{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T23:32:53Z","timestamp":1787009573595,"version":"build-2736575974"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":1,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,5,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the root apical meristem, the stem cell niche (SCN) comprises a mitotically inactive quiescent center (QC) and adjacent, mitotically active stem cells that divide to form root tissues. Auxin dynamics are essential for specification and maintenance of the root SCN; however, the underlying mechanisms remain to be explored. Here, we report that Arabidopsis (Arabidopsis thaliana) AUXIN RESPONSE FACTOR3 (ARF3), ARF3-INTERACTING PROTEIN1\/2 (AIP1\/2), and SIN3-ASSOCIATED POLYPEPTIDE OF 18 KDA (SAP18) form a protein complex that specifies root SCN cell fate in response to auxin level. In cells proximal to the QC, the ARF3-AIP1\/2-SAP18 complex bound the WOX5 promoter and restricted WOX5 expression to the QC by decreasing H3 histone acetylation, thereby maintaining the SCN. Disrupting the ARF3-AIP1\/2-SAP18 complex via mutation or exposure to excessive amounts of auxin resulted in proximal and lateral expansion of WOX5 expression and inhibited root elongation by repressing cell division. During de novo specification of the SCN in lateral root primordia or regenerating root tips, accumulated auxin caused the ARF3-AIP1\/2-SAP18 complex to dissociate, allowing the induction of WOX5 expression. In the reestablished meristem, the ARF3-AIP1\/2-SAP18 complex confines WOX5 expression to the newly formed QC. Our findings provide insights into the roles of auxin dynamics in determining root SCN.<\/jats:p>","DOI":"10.1093\/plcell\/koag108","type":"journal-article","created":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T11:48:59Z","timestamp":1775735339000},"source":"Crossref","is-referenced-by-count":2,"title":["The Arabidopsis ARF3-AIP1\/2-SAP18 module specifies the root stem cell niche in response to auxin"],"prefix":"10.1093","volume":"38","author":[{"given":"Zhi Juan","family":"Cheng","sequence":"first","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng Ru","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan Kai","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]},{"name":"College of Life Sciences, Zaozhuang University , Zaozhuang 277160 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Li","family":"Chu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao Miao","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia Yang","family":"Li","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan Chen","family":"Dong","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-2707-172X","authenticated-orcid":false,"given":"De Hao","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Qi","family":"Xin","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin Lin","family":"Han","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cai Yu","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]},{"name":"College of Life Sciences, Zaozhuang University , Zaozhuang 277160 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao Hang","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiong Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3129-5206","authenticated-orcid":false,"given":"Xian Sheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Life Sciences, College of Forestry,State Key Laboratory of Wheat Improvement, Key Laboratory for Warm Temperate Forest Ecosystem Conservation and Restoration of National Forestry and Grassland Administration, Shandong Agricultural University , Taian, Shandong 271018 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