{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T03:21:01Z","timestamp":1791688861130,"version":"4.3.4"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2019,9,16]],"date-time":"2019-09-16T00:00:00Z","timestamp":1568592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Spanish Ministry of Economy and Competitiveness"},{"name":"State Research Agency-European Regional Developmental Fund","award":["AGL2017-85775-R"],"award-info":[{"award-number":["AGL2017-85775-R"]}]},{"name":"Arag\ufffdn Government","award":["A09_17R"],"award-info":[{"award-number":["A09_17R"]}]},{"DOI":"10.13039\/501100001732","name":"Danish National Research Foundation","doi-asserted-by":"publisher","award":["DNRF79"],"award-info":[{"award-number":["DNRF79"]}],"id":[{"id":"10.13039\/501100001732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Nitric oxide (NO) is a crucial signaling molecule that conveys its bioactivity mainly through protein S-nitrosylation. This is a reversible post-translational modification (PTM) that may affect protein function. S-nitrosoglutathione (GSNO) is a cellular NO reservoir and NO donor in protein S-nitrosylation. The enzyme S-nitrosoglutathione reductase (GSNOR) degrades GSNO, thereby regulating indirectly signaling cascades associated with this PTM. Here, the two GSNORs of the legume Lotus japonicus, LjGSNOR1 and LjGSNOR2, have been functionally characterized. The LjGSNOR1 gene is very active in leaves and roots, whereas LjGSNOR2 is highly expressed in nodules. The enzyme activities are regulated in vitro by redox-based PTMs. Reducing conditions and hydrogen sulfide-mediated cysteine persulfidation induced both activities, whereas cysteine oxidation or glutathionylation inhibited them. Ljgsnor1 knockout mutants contained higher levels of S-nitrosothiols. Affinity chromatography and subsequent shotgun proteomics allowed us to identify 19 proteins that are differentially S-nitrosylated in the mutant and the wild-type. These include proteins involved in biotic stress, protein degradation, antioxidant protection and photosynthesis. We propose that, in the mutant plants, deregulated protein S-nitrosylation contributes to developmental alterations, such as growth inhibition, impaired nodulation and delayed flowering and fruiting. Our results highlight the importance of GSNOR function in legume biology.<\/jats:p>","DOI":"10.1093\/pcp\/pcz182","type":"journal-article","created":{"date-parts":[[2019,9,12]],"date-time":"2019-09-12T07:37:00Z","timestamp":1568273820000},"page":"105-117","source":"Crossref","is-referenced-by-count":39,"title":["Altered Plant and Nodule Development and Protein S-Nitrosylation in Lotus japonicus Mutants Deficient in S-Nitrosoglutathione Reductases"],"prefix":"10.1093","volume":"61","author":[{"given":"Manuel A","family":"Matamoros","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\ufffdn Vegetal, Estaci\ufffdn Experimental de Aula Dei, Consejo Superior de Investigaciones Cient\ufffdficas, Apartado 13034, 50080 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria C","family":"Cutrona","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\ufffdn Vegetal, Estaci\ufffdn Experimental de Aula Dei, Consejo Superior de Investigaciones Cient\ufffdficas, Apartado 13034, 50080 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Wienkoop","sequence":"first","affiliation":[{"name":"Division of Molecular Systems Biology, Department of Ecogenomics and Systems Biology, University of Vienna, Vienna 1090, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9017-4597","authenticated-orcid":false,"given":"Juan C","family":"Begara-Morales","sequence":"first","affiliation":[{"name":"Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Faculty of Experimental Sciences, Center for Advanced Studies in Olive Grove and Olive Oils, Campus Universitario \u201cLas Lagunillas\u201d, University of Ja\ufffdn, 23071 Ja\ufffdn, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niels","family":"Sandal","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Centre for Carbohydrate Recognition and Signalling, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Orera","sequence":"first","affiliation":[{"name":"Proteomics Unit, Centro Investigaciones Biom\ufffddicas de Arag\ufffdn, Instituto Aragon\ufffds de Ciencias de la Salud, 50059 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan B","family":"Barroso","sequence":"first","affiliation":[{"name":"Group of Biochemistry and Cell Signaling in Nitric Oxide, Department of Experimental Biology, Faculty of Experimental Sciences, Center for Advanced Studies in Olive Grove and Olive Oils, Campus Universitario \u201cLas Lagunillas\u201d, University of Ja\ufffdn, 23071 Ja\ufffdn, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens","family":"Stougaard","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Genetics, Centre for Carbohydrate Recognition and Signalling, Aarhus University, Gustav Wieds Vej 10, 8000 Aarhus C, Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Becana","sequence":"first","affiliation":[{"name":"Departamento de Nutrici\ufffdn Vegetal, Estaci\ufffdn Experimental de Aula Dei, Consejo Superior de Investigaciones Cient\ufffdficas, Apartado 13034, 50080 Zaragoza, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,9,16]]},"reference":[{"key":"2020021705495748300_pcz182-B1","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.3389\/fpls.2018.01369","article-title":"Hydrogen sulfide signaling in plants: emerging roles of protein persulfidation","volume":"9","author":"Aroca","year":"2018","journal-title":"Front. 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