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However, the molecular mechanisms underlying environmental regulation of seed isoflavonoid biosynthesis in soybean remain largely elusive. Here, our genome-wide association study identifies isoflavone content regulator 1 (ICR1), encoding a regulator of chromosome condensation (RCC1) family protein, as a positive regulator of seed isoflavonoid accumulation in soybean. The CONSTANS (CO) homolog GmCOL2b directly suppresses ICR1 transcription by binding to a CORE cis-element. Notably, natural variations flanking the CORE sequence influence GmCOL2b binding affinity, thereby modulating ICR1 transcription and seed isoflavone content. We further demonstrate that photoperiod significantly affects seed isoflavone content, with short-day conditions promoting isoflavonoid accumulation by relieving GmCOL2b-mediated repression of ICR1, while UV-B radiation facilitates ICR1 protein accumulation. Subsequently, ICR1 interacts with GmMYB12B2 to enhance seed isoflavonoid biosynthesis. Our findings elucidate how soybean integrates environmental light signals, including photoperiod and UV-B signaling that vary across seasons or latitudes, to coordinate seed isoflavonoid biosynthesis, providing a valuable genetic resource for improving soybean nutritional quality.<\/jats:p>","DOI":"10.1093\/plcell\/koag268","type":"journal-article","created":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:43:33Z","timestamp":1788799413000},"source":"Crossref","is-referenced-by-count":0,"title":["Photoperiod and UV-B orchestrate ICR1 to control seed isoflavonoid accumulation in soybean"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9981-5426","authenticated-orcid":false,"given":"Mingyang","family":"Jian","sequence":"first","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany and State Key Laboratory of Plant Diversity and Specialty Crops, South China Botanical Garden, Chinese Academy of Sciences , No.723 Xingke St, Tianhe District, Guangzhou 510650 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , No.1 Yanqihu East Rd, Huairou District, Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huan","family":"Wu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany and State Key Laboratory of Plant Diversity and Specialty Crops, South China Botanical Garden, Chinese Academy of Sciences , No.723 Xingke St, Tianhe District, Guangzhou 510650 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , No.1 Yanqihu East Rd, Huairou District, Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuirong","family":"Tan","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany and State Key Laboratory of Plant Diversity and Specialty Crops, South China Botanical Garden, Chinese Academy 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,","place":["China"]},{"name":"University of Chinese Academy of Sciences , No.1 Yanqihu East Rd, Huairou District, Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8622-5152","authenticated-orcid":false,"given":"Yilong","family":"Hu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Applied Botany and State Key Laboratory of Plant Diversity and Specialty Crops, South China Botanical Garden, Chinese Academy of Sciences , No.723 Xingke St, Tianhe District, Guangzhou 510650 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , No.1 Yanqihu East Rd, Huairou District, Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3964-2372","authenticated-orcid":false,"given":"Xingliang","family":"Hou","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory 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