{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:02:53Z","timestamp":1787727773955,"version":"build-2784847793"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"EpiHYBRIDS"},{"name":"French National Agency of Research","award":["ANR-19-CE12-0008"],"award-info":[{"award-number":["ANR-19-CE12-0008"]}]},{"name":"Plant Biology and Breeding (BAP) department of the French National Research Institute for Agriculture, Food and Environment"},{"name":"EUR SPS-GSR","award":["ANR-17-EUR-0007"],"award-info":[{"award-number":["ANR-17-EUR-0007"]}]},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["#2018-0206"],"award-info":[{"award-number":["#2018-0206"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2022,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The triploid block, which prevents interploidy hybridizations in flowering plants, is characterized by a failure in endosperm development, arrest in embryogenesis, and seed collapse. Many genetic components of triploid seed lethality have been successfully identified in the model plant Arabidopsis thaliana, most notably the paternally expressed genes (PEGs), which are upregulated in tetraploid endosperm with paternal excess. Previous studies have shown that the paternal epigenome is a key determinant of the triploid block response, as the loss of DNA methylation in diploid pollen suppresses the triploid block almost completely. Here, we demonstrate that triploid seed collapse is bypassed in Arabidopsis plants treated with the DNA methyltransferase inhibitor 5-Azacytidine during seed germination and early growth. We identified strong suppressor lines showing stable transgenerational inheritance of hypomethylation in the CG context, as well as normalized expression of PEGs in triploid seeds. Importantly, differentially methylated loci segregate in the progeny of \u201cepimutagenized\u201d plants, which may allow epialleles involved in the triploid block response to be identified in future studies. Finally, we demonstrate that chemically induced epimutagenesis facilitates hybridization between different Capsella species, thus potentially emerging as a strategy for producing triploids and interspecific hybrids with high agronomic interest.<\/jats:p>","DOI":"10.1093\/plcell\/koab284","type":"journal-article","created":{"date-parts":[[2021,11,15]],"date-time":"2021-11-15T08:48:16Z","timestamp":1636966096000},"page":"989-1001","source":"Crossref","is-referenced-by-count":30,"title":["Bypassing reproductive barriers in hybrid seeds using chemically induced epimutagenesis"],"prefix":"10.1093","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4452-2858","authenticated-orcid":false,"given":"Jonathan","family":"Huc","sequence":"first","affiliation":[{"name":"Institut Jean-Pierre Bourgin, INRAE, AgroParisTech, Universit\u00e9 Paris-Saclay, 78000, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7279-1417","authenticated-orcid":false,"given":"Katarzyna","family":"Dziasek","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, Uppsala Biocenter, Swedish University of Agricultural Sciences, Linnean Center of Plant Biology, Uppsala, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9823-044X","authenticated-orcid":false,"given":"Kannan","family":"Pachamuthu","sequence":"additional","affiliation":[{"name":"Institut Jean-Pierre Bourgin, INRAE, AgroParisTech, Universit\u00e9 Paris-Saclay, 78000, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6916-0174","authenticated-orcid":false,"given":"Tristan","family":"Woh","sequence":"additional","affiliation":[{"name":"Institut Jean-Pierre Bourgin, INRAE, AgroParisTech, Universit\u00e9 Paris-Saclay, 78000, Versailles, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2619-4857","authenticated-orcid":false,"given":"Claudia","family":"K\u00f6hler","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, Uppsala Biocenter, Swedish University of Agricultural Sciences, Linnean Center of Plant Biology, Uppsala, Sweden"},{"name":"Max Planck Institute of Molecular Plant Physiology, Potsdam-Golm, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7388-2118","authenticated-orcid":false,"given":"Filipe","family":"Borges","sequence":"additional","affiliation":[{"name":"Institut Jean-Pierre Bourgin, INRAE, AgroParisTech, Universit\u00e9 Paris-Saclay, 78000, Versailles, 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