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This response to iron deficiency is regulated by transcriptional networks mediated by transcription factors (TFs) and protein-level modification of key factors by ubiquitin ligases. Several of the basic helix\u2013loop\u2013helix TFs and the HRZ\/BTS ubiquitin ligases are conserved across graminaceous and non-graminaceous plants. Other regulators are specific, such as IDEF1 and IDEF2 in graminaceous plants and FIT\/FER and MYB10\/72 in non-graminaceous plants. IMA\/FEP peptides positively regulate the iron-deficiency responses in a wide range of plants by unknown mechanisms. Direct binding of iron or other metals to some key regulators, including HRZ\/BTS and IDEF1, may be responsible for intracellular iron-sensing and -signaling events. In addition, key TFs such as FIT and IDEF1 interact with various proteins involved in signaling pathways of plant hormones, oxidative stress and metal abundance. Thus, FIT and IDEF1 might function as hubs for the integration of environmental signals to modulate the responses to iron deficiency. In addition to local iron signaling, root iron responses are modulated by shoot-derived long-distance signaling potentially mediated by phloem-mobile substances such as iron, iron chelates and IMA\/FEP peptides.<\/jats:p>","DOI":"10.1093\/pcp\/pcz038","type":"journal-article","created":{"date-parts":[[2019,2,22]],"date-time":"2019-02-22T12:11:06Z","timestamp":1550837466000},"page":"1440-1446","source":"Crossref","is-referenced-by-count":93,"title":["Understanding the Complexity of Iron Sensing and Signaling Cascades in Plants"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7118-6955","authenticated-orcid":false,"given":"Takanori","family":"Kobayashi","sequence":"first","affiliation":[{"name":"Research Institute for Bioresources and Biotechnology, Ishikawa Prefectural University, 1-308 Suematsu, Nonoichi, Ishikawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,2,23]]},"reference":[{"key":"2020071623114064300_pcz038-B1","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/ppl.12698","article-title":"Rice HRZ ubiquitin ligases are crucial for response to excess iron","volume":"163","author":"Aung","year":"2018","journal-title":"Physiol. 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Plant Biol."},{"key":"2020071623114064300_pcz038-B25","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.plantsci.2014.04.002","article-title":"Iron sensors and signals in response to iron deficiency","volume":"224","author":"Kobayashi","year":"2014","journal-title":"Plant Sci."},{"key":"2020071623114064300_pcz038-B26","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.freeradbiomed.2018.10.439","article-title":"Iron transport and its regulation in plants","volume":"133","author":"Kobayashi","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"2020071623114064300_pcz038-B27","doi-asserted-by":"crossref","first-page":"19150","DOI":"10.1073\/pnas.0707010104","article-title":"The transcription factor IDEF1 regulates the response to and tolerance of iron deficiency in plants","volume":"104","author":"Kobayashi","year":"2007","journal-title":"Proc. Natl. Acad. Sci. 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Biol."},{"key":"2020071623114064300_pcz038-B40","doi-asserted-by":"crossref","first-page":"2867","DOI":"10.1093\/jxb\/erl054","article-title":"Isolation and characterization of IRO2, a novel iron-regulated bHLH transcription factor in graminaceous plants","volume":"57","author":"Ogo","year":"2006","journal-title":"J. Exp. Bot."},{"key":"2020071623114064300_pcz038-B41","doi-asserted-by":"crossref","first-page":"13407","DOI":"10.1074\/jbc.M708732200","article-title":"A novel NAC transcription factor, IDEF2, that recognizes the iron deficiency-responsive element 2 regulates the genes involved in iron homeostasis in plants","volume":"283","author":"Ogo","year":"2008","journal-title":"J. Biol. Chem."},{"key":"2020071623114064300_pcz038-B42","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1111\/j.1365-313X.2007.03149.x","article-title":"The rice bHLH protein OsIRO2 is an essential regulator of the genes involved in Fe uptake under Fe-deficient conditions","volume":"51","author":"Ogo","year":"2007","journal-title":"Plant J"},{"key":"2020071623114064300_pcz038-B43","doi-asserted-by":"crossref","first-page":"e1003953","DOI":"10.1371\/journal.pgen.1003953","article-title":"MYB10 and MYB72 are required for growth under iron-limiting conditions","volume":"9","author":"Palmer","year":"2013","journal-title":"PLoS Genet."