{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T08:03:05Z","timestamp":1779350585401,"version":"3.51.4"},"reference-count":56,"publisher":"Oxford University Press (OUP)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2015,3]]},"DOI":"10.1093\/pcp\/pcu180","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T22:27:09Z","timestamp":1417213629000},"page":"442-454","source":"Crossref","is-referenced-by-count":42,"title":["Defective Copper Transport in the \n            copt5\n             Mutant Affects Cadmium Tolerance"],"prefix":"10.1093","volume":"56","author":[{"given":"Angela","family":"Carri\u00f3-Segu\u00ed","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoni","family":"Garcia-Molina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amparo","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lola","family":"Pe\u00f1arrubia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[2014,11,27]]},"reference":[{"key":"key\n\t\t\t\t20170627033850_pcu180-B1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1105\/tpc.104.030452","article-title":"Two P-type ATPases are required for copper delivery in Arabidopsis thaliana chloroplasts","volume":"17","author":"Abdel-Ghany","year":"2005","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B2","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-313X.2005.02601.x","article-title":"The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots","volume":"45","author":"Andr\u00e9s-Col\u00e1s","year":"2006","journal-title":"Plant J."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B3","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1039\/c3mt00025g","article-title":"Comparison of global responses to mild deficiency and excess copper levels in \n              Arabidopsis\n               seedlings","volume":"5","author":"Andr\u00e9s-Col\u00e1s","year":"2013","journal-title":"Metallomics"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B4","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/j.jplph.2006.09.006","article-title":"Heavy-metal-induced ethylene production in \n              Arabidopsis thaliana","volume":"164","author":"Arteca","year":"2007","journal-title":"J. Plant Physiol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B5","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1105\/tpc.111.090431","article-title":"Transcriptome sequencing identifies SPL7-regulated copper acquisition genes \n              FRO4\/FRO5\n               and the copper dependence of iron homeostasis in \n              Arabidopsis","volume":"24","author":"Bernal","year":"2012","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B6","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1016\/j.biochi.2006.07.003","article-title":"Toxic metal accumulation, responses to exposure and mechanisms of tolerance in plants","volume":"88","author":"Clemens","year":"2006","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B7","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.tplants.2012.08.003","article-title":"Plant science: the key to preventing slow cadmium poisoning","volume":"18","author":"Clemens","year":"2013","journal-title":"Trends Plant Sci."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B8","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1007\/s10534-010-9329-x","article-title":"Cadmium stress: an oxidative challenge","volume":"23","author":"Cuypers","year":"2010","journal-title":"Biometals"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B9","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jplph.2010.07.010","article-title":"The cellular redox state as a modulator in cadmium and copper responses in \n              Arabidopsis thaliana\n               seedlings","volume":"168","author":"Cuypers","year":"2011","journal-title":"J. Plant Physiol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B10","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1105\/tpc.111.095000","article-title":"Elevated nicotianamine levels in Arabidopsis halleri roots play a key role in zinc hyperaccumulation","volume":"24","author":"Deinlein","year":"2012","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B11","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1023\/A:1012456507827","article-title":"Phytotoxic effects of Cd, Zn, Pb, Cu and Fe on \n              Sinapis alba\n               L. seedlings and their accumulation in roots and shoots","volume":"44","author":"Fargasova","year":"2001","journal-title":"Biol. Plant."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B12","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1111\/j.1365-313X.2010.04472.x","article-title":"The intracellular Arabidopsis COPT5 transport protein is required for photosynthetic electron transport under severe copper deficiency","volume":"65","author":"Garcia-Molina","year":"2011","journal-title":"Plant J."