{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T19:01:04Z","timestamp":1791486064627,"version":"4.3.4"},"reference-count":66,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2019YFA0903904"],"award-info":[{"award-number":["2019YFA0903904"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32470367"],"award-info":[{"award-number":["32470367"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32170345"],"award-info":[{"award-number":["32170345"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32011540381"],"award-info":[{"award-number":["32011540381"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200271"],"award-info":[{"award-number":["32200271"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Beijing Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["5232015"],"award-info":[{"award-number":["5232015"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation (NRF) of Korea","doi-asserted-by":"crossref","award":["2021R1A2C3011104"],"award-info":[{"award-number":["2021R1A2C3011104"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation (NRF) of Korea","doi-asserted-by":"crossref","award":["RS-2023-00245912"],"award-info":[{"award-number":["RS-2023-00245912"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation (NRF) of Korea","doi-asserted-by":"crossref","award":["RS-2024-00345045"],"award-info":[{"award-number":["RS-2024-00345045"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100012138","name":"Beijing Forestry University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012138","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2025,4,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Arabidopsis thaliana (Arabidopsis) Ataxia Telangiectasia Mutated (ATM) kinase plays a vital role in orchestrating leaf senescence; however, the precise mechanisms remain elusive. Here, our study demonstrates that ATM kinase activity is essential for mitigating age- and reactive oxygen species-induced senescence, as restoration of wild-type ATM reverses premature senescence in the atm mutant, while a kinase-dead ATM variant is ineffective. ATM physically interacts with and phosphorylates Mitogen-Activated Protein Kinase Phosphatase 2 (MKP2) to enhance stability under oxidative stress. Mutations in putative phosphorylation sites S15\/154 on MKP2 disrupt its phosphorylation, stability, and senescence-delaying function. Moreover, mutation of mitogen-activated protein kinase 6, a downstream target of MKP2, alleviates the premature senescence phenotype of the atm mutant. Notably, the dual-specificity protein phosphatase 19 (HsDUSP19), a predicted human counter protein of MPK2, interacts with both ATM and HsATM and extends leaf longevity in Arabidopsis when overexpressed. These findings elucidate the molecular mechanisms underlying the role of ATM in leaf senescence and suggest that the ATM-MKP2 module is likely evolutionarily conserved in regulating the aging process across eukaryotes.<\/jats:p>","DOI":"10.1093\/plcell\/koaf066","type":"journal-article","created":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T10:45:16Z","timestamp":1743245116000},"source":"Crossref","is-referenced-by-count":6,"title":["The kinase ATM delays Arabidopsis leaf senescence by stabilizing the phosphatase MKP2 in a phosphorylation-dependent manner"],"prefix":"10.1093","volume":"37","author":[{"given":"Yi","family":"Zhang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 ,","place":["China"]},{"name":"Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech) , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0078-5239","authenticated-orcid":false,"given":"Shuya","family":"Tan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hee","family":"Kim","sequence":"additional","affiliation":[{"name":"Subtropical Horticulture Research Institute, Jeju National University , Jeju 63243 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Cao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaning","family":"Zhao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3003-1569","authenticated-orcid":false,"given":"Zhenpei","family":"Pang","sequence":"additional","affiliation":[{"name":"Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech) , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjie","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech) , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonglun","family":"Lv","sequence":"additional","affiliation":[{"name":"Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech) , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ding","sequence":"additional","affiliation":[{"name":"Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech) , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2729-6003","authenticated-orcid":false,"given":"Jeongsik","family":"Kim","sequence":"additional","affiliation":[{"name":"Faculty