{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T12:53:25Z","timestamp":1791464005417,"version":"4.3.4"},"reference-count":83,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T00:00:00Z","timestamp":1789689600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"name":"National Research Foundation Competitive Research Programme","award":["NRF-CRP22-2019-0001"],"award-info":[{"award-number":["NRF-CRP22-2019-0001"]}]},{"DOI":"10.13039\/501100010730","name":"Temasek Life Sciences Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010730","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2026,10,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>N 6-Methyladenosine (m6A) is a context-dependent mRNA modification, yet how its dynamics integrate with endogenous signaling to shape plant development remains unclear. Here, we provide further evidence for HIZ2 as an essential component of the m6A writer complex in Arabidopsis, which methylates and destabilizes mRNAs decoding multiple enzymes acting in sequential steps of jasmonic acid biosynthesis, thereby ensuring jasmonic acid homeostasis required for timely leaf senescence. HIZ2 interacts with and is indispensable for maintaining the abundance of key m6A writer complex components, including MTA. HIZ2 is required for transcriptome-wide m6A deposition, notably on transcripts of multiple jasmonic acid biosynthesis genes, which are subsequently recognized and destabilized by the m6A readers ECT2\/3\/4. During aging, reduced m6A deposition on these transcripts permits their accumulation, thus elevating jasmonic acid levels that drive the progression of leaf senescence. Our findings indicate that coordinated m6A-dependent regulation of multiple jasmonic acid biosynthesis transcripts fine-tunes jasmonic acid homeostasis and contributes to the timely progression of leaf senescence.<\/jats:p>","DOI":"10.1093\/plcell\/koag287","type":"journal-article","created":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:16:27Z","timestamp":1789672587000},"source":"Crossref","is-referenced-by-count":0,"title":["RNA m6A methylation fine-tunes the jasmonic acid biosynthesis pathway to modulate plant aging"],"prefix":"10.1093","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6430-3452","authenticated-orcid":false,"given":"Yu","family":"Zhang","sequence":"first","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7062-4327","authenticated-orcid":false,"given":"Ping","family":"Li","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5030-2320","authenticated-orcid":false,"given":"Changmei","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , 14 Science Drive 4, Singapore 117543 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5674-4023","authenticated-orcid":false,"given":"Jinqi","family":"Ma","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]},{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , 14 Science Drive 4, Singapore 117543 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-1549-5167","authenticated-orcid":false,"given":"Kuan Nam","family":"Kong","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2477-2884","authenticated-orcid":false,"given":"Songyao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , 14 Science Drive 4, Singapore 117543 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-7863-5554","authenticated-orcid":false,"given":"Xiaowei","family":"Wu","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]},{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , 14 Science Drive 4, Singapore 117543 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3094-6576","authenticated-orcid":false,"given":"Jean","family":"Loi","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-8427-0496","authenticated-orcid":false,"given":"Ian Kin Yuen","family":"Choi","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1719-6794","authenticated-orcid":false,"given":"Chongsheng","family":"He","sequence":"additional","affiliation":[{"name":"Hunan Key Laboratory of Plant Functional Genomics and Developmental Regulation, College of Biology, Hunan University , Lushan South Road, Yuelu District, Changsha, Hunan 410082 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9408-4273","authenticated-orcid":false,"given":"In-Cheol","family":"Jang","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]},{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , 