants and a role for beta-sitosterol in oriented cell plate formation and polarized growth","volume":"84","author":"Nakamoto","year":"2015","journal-title":"Plant J."},{"key":"2026041410172578100_ref86","doi-asserted-by":"crossref","first-page":"1587","DOI":"10.1083\/jcb.105.4.1587","article-title":"Characterization of new mutants in the early part of the yeast secretory pathway isolated by a [3H]mannose suicide selection","volume":"105","author":"Newman","year":"1987","journal-title":"J. Cell Biol."},{"key":"2026041410172578100_ref87","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1248\/cpb.55.1518","article-title":"Chemical phenotypes of the hmg1 and hmg2 mutants of Arabidopsis demonstrate the in-planta role of HMG-CoA reductase in triterpene biosynthesis","volume":"55","author":"Ohyama","year":"2007","journal-title":"Chem. Pharm. Bull. (Tokyo)"},{"key":"2026041410172578100_ref88","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1073\/pnas.0807675106","article-title":"Dual biosynthetic pathways to phytosterol via cycloartenol and lanosterol in Arabidopsis","volume":"106","author":"Ohyama","year":"2009","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041410172578100_ref89","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.pbi.2006.03.004","article-title":"Biosynthetic diversity in plant triterpene cyclization","volume":"9","author":"Phillips","year":"2006","journal-title":"Curr. Opin. Plant Biol."},{"key":"2026041410172578100_ref90","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1105\/tpc.107.053926","article-title":"The Arabidopsis thaliana type I isopentenyl diphosphate isomerases are targeted to multiple subcellular compartments and have overlapping functions in isoprenoid biosynthesis","volume":"20","author":"Phillips","year":"2008","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref91","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.1242\/jcs.050625","article-title":"Genetic evidence that the higher plant Rab-D1 and Rab-D2 GTPases exhibit distinct but overlapping interactions in the early secretory pathway","volume":"122","author":"Pinheiro","year":"2009","journal-title":"J. Cell Sci."},{"key":"2026041410172578100_ref92","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1365-313X.2009.03849.x","article-title":"Identification of the Arabidopsis dry2\/sqe1-5 mutant reveals a central role for sterols in drought tolerance and regulation of reactive oxygen species","volume":"59","author":"Pose","year":"2009","journal-title":"Plant J."},{"key":"2026041410172578100_ref93","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1111\/jipb.13076","article-title":"An update on the function and regulation of methylerythritol phosphate and mevalonate pathways and their evolutionary dynamics","volume":"63","author":"Pu","year":"2021","journal-title":"J. Integr. Plant Biol."},{"key":"2026041410172578100_ref94","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1042\/BJ20131239","article-title":"Plant cyclopropylsterol-cycloisomerase: key amino acids affecting activity and substrate specificity","volume":"459","author":"Rahier","year":"2014","journal-title":"Biochem. J."},{"key":"2026041410172578100_ref95","first-page":"433","article-title":"Protein isoprenylation in suspension-cultured tobacco cells","volume":"5","author":"Randall","year":"1993","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref96","doi-asserted-by":"crossref","first-page":"17002","DOI":"10.1074\/jbc.M611831200","article-title":"Arabidopsis thaliana squalene epoxidase 1 is essential for root and seed development","volume":"282","author":"Rasbery","year":"2007","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref97","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1039\/D1NP00025J","article-title":"Alternative metabolic pathways and strategies to high-titre terpenoid production in Escherichia coli","volume":"39","author":"Rinaldi","year":"2022","journal-title":"Nat. Prod. Rep."},{"key":"2026041410172578100_ref98","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.pbi.2015.04.001","article-title":"Breaking new ground in the regulation of the early steps of plant isoprenoid biosynthesis","volume":"25","author":"Rodriguez-Concepcion","year":"2015","journal-title":"Curr. Opin. Plant Biol."},{"key":"2026041410172578100_ref99","doi-asserted-by":"crossref","first-page":"865","DOI":"10.1023\/A:1006170020836","article-title":"Protein prenylation in plants: old friends and new targets","volume":"39","author":"Rodriguez-Concepcion","year":"1999","journal-title":"Plant Mol. Biol."},{"key":"2026041410172578100_ref100","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1093\/jxb\/eraa430","article-title":"Rab-dependent vesicular traffic affects female gametophyte development in Arabidopsis","volume":"72","author":"Rojek","year":"2021","journal-title":"J. Exp. Bot."