{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T22:08:24Z","timestamp":1780524504031,"version":"3.54.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"12","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2013,12]]},"DOI":"10.1093\/pcp\/pct130","type":"journal-article","created":{"date-parts":[[2013,9,29]],"date-time":"2013-09-29T00:24:39Z","timestamp":1380414279000},"page":"1951-1962","source":"Crossref","is-referenced-by-count":44,"title":["HISN3 Mediates Adaptive Response of Chlamydomonas reinhardtii to Excess Nickel"],"prefix":"10.1093","volume":"54","author":[{"given":"Qi","family":"Zheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhen Zhen","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Min","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2013,10,10]]},"reference":[{"key":"key\n\t\t\t\t20170515162834_pct130-B1","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1081\/PLN-100103805","article-title":"Nickel toxicity induces oxidative damage in Zea mays roots","volume":"24","author":"Baccouch","year":"2001","journal-title":"J. Plant Nutr."},{"key":"key\n\t\t\t\t20170515162834_pct130-B2","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jhazmat.2012.10.021","article-title":"Phytotoxicity, bioaccumulation and degradation of isoproturon in green algae","volume":"243","author":"Bi","year":"2012","journal-title":"J. Hazard. Mater."},{"key":"key\n\t\t\t\t20170515162834_pct130-B3","first-page":"375","article-title":"Nickel: a review of its sources and environmental toxicology","volume":"15","author":"Cempel","year":"2006","journal-title":"Polish J. Environ. Stud."},{"key":"key\n\t\t\t\t20170515162834_pct130-B4","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.ecoenv.2007.07.001","article-title":"The ecotoxicity of ionic liquids and traditional organic solvents on microalga Selenastrum capricornutum","volume":"71","author":"Choa","year":"2008","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"key\n\t\t\t\t20170515162834_pct130-B5","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1146\/annurev.arplant.53.100301.135154","article-title":"Phytochelatins and metallothioneins: roles in heavy metal detoxification and homeostasis","volume":"53","author":"Cobbett","year":"2002","journal-title":"Annu. Rev. Plant Biol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B6","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1016\/j.jplph.2007.01.017","article-title":"Effects of cadmium on antioxidant enzyme and photosynthetic activities in leaves of two maize cultivars","volume":"165","author":"Ekmekci","year":"2008","journal-title":"J. Plant Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B7","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1007\/s10646-010-0514-z","article-title":"Mercury-induced oxidative stress and impact on antioxidant enzymes in Chlamydomonas reinhardtii","volume":"19","author":"Elbaz","year":"2010","journal-title":"Ecotoxicology"},{"key":"key\n\t\t\t\t20170515162834_pct130-B8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1034\/j.1399-3054.2001.1130409.x","article-title":"Nickel and copper tolerance and toxicity in three Tuscan populations of Silene paradoxa","volume":"113","author":"Gonnelli","year":"2001","journal-title":"Physiol. Plant."},{"key":"key\n\t\t\t\t20170515162834_pct130-B9","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00114-002-0373-4","article-title":"Industrial age anthropogenic inputs of heavy metals into the pedosphere","volume":"89","author":"Han","year":"2002","journal-title":"Naturwissenschaften"},{"key":"key\n\t\t\t\t20170515162834_pct130-B10","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.plantsci.2005.08.014","article-title":"Involvement of plasma-membrane NADPH oxidase in nickel-induced oxidative stress in roots of wheat seedlings","volume":"170","author":"Hao","year":"2006","journal-title":"Plant Sci."},{"key":"key\n\t\t\t\t20170515162834_pct130-B11","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.biochi.2006.04.018","article-title":"Genome-wide transcriptome profiling of the early cadmium response of Arabidopsis roots and shoots","volume":"88","author":"Herbette","year":"2006","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170515162834_pct130-B12","doi-asserted-by":"crossref","first-page":"2089","DOI":"10.1105\/tpc.104.030577","article-title":"Constitutively high expression of the histidine biosynthetic pathway contributes to nickel tolerance in hyperaccumulator plants","volume":"17","author":"Ingle","year":"2005","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170515162834_pct130-B13","first-page":"181","article-title":"Phytoremediation