14 Science Drive 4, Singapore 117543 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1808-6370","authenticated-orcid":false,"given":"Lisha","family":"Shen","sequence":"additional","affiliation":[{"name":"Temasek Life Sciences Laboratory, 1 Research Link, National University of Singapore , Singapore 117604 ,","place":["Singapore"]},{"name":"Department of Biological Sciences, Faculty of Science, National University of Singapore , 14 Science Drive 4, Singapore 117543 ,","place":["Singapore"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,9,18]]},"reference":[{"key":"2026100807570777100_koag287-B1","doi-asserted-by":"publisher","first-page":"417","DOI":"10.3389\/fpls.2014.00417","article-title":"Validated method for phytohormone quantification in plants","volume":"5","author":"Almeida Trapp","year":"2014","journal-title":"Front Plant Sci"},{"key":"2026100807570777100_koag287-B2","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1016\/j.molp.2023.04.005","article-title":"FLK is an mRNA m6A reader that regulates floral transition by modulating the stability and splicing of FLC in Arabidopsis","volume":"16","author":"Amara","year":"2023","journal-title":"Mol Plant"},{"key":"2026100807570777100_koag287-B3","doi-asserted-by":"publisher","first-page":"1146","DOI":"10.1016\/j.celrep.2018.10.020","article-title":"N6-Methyladenosine inhibits local ribonucleolytic cleavage to stabilize mRNAs in Arabidopsis","volume":"25","author":"Anderson","year":"2018","journal-title":"Cell Rep"},{"key":"2026100807570777100_koag287-B4","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1104\/pp.24.1.1","article-title":"Copper enzymes in isolated chloroplasts. Polyphenoloxidase in Beta vulgaris","volume":"24","author":"Arnon","year":"1949","journal-title":"Plant Physiol"},{"key":"2026100807570777100_koag287-B5","doi-asserted-by":"publisher","first-page":"952","DOI":"10.1105\/tpc.17.00833","article-title":"An m6A-YTH module controls developmental timing and morphogenesis in Arabidopsis","volume":"30","author":"Arribas-Hern\u00e1ndez","year":"2018","journal-title":"Plant Cell"},{"key":"2026100807570777100_koag287-B6","doi-asserted-by":"publisher","first-page":"189134","DOI":"10.1242\/dev.189134","article-title":"Recurrent requirement for the m6A-ECT2\/ECT3\/ECT4 axis in the control of cell proliferation during plant organogenesis","volume":"147","author":"Arribas-Hern\u00e1ndez","year":"2020","journal-title":"Development"},{"key":"2026100807570777100_koag287-B7","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72375","article-title":"Principles of mRNA targeting via the Arabidopsis m6A-binding protein ECT2","volume":"10","author":"Arribas-Hern\u00e1ndez","year":"2021","journal-title":"Elife"},{"key":"2026100807570777100_koag287-B8","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.72377","article-title":"The YTHDF proteins ECT2 and ECT3 bind largely overlapping target sets and influence target mRNA abundance, not alternative polyadenylation","volume":"10","author":"Arribas-Hern\u00e1ndez","year":"2021","journal-title":"Elife"},{"key":"2026100807570777100_koag287-B9","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2405100121","article-title":"The m6A reader SlYTH2 negatively regulates tomato fruit aroma by impeding the translation process","volume":"121","author":"Bian","year":"2024","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026100807570777100_koag287-B10","doi-asserted-by":"publisher","first-page":"48","DOI":"10.3389\/fpls.2012.00048","article-title":"Adenosine methylation in Arabidopsis mRNA is associated with the 3\u2032 end and reduced levels cause developmental defects","volume":"3","author":"Bodi","year":"2012","journal-title":"Front Plant Sci"},{"key":"2026100807570777100_koag287-B11","doi-asserted-by":"publisher","first-page":"2908","DOI":"10.1093\/plcell\/koae149","article-title":"The m6A reader ECT8 is an abiotic stress sensor that accelerates mRNA decay in Arabidopsis","volume":"36","author":"Cai","year":"2024","journal-title":"Plant Cell"},{"key":"2026100807570777100_koag287-B12","doi-asserted-by":"publisher","first-page":"246","DOI":"10.1016\/j.devcel.2021.12.014","article-title":"RNA N6-methyladenosine modification promotes auxin biosynthesis required for male meiosis in