{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T12:13:13Z","timestamp":1789992793631,"version":"4.0.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T00:00:00Z","timestamp":1789948800000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>BR-ENHANCED EXPRESSION1 (BEE1), BEE2, and BEE3, key transcriptional components of brassinosteroid signaling, have been shown to play critical roles in regulating light signaling. However, the precise molecular mechanism by which BEE1\/2\/3 repress photomorphogenesis remains elusive. In this study, we found that light triggers the degradation of BEE1\/2\/3 proteins through the 26S proteasome system. BEE1\/2\/3 interact with phyA and phyB, and this interaction promotes the degradation of BEE3. Mutations in BEE1\/2\/3 exhibit short hypocotyls and partially suppress the long hypocotyl phenotype of the phyA phyB double mutant. BEE1\/2\/3 attenuate the interaction between phyB and PIF3, leading to PIF3 stabilization and subsequent repression of photomorphogenesis. In addition, BEE1\/2\/3 interact with SPAs to disrupt the phyA\/B-SPA1 association, thereby further attenuating the exaggerated light signaling. The COP1-SPAs complexes stabilize BEE1\/3 under both dark and light conditions. Mutations in BEE1\/2\/3 enhance the constitutively photomorphogenic phenptype of spa1\/2\/4, whereas overexpression of BEE1\/3 partially rescue the short hypocotyls of cop1 and spa1\/2\/4. Collectively, these findings demonatrate that BEE1\/2\/3 fine-tune the phyA\/B-COP1\/SPA1 signaling hub to negatively regulate photomorphogenesis in response to excessive light signaling. Our study provides insights into the pivotal roles of BEE1\/2\/3 as photomorphogenic repressors, facilitating adaptation to complex light conditions.<\/jats:p>","DOI":"10.1093\/plcell\/koag284","type":"journal-article","created":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:36:22Z","timestamp":1789817782000},"source":"Crossref","is-referenced-by-count":0,"title":["BR-ENHANCED EXPRESSION 1\/2\/3 fine-tune plant photomorphogenesis by regulating the phyA\/B-SPA1 cascade"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9475-1192","authenticated-orcid":false,"given":"Jiale","family":"Yuan","sequence":"first","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]},{"name":"Gansu Province Key Laboratory of Gene Editing Breeding, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1353-7264","authenticated-orcid":false,"given":"Jing","family":"Cao","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]},{"name":"Gansu Province Key Laboratory of Gene Editing Breeding, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qizhang","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]},{"name":"Gansu Province Key Laboratory of Gene Editing Breeding, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-7749-6494","authenticated-orcid":false,"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Technology, College of Life Sciences, Nanjing Normal University , Nanjing 210023 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxia","family":"Liang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-1989-0814","authenticated-orcid":false,"given":"Ruiyun","family":"Wang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Huang","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]},{"name":"Gansu Province Key Laboratory of Gene Editing Breeding, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4944-058X","authenticated-orcid":false,"given":"Hua","family":"Zhou","sequence":"additional","affiliation":[{"name":"Laboratory of Plant and Environment Interaction Study, Tsientang Institute for Advanced Study , Hangzhou 310000 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-6568","authenticated-orcid":false,"given":"Dongqing","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, National Center for Soybean Improvement, College of Agriculture, Nanjing Agricultural University , Nanjing 210095 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6901-2048","authenticated-orcid":false,"given":"Fang","family":"Lin","sequence":"additional","affiliation":[{"name":"Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University , Lanzhou 730000 ,","place":["China"]},{"name":"Gansu Province Key Laboratory of Gene Editing Breeding, School of Life Sciences, Lanzhou University , Lanzhou 730000 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