of heavy metal\/metalloid-contaminated soils","volume-title":"Contaminated Soils: Environmental Impact, Disposal and Treatment","author":"Jian","year":"2009"},{"key":"key\n\t\t\t\t20170515162834_pct130-B14","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.chemosphere.2011.12.071","article-title":"Bioaccumulation and biodegradation of prometryne by Chlamydonomas reinhardti","volume":"87","author":"Jin","year":"2012","journal-title":"Chemosphere"},{"key":"key\n\t\t\t\t20170515162834_pct130-B15","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1104\/pp102.010686","article-title":"The role of free histidine in xylem loading of nickel in Alyssum lesbiacum and Brassica juncea","volume":"131","author":"Kerkeb","year":"2003","journal-title":"Plant Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B16","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1073\/pnas.87.3.1228","article-title":"High-frequency nuclear transformation of Chlamydomonas reinhardtii","volume":"87","author":"Kindle","year":"1990","journal-title":"Proc. Natl Acad. Sci. USA"},{"key":"key\n\t\t\t\t20170515162834_pct130-B17","volume-title":"\u00d6kophysiologie der Algen. Wachstum und Ressourcennutzung","author":"Kohl","year":"1988"},{"key":"key\n\t\t\t\t20170515162834_pct130-B18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1038\/379635a0","article-title":"Free histidine as a metal chelator in plants that accumulate nickel","volume":"379","author":"Kr\u00e4mer","year":"1996","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170515162834_pct130-B19","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1081\/PLN-120028874","article-title":"In situ remediation of nickel phytotoxicity for different plant species","volume":"27","author":"Kukier","year":"2004","journal-title":"J. Plant Nutr."},{"key":"key\n\t\t\t\t20170515162834_pct130-B20","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aquatox.2008.12.007","article-title":"Cadmium detoxification strategies in two phytoplankton species: metal binding by newly synthesized thiolated peptides and metal sequestration in granules","volume":"92","author":"Lavoie","year":"2009","journal-title":"Aquat. Toxicol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B21","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2\u2212\u0394\u0394Ct method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"key\n\t\t\t\t20170515162834_pct130-B22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1042\/bj0360059","article-title":"Modified procedures for the colorimetric estimation of arginine and histidine","volume":"36","author":"Macpherson","year":"1942","journal-title":"Biochem. J."},{"key":"key\n\t\t\t\t20170515162834_pct130-B23","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S0147-6513(02)00122-7","article-title":"Use of chlorophyll fluorescence in metal-stress research: a case study with the green microalga Scenedesmus","volume":"55","author":"Mallicka","year":"2003","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"key\n\t\t\t\t20170515162834_pct130-B24","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/S0021-9258(19)81458-8","article-title":"Physical and chemical characterization of the isomerase of histidine biosynthesis in Salmonella typhimurium","volume":"242","author":"Margolies","year":"1967","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170515162834_pct130-B25","volume-title":"Mineral Nutrition of Higher Plants","author":"Marschner","year":"1995"},{"key":"key\n\t\t\t\t20170515162834_pct130-B26","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1126\/science.1143609","article-title":"The Chlamydomonas genome reveals the evolution of key animal and plant functions","volume":"318","author":"Merchant","year":"2007","journal-title":"Science"},{"key":"key\n\t\t\t\t20170515162834_pct130-B56","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.aquatox.2005.02.007","article-title":"Toxicity of selenite in the unicellular green alga Chlamydomonas reinhardtii: comparison between effects at the population and sub-cellular level","volume":"73","author":"Morlon","year":"2005","journal-title":"Aquat Toxicol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B27","doi-asserted-by":"crossref","first-page":"e1002013","DOI":"10.1371\/journal.pgen.1002013","article-title":"Histidine protects against zinc and nickel toxicity in Caenorhabditis elegans","volume":"7","author":"Murphy","year":"2011","journal-title":"PLoS Genet."