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However, their role in regulating plant performance under abiotic stress remains largely unexplored. Here, we integrated multi-omics data in 6 Sorghum bicolor accessions under water-limiting conditions in the field to explore the relationship between RCMs and drought response. Within a stress- and photosynthesis-associated gene co-expression module, we identified SbDUS2, a member of a family of enzymes conserved across eukaryotes, that catalyzes the reduction of uracil to dihydrouridine (DHU) on RNA molecules. DHU-modified transcripts in this module were enriched for photosynthetic functions and showed strong correlation with photosynthetic traits. To elucidate the function of this RCM, we characterized loss-of-function dus2 mutants in Arabidopsis thaliana. Under control conditions, these DHU-deficient mutants exhibited impaired germination and delayed development. Furthermore, under water-limiting or heat conditions, these mutants showed significantly reduced net CO2 assimilation and survival. Using multiple transcriptome-wide RNA stability assays, we demonstrated that transcripts associated with lower DHU levels in a dus2 background generally exhibited increased stability compared to Col-0 controls. Particularly, lack of DUS2 led to the hyperstability of photosynthesis-related transcripts, impeding their turnover and likely preventing proper photosynthetic acclimation during stress. We propose a model where DHU acts as a critical post-transcriptional regulator marking mRNAs for rapid turnover under stress, highlighting an overlooked regulatory layer contributing to plant resilience.<\/jats:p>","DOI":"10.1093\/plcell\/koag196","type":"journal-article","created":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T11:55:23Z","timestamp":1782302123000},"source":"Crossref","is-referenced-by-count":0,"title":["The mRNA covalent modification dihydrouridine regulates transcript turnover and photosynthetic capacity during plant abiotic stress"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9556-011X","authenticated-orcid":false,"given":"Li\u2019ang","family":"Yu","sequence":"first","affiliation":[{"name":"Boyce Thompson Institute, Cornell University , 533 Tower Road, Ithaca, NY 14853 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0877-5009","authenticated-orcid":false,"given":"Giovanni","family":"Melandri","sequence":"additional","affiliation":[{"name":"School of Plant Sciences, University of Arizona , 1140 E South Campus Dr., Tucson, AZ 85721 ,","place":["United States"]},{"name":"Center for Agroecosystem Research in the Desert (ARID), University of Arizona , 1140 E. South Campus Drive, Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna C Nelson","family":"Dittrich","sequence":"additional","affiliation":[{"name":"Boyce Thompson Institute, Cornell University , 533 Tower Road, Ithaca, NY 14853 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9401-4494","authenticated-orcid":false,"given":"Sebastian","family":"Calleja","sequence":"additional","affiliation":[{"name":"School of Plant Sciences, University of Arizona , 1140 E South Campus Dr., Tucson, AZ 85721 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6746-0181","authenticated-orcid":false,"given":"Diep R","family":"Ganguly","sequence":"additional","affiliation":[{"name":"Department of Biology, University of Pennsylvania , 433 South University Avenue, Philadelphia, PA 19104 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