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B13","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1186\/s12870-014-0231-5","article-title":"Functional characterisation of Arabidopsis SPL7 conserved protein domains suggests novel regulatory mechanisms in the Cu deficiency response","volume":"14","author":"Garcia-Molina","year":"2014","journal-title":"BMC Plant Biol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B14","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1039\/c3mt00111c","article-title":"The CTR\/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in \n              A\n              . thaliana","volume":"5","author":"Gayomba","year":"2013","journal-title":"Metallomics"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B15","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.tplants.2014.06.013","article-title":"A tidal wave of signals: calcium and ROS at the forefront of rapid systemic signaling","volume":"19","author":"Gilroy","year":"2014","journal-title":"Trends Plant Sci."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1105\/tpc.2.6.513","article-title":"Exploiting the triple response of Arabidopsis to identify ethylene-related mutants","volume":"2","author":"Guzm\u00e1n","year":"1990","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B17","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1038\/nature06877","article-title":"Evolution of metal hyperaccumulation required cis-regulatory changes and triplication of HMA4","volume":"453","author":"Hanikenne","year":"2008","journal-title":"Nature"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B18","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1089\/15230860152542970","article-title":"Zinc finger proteins as potential targets for toxic metal ions: differential effects on structure and function","volume":"3","author":"Hartwig","year":"2001","journal-title":"Antiox. Redox Signal."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B19","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1007\/s10529-011-0763-9","article-title":"Cd\n              2+\n               binds to Atx1 and affects the physical interaction between Atx1 and Ccc2 in \n              Saccharomyces cerevisiae","volume":"34","author":"Heo","year":"2012","journal-title":"Biotechnol. Lett."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B20","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1016\/j.biochi.2006.04.018","article-title":"Genome-wide transcriptome profiling of the early cadmium response of \n              Arabidopsis\n               roots and shoots","volume":"88","author":"Herbette","year":"2006","journal-title":"Biochimie"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B21","doi-asserted-by":"crossref","first-page":"2153","DOI":"10.1093\/jxb\/eri215","article-title":"Physiological characterization of Mg deficiency in \n              Arabidopsis thaliana","volume":"56","author":"Hermans","year":"2005","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B22","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0092-8674(00)80747-3","article-title":"RESPONSIVE-TO ANTAGONIST1, a Menkes\/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis","volume":"97","author":"Hirayama","year":"1999","journal-title":"Cell"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B23","doi-asserted-by":"crossref","first-page":"3535","DOI":"10.1105\/tpc.113.115659","article-title":"An Arabidopsis soil-salinity-tolerance mutation confers ethylene-mediated enhancement of sodium\/potassium homeostasis","volume":"25","author":"Jiang","year":"2013","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B24","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.plaphy.2012.12.005","article-title":"A mutant of the \n              Arabidopsis thaliana\n               LIPOXYGENASE1 gene shows altered signalling and oxidative stress related responses after cadmium exposure","volume":"63","author":"Keunen","year":"2013","journal-title":"Plant Physiol. Biochem."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B25","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1469-8137.2011.03798.x","article-title":"The tonoplast copper transporter COPT5 acts as an exporter and is required for interorgan allocation of copper in \n              Arabidopsis thaliana","volume":"192","author":"Klaumann","year":"2011","journal-title":"New Phytol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B26","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-arplant-042809-112156","article-title":"Metal hyperaccumulation in plants","volume":"61","author":"Kramer","year":"2010","journal-title":"Annu. Rev. Plant Biol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B27","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1023\/A:1020359825056","article-title":"Amonium ion, ethylene, and NaCl-induced senescence of detached rice leaves","volume":"37","author":"Lin","year":"2002","journal-title":"Plant Growth Regul."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B28","doi-asserted-by":"crossref","first-page":"3187","DOI":"10.1007\/s00018-012-1089-z","article-title":"The molecular mechanism of zinc and cadmium stress response in plants","volume":"69","author":"Lin","year":"2012","journal-title":"Cell. Mol. Life Sci."