rice","volume":"57","author":"Cheng","year":"2022","journal-title":"Dev Cell"},{"key":"2026100807570777100_koag287-B13","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1046\/j.1365-313x.1998.00343.x","article-title":"Floral dip: a simplified method for Agrobacterium-mediated transformation of Arabidopsis thaliana","volume":"16","author":"Clough","year":"1998","journal-title":"Plant J"},{"key":"2026100807570777100_koag287-B14","doi-asserted-by":"publisher","first-page":"1367","DOI":"10.1038\/nbt.1511","article-title":"MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification","volume":"26","author":"Cox","year":"2008","journal-title":"Nat Biotechnol"},{"key":"2026100807570777100_koag287-B15","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1016\/j.molp.2024.05.002","article-title":"The RNA binding protein EHD6 recruits the m6A reader YTH07 and sequesters OsCOL4 mRNA into phase-separated ribonucleoprotein condensates to promote rice flowering","volume":"17","author":"Cui","year":"2024","journal-title":"Mol Plant"},{"key":"2026100807570777100_koag287-B16","doi-asserted-by":"publisher","first-page":"R365","DOI":"10.1016\/j.cub.2011.03.013","article-title":"Hormone signalling crosstalk in plant growth regulation","volume":"21","author":"Depuydt","year":"2011","journal-title":"Curr Biol"},{"key":"2026100807570777100_koag287-B17","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1038\/nprot.2012.148","article-title":"Transcriptome-wide mapping of N(6)-methyladenosine by m6A-seq based on immunocapturing and massively parallel sequencing","volume":"8","author":"Dominissini","year":"2013","journal-title":"Nat Protoc"},{"key":"2026100807570777100_koag287-B18","doi-asserted-by":"publisher","first-page":"765068","DOI":"10.3389\/fagro.2022.765068","article-title":"Phytohormones as growth regulators during abiotic stress tolerance in plants","volume":"4","author":"El Sabagh","year":"2022","journal-title":"Fronti Agron"},{"key":"2026100807570777100_koag287-B19","doi-asserted-by":"publisher","first-page":"eadf3292","DOI":"10.1126\/sciadv.adf3292","article-title":"m6A RNA demethylase AtALKBH9B promotes mobilization of a heat-activated long terminal repeat retrotransposon in Arabidopsis","volume":"9","author":"Fan","year":"2023","journal-title":"Sci Adv"},{"key":"2026100807570777100_koag287-B20","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1186\/s43897-021-00006-9","article-title":"Leaf senescence: progression, regulation, and application","volume":"1","author":"Guo","year":"2021","journal-title":"Mol Hortic"},{"key":"2026100807570777100_koag287-B21","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1104\/pp.010843","article-title":"Evidence supporting a role of jasmonic acid in Arabidopsis leaf senescence","volume":"128","author":"He","year":"2002","journal-title":"Plant Physiol"},{"key":"2026100807570777100_koag287-B22","doi-asserted-by":"publisher","first-page":"1759","DOI":"10.1111\/tpj.15270","article-title":"N6-Methyladenosine mRNA methylation is important for salt stress tolerance in Arabidopsis","volume":"106","author":"Hu","year":"2021","journal-title":"Plant J"},{"key":"2026100807570777100_koag287-B23","doi-asserted-by":"publisher","first-page":"101037","DOI":"10.1016\/j.xplc.2024.101037","article-title":"Crosstalk between RNA m6A modification and epigenetic factors for gene regulation in plants","volume":"5","author":"Hu","year":"2024","journal-title":"Plant Commun"},{"key":"2026100807570777100_koag287-B24","doi-asserted-by":"publisher","first-page":"13985","DOI":"10.1073\/pnas.97.25.13985","article-title":"Novel features of the XRN-family in Arabidopsis: evidence that AtXRN4, one of several orthologs of nuclear Xrn2p\/Rat1p, functions in the cytoplasm","volume":"97","author":"Kastenmayer","year":"2000","journal-title":"Proc Natl Acad Sci U S A."