},{"key":"2026041410172578100_ref101","doi-asserted-by":"crossref","first-page":"7907","DOI":"10.3390\/ijms22157907","article-title":"The Rab geranylgeranyl transferase Beta subunit is essential for embryo and seed development in Arabidopsis thaliana","volume":"22","author":"Rojek","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"2026041410172578100_ref102","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1104\/pp.16.01392","article-title":"A single Arabidopsis gene encodes two differentially targeted geranylgeranyl diphosphate synthase isoforms","volume":"172","author":"Ruiz-Sola","year":"2016","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref103","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1111\/nph.13580","article-title":"Arabidopsis geranylgeranyl diphosphate synthase 11 is a hub isozyme required for the production of most photosynthesis-related isoprenoids","volume":"209","author":"Ruiz-Sola","year":"2016","journal-title":"New Phytol."},{"key":"2026041410172578100_ref104","doi-asserted-by":"crossref","first-page":"50","DOI":"10.3389\/fpls.2014.00050","article-title":"The role of lipid post-translational modification in plant developmental processes","volume":"5","author":"Running","year":"2014","journal-title":"Front. Plant Sci."},{"key":"2026041410172578100_ref105","doi-asserted-by":"crossref","first-page":"7815","DOI":"10.1073\/pnas.0402385101","article-title":"Enlarged meristems and delayed growth in plp mutants result from lack of CaaX prenyltransferases","volume":"101","author":"Running","year":"2004","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2026041410172578100_ref106","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1046\/j.1365-313x.2001.00994.x","article-title":"The ratio of campesterol to sitosterol that modulates growth in Arabidopsis is controlled by sterol methyltransferase 2;1","volume":"25","author":"Schaeffer","year":"2001","journal-title":"Plant J."},{"key":"2026041410172578100_ref107","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1021\/ol006016b","article-title":"Arabidopsis thaliana LUP1 converts oxidosqualene to multiple triterpene alcohols and a triterpene diol","volume":"2","author":"Segura","year":"2000","journal-title":"Org. Lett."},{"key":"2026041410172578100_ref108","doi-asserted-by":"crossref","first-page":"17549","DOI":"10.1074\/jbc.REV120.010723","article-title":"Post-translational control of the long and winding road to cholesterol","volume":"295","author":"Sharpe","year":"2020","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref109","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1074\/jbc.M115.673491","article-title":"Arabidopsis Rab geranylgeranyltransferases demonstrate redundancy and broad substrate specificity in vitro","volume":"291","author":"Shi","year":"2016","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref110","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.plaphy.2008.09.007","article-title":"Identification of a product specific beta-amyrin synthase from Arabidopsis thaliana","volume":"47","author":"Shibuya","year":"2009","journal-title":"Plant Physiol. Biochem."},{"key":"2026041410172578100_ref111","doi-asserted-by":"crossref","first-page":"1154","DOI":"10.1038\/s41477-019-0537-2","article-title":"High sterol ester 1 is a key factor in plant sterol homeostasis","volume":"5","author":"Shimada","year":"2019","journal-title":"Nat. Plants"},{"key":"2026041410172578100_ref112","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1074\/jbc.270.2.566","article-title":"Isoprenylation of plant proteins in vivo. Isoprenylated proteins are abundant in the mitochondria and nuclei of spinach","volume":"270","author":"Shipton","year":"1995","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref113","doi-asserted-by":"crossref","first-page":"e104120","DOI":"10.15252\/embj.2019104120","article-title":"A SNARE geranylgeranyltransferase essential for the organization of the Golgi apparatus","volume":"39","author":"Shirakawa","year":"2020","journal-title":"EMBO J."},{"key":"2026041410172578100_ref114","doi-asserted-by":"crossref","first-page":"16205","DOI":"10.1038\/nplants.2016.205","article-title":"Plant cholesterol biosynthetic pathway overlaps with phytosterol metabolism","volume":"3","author":"Sonawane","year":"2016","journal-title":"Nat. Plants"},{"key":"2026041410172578100_ref115","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.cmet.2005.01.001","article-title":"Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol","volume":"1","author":"Song","year":"2005","journal-title":"Cell Metab."