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In this vignette, we explore the role of Arabidopsis in elucidating immune mechanisms, where plant studies have informed mammalian immunity and translational regulation. We discuss how Arabidopsis-driven advancements in pangenomics and repeat expansions have reshaped our understanding of genomic variability and its implications for diseases like Friedreich's ataxia. Breakthroughs in synthetic biology and bioproduction underscore the role of Arabidopsis as a testbed for engineering specialized metabolites and advancing biotechnological applications. Finally, we examine how the development of tools like auxin-inducible degradation has extended beyond plant research, providing critical methodologies to study protein function and develop novel therapeutics.<\/jats:p>","DOI":"10.1093\/plcell\/koaf141","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T14:15:11Z","timestamp":1749219311000},"source":"Crossref","is-referenced-by-count":2,"title":["Core biological principles and tools stemming from basic Arabidopsis research"],"prefix":"10.1093","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-7204","authenticated-orcid":false,"given":"Lucia C","family":"Strader","sequence":"first","affiliation":[{"name":"Department of Biology, Duke University , Durham, NC 27708 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