of Science Education and Interdisciplinary Graduate Program in Advanced Convergence Technology and Science, Jeju National University , Jeju 63243 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0546-052X","authenticated-orcid":false,"given":"Hye Ryun","family":"Woo","sequence":"additional","affiliation":[{"name":"Department of New Biology, DGIST , Daegu 42988 ,","place":["Republic of Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3731-4970","authenticated-orcid":false,"given":"Xinli","family":"Xia","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4819-5874","authenticated-orcid":false,"given":"Hongwei","family":"Guo","sequence":"additional","affiliation":[{"name":"Institute of Plant and Food Science, Department of Biology, School of Life Sciences, Southern University of Science and Technology (SUSTech) , Shenzhen, Guangdong 518055 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4913-7641","authenticated-orcid":false,"given":"Zhonghai","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Tree Genetics and Breeding, College of Biological Sciences and Technology, Beijing Forestry University , Beijing 100083 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"issue":"8016","key":"2025040907571166000_koaf066-B1","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1038\/s41586-024-07487-w","article-title":"Accurate structure prediction of biomolecular interactions with AlphaFold 3","volume":"630","author":"Abramson","year":"2024","journal-title":"Nature"},{"issue":"7","key":"2025040907571166000_koaf066-B2","doi-asserted-by":"publisher","first-page":"e09895","DOI":"10.1016\/j.heliyon.2022.e09895","article-title":"Paraquat induced oxidative stress, DNA damage, and cytotoxicity in lymphocytes","volume":"8","author":"Alizadeh","year":"2022","journal-title":"Heliyon"},{"issue":"1","key":"2025040907571166000_koaf066-B3","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1146\/annurev.arplant.55.031903.141701","article-title":"Reactive oxygen species: metabolism, oxidative stress, and signal transduction","volume":"55","author":"Apel","year":"2004","journal-title":"Annu Rev Plant Biol"},{"issue":"4","key":"2025040907571166000_koaf066-B4","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1016\/j.cell.2005.02.001","article-title":"Mitochondria, oxidants, and aging","volume":"120","author":"Balaban","year":"2005","journal-title":"Cell"},{"issue":"5","key":"2025040907571166000_koaf066-B5","doi-asserted-by":"publisher","first-page":"e1700933","DOI":"10.1126\/sciadv.1700933","article-title":"Structures of closed and open conformations of dimeric human ATM","volume":"3","author":"Baretic","year":"2017","journal-title":"Sci Adv"},{"issue":"8","key":"2025040907571166000_koaf066-B6","doi-asserted-by":"publisher","first-page":"540","DOI":"10.1111\/j.1744-7909.2012.01147.x","article-title":"Senescence-specific alteration of hydrogen peroxide levels in Arabidopsis thaliana and oilseed rape spring variety Brassica napus L. cv. Mozart","volume":"54","author":"Bieker","year":"2012","journal-title":"J Integr Plant Biol"},{"issue":"6","key":"2025040907571166000_koaf066-B7","doi-asserted-by":"publisher","first-page":"1633","DOI":"10.1002\/pmic.200300771","article-title":"Prediction of post-translational glycosylation and phosphorylation of proteins from the amino acid sequence","volume":"4","author":"Blom","year":"2004","journal-title":"Proteomics"},{"issue":"5383","key":"2025040907571166000_koaf066-B8","doi-asserted-by":"publisher","first-page":"1677","DOI":"10.1126\/science.281.5383.1677","article-title":"Activation of the ATM kinase by ionizing radiation and phosphorylation of p53","volume":"281","author":"Canman","year":"1998","journal-title":"Science"},{"issue":"2","key":"2025040907571166000_koaf066-B9","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1111\/j.1742-4658.2012.08716.x","article-title":"Dual-specificity MAP kinase phosphatases (MKPs): shaping the outcome of MAP kinase signalling","volume":"280","author":"Caunt","year":"2013","journal-title":"FEBS J"},{"issue":"2","key":"2025040907571166000_koaf066-B10","doi-asserted-by":"publisher","first-page":"179","DOI":"10.1016\/j.molcel.2010.09.019","article-title":"The DNA damage response: making it safe to play with knives","volume":"40","author":"Ciccia","year":"2010","journal-title":"Mol