},{"key":"2026041410172578100_ref116","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1104\/pp.19.00144","article-title":"The SMO1 family of sterol 4alpha-methyl oxidases is essential for auxin- and cytokinin-regulated embryogenesis","volume":"181","author":"Song","year":"2019","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref117","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.bbrc.2011.03.059","article-title":"Polyisoprenoids - secondary metabolites or physiologically important superlipids?","volume":"407","author":"Surmacz","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026041410172578100_ref118","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1093\/pcp\/pcj031","article-title":"Lanosterol synthase in dicotyledonous plants","volume":"47","author":"Suzuki","year":"2006","journal-title":"Plant Cell Physiol."},{"key":"2026041410172578100_ref119","doi-asserted-by":"crossref","first-page":"2055","DOI":"10.1093\/jxb\/erp073","article-title":"Complete blockage of the mevalonate pathway results in male gametophyte lethality","volume":"60","author":"Suzuki","year":"2009","journal-title":"J. Exp. Bot."},{"key":"2026041410172578100_ref120","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1006\/bbrc.1993.1395","article-title":"Occurrence of prenylated proteins in plant cells","volume":"192","author":"Swiezewska","year":"1993","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2026041410172578100_ref121","doi-asserted-by":"crossref","first-page":"108384","DOI":"10.1016\/j.jbc.2025.108384","article-title":"Double prenylation of budding yeast Ykt6 regulates cell wall integrity and autophagy","volume":"301","author":"Tateishi","year":"2025","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref122","doi-asserted-by":"crossref","first-page":"8519","DOI":"10.1074\/jbc.M112.404517","article-title":"Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast","volume":"288","author":"Theesfeld","year":"2013","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref123","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.pbi.2017.07.007","article-title":"Fats and function: protein lipid modifications in plant cell signalling","volume":"40","author":"Turnbull","year":"2017","journal-title":"Curr. Opin. Plant Biol."},{"key":"2026041410172578100_ref124","doi-asserted-by":"crossref","first-page":"2742","DOI":"10.1016\/S0021-9258(18)89424-8","article-title":"The influence of dolichol, dolichol esters, and dolichyl phosphate on phospholipid polymorphism and fluidity in model membranes","volume":"260","author":"Valtersson","year":"1985","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref125","doi-asserted-by":"crossref","first-page":"110773","DOI":"10.1016\/j.plantsci.2020.110773","article-title":"A central role for polyprenol reductase in plant dolichol biosynthesis","volume":"303","author":"Van Gelder","year":"2021","journal-title":"Plant Sci."},{"key":"2026041410172578100_ref126","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1007\/s11745-015-4008-x","article-title":"Plant sterol diversity in pollen from angiosperms","volume":"50","author":"Villette","year":"2015","journal-title":"Lipids"},{"key":"2026041410172578100_ref127","doi-asserted-by":"crossref","first-page":"1655","DOI":"10.1104\/pp.111.177758","article-title":"AtIPD: a curated database of Arabidopsis isoprenoid pathway models and genes for isoprenoid network analysis","volume":"156","author":"Vranova","year":"2011","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref128","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1038\/nrm.2015.11","article-title":"Protein prenylation: unique fats make their mark on biology","volume":"17","author":"Wang","year":"2016","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"2026041410172578100_ref129","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1039\/D2NP00054G","article-title":"Plant (di)terpenoid evolution: from pigments to hormones and beyond","volume":"40","author":"Wang","year":"2023","journal-title":"Nat. Prod. Rep."},{"key":"2026041410172578100_ref130","doi-asserted-by":"crossref","first-page":"14937","DOI":"10.1074\/jbc.RA118.001808","article-title":"\u201cMallostery\u201d-ligand-dependent protein misfolding enables physiological regulation by ERAD","volume":"293","author":"Wangeline","year":"2018","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref131","doi-asserted-by":"crossref","first-page":"100063","DOI":"10.1074\/jbc.RA120.015910","article-title":"An autonomous, but INSIG-modulated, role for the sterol sensing domain in mallostery-regulated ERAD of yeast HMG-CoA reductase","volume":"296","author":"Wangeline","year":"2021","journal-title":"J. Biol. Chem."