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B29","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1023\/A:1004753521646","article-title":"Cd\n              2+\n               effects on transmembrane electrical potential difference, respiration and membrane permeability of rice (\n              Oryza sativa\n               L) roots","volume":"219","author":"Llamas","year":"2000","journal-title":"Plant Soil"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B30","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1007\/BF00282924","article-title":"Genotypic tolerance to metals as indicated by ethylene production","volume":"57\u201358","author":"Lu","year":"1991","journal-title":"Water Air Soil Pollut."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B31","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1093\/jxb\/erq281","article-title":"Root responses to cadmium in the rhizosphere: a review","volume":"62","author":"Lux","year":"2011","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.envexpbot.2011.12.017","article-title":"The early response of \n              Arabidopsis thaliana\n               to cadmium- and copper-induced stress","volume":"78","author":"Mart\u00ednez-Pe\u00f1alver","year":"2012","journal-title":"Environ. Exp. Bot."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B33","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1111\/j.1365-3040.2011.02432.x","article-title":"Role of ethylene in alleviation of cadmium-induced photosynthetic capacity inhibition by sulphur in mustard","volume":"35","author":"Masood","year":"2012","journal-title":"Plant Cell Environ."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B34","doi-asserted-by":"crossref","first-page":"804","DOI":"10.1111\/pce.12016","article-title":"Mutants impaired in vacuolar metal mobilization identify chloroplasts as a target for cadmium hypersensitivity in \n              Arabidopsis thaliana","volume":"36","author":"Molins","year":"2013","journal-title":"Plant Cell Environ."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B35","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1007\/s00775-009-0591-8","article-title":"Regulation of copper transport in \n              Arabidopsis thaliana\n              : a biochemical oscillator?","volume":"15","author":"Pe\u00f1arrubia","year":"2010","journal-title":"J. Biol. Inorg. Chem."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B36","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1093\/nar\/30.9.e36","article-title":"Relative expression software tool (REST) for group-wise comparison and statistical analysis of relative expression results in real-time PCR","volume":"30","author":"Pfaffl","year":"2002","journal-title":"Nucleic Acids Res."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B37","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1111\/j.1469-8137.2011.03869.x","article-title":"Moving copper in plants","volume":"192","author":"Pilon","year":"2012","journal-title":"New Phytol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B38","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1111\/j.1399-3054.1993.tb00173.x","article-title":"Chromium-induced inhibition of ethylene evolution in bean (\n              Phaseolus vulgaris\n              ) leaves","volume":"89","author":"Poschenrieder","year":"1993","journal-title":"Physiol. Plant."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B39","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1111\/pce.12020","article-title":"Calcium- and potassium-permeable plasma membrane transporters are activated by copper in \n              Arabidopsis\n               root tips: linking copper transport with cytosolic hydroxyl radical production","volume":"36","author":"Rodrigo-Moreno","year":"2013","journal-title":"Plant Cell Environ."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B40","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1126\/science.283.5404.996","article-title":"A copper cofactor for the ethylene receptor ETR1 from \n              Arabidopsis","volume":"283","author":"Rodr\u00edguez","year":"1999","journal-title":"Science"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B41","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1104\/pp.108.131524","article-title":"Cellular response of pea plants to cadmium toxicity: crosstalk between reactive oxygen species, nitric oxide, and calcium","volume":"150","author":"Rodr\u00edguez-Serrano","year":"2009","journal-title":"Plant Physiol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B42","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00025217","article-title":"Cadmium and nickel accumulation in rice plants. Effects on mineral nutrition and possible interactions of abscisic and gibberellic acids","volume":"14","author":"Rubio","year":"1994","journal-title":"Plant Growth Regul."