Cell"},{"issue":"8","key":"2025040907571166000_koaf066-B11","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nrm2450","article-title":"ATR: an essential regulator of genome integrity","volume":"9","author":"Cimprich","year":"2008","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"5","key":"2025040907571166000_koaf066-B12","doi-asserted-by":"publisher","first-page":"1091","DOI":"10.1105\/tpc.018903","article-title":"ATR regulates a G2-phase cell-cycle checkpoint in Arabidopsis thaliana","volume":"16","author":"Culligan","year":"2004","journal-title":"Plant Cell"},{"issue":"7","key":"2025040907571166000_koaf066-B13","doi-asserted-by":"publisher","first-page":"3718","DOI":"10.1073\/pnas.97.7.3718","article-title":"Random GFP::cDNA fusions enable visualization of subcellular structures in cells of Arabidopsis at a high frequency","volume":"97","author":"Cutler","year":"2000","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"6","key":"2025040907571166000_koaf066-B14","doi-asserted-by":"publisher","first-page":"1717","DOI":"10.1073\/pnas.0510664103","article-title":"Activation of the E3 ubiquitin ligase itch through a phosphorylation-induced conformational change","volume":"103","author":"Gallagher","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2025040907571166000_koaf066-B15","doi-asserted-by":"publisher","first-page":"1274","DOI":"10.1111\/nph.17870","article-title":"Pseudomonas syringae activates ZAT18 to inhibit salicylic acid accumulation by repressing EDS1 transcription for bacterial infection","volume":"233","author":"Gao","year":"2022","journal-title":"New Phytol"},{"issue":"1","key":"2025040907571166000_koaf066-B16","doi-asserted-by":"publisher","first-page":"119","DOI":"10.1105\/tpc.006577","article-title":"AtATM is essential for meiosis and the somatic response to DNA damage in plants","volume":"15","author":"Garcia","year":"2003","journal-title":"Plant Cell"},{"issue":"11","key":"2025040907571166000_koaf066-B17","doi-asserted-by":"publisher","first-page":"2854","DOI":"10.1105\/tpc.17.00438","article-title":"A tripartite amplification loop involving the transcription factor WRKY75, salicylic acid, and reactive oxygen species accelerates leaf senescence","volume":"29","author":"Guo","year":"2017","journal-title":"Plant Cell"},{"key":"2025040907571166000_koaf066-B18","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1016\/S0070-2153(05)71003-6","article-title":"Leaf senescence: signals, execution, and regulation","volume":"71","author":"Guo","year":"2005","journal-title":"Curr Top Dev Biol"},{"issue":"6003","key":"2025040907571166000_koaf066-B19","doi-asserted-by":"publisher","first-page":"517","DOI":"10.1126\/science.1192912","article-title":"ATM activation by oxidative stress","volume":"330","author":"Guo","year":"2010","journal-title":"Science"},{"issue":"2","key":"2025040907571166000_koaf066-B20","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1007\/BF00421050","article-title":"Free radicals in aging","volume":"84","author":"Harman","year":"1988","journal-title":"Mol Cell Biochem"},{"issue":"1","key":"2025040907571166000_koaf066-B21","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1146\/annurev-arplant-043015-111902","article-title":"Mechanisms used by plants to cope with DNA damage","volume":"67","author":"Hu","year":"2016","journal-title":"Annu Rev Plant Biol"},{"key":"2025040907571166000_koaf066-B22","doi-asserted-by":"publisher","first-page":"800","DOI":"10.3389\/fpls.2019.00800","article-title":"Mechanisms of ROS regulation of plant development and stress responses","volume":"10","author":"Huang","year":"2019","journal-title":"Front Plant Sci"},{"issue":"7267","key":"2025040907571166000_koaf066-B23","doi-asserted-by":"publisher","first-page":"1071","DOI":"10.1038\/nature08467","article-title":"The DNA-damage response in human biology and disease","volume":"461","author":"Jackson","year":"2009","journal-title":"Nature"},{"issue":"5271","key":"2025040907571166000_koaf066-B24","doi-asserted-by":"publisher","first-page":"54","DOI":"10.1126\/science.273.5271.54","article-title":"Longevity, genes, and aging","volume":"273","author":"Jazwinski","year":"1996","journal-title":"Science"},{"key":"2025040907571166000_koaf066-B25","doi-asserted-by":"publisher","first-page":"634040","DOI":"10.3389\/fpls.2021.634040","article-title":"Transcription factor NAC075 delays leaf senescence by deterring reactive oxygen species accumulation in Arabidopsis","volume":"12","author":"Kan","year":"2021","journal-title":"Front Plant