},{"key":"2026100807570777100_koag287-B25","doi-asserted-by":"publisher","first-page":"415","DOI":"10.1101\/gad.309146.117","article-title":"Zc3h13\/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15\/Spenito to the m6A machinery component Wtap\/Fl(2)d","volume":"32","author":"Knuckles","year":"2018","journal-title":"Genes Dev"},{"key":"2026100807570777100_koag287-B26","doi-asserted-by":"publisher","first-page":"746","DOI":"10.1093\/plcell\/koad300","article-title":"The m6A reader ECT1 drives mRNA sequestration to dampen salicylic acid-dependent stress responses in Arabidopsis","volume":"36","author":"Lee","year":"2024","journal-title":"Plant Cell"},{"key":"2026100807570777100_koag287-B27","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/978-1-62703-532-3_12","article-title":"In vivo localization in Arabidopsis protoplasts and root tissue","volume":"1043","author":"Lee","year":"2013","journal-title":"Methods Mol Biol"},{"key":"2026100807570777100_koag287-B28","doi-asserted-by":"publisher","first-page":"114597","DOI":"10.1016\/j.celrep.2024.114597","article-title":"TMK4-mediated FIP37 phosphorylation regulates auxin-triggered N6-methyladenosine modification of auxin biosynthetic genes in Arabidopsis","volume":"43","author":"Li","year":"2024","journal-title":"Cell Rep"},{"key":"2026100807570777100_koag287-B29","doi-asserted-by":"publisher","first-page":"100231","DOI":"10.1016\/j.xplc.2021.100231","article-title":"Metabolism, signaling, and transport of jasmonates","volume":"2","author":"Li","year":"2021","journal-title":"Plant Commun"},{"key":"2026100807570777100_koag287-B30","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.70055","article-title":"METTL5-mediated 18S rRNA m6A modification enhances ribosome assembly and ABA response in Arabidopsis","volume":"4","author":"Li","year":"2025","journal-title":"iMeta"},{"key":"2026100807570777100_koag287-B31","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1038\/nchembio.1432","article-title":"A METTL3\u2013METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation","volume":"10","author":"Liu","year":"2014","journal-title":"Nat Chem Bio"},{"key":"2026100807570777100_koag287-B32","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1038\/nmeth.3444","article-title":"A complete bacterial genome assembled de novo using only nanopore sequencing data","volume":"12","author":"Loman","year":"2015","journal-title":"Nat Methods"},{"key":"2026100807570777100_koag287-B33","doi-asserted-by":"publisher","first-page":"5630","DOI":"10.1038\/ncomms6630","article-title":"Unique features of the m6A methylome in Arabidopsis thaliana","volume":"5","author":"Luo","year":"2014","journal-title":"Nat Commun"},{"key":"2026100807570777100_koag287-B34","doi-asserted-by":"publisher","first-page":"332","DOI":"10.1104\/pp.19.00987","article-title":"Natural variation in RNA m6A methylation and its relationship with translational status","volume":"182","author":"Luo","year":"2020","journal-title":"Plant Physiol"},{"key":"2026100807570777100_koag287-B35","doi-asserted-by":"publisher","first-page":"4288","DOI":"10.1093\/nar\/gks042","article-title":"Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation","volume":"40","author":"McCarthy","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2026100807570777100_koag287-B36","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1104\/pp.19.00323","article-title":"Evolution of the RNA N6-methyladenosine methylome mediated by genomic duplication","volume":"182","author":"Miao","year":"2020","journal-title":"Plant Physiol"},{"key":"2026100807570777100_koag287-B37","doi-asserted-by":"publisher","first-page":"2236","DOI":"10.1016\/j.molcel.2022.05.029","article-title":"Hidden codes in mRNA: control of gene expression by m6A","volume":"82","author":"Murakami","year":"2022","journal-title":"Mol Cell"},{"key":"2026100807570777100_koag287-B38","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.49658","article-title":"Nanopore direct RNA sequencing maps the complexity of Arabidopsis mRNA processing and m6A modification","volume":"9","author":"Parker","year":"2020","journal-title":"Elife"},{"key":"2026100807570777100_koag287-B39","doi-asserted-by":"publisher","first-page":"4155","DOI":"10.1093\/plcell\/koad224","article-title":"Pathogen-induced m6A dynamics affect plant immunity","volume":"35","author":"Prall","year":"2023","journal-title":"Plant Cell"},{"key":"2026100807570777100_koag287-B40","doi-asserted-by":"publisher","first-page":"2479","DOI":"10.3390\/ijms20102479","article-title":"Jasmonic acid signaling pathway in plants","volume":"20","author":"Ruan","year":"2019","journal-title":"Int J Mol Sci"},{"key":"2026100807570777100_koag287-B41","doi-asserted-by":"publisher","first-page":"157","DOI":"10.1111\/nph.14586","article-title":"Identification of factors required