},{"key":"2026041410172578100_ref132","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1111\/jam.13053","article-title":"Genetic engineering and molecular characterization of yeast strain expressing hybrid human-yeast squalene synthase as a tool for anti-cholesterol drug assessment","volume":"120","author":"Warchol","year":"2016","journal-title":"J. Appl. Microbiol."},{"key":"2026041410172578100_ref133","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1104\/pp.98.2.427","article-title":"Herbicide clomazone does not inhibit in vitro geranylgeranyl synthesis from mevalonate","volume":"98","author":"Weimer","year":"1992","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref134","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1104\/pp.004655","article-title":"Inhibition of squalene synthase and squalene epoxidase in tobacco cells triggers an up-regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase","volume":"130","author":"Wentzinger","year":"2002","journal-title":"Plant Physiol."},{"key":"2026041410172578100_ref135","doi-asserted-by":"crossref","first-page":"R92","DOI":"10.1186\/gb-2004-5-11-r92","article-title":"Sparse graphical gaussian modeling of the isoprenoid gene network in Arabidopsis thaliana","volume":"5","author":"Wille","year":"2004","journal-title":"Genome Biol."},{"key":"2026041410172578100_ref136","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1105\/tpc.008433","article-title":"Cell polarity and PIN protein positioning in Arabidopsis require sterol methyltransferase1 function","volume":"15","author":"Willemsen","year":"2003","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref137","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1111\/j.1469-8137.2011.03997.x","article-title":"Divergent evolution of oxidosqualene cyclases in plants","volume":"193","author":"Xue","year":"2012","journal-title":"New Phytol."},{"key":"2026041410172578100_ref138","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1093\/jxb\/ery038","article-title":"Function and molecular regulation of DWARF1 as a C-24 reductase in brassinosteroid biosynthesis in Arabidopsis","volume":"69","author":"Youn","year":"2018","journal-title":"J. Exp. Bot."},{"key":"2026041410172578100_ref139","doi-asserted-by":"crossref","first-page":"5598","DOI":"10.1038\/s41467-021-25908-6","article-title":"Sterols are required for the coordinated assembly of lipid droplets in developing seeds","volume":"12","author":"Yu","year":"2021","journal-title":"Nat. Commun."},{"key":"2026041410172578100_ref140","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1105\/tpc.108.061150","article-title":"Dolichol biosynthesis and its effects on the unfolded protein response and abiotic stress resistance in Arabidopsis","volume":"20","author":"Zhang","year":"2008","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref141","doi-asserted-by":"crossref","first-page":"2020","DOI":"10.1105\/tpc.105.031112","article-title":"A Rab-E GTPase mutant acts downstream of the Rab-D subclass in biosynthetic membrane traffic to the plasma membrane in tobacco leaf epidermis","volume":"17","author":"Zheng","year":"2005","journal-title":"Plant Cell"},{"key":"2026041410172578100_ref142","doi-asserted-by":"crossref","first-page":"884720","DOI":"10.3389\/fpls.2022.884720","article-title":"Phytoene synthase: the key rate-limiting enzyme of carotenoid biosynthesis in plants","volume":"13","author":"Zhou","year":"2022","journal-title":"Front. Plant Sci."},{"key":"2026041410172578100_ref143","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1111\/nph.17227","article-title":"Pollen sterols are associated with phylogeny and environment but not with pollinator guilds","volume":"230","author":"Zu","year":"2021","journal-title":"New Phytol."}],"container-title":["Plant and Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/pcp\/advance-article-pdf\/doi\/10.1093\/pcp\/pcaf166\/65828463\/pcaf166.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcp\/article-pdf\/67\/3\/346\/65828463\/pcaf166.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/pcp\/article-pdf\/67\/3\/346\/65828463\/pcaf166.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T14:21:30Z","timestamp":1776176490000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pcp\/article\/67\/3\/346\/8376538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,10]]},"references-count":141,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2025,12,10]]},"published-print":{"date-parts":[[2026,4,14]]}},"URL":"https:\/\/doi.org\/10.1093\/pcp\/pcaf166","relation":{},"ISSN":["0032-0781","1471-9053"],"issn-type":[{"value":"0032-0781","type":"print"},{"value":"1471-9053","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,3]]},"published":{"date-parts":[[2025,12,10]]}}}