Sci"},{"issue":"6","key":"2025040907571166000_koaf066-B26","doi-asserted-by":"publisher","first-page":"616","DOI":"10.1038\/nchembio.2342","article-title":"Chemical screening identifies ATM as a target for alleviating senescence","volume":"13","author":"Kang","year":"2017","journal-title":"Nat Chem Biol"},{"issue":"21","key":"2025040907571166000_koaf066-B27","doi-asserted-by":"publisher","first-page":"E4930","DOI":"10.1073\/pnas.1721523115","article-title":"Time-evolving genetic networks reveal a NAC troika that negatively regulates leaf senescence in Arabidopsis","volume":"115","author":"Kim","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"23","key":"2025040907571166000_koaf066-B28","doi-asserted-by":"publisher","first-page":"12492","DOI":"10.1016\/S0021-9258(17)38898-1","article-title":"Studies on the phosphorylation of myelin basic protein by protein kinase C and adenosine 3\u2032:5\u2032-monophosphate-dependent protein kinase","volume":"260","author":"Kishimoto","year":"1985","journal-title":"J Biol Chem"},{"issue":"34","key":"2025040907571166000_koaf066-B29","doi-asserted-by":"publisher","first-page":"25020","DOI":"10.1074\/jbc.M701888200","article-title":"Arabidopsis MAPK phosphatase 2 (MKP2) positively regulates oxidative stress tolerance and inactivates the MPK3 and MPK6 MAPKs","volume":"282","author":"Lee","year":"2007","journal-title":"J Biol Chem"},{"issue":"11","key":"2025040907571166000_koaf066-B30","doi-asserted-by":"publisher","first-page":"830","DOI":"10.1016\/j.tig.2023.08.005","article-title":"The evolution of aging and lifespan","volume":"39","author":"Li","year":"2023","journal-title":"Trends Genet"},{"issue":"2","key":"2025040907571166000_koaf066-B31","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1111\/nph.16535","article-title":"ATM suppresses leaf senescence triggered by DNA double-strand break through epigenetic control of senescence-associated genes in Arabidopsis","volume":"227","author":"Li","year":"2020","journal-title":"New Phytol"},{"issue":"8","key":"2025040907571166000_koaf066-B32","doi-asserted-by":"publisher","first-page":"526","DOI":"10.1111\/j.1744-7909.2012.01136.x","article-title":"Gene network analysis and functional studies of senescence-associated genes reveal novel regulators of Arabidopsis leaf senescence","volume":"54","author":"Li","year":"2012","journal-title":"J Integr Plant Biol"},{"issue":"9","key":"2025040907571166000_koaf066-B33","doi-asserted-by":"publisher","first-page":"3311","DOI":"10.1105\/tpc.113.113340","article-title":"Ethylene-insensitive3 is a senescence-associated gene that accelerates age-dependent leaf senescence by directly repressing miR164 transcription in Arabidopsis","volume":"25","author":"Li","year":"2013","journal-title":"Plant Cell"},{"issue":"1","key":"2025040907571166000_koaf066-B34","doi-asserted-by":"publisher","first-page":"115","DOI":"10.1146\/annurev.arplant.57.032905.105316","article-title":"Leaf senescence","volume":"58","author":"Lim","year":"2007","journal-title":"Annu Rev Plant Biol"},{"issue":"1","key":"2025040907571166000_koaf066-B35","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1038\/ng0596-25","article-title":"Genetic analysis of ageing: role of oxidative damage and environmental stresses","volume":"13","author":"Martin","year":"1996","journal-title":"Nat Genet"},{"issue":"10","key":"2025040907571166000_koaf066-B36","doi-asserted-by":"publisher","first-page":"663","DOI":"10.1038\/s41580-022-00499-2","article-title":"Reactive oxygen species signalling in plant stress responses","volume":"23","author":"Mittler","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025040907571166000_koaf066-B37","doi-asserted-by":"publisher","first-page":"653","DOI":"10.3389\/fpls.2019.00653","article-title":"The plant DNA damage response: signaling pathways leading to growth inhibition and putative role in response to stress conditions","volume":"10","author":"Nisa","year":"2019","journal-title":"Front Plant Sci"},{"issue":"2","key":"2025040907571166000_koaf066-B38","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1023\/A:1006342412688","article-title":"Identification of a promoter region responsible for the senescence-specific expression of SAG12","volume":"41","author":"Noh","year":"1999","journal-title":"Plant Mol Biol"},{"issue":"1","key":"2025040907571166000_koaf066-B39","doi-asserted-by":"publisher","first-page":"123","DOI":"10.3390\/biom11010123","article-title":"DNa damage response","volume":"11","author":"Oksenych","year":"2021","journal-title":"Biomolecules"},{"issue":"2","key":"2025040907571166000_koaf066-B40","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1016\/S0092-8674(03)00033-3","article-title":"The