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B43","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1023\/A:1022345507112","article-title":"Identification of a copper transporter family in \n              Arabidopsis thaliana","volume":"51","author":"Sancen\u00f3n","year":"2003","journal-title":"Plant Mol. Biol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B44","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1093\/jexbot\/52.364.2115","article-title":"Cadmium-induced changes in the growth and oxidative metabolism of pea plants","volume":"52","author":"Sandalio","year":"2001","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B45"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B46","doi-asserted-by":"crossref","first-page":"980","DOI":"10.4161\/psb.4.10.9668","article-title":"Distinctive phytotoxic effects of Cd and Ni on membrane functionality","volume":"4","author":"Sanz","year":"2009","journal-title":"Plant Signal. Behav."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B47","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1186\/s12870-014-0214-6","article-title":"Cadmium-induced ethylene production and responses in \n              Arabidopsis thaliana\n               rely on ACS2 and ACS6 gene expression","volume":"14","author":"Schellingen","year":"2014","journal-title":"BMC Plant Biol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B48","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1111\/pce.12056","article-title":"The role of the kinase OXI1 in cadmium- and copper-induced molecular responses in \n              Arabidopsis thaliana","volume":"36","author":"Smeets","year":"2013","journal-title":"Plant Cell Environ."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B49","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1016\/j.jplph.2009.06.014","article-title":"Oxidative stress-related responses at transcriptional and enzymatic levels after exposure to Cd or Cu in a multipollution context","volume":"166","author":"Smeets","year":"2009","journal-title":"J. Plant Physiol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B50","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1093\/aob\/mcl261","article-title":"A chemically induced new pea (\n              Pisum sativum\n              ) mutant SGECdt with increased tolerance to, and accumulation of, cadmium","volume":"99","author":"Tsyganov","year":"2007","journal-title":"Ann. Bot."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B51","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/jxb\/erp119","article-title":"Root-to-shoot Cd translocation via the xylem is the major process determining shoot and grain cadmium accumulation in rice","volume":"60","author":"Uraguchi","year":"2009","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B52","first-page":"551","article-title":"How cobalt facilitates cadmium- and ethylene precursor-induced growth inhibition and radial cell expansion in barley root tips","volume":"7","author":"Valentovicova","year":"2012","journal-title":"Cent. Eur. J. Biol."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B53","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1093\/jxb\/erp313","article-title":"Gene expression analysis in cadmium-stressed roots of a low cadmium-accumulating solanaceous plant, \n              Solanum torvum","volume":"61","author":"Yamaguchi","year":"2010","journal-title":"J. Exp. Bot."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B54","doi-asserted-by":"crossref","first-page":"16369","DOI":"10.1074\/jbc.M700138200","article-title":"Regulation of copper homeostasis by micro-RNA in \n              Arabidopsis","volume":"282","author":"Yamasaki","year":"2007","journal-title":"J. Biol. Chem."},{"key":"key\n\t\t\t\t20170627033850_pcu180-B55","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1105\/tpc.108.060137","article-title":"SQUAMOSA Promoter Binding Protein-Like7 is a central regulator for copper homeostasis in Arabidopsis","volume":"21","author":"Yamasaki","year":"2009","journal-title":"Plant Cell"},{"key":"key\n\t\t\t\t20170627033850_pcu180-B56","doi-asserted-by":"crossref","first-page":"1090","DOI":"10.1039\/c3mt00086a","article-title":"Transition metals in plant photosynthesis","volume":"5","author":"Yruela","year":"2013","journal-title":"Metallomics"}],"container-title":["Plant and Cell Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/pcp\/article-pdf\/56\/3\/442\/17912338\/pcu180.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,8,24]],"date-time":"2017-08-24T08:25:07Z","timestamp":1503563107000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/pcp\/article-lookup\/doi\/10.1093\/pcp\/pcu180"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,11,27]]},"references-count":56,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2014,11,27]]},"published-print":{"date-parts":[[2015,3]]}},"URL":"https:\/\/doi.org\/10.1093\/pcp\/pcu180","relation":{},"ISSN":["1471-9053","0032-0781"],"issn-type":[{"value":"1471-9053","type":"electronic"},{"value":"0032-0781","type":"print"}],"subject":[],"published":{"date-parts":[[2014,11,27]]}}}