},{"key":"2020071623114064300_pcz038-B44","article-title":"BRUTUS-LIKE proteins moderate the transcriptional response to iron deficiency in roots","author":"Rodr\ufffdguez-Celma","year":"2017","journal-title":"bioRxiv"},{"key":"2020071623114064300_pcz038-B45","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1104\/pp.80.1.175","article-title":"Evidence for a specific uptake system for iron phytosiderophores in roots of grasses","volume":"80","author":"R\ufffdmheld","year":"1986","journal-title":"Plant Physiol."},{"key":"2020071623114064300_pcz038-B46","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1007\/s11103-018-0735-8","article-title":"The bHLH transcription factor ILR3 modulates multiple stress responses in Arabidopsis","volume":"97","author":"Samira","year":"2018","journal-title":"Plant Mol. Biol."},{"key":"2020071623114064300_pcz038-B47","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1016\/j.plaphy.2010.12.001","article-title":"A hitchhiker's guide to the Arabidopsis ferrome","volume":"49","author":"Schmidt","year":"2011","journal-title":"Plant Physiol. Biochem."},{"key":"2020071623114064300_pcz038-B48","doi-asserted-by":"crossref","first-page":"2463","DOI":"10.1111\/pce.13363","article-title":"The E3 ligase BRUTUS facilitates degradation of VOZ1\/2 transcription factors","volume":"41","author":"Selote","year":"2018","journal-title":"Plant. Cell Environ."},{"key":"2020071623114064300_pcz038-B49","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1104\/pp.114.250837","article-title":"Iron-binding E3 ligase mediates iron response in plants by targeting basic helix-loop-helix transcription factors","volume":"167","author":"Selote","year":"2015","journal-title":"Plant Physiol."},{"key":"2020071623114064300_pcz038-B50","doi-asserted-by":"crossref","first-page":"e44843","DOI":"10.1371\/journal.pone.0044843","article-title":"Arabidopsis bHLH100 and bHLH101 control iron homeostasis via a FIT-independent pathway","volume":"7","author":"Sivitz","year":"2012","journal-title":"PLoS One."},{"key":"2020071623114064300_pcz038-B51","doi-asserted-by":"crossref","first-page":"E5213","DOI":"10.1073\/pnas.1722335115","article-title":"MYB72-dependent coumarin exudation shapes root microbiome assembly to promote plant health","volume":"115","author":"Stringlis","year":"2018","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"2020071623114064300_pcz038-B52","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/00380768.1976.10433004","article-title":"Naturally occurring iron-chelating compounds in oat- and rice-root washing. I. Activity measurement and preliminary characterization","volume":"22","author":"Takagi","year":"1976","journal-title":"Soil Sci. Plant Nutr"},{"key":"2020071623114064300_pcz038-B53","doi-asserted-by":"crossref","first-page":"25485","DOI":"10.1038\/srep25485","article-title":"CSN6, a subunit of the COP9 signalosome, is involved in early response to iron deficiency in Oryza sativa","volume":"6","author":"Tan","year":"2016","journal-title":"Sci. Rep."},{"key":"2020071623114064300_pcz038-B54","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10265-018-1068-z","article-title":"The basic helix-loop-helix transcription factor, bHLH11 functions in the iron-uptake system in Arabidopsis thaliana","volume":"132","author":"Tanabe","year":"2019","journal-title":"J. Plant Res."},{"key":"2020071623114064300_pcz038-B55","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.tplants.2017.03.008","article-title":"Mobilization of iron by plant-borne coumarins","volume":"22","author":"Tsai","year":"2017","journal-title":"Trends Plant Sci."},{"key":"2020071623114064300_pcz038-B56","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1104\/pp.102.016089","article-title":"Dual regulation of the Arabidopsis high-affinity root iron uptake system by local and long-distance signals","volume":"132","author":"Vert","year":"2003","journal-title":"Plant Physiol."},{"key":"2020071623114064300_pcz038-B57","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1093\/mp\/sss089","article-title":"Requirement and functional redundancy of Ib subgroup bHLH proteins for iron deficiency responses and uptake in Arabidopsis thaliana","volume":"6","author":"Wang","year":"2013","journal-title":"Mol. 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