ATRs, ATMs, and TORs are giant HEAT repeat proteins","volume":"112","author":"Perry","year":"2003","journal-title":"Cell"},{"key":"2025040907571166000_koaf066-B41","doi-asserted-by":"publisher","first-page":"101601","DOI":"10.1016\/j.arr.2022.101601","article-title":"Genetic mechanisms of aging in plants: what can we learn from them?","volume":"77","author":"Popov","year":"2022","journal-title":"Ageing Res Rev"},{"issue":"5","key":"2025040907571166000_koaf066-B42","doi-asserted-by":"publisher","first-page":"981","DOI":"10.1016\/j.cellsig.2012.01.008","article-title":"Reactive oxygen species (ROS) homeostasis and redox regulation in cellular signaling","volume":"24","author":"Ray","year":"2012","journal-title":"Cell Signal"},{"issue":"9","key":"2025040907571166000_koaf066-B43","doi-asserted-by":"publisher","first-page":"3175","DOI":"10.1073\/pnas.0500367102","article-title":"Balancing the generation and elimination of reactive oxygen species","volume":"102","author":"Rodriguez","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"3","key":"2025040907571166000_koaf066-B44","doi-asserted-by":"publisher","first-page":"556","DOI":"10.1074\/mcp.M114.040352","article-title":"Quantitative phosphoproteomics of the ataxia telangiectasia-mutated (ATM) and ataxia telangiectasia-mutated and Rad3-related (ATR) dependent DNA damage response in Arabidopsis thaliana","volume":"14","author":"Roitinger","year":"2015","journal-title":"Mol Cell Proteomics"},{"issue":"4","key":"2025040907571166000_koaf066-B45","doi-asserted-by":"publisher","first-page":"845","DOI":"10.1093\/jxb\/erx235","article-title":"Stress-induced senescence and plant tolerance to abiotic stress","volume":"69","author":"Sade","year":"2018","journal-title":"J Exp Bot"},{"issue":"4","key":"2025040907571166000_koaf066-B46","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1038\/nrm3546","article-title":"The ATM protein kinase: regulating the cellular response to genotoxic stress, and more","volume":"14","author":"Shiloh","year":"2013","journal-title":"Nat Rev Mol Cell Biol"},{"issue":"1","key":"2025040907571166000_koaf066-B47","doi-asserted-by":"publisher","first-page":"715","DOI":"10.1146\/annurev-biochem-061516-045037","article-title":"Oxidative stress","volume":"86","author":"Sies","year":"2017","journal-title":"Annu Rev Biochem"},{"issue":"7","key":"2025040907571166000_koaf066-B48","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1038\/s41580-020-0230-3","article-title":"Reactive oxygen species (ROS) as pleiotropic physiological signalling agents","volume":"21","author":"Sies","year":"2020","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2025040907571166000_koaf066-B49","doi-asserted-by":"publisher","author":"Skeens","DOI":"10.1101\/2024.09.05.611520"},{"issue":"5271","key":"2025040907571166000_koaf066-B50","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1126\/science.273.5271.59","article-title":"Oxidative stress, caloric restriction, and aging","volume":"273","author":"Sohal","year":"1996","journal-title":"Science"},{"issue":"10","key":"2025040907571166000_koaf066-B51","doi-asserted-by":"publisher","first-page":"789","DOI":"10.1038\/s41594-021-00654-x","article-title":"Molecular basis of human ATM kinase inhibition","volume":"28","author":"Stakyte","year":"2021","journal-title":"Nat Struct Mol Biol"},{"issue":"W1","key":"2025040907571166000_koaf066-B52","doi-asserted-by":"publisher","first-page":"W270","DOI":"10.1093\/nar\/gkz357","article-title":"Evolview v3: a webserver for visualization, annotation, and management of phylogenetic trees","volume":"47","author":"Subramanian","year":"2019","journal-title":"Nucleic Acids Res"},{"issue":"7","key":"2025040907571166000_koaf066-B53","doi-asserted-by":"publisher","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11: molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura","year":"2021","journal-title":"Mol Biol Evol"},{"issue":"15","key":"2025040907571166000_koaf066-B54","doi-asserted-by":"publisher","first-page":"11996","DOI":"10.3390\/ijms241511996","article-title":"Abiotic stress-induced leaf senescence: regulatory mechanisms and application","volume":"24","author":"Tan","year":"2023","journal-title":"Int J Mol Sci"},{"issue":"7","key":"2025040907571166000_koaf066-B55","doi-asserted-by":"publisher","first-page":"REVIEWS3009","DOI":"10.1186\/gb-2002-3-7-reviews3009","article-title":"MAP kinase phosphatases","volume":"3","author":"Theodosiou","year":"2002","journal-title":"Genome