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Here, in maize, we characterized an EMS-induced additive delayed-flowering mutant, edf1. edf1 and its heterozygotes are late-flowering under both long- and short-day photoperiods in the field, and harbor a splice-donor mutation in ALTERED PHLOEM DEVELOPMENT (APL). This mutation leads to the accumulation of the minor APL-\u03b2 transcript, a splice variant expressed across a large natural maize population. Expression of the major splice variant APL-\u03b1 is associated with flowering initiation; APL knockdown delays flowering and results in taller plants with increased biomass and plot yield. APL-\u03b1 binds to and activates the promoter of ZCN8 to trigger flowering, while APL-\u03b2 has impaired DNA-binding activity and antagonizes APL-\u03b1 function. Base editing of the APL MYB domain in an elite rice cultivar and Arabidopsis results in delayed flowering, providing a feasible approach to regulate flowering time for the molecular breeding of staple crops.<\/jats:p>","DOI":"10.1093\/plcell\/koag215","type":"journal-article","created":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T20:15:48Z","timestamp":1784146548000},"source":"Crossref","is-referenced-by-count":2,"title":["The MYB transcription factor APL is a rational target for base editing to engineer flowering time"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5624-3886","authenticated-orcid":false,"given":"Zhiwei","family":"Zhao","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory for Plant Epigenetics, Shenzhen Key Laboratory of High-Efficiency Utilization of Light in Plants, College of Life Sciences and Oceanography, Shenzhen University , Shenzhen 518060 ,","place":["China"]},{"name":"National Key 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