{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T22:29:02Z","timestamp":1792448942811,"version":"4.5.0"},"reference-count":94,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T00:00:00Z","timestamp":1692748800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"United States National Science Foundation","award":["IOS-2023310"],"award-info":[{"award-number":["IOS-2023310"]}]},{"name":"United States National Science Foundation","award":["IOS-1849708"],"award-info":[{"award-number":["IOS-1849708"]}]},{"DOI":"10.13039\/501100004052","name":"King Abdullah University of Science and Technology","doi-asserted-by":"publisher","award":["BAS\/1\/1062-01-01"],"award-info":[{"award-number":["BAS\/1\/1062-01-01"]}],"id":[{"id":"10.13039\/501100004052","id-type":"DOI","asserted-by":"publisher"}]},{"name":"KAUST International Program OCRF-2014-CRG4"},{"name":"Saclay Plant Sciences-SPS","award":["ANR-17-EUR-0007"],"award-info":[{"award-number":["ANR-17-EUR-0007"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2023,10,30]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Posttranscriptional regulation of mRNA mediated by methylation at the N6 position of adenine (N6-methyladenosine [m6A]) has profound effects on transcriptome regulation in plants. Focused studies across eukaryotes offer glimpses into the processes governed by m6A throughout developmental and disease states. However, we lack an understanding of the dynamics and the regulatory potential of m6A during biotic stress in plants. Here, we provide a comprehensive look into the effects of m6A on both the short-term and long-term responses to pathogen signaling in Arabidopsis (Arabidopsis thaliana). We demonstrate that m6A-deficient plants are more resistant to bacterial and fungal pathogen infections and have altered immune responses. Furthermore, m6A deposition is specifically coordinated on transcripts involved in defense and immunity prior to and proceeding the pathogen signal flagellin. Consequently, the dynamic modulation of m6A on specific stress-responsive transcripts is correlated with changes in abundance and cleavage of these transcripts. Overall, we show that the m6A methylome is regulated prior to and during simulated and active pathogen stress and functions in the coordination and balancing of normal growth and pathogen responses.<\/jats:p>","DOI":"10.1093\/plcell\/koad224","type":"journal-article","created":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T18:31:48Z","timestamp":1692815508000},"page":"4155-4172","source":"Crossref","is-referenced-by-count":63,"title":["Pathogen-induced m6A dynamics affect plant immunity"],"prefix":"10.1093","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3270-7636","authenticated-orcid":false,"given":"Wil","family":"Prall","sequence":"first","affiliation":[{"name":"Department of Biology, University of Pennsylvania , Philadelphia, PA 19104, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1883-5439","authenticated-orcid":false,"given":"Arsheed H","family":"Sheikh","sequence":"additional","affiliation":[{"name":"Center for Desert Agriculture, King Abdullah University of Science and Technology , Thuwal 23955-6900, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7713-5278","authenticated-orcid":false,"given":"Jeremie","family":"Bazin","sequence":"additional","affiliation":[{"name":"CNRS, INRA, Institute of Plant Sciences Paris-Saclay IPS2, Universite Paris Sud, Universite Evry, Universite Paris-Diderot, Sorbonne Paris-Cite, Universite Paris-Saclay , 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4762-8423","authenticated-orcid":false,"given":"Jean","family":"Bigeard","sequence":"additional","affiliation":[{"name":"CNRS, INRA, Institute of Plant Sciences Paris-Saclay IPS2, Universite Paris Sud, Universite Evry, Universite Paris-Diderot, Sorbonne Paris-Cite, Universite Paris-Saclay , 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9980-322X","authenticated-orcid":false,"given":"Marilia","family":"Almeida-Trapp","sequence":"additional","affiliation":[{"name":"Center for Desert Agriculture, King Abdullah University of Science and Technology , Thuwal 23955-6900, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-9482","authenticated-orcid":false,"given":"Martin","family":"Crespi","sequence":"additional","affiliation":[{"name":"CNRS, INRA, Institute of Plant Sciences Paris-Saclay IPS2, Universite Paris Sud, Universite Evry, Universite Paris-Diderot, Sorbonne Paris-Cite, Universite Paris-Saclay , 91190 Gif-sur-Yvette, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3119-9633","authenticated-orcid":false,"given":"Heribert","family":"Hirt","sequence":"additional","affiliation":[{"name":"Center for Desert Agriculture, King Abdullah University of Science and Technology , Thuwal 23955-6900, Saudi Arabia"},{"name":"Max F. 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