Biol"},{"issue":"12","key":"2025040907571166000_koaf066-B56","doi-asserted-by":"publisher","first-page":"1621","DOI":"10.4161\/psb.22455","article-title":"Reactive oxygen species generation and signaling in plants","volume":"7","author":"Tripathy","year":"2012","journal-title":"Plant Signal Behav"},{"key":"2025040907571166000_koaf066-B57","doi-asserted-by":"publisher","first-page":"1184","DOI":"10.1016\/j.csbj.2021.01.044","article-title":"Mechanistic insights into the effect of phosphorylation on Ras conformational dynamics and its interactions with cell signaling proteins","volume":"19","author":"Wang","year":"2021","journal-title":"Comput Struct Biotechnol J"},{"issue":"1","key":"2025040907571166000_koaf066-B58","doi-asserted-by":"publisher","first-page":"209","DOI":"10.1146\/annurev-arplant-042817-040322","article-title":"Reactive oxygen species in plant signaling","volume":"69","author":"Waszczak","year":"2018","journal-title":"Annu Rev Plant Biol"},{"issue":"7","key":"2025040907571166000_koaf066-B59","doi-asserted-by":"publisher","first-page":"923","DOI":"10.1093\/pcp\/pch110","article-title":"The delayed leaf senescence mutants of Arabidopsis, ore1, ore3, and ore9 are tolerant to oxidative stress","volume":"45","author":"Woo","year":"2004","journal-title":"Plant Cell Physiol"},{"key":"2025040907571166000_koaf066-B60","doi-asserted-by":"publisher","first-page":"864986","DOI":"10.3389\/fpls.2022.864986","article-title":"Regulation of Arabidopsis matrix metalloproteinases by mitogen-activated protein kinases and their function in leaf senescence","volume":"13","author":"Wu","year":"2022","journal-title":"Front Plant Sci"},{"issue":"31","key":"2025040907571166000_koaf066-B61","doi-asserted-by":"publisher","first-page":"12843","DOI":"10.1073\/pnas.0810304106","article-title":"Suppressor of gamma response 1 (SOG1) encodes a putative transcription factor governing multiple responses to DNA damage","volume":"106","author":"Yoshiyama","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"2025040907571166000_koaf066-B62","doi-asserted-by":"publisher","first-page":"3255","DOI":"10.1105\/tpc.17.00267","article-title":"Increased phosphorylation of Ser-Gln sites on SUPPRESSOR OF GAMMA RESPONSE1 strengthens the DNA damage response in Arabidopsis thaliana","volume":"29","author":"Yoshiyama","year":"2017","journal-title":"Plant Cell"},{"issue":"9","key":"2025040907571166000_koaf066-B63","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1038\/embor.2013.112","article-title":"ATM-mediated phosphorylation of SOG1 is essential for the DNA damage response in Arabidopsis","volume":"14","author":"Yoshiyama","year":"2013","journal-title":"EMBO Rep"},{"issue":"1","key":"2025040907571166000_koaf066-B64","doi-asserted-by":"publisher","first-page":"4","DOI":"10.1186\/s11658-021-00300-w","article-title":"Specificity of H2O2 signaling in leaf senescence: is the ratio of H2O2 contents in different cellular compartments sensed in Arabidopsis plants?","volume":"27","author":"Zentgraf","year":"2022","journal-title":"Cell Mol Biol Lett"},{"issue":"11","key":"2025040907571166000_koaf066-B65","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1016\/j.molp.2021.07.014","article-title":"Verticillium dahliae secretory effector PevD1 induces leaf senescence by promoting ORE1-mediated ethylene biosynthesis","volume":"14","author":"Zhang","year":"2021","journal-title":"Mol Plant"},{"issue":"1","key":"2025040907571166000_koaf066-B66","doi-asserted-by":"publisher","first-page":"167","DOI":"10.1104\/pp.108.133439","article-title":"An arabidopsis mitogen-activated protein kinase cascade, MKK9-MPK6, plays a role in leaf senescence","volume":"150","author":"Zhou","year":"2009","journal-title":"Plant Physiol"}],"container-title":["The Plant Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/plcell\/article-pdf\/37\/4\/koaf066\/62711127\/koaf066.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plcell\/article-pdf\/37\/4\/koaf066\/62711127\/koaf066.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T03:57:40Z","timestamp":1744171060000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plcell\/article\/doi\/10.1093\/plcell\/koaf066\/8093449"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,25]]},"references-count":66,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4,2]]}},"URL":"https:\/\/doi.org\/10.1093\/plcell\/koaf066","relation":{},"ISSN":["1040-4651","1532-298X"],"issn-type":[{"value":"1040-4651","type":"print"},{"value":"1532-298X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2025,4]]},"published":{"date-parts":[[2025,3,25]]},"article-number":"koaf066"}}