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Using elongating Arabidopsis thaliana cells as a model, we developed quantitative methods to move beyond coarse correlation and reveal the precise spatial relationship between cortical microtubules and secretion. We identify KEULE, an essential SEC\/MUNC protein, as a dynamic exocytosis marker that forms clusters with stereotyped assembly and disassembly kinetics at discrete secretion sites. Combining confocal microscopy with super-resolution analysis and Bayesian inference, we quantified microtubule-exocytosis positioning at nanometer precision. This analysis revealed that microtubules create \u223c180-nm enrichment zones flanked by \u223c520-nm depletion zones, generating a spatial pattern that replicates the cortical array structure. Unexpectedly, Bayesian inference showed strong evidence for a flat enrichment profile within these zones rather than peaked distributions. This flat profile, combined with the \u223c180-nm width, challenges a direct vesicle capture mechanism, suggesting consideration of alternative models such as a mechanism where microtubules organize the local membrane environment to create preferred exocytosis territories. These findings establish quantitative spatial rules for how non-centrosomal microtubule arrays organize secretion.<\/jats:p>","DOI":"10.1093\/plcell\/koag222","type":"journal-article","created":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T11:50:53Z","timestamp":1787140253000},"source":"Crossref","is-referenced-by-count":1,"title":["Sub-resolution imaging and Bayesian analysis of exocytosis events reveals nanoscale patterning by cortical microtubule arrays"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4294-4838","authenticated-orcid":false,"given":"Jelmer J","family":"Lindeboom","sequence":"first","affiliation":[{"name":"Department of Plant Biology, Carnegie Institution for Science , 260 Panama St, Stanford, CA 94305 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-0336-3707","authenticated-orcid":false,"given":"Ryan","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Department of Plant Biology, Carnegie Institution for Science , 260 Panama St, Stanford, CA 94305 ,","place":["United States"]},{"name":"Department of Biology, Stanford University , 371 Jane Stanford Way, Stanford, CA 94305 ,","place":["United States"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3401-5599","authenticated-orcid":false,"given":"Viktor","family":"Kirik","sequence":"additional","affiliation":[{"name":"School of Biological Sciences, Illinois State University , 251 S. 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