for m6A mRNA methylation in Arabidopsis reveals a role for the conserved E3 ubiquitin ligase HAKAI","volume":"215","author":"Ruzicka","year":"2017","journal-title":"New Phytol"},{"key":"2026100807570777100_koag287-B42","doi-asserted-by":"publisher","first-page":"102047","DOI":"10.1016\/j.pbi.2021.102047","article-title":"N6-methyladenosine modification underlies messenger RNA metabolism and plant development","volume":"63","author":"Shao","year":"2021","journal-title":"Curr Opin Plant Biol"},{"key":"2026100807570777100_koag287-B43","doi-asserted-by":"publisher","first-page":"468","DOI":"10.1038\/s41477-025-01945-7","article-title":"NERD-dependent m6A modification of the nascent FLC transcript regulates flowering time in Arabidopsis","volume":"11","author":"Shao","year":"2025","journal-title":"Nat Plants"},{"key":"2026100807570777100_koag287-B44","doi-asserted-by":"publisher","first-page":"53","DOI":"10.1146\/annurev-arplant-071122-085813","article-title":"The diversity and functions of plant RNA modifications: what we know and where we go from here","volume":"74","author":"Sharma","year":"2023","journal-title":"Annu Rev Plant Biol"},{"key":"2026100807570777100_koag287-B45","doi-asserted-by":"publisher","first-page":"2663","DOI":"10.1093\/plphys\/kiad660","article-title":"m6A RNA methylation counteracts dark-induced leaf senescence in Arabidopsis","volume":"194","author":"Sheikh","year":"2024","journal-title":"Plant Physiol"},{"key":"2026100807570777100_koag287-B46","doi-asserted-by":"publisher","first-page":"1901","DOI":"10.1093\/plcell\/koad070","article-title":"Functional interdependence of N6-methyladenosine methyltransferase complex subunits in Arabidopsis","volume":"35","author":"Shen","year":"2023","journal-title":"Plant Cell"},{"key":"2026100807570777100_koag287-B47","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1242\/dev.104513","article-title":"The putative PRC1 RING-finger protein AtRING1A regulates flowering through repressing MADS AFFECTING FLOWERING genes in Arabidopsis","volume":"141","author":"Shen","year":"2014","journal-title":"Development"},{"key":"2026100807570777100_koag287-B48","doi-asserted-by":"publisher","first-page":"186","DOI":"10.1016\/j.devcel.2016.06.008","article-title":"N(6)-methyladenosine RNA modification regulates shoot stem cell fate in Arabidopsis","volume":"38","author":"Shen","year":"2016","journal-title":"Dev Cell"},{"key":"2026100807570777100_koag287-B49","doi-asserted-by":"publisher","first-page":"328","DOI":"10.1016\/j.tplants.2019.01.005","article-title":"Messenger RNA modifications in plants","volume":"24","author":"Shen","year":"2019","journal-title":"Trends Plant Sci"},{"key":"2026100807570777100_koag287-B50","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1186\/s13059-023-02872-6","article-title":"Recent advances in the plant epitranscriptome","volume":"24","author":"Shen","year":"2023","journal-title":"Genome Biol"},{"key":"2026100807570777100_koag287-B51","doi-asserted-by":"publisher","first-page":"686","DOI":"10.1038\/s41477-025-01947-5","article-title":"RNA m6A modification meets plant hormones","volume":"11","author":"Shen","year":"2025","journal-title":"Nat Plants"},{"key":"2026100807570777100_koag287-B52","doi-asserted-by":"publisher","first-page":"818","DOI":"10.1093\/plcell\/koab286","article-title":"A molecular switch for FLOWERING LOCUS C activation determines flowering time in Arabidopsis","volume":"34","author":"Shen","year":"2022","journal-title":"Plant Cell"},{"key":"2026100807570777100_koag287-B53","doi-asserted-by":"publisher","first-page":"640","DOI":"10.1016\/j.molcel.2019.04.025","article-title":"Where, when, and how: context-dependent functions of RNA methylation writers, readers, and erasers","volume":"74","author":"Shi","year":"2019","journal-title":"Mol Cell"},{"key":"2026100807570777100_koag287-B54","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1186\/s13059-023-02947-4","article-title":"m6A readers ECT2\/ECT3\/ECT4 enhance mRNA stability through direct recruitment of the poly(A) binding proteins in Arabidopsis","volume":"24","author":"Song","year":"2023","journal-title":"Genome Biol"},{"key":"2026100807570777100_koag287-B55","doi-asserted-by":"publisher","first-page":"571","DOI":"10.1016\/j.molp.2021.01.014","article-title":"Arabidopsis N6-methyladenosine reader