{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:01:09Z","timestamp":1790776869593,"version":"4.1.0"},"reference-count":51,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,1,11]],"date-time":"2021-01-11T00:00:00Z","timestamp":1610323200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Goettingen Graduate School for Neurosciences, Biophysics, and Molecular Biosciences in frame of the PRoTECT program at the Georg August University Goettingen"},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["GRK 2172-PRoTECT"],"award-info":[{"award-number":["GRK 2172-PRoTECT"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 186\/822-1"],"award-info":[{"award-number":["INST 186\/822-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["ZUK 45\/2010"],"award-info":[{"award-number":["ZUK 45\/2010"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Natural Sciences and Engineering Research Council (NSERC) Discovery Program"},{"name":"China Scholarship Council and NSERC-CREATE"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The tradeoff between growth and defense is a critical aspect of plant immunity. Therefore, the plant immune response needs to be tightly regulated. Salicylic acid (SA) is an important plant hormone regulating defense against biotrophic pathogens. Recently, N-hydroxy-pipecolic acid (NHP) was identified as another regulator for plant innate immunity and systemic acquired resistance (SAR). Although the biosynthetic pathway leading to NHP formation is already been identified, how NHP is further metabolized is unclear. Here, we present UGT76B1 as a uridine diphosphate-dependent glycosyltransferase (UGT) that modifies NHP by catalyzing the formation of 1-O-glucosyl-pipecolic acid in Arabidopsis thaliana. Analysis of T-DNA and clustered regularly interspaced short palindromic repeats (CRISPR) knock-out mutant lines of UGT76B1 by targeted and nontargeted ultra-high performance liquid chromatography coupled to high-resolution mass spectrometry (UHPLC-HRMS) underlined NHP and SA as endogenous substrates of this enzyme in response to Pseudomonas infection and UV treatment. ugt76b1 mutant plants have a dwarf phenotype and constitutive defense response which can be suppressed by loss of function of the NHP biosynthetic enzyme FLAVIN-DEPENDENT MONOOXYGENASE 1 (FMO1). This suggests that elevated accumulation of NHP contributes to the enhanced disease resistance in ugt76b1. Externally applied NHP can move to distal tissue in ugt76b1 mutant plants. Although glycosylation is not required for the long-distance movement of NHP during SAR, it is crucial to balance growth and defense.<\/jats:p>","DOI":"10.1093\/plcell\/koaa045","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T23:13:05Z","timestamp":1609456385000},"page":"735-749","source":"Crossref","is-referenced-by-count":122,"title":["The glycosyltransferase UGT76B1 modulates\n                    <i>N<\/i>\n                    -hydroxy-pipecolic acid homeostasis and plant immunity"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9911-7158","authenticated-orcid":false,"given":"Lennart","family":"Mohnike","sequence":"first","affiliation":[{"name":"Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Goettingen, D-37077 Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0453-8858","authenticated-orcid":false,"given":"Dmitrij","family":"Rekhter","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Goettingen, D-37077 Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1272-1297","authenticated-orcid":false,"given":"Weijie","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1634-8258","authenticated-orcid":false,"given":"Kirstin","family":"Feussner","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Goettingen, D-37077 Goettingen, Germany"},{"name":"Service Unit for Metabolomics and Lipidomics, Goettingen center for Molecular Biosciences (GZMB), University of Goettingen, D-37077 Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7497-5324","authenticated-orcid":false,"given":"Hainan","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8255-3255","authenticated-orcid":false,"given":"Cornelia","family":"Herrfurth","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Goettingen, D-37077 Goettingen, Germany"},{"name":"Service Unit for Metabolomics and Lipidomics, Goettingen center for Molecular Biosciences (GZMB), University of Goettingen, D-37077 Goettingen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3480-5478","authenticated-orcid":false,"given":"Yuelin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Botany, University of British Columbia, Vancouver, BC V6T 1Z4, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9888-7003","authenticated-orcid":false,"given":"Ivo","family":"Feussner","sequence":"additional","affiliation":[{"name":"Department of Plant Biochemistry, Albrecht-von-Haller-Institute for Plant Sciences, University of Goettingen, D-37077 Goettingen, Germany"},{"name":"Service Unit for Metabolomics and Lipidomics, Goettingen center for Molecular Biosciences (GZMB), University of Goettingen, D-37077 Goettingen, Germany"},{"name":"Department of Plant Biochemistry, Goettingen Center for Molecular Biosciences (GZMB), University of Goettingen, D-37077 Goettingen, 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