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The evolutionarily conserved kinases ATR (ATM and RAD3-related) and WEE1 are essential for the activation of replication stress responses. Translational control is an important mechanism that regulates gene expression, but its role in replication stress responses is largely unknown. Here we show that ATR\u2013WEE1 control the translation of SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1), a master transcription factor required for replication stress responses in Arabidopsis thaliana. Through genetic screening, we found that the loss of GENERAL CONTROL NONDEREPRESSIBLE 20 (GCN20) or GCN1, which function together to inhibit protein translation, suppressed the hypersensitivity of the atr or wee1 mutant to replication stress. Biochemically, WEE1 inhibits GCN20 by phosphorylating it; phosphorylated GCN20 is subsequently polyubiquitinated and degraded. Ribosome profiling experiments revealed that that loss of GCN20 enhanced the translation efficiency of SOG1, while overexpressing GCN20 had the opposite effect. The loss of SOG1 reduced the resistance of wee1 gcn20 to replication stress, whereas overexpressing SOG1 enhanced the resistance to atr or wee1 to replication stress. These results suggest that ATR\u2013WEE1 inhibits GCN20\u2013GCN1 activity to promote the translation of SOG1 during replication stress. These findings link translational control to replication stress responses in Arabidopsis.<\/jats:p>","DOI":"10.1093\/plcell\/koad126","type":"journal-article","created":{"date-parts":[[2023,5,11]],"date-time":"2023-05-11T03:13:23Z","timestamp":1683774803000},"page":"3021-3034","source":"Crossref","is-referenced-by-count":20,"title":["The ATR\u2013WEE1 kinase module promotes SUPPRESSOR OF GAMMA RESPONSE 1 translation to activate replication stress responses"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-5323-6989","authenticated-orcid":false,"given":"Hanchen","family":"Chen","sequence":"first","affiliation":[{"name":"Hubei Hongshan Laboratory , Wuhan 430070 , China"},{"name":"College of Life Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"},{"name":"Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University , Shenzhen 518000 , China"},{"name":"Shenzhen Branch, Guangdong Laboratory for Lingnan Modern 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6204-7611","authenticated-orcid":false,"given":"Xueao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory , Wuhan 430070 , China"},{"name":"College of Life Science and Technology, Huazhong Agricultural University , Wuhan 430070 , China"},{"name":"Shenzhen Institute of Nutrition and Health, Huazhong Agricultural University , Shenzhen 518000 , China"},{"name":"Shenzhen Branch, Guangdong Laboratory for Lingnan Modern Agriculture , Shenzhen 518000 , China"},{"name":"Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences , Shenzhen 518000 , China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3938-529X","authenticated-orcid":false,"given":"Yongchi","family":"Huang","sequence":"additional","affiliation":[{"name":"Hubei Hongshan Laboratory , Wuhan 430070 , 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