{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T12:14:12Z","timestamp":1790684052961,"version":"4.1.0"},"reference-count":78,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2021,6,4]],"date-time":"2021-06-04T00:00:00Z","timestamp":1622764800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G011420N"],"award-info":[{"award-number":["G011420N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","award":["G010820N"],"award-info":[{"award-number":["G010820N"]}],"id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Don Carlos Antonio Lopez"},{"name":"El Programa Nacional de Becas from Paraguay","award":["164\/2017"],"award-info":[{"award-number":["164\/2017"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,8,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The ataxia-telangiectasia mutated (ATM) and ATM and Rad3-related (ATR) kinases coordinate the DNA damage response. The roles described for Arabidopsis thaliana ATR and ATM are assumed to be conserved over other plant species, but molecular evidence is scarce. Here, we demonstrate that the functions of ATR and ATM are only partially conserved between Arabidopsis and maize (Zea mays). In both species, ATR and ATM play a key role in DNA repair and cell cycle checkpoint activation, but whereas Arabidopsis plants do not suffer from the absence of ATR under control growth conditions, maize mutant plants accumulate replication defects, likely due to their large genome size. Moreover, contrarily to Arabidopsis, maize ATM deficiency does not trigger meiotic defects, whereas the ATR kinase appears to be crucial for the maternal fertility. Strikingly, ATR is required to repress premature endocycle onset and cell death in the maize endosperm. Its absence results in a reduction of kernel size, protein and starch content, and a stochastic death of kernels, a process being counteracted by ATM. Additionally, while Arabidopsis atr atm double mutants are viable, no such mutants could be obtained for maize. Therefore, our data highlight that the mechanisms maintaining genome integrity may be more important for vegetative and reproductive development than previously anticipated.<\/jats:p>","DOI":"10.1093\/plcell\/koab158","type":"journal-article","created":{"date-parts":[[2021,6,3]],"date-time":"2021-06-03T12:48:45Z","timestamp":1622724525000},"page":"2662-2684","source":"Crossref","is-referenced-by-count":38,"title":["Maize ATR safeguards genome stability during kernel development to prevent early endosperm endocycle onset and cell death"],"prefix":"10.1093","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8258-0157","authenticated-orcid":false,"given":"Jose Antonio","family":"Pedroza-Garcia","sequence":"first","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-1553","authenticated-orcid":false,"given":"Thomas","family":"Eekhout","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4553-1257","authenticated-orcid":false,"given":"Ignacio","family":"Achon","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6135-4836","authenticated-orcid":false,"given":"Maher-Un","family":"Nisa","sequence":"additional","affiliation":[{"name":"Institute of Plant Sciences Paris-Saclay (IPS2), CNRS, INRA, University Paris-Sud, University of Evry, Paris University, Sorbonne Paris-Cite, University of Paris-Saclay , 91405, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2285-5782","authenticated-orcid":false,"given":"Griet","family":"Coussens","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9561-8468","authenticated-orcid":false,"given":"Ilse","family":"Vercauteren","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4271-6694","authenticated-orcid":false,"given":"Hilde","family":"Van den Daele","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-9052","authenticated-orcid":false,"given":"Laurens","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7632-1463","authenticated-orcid":false,"given":"Mieke","family":"Van Lijsebettens","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5231-8120","authenticated-orcid":false,"given":"C\u00e9cile","family":"Raynaud","sequence":"additional","affiliation":[{"name":"Institute of Plant Sciences Paris-Saclay (IPS2), CNRS, INRA, University Paris-Sud, University of Evry, Paris University, Sorbonne Paris-Cite, University of Paris-Saclay , 91405, Orsay, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1150-4426","authenticated-orcid":false,"given":"Lieven","family":"De Veylder","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University , Ghent B-9052, Belgium"},{"name":"Center for Plant Systems Biology, VIB , Ghent B-9052, 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