},{"key":"key\n\t\t\t\t20170515162834_pct130-B28","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.envexpbot.2010.04.004","article-title":"The role of sulfur assimilation and sulfur-containing compounds in trace element homeostasis in plants","volume":"72","author":"Na","year":"2011","journal-title":"Environ. Exp. Bot."},{"key":"key\n\t\t\t\t20170515162834_pct130-B29","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0168-9452(00)00281-8","article-title":"A rapid and sensitive assay method for measuring amine oxidase based on hydrogen peroxide\u2013titanium complex formation","volume":"157","author":"Nag","year":"2000","journal-title":"Plant Sci."},{"key":"key\n\t\t\t\t20170515162834_pct130-B30","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.jmb.2010.09.016","article-title":"The roles of stress-activated Sty1 and Gcn2 kinases and of the protooncoprotein homologue Int6\/eIF3e in responses to endogenous oxidative stress during histidine starvation","volume":"404","author":"Nemoto","year":"2010","journal-title":"J. Mol. Biol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B31","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1093\/pcp\/pcr089","article-title":"AtIRT, the primary iron uptake transporter in the root, mediates excess nickel accumulation in Arabidopsis thaliana","volume":"52","author":"Nishida","year":"2011","journal-title":"Plant Cell Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B32","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1093\/pcp\/pci119","article-title":"ALBINO AND PALE GREEN 10 encodes BBMII isomerase involved in histidine biosynthesis in Arabidopsis thaliana","volume":"46","author":"Noutoshi","year":"2005","journal-title":"Plant Cell Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B33","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0304-4165(01)00214-8","article-title":"Protective effect of histidine on para-nonylphenol-enhanced hydroxyl free radical generation induced by 1-methyl-4-phenylpyridium ion (MPP+) in rat striatum","volume":"1568","author":"Obata","year":"2001","journal-title":"Biochim. Biophys. Acta"},{"key":"key\n\t\t\t\t20170515162834_pct130-B34","article-title":"Guideline for Testing of Chemicals. Proposal for Updating Guideline 201, Freshwater Alga and Cyanobacteria. Growth Inhibition Test","author":"OECD","year":"2002"},{"key":"key\n\t\t\t\t20170515162834_pct130-B35","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1104\/pp.122.3.907","article-title":"Molecular cloning and characterization of ATP-phosphoribosyl transferase from Arabidopsis, a key enzyme in the histidine biosynthetic pathway","volume":"122","author":"Ohta","year":"2000","journal-title":"Plant Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B36","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s002440010144","article-title":"Antioxidant modulation in response to metal-induced oxidative stress in algal chloroplasts","volume":"40","author":"Okamoto","year":"2001","journal-title":"Arch. Environ. Contamin. Toxicol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B38","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/j.freeradbiomed.2010.05.023","article-title":"Histidine, cystine, glutamine, and threonine collectively protect astrocytes from the toxicity of zinc","volume":"49","author":"Ralph","year":"2010","journal-title":"Free Radic. Biol. Med."},{"key":"key\n\t\t\t\t20170515162834_pct130-B39","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1111\/j.1467-7652.2009.00419.x","article-title":"Relative contribution of nine genes in the pathway of histidine biosynthesis to the control of free histidine concentrations in Arabidopsis thaliana","volume":"7","author":"Rees","year":"2009","journal-title":"Plant Biotechnol. J."},{"key":"key\n\t\t\t\t20170515162834_pct130-B40","first-page":"1351","article-title":"Plant responses to abiotic stresses: heavy metal-induced oxidative stress and protection by mycorrhization","volume":"53","author":"Sch\u00fctzend\u00fcbel","year":"2002","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20170515162834_pct130-B41","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1111\/j.1365-3040.2011.02279.x","article-title":"Expression of a Brassica napus heme oxygenase confers plant tolerance to mercury toxicity","volume":"34","author":"Shen","year":"2011","journal-title":"Plant Cell Environ."