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Therefore, this study examines the interplay between H2O2 metabolism and GSNO signaling in Arabidopsis. Comparing the Zn tolerance of the wild type (WT), GSNO reductase (GSNOR) overexpressor 35S::FLAG-GSNOR1 and GSNOR-deficient gsnor1-3, we observed relative Zn tolerance of gsnor1-3, which was not accompanied by altered Zn accumulation capacity. Moreover, in gsnor1-3 plants Zn did not induce NO\/S-nitrosothiol (SNO) signaling, possibly due to the enhanced activity of NADPH-dependent thioredoxin reductase. In WT and 35S::FLAG-GSNOR1, GSNOR was inactivated by Zn, and Zn-induced H2O2 is directly involved in the GSNOR activity loss. In WT seedlings, Zn resulted in a slight intensification of protein nitration detected by Western blot and protein S-nitrosation observed by resin-assisted capture of SNO proteins (RSNO-RAC). LC-MS\/MS analyses indicate that Zn induces the S-nitrosation of ascorbate peroxidase 1. Our data collectively show that Zn-induced H2O2 may influence its own level, which involves GSNOR inactivation-triggered SNO signaling. These data provide new evidence for the interplay between H2O2 and SNO signaling in Arabidopsis plants affected by metal stress.<\/jats:p>","DOI":"10.1093\/pcp\/pcz138","type":"journal-article","created":{"date-parts":[[2019,7,23]],"date-time":"2019-07-23T15:07:36Z","timestamp":1563894456000},"page":"2449-2463","source":"Crossref","is-referenced-by-count":39,"title":["S-Nitrosothiol Signaling Is involved in Regulating Hydrogen Peroxide Metabolism of Zinc-Stressed Arabidopsis"],"prefix":"10.1093","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7819-4672","authenticated-orcid":false,"given":"Zs","family":"Kolbert","sequence":"first","affiliation":[{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00ef\u00bf\u00bd","family":"Moln\u00ef\u00bf\u00bdr","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Ol\u00ef\u00bf\u00bdh","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Feigl","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Horv\u00ef\u00bf\u00bdth","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Erdei","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"\u00ef\u00bf\u00bdrd\u00ef\u00bf\u00bdg","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, University of Szeged, Szeged, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E","family":"Rudolf","sequence":"additional","affiliation":[{"name":"Institute of Biochemical Plant Pathology, Helmholtz Zentrum M\u00ef\u00bf\u00bdnchen\u2014German Research Center for Environmental Health, M\u00ef\u00bf\u00bdnchen\/Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Barth","sequence":"additional","affiliation":[{"name":"Research Unit Protein Science, Helmholtz Zentrum M\u00ef\u00bf\u00bdnchen\u2014German Research Center for Environmental Health, M\u00ef\u00bf\u00bdnchen\/Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9343-4996","authenticated-orcid":false,"given":"C","family":"Lindermayr","sequence":"additional","affiliation":[{"name":"Institute of Biochemical Plant Pathology, Helmholtz Zentrum M\u00ef\u00bf\u00bdnchen\u2014German Research Center for Environmental Health, M\u00ef\u00bf\u00bdnchen\/Neuherberg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,7,24]]},"reference":[{"key":"2019110807083410400_pcz138-B1","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0076-6879(99)00129-9","article-title":"Preparation and assay of mammalian thioredoxin and thioredoxin reductase","volume":"300","author":"Arn\u00ef\u00bf\u00bdr","year":"1999","journal-title":"Methods Enzymol"},{"key":"2019110807083410400_pcz138-B2","doi-asserted-by":"crossref","first-page":"2635","DOI":"10.1007\/s11738-013-1291-0","article-title":"Immunolocalization of S-nitrosoglutathione, S-nitrosoglutathione reductase and tyrosine nitration in pea leaf organelles","volume":"35","author":"Barroso","year":"2013","journal-title":"Acta Physiol. 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