CPSF30-L recognizes FUE signals to control polyadenylation site choice in liquid-like nuclear bodies","volume":"14","author":"Song","year":"2021","journal-title":"Mol Plant"},{"key":"2026100807570777100_koag287-B56","doi-asserted-by":"publisher","first-page":"982","DOI":"10.1038\/s41422-022-00725-8","article-title":"Cryo-EM structures of human m6A writer complexes","volume":"32","author":"Su","year":"2022","journal-title":"Cell Res"},{"key":"2026100807570777100_koag287-B57","doi-asserted-by":"publisher","first-page":"2410","DOI":"10.1111\/pbi.14354","article-title":"OsALKBH9-mediated m6A demethylation regulates tapetal PCD and pollen exine accumulation in rice","volume":"22","author":"Tang","year":"2024","journal-title":"Plant Biotechno J"},{"key":"2026100807570777100_koag287-B58","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1038\/s41477-026-02284-x","article-title":"Emerging roles of non-m6A mRNA modifications in plants","volume":"12","author":"Teng","year":"2026","journal-title":"Nat Plants"},{"key":"2026100807570777100_koag287-B59","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-6807-7_1","article-title":"LC-MS analysis of methylated RNA","volume":"1562","author":"Thuring","year":"2017","journal-title":"Methods Mol Biol"},{"key":"2026100807570777100_koag287-B60","doi-asserted-by":"publisher","first-page":"731","DOI":"10.1038\/nmeth.3901","article-title":"The Perseus computational platform for comprehensive analysis of (prote)omics data","volume":"13","author":"Tyanova","year":"2016","journal-title":"Nat Methods"},{"key":"2026100807570777100_koag287-B61","doi-asserted-by":"publisher","first-page":"680","DOI":"10.1038\/s41580-022-00479-6","article-title":"Plant hormone regulation of abiotic stress responses","volume":"23","author":"Waadt","year":"2022","journal-title":"Nat Rev Mol Cell Biol"},{"key":"2026100807570777100_koag287-B62","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1186\/s13059-015-0839-2","article-title":"Transcriptome-wide high-throughput deep m6A-seq reveals unique differential m6A methylation patterns between three organs in Arabidopsis thaliana","volume":"16","author":"Wan","year":"2015","journal-title":"Genome Biol"},{"key":"2026100807570777100_koag287-B63","doi-asserted-by":"publisher","first-page":"4881","DOI":"10.1038\/s41467-024-48941-7","article-title":"Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis","volume":"15","author":"Wang","year":"2024","journal-title":"Nat Commun"},{"key":"2026100807570777100_koag287-B64","doi-asserted-by":"publisher","first-page":"48","DOI":"10.1186\/s12935-022-02452-x","article-title":"Dynamic regulation and functions of mRNA m6A modification","volume":"22","author":"Wang","year":"2022","journal-title":"Cancer Cell Int"},{"key":"2026100807570777100_koag287-B65","doi-asserted-by":"publisher","first-page":"8568","DOI":"10.3390\/ijms22168568","article-title":"Function and mechanism of jasmonic acid in plant responses to abiotic and biotic stresses","volume":"22","author":"Wang","year":"2021","journal-title":"Int J Mol Sci"},{"key":"2026100807570777100_koag287-B66","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1016\/j.tplants.2018.02.011","article-title":"A bypass in jasmonate biosynthesis\u2014the OPR3-independent formation","volume":"23","author":"Wasternack","year":"2018","journal-title":"Trends Plant Sci"},{"key":"2026100807570777100_koag287-B67","doi-asserted-by":"publisher","first-page":"1028","DOI":"10.1016\/j.molcel.2018.02.015","article-title":"Zc3h13 regulates nuclear RNA m6A methylation and mouse embryonic stem cell self-renewal","volume":"69","author":"Wen","year":"2018","journal-title":"Mol Cell"},{"key":"2026100807570777100_koag287-B68","doi-asserted-by":"publisher","first-page":"2045","DOI":"10.1093\/plphys\/kiad010","article-title":"Shaping the landscape of N6-methyladenosine RNA methylation in Arabidopsis","volume":"191","author":"Wong","year":"2023","journal-title":"Plant Physiol"},{"key":"2026100807570777100_koag287-B69","doi-asserted-by":"publisher","first-page":"347","DOI":"10.1146\/annurev-arplant-050718-095859","article-title":"Leaf senescence: systems and dynamics aspects","volume":"70","author":"Woo","year":"2019","journal-title":"Annu Rev Plant Biol"},{"key":"2026100807570777100_koag287-B70","doi-asserted-by":"publisher","first-page":"16","DOI":"10.1186\/1746-4811-5-16","article-title":"Tape-Arabidopsis