{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T22:13:46Z","timestamp":1790115226488,"version":"4.0.1"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T00:00:00Z","timestamp":1784073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"funder":[{"name":"Hubei Province Science and Technology Innovation Key Research and Development Project","award":["2023BBB035"],"award-info":[{"award-number":["2023BBB035"]}]},{"name":"Hubei Province Supports High- Quality Development Fund Projects for Seed Industry","award":["HBZY2023B002-3"],"award-info":[{"award-number":["HBZY2023B002-3"]}]},{"DOI":"10.13039\/501100010203","name":"China Agriculture Research System","doi-asserted-by":"publisher","award":["CARS-09"],"award-info":[{"award-number":["CARS-09"]}],"id":[{"id":"10.13039\/501100010203","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Sichuan Science and Technology Program","award":["2025ZNSFSC0180"],"award-info":[{"award-number":["2025ZNSFSC0180"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,8,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Potato, the fourth largest food crop in the world, stores nutrients in underground tubers. However, light exposure induces tuber accumulation of chlorophyll and toxic steroidal glycoalkaloids (SGAs); this unwanted trait called tuber greening causes a decline in potato quality and renders parts of tuber inedible. Despite progress in enzymatic cascades governing SGAs biosynthesis, the regulatory scheme of SGAs and chlorophyll metabolism in light-exposed tubers persists as a critical knowledge gap. Here, we identify that the blue light receptor StCRY1 plays a predominant role in light-induced tuber greening and SGA elevation, functioning as a light-controlled transcriptional switch for genes involved in SGAs and chlorophyll biosynthesis. We show that the transcription factor StHY5 acts downstream of StCRY1 to coregulate both chlorophyll and SGA metabolism. However, StMYB4, a transcription factor regulated by StHY5, promotes SGA synthesis by directly binding to SGA biosynthetic genes without affecting chlorophyll homeostasis. Furthermore, StCRY1 employs a dual strategy by modulating StMYB4 expression and physically interacting with StMYB4 to regulate its transcriptional activity. Collectively, these findings uncover a modularly coordinated control of SGA accumulation and chlorophyll biosynthesis by bifurcation of the StCRY1\u2013StHY5 axis, providing a promising strategy to concurrently curb light-induced tuber greening and glycoalkaloids accumulation.<\/jats:p>","DOI":"10.1093\/plcell\/koag218","type":"journal-article","created":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T11:39:52Z","timestamp":1784029192000},"source":"Crossref","is-referenced-by-count":1,"title":["Bifurcation of StCRY1\u2013StHY5 axis orchestrates blue light\u2013enhanced glycoalkaloid and chlorophyll accumulation in potato tubers"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5589-7308","authenticated-orcid":false,"given":"Jun","family":"Qin","sequence":"first","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1442-6673","authenticated-orcid":false,"given":"Shenglin","family":"Jing","sequence":"additional","affiliation":[{"name":"Department of Biological Science, College of Life Sciences, Sichuan Normal University , Chengdu, Sichuan 610101 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3578-3005","authenticated-orcid":false,"given":"Shengxuan","family":"Liu","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7257-9486","authenticated-orcid":false,"given":"Huiling","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Horticulture and Plant Protection, Henan University of Science and Technology , Luoyang 471000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingtao","family":"Zuo","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6449-5290","authenticated-orcid":false,"given":"Enshuang","family":"Wang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4828-8560","authenticated-orcid":false,"given":"Xijuan","family":"Zhao","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9606-5746","authenticated-orcid":false,"given":"Jianke","family":"Dong","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5629-0649","authenticated-orcid":false,"given":"Peng","family":"Jiang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1200-4792","authenticated-orcid":false,"given":"Xiaomeng","family":"Sun","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Wang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shijie","family":"He","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-5819-6121","authenticated-orcid":false,"given":"Qingwei","family":"Wang","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2614-5955","authenticated-orcid":false,"given":"Xiantao","family":"Ye","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0336-8375","authenticated-orcid":false,"given":"Xingkui","family":"Cai","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8493-1181","authenticated-orcid":false,"given":"Botao","family":"Song","sequence":"additional","affiliation":[{"name":"National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Huazhong Agricultural University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Key Laboratory of Potato Biology and Biotechnology, Ministry of Agriculture and Rural Affairs, Huazhong Agriculture University , Wuhan, Hubei 430070 ,","place":["China"]},{"name":"Hubei Hongshan Laboratory (HZAU) , Wuhan, Hubei 430070 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,7,15]]},"reference":[{"key":"2026081013511759400_koag218-B1","doi-asserted-by":"publisher","first-page":"2632","DOI":"10.1111\/nph.20411","article-title":"Two reductases complete steroidal glycoalkaloids biosynthesis in potato","volume":"245","author":"Akiyama","year":"2025","journal-title":"New Phytol"},{"key":"2026081013511759400_koag218-B2","doi-asserted-by":"publisher","first-page":"2511","DOI":"10.1093\/jxb\/ery083","article-title":"The FBH family of bHLH transcription factors controls ACC synthase expression in sugarcane","volume":"69","author":"Alessio","year":"2018","journal-title":"J Exp 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