},{"key":"key\n\t\t\t\t20170515162834_pct130-B42","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1105\/tpc.004853","article-title":"Molecular mechanisms of proline-mediated tolerance to toxic heavy metals in transgenic microalgae","volume":"14","author":"Siripornadulsil","year":"2002","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170515162834_pct130-B43","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1016\/j.chemosphere.2009.08.007","article-title":"Differential alterations of antioxidant defenses as bioindicators of mercury and cadmium toxicity in alfalfa","volume":"77","author":"Sobrino-Plata","year":"2009","journal-title":"Chemosphere"},{"key":"key\n\t\t\t\t20170515162834_pct130-B44"},{"key":"key\n\t\t\t\t20170515162834_pct130-B45","first-page":"55","article-title":"Quantitative relation between the reaction of hydroxylamine and superoxide anion radicals in plants","volume":"6","author":"Wang","year":"1990","journal-title":"Plant Physiol. Commun."},{"key":"key\n\t\t\t\t20170515162834_pct130-B46","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.1093\/pcp\/pci202","article-title":"Nitric oxide reduces aluminum toxicity by preventing oxidative stress in the roots of Cassia tora L","volume":"46","author":"Wang","year":"2005","journal-title":"Plant Cell Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B47","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1093\/pcp\/pcr102","article-title":"Regulation of tolerance of Chlamydomonas reinhardtii to heavy metal toxicity by heme oxygenase-1 and carbon monoxide","volume":"52","author":"Wei","year":"2011","journal-title":"Plant Cell Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B48","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1023\/A:1006188004189","article-title":"Rapid light curves: a new fluorescence method to assess the state of the photosynthetic apparatus","volume":"59","author":"White","year":"1999","journal-title":"Photosynth. Res."},{"key":"key\n\t\t\t\t20170515162834_pct130-B49","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.febslet.2004.10.086","article-title":"Enhancing the first enzymatic step in the histidine biosynthesis pathway increases the free histidine pool and nickel tolerance in Arabidopsis thaliana","volume":"578","author":"Wycisk","year":"2004","journal-title":"FEBS Lett."},{"key":"key\n\t\t\t\t20170515162834_pct130-B50","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s00244-010-9535-0","article-title":"Protective responses of 28-homobrassinolide in cultivars of Triticum aestivum with different levels of nickel","volume":"60","author":"Yusuf","year":"2011","journal-title":"Arch. Environ. Contamin. Toxicol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B51","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1093\/pcp\/pcn017","article-title":"Copper-induced proline synthesis is associated with nitric oxide generation in Chlamydomonas reinhardtii","volume":"49","author":"Zhang","year":"2008","journal-title":"Plant Cell Physiol."},{"key":"key\n\t\t\t\t20170515162834_pct130-B52","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.jhazmat.2013.01.053","article-title":"miR395 is involved in detoxification of cadmium in Brassica napus","volume":"250\u2013251","author":"Zhang","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"key\n\t\t\t\t20170515162834_pct130-B53","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s10646-010-0583-z","article-title":"Bioaccumulation and degradation of pesticide fluroxypyr are associated with toxic tolerance in green alga Chlamydomonas reinhardtii","volume":"20","author":"Zhang","year":"2011","journal-title":"Ecotoxicology"},{"key":"key\n\t\t\t\t20170515162834_pct130-B54","first-page":"3443","article-title":"Genome-wide identification of Brassica napus microRNAs and their targets reveals their differential regulation by cadmium","volume":"59","author":"Zhou","year":"2012","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20170515162834_pct130-B55","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/j.chemosphere.2007.08.028","article-title":"Biological detection and analysis of mercury toxicity to alfalfa (Medicago sativa) plants","volume":"70","author":"Zhou","year":"2008","journal-title":"Chemosphere"}],"container-title":["Plant and Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/pcp\/article-pdf\/54\/12\/1951\/17116612\/pct130.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T04:01:43Z","timestamp":1646625703000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pcp\/article-lookup\/doi\/10.1093\/pcp\/pct130"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2013,10,10]]},"references-count":55,"journal-issue":{"issue":"12","published-online":{"date-parts":[[2013,10,10]]},"published-print":{"date-parts":[[2013,12]]}},"URL":"https:\/\/doi.org\/10.1093\/pcp\/pct130","relation":{},"ISSN":["1471-9053","0032-0781"],"issn-type":[{"value":"1471-9053","type":"electronic"},{"value":"0032-0781","type":"print"}],"subject":[],"published":{"date-parts":[[2013,10,10]]}}}