sandwich\u2014a simpler Arabidopsis protoplast isolation method","volume":"5","author":"Wu","year":"2009","journal-title":"Plant Methods"},{"key":"2026100807570777100_koag287-B71","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1038\/s41477-024-01638-7","article-title":"N6-methyladenosine-mediated feedback regulation of abscisic acid perception via phase-separated ECT8 condensates in Arabidopsis","volume":"10","author":"Wu","year":"2024","journal-title":"Nat Plants"},{"key":"2026100807570777100_koag287-B72","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202103628","article-title":"FIONA1-mediated m6A modification regulates the floral transition in Arabidopsis","volume":"9","author":"Xu","year":"2022","journal-title":"Adv Sci"},{"key":"2026100807570777100_koag287-B73","doi-asserted-by":"publisher","first-page":"201775","DOI":"10.1242\/dev.201775","article-title":"N6-adenosine methylation of mRNA integrates multilevel auxin response and ground tissue development in Arabidopsis","volume":"150","author":"Zemlyanskaya","year":"2023","journal-title":"Development"},{"key":"2026100807570777100_koag287-B74","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.1016\/j.devcel.2024.06.012","article-title":"Defining context-dependent m6A RNA methylomes in Arabidopsis","volume":"59","author":"Zhang","year":"2024","journal-title":"Dev Cell"},{"key":"2026100807570777100_koag287-B75","doi-asserted-by":"publisher","first-page":"1127","DOI":"10.1038\/s41467-022-28753-3","article-title":"Two zinc finger proteins with functions in m6A writing interact with HAKAI","volume":"13","author":"Zhang","year":"2022","journal-title":"Nat Commun"},{"key":"2026100807570777100_koag287-B76","doi-asserted-by":"publisher","first-page":"7700","DOI":"10.1093\/nar\/gkaa588","article-title":"New insights into Arabidopsis transcriptome complexity revealed by direct sequencing of native RNAs","volume":"48","author":"Zhang","year":"2020","journal-title":"Nucleic Acids Res"},{"key":"2026100807570777100_koag287-B77","doi-asserted-by":"publisher","first-page":"eabn5488","DOI":"10.1126\/sciadv.abn5488","article-title":"Phase separation of HRLP regulates flowering time in Arabidopsis","volume":"8","author":"Zhang","year":"2022","journal-title":"Sci Adv"},{"key":"2026100807570777100_koag287-B78","doi-asserted-by":"publisher","first-page":"100779","DOI":"10.1016\/j.xplc.2023.100779","article-title":"A dephosphorylation-dependent molecular switch for FT repression mediates flowering in Arabidopsis","volume":"5","author":"Zhang","year":"2024","journal-title":"Plant Commun"},{"key":"2026100807570777100_koag287-B79","doi-asserted-by":"publisher","first-page":"788996","DOI":"10.3389\/fpls.2021.788996","article-title":"Multiple layers of regulation on leaf senescence: new advances and perspectives","volume":"12","author":"Zhang","year":"2021","journal-title":"Front Plant Sci"},{"key":"2026100807570777100_koag287-B80","doi-asserted-by":"publisher","first-page":"1278","DOI":"10.1105\/tpc.108.058883","article-title":"MTA is an Arabidopsis messenger RNA adenosine methylase and interacts with a homolog of a sex-specific splicing factor","volume":"20","author":"Zhong","year":"2008","journal-title":"Plant Cell"},{"key":"2026100807570777100_koag287-B81","doi-asserted-by":"publisher","first-page":"168","DOI":"10.1186\/s13059-021-02385-0","article-title":"N6-methyladenosine RNA modification regulates strawberry fruit ripening in an ABA-dependent manner","volume":"22","author":"Zhou","year":"2021","journal-title":"Genome Biol"},{"key":"2026100807570777100_koag287-B82","doi-asserted-by":"publisher","first-page":"1447","DOI":"10.1111\/pbi.13792","article-title":"m6A-mediated regulation of crop development and stress responses","volume":"20","author":"Zhou","year":"2022","journal-title":"Plant Biotechnol J"},{"key":"2026100807570777100_koag287-B83","doi-asserted-by":"publisher","first-page":"156","DOI":"10.1186\/s13059-019-1771-7","article-title":"RNA methylomes reveal the m6A-mediated regulation of DNA demethylase gene SlDML2 in tomato fruit ripening","volume":"20","author":"Zhou","year":"2019","journal-title":"Genome Biol"}],"container-title":["The Plant Cell"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/plcell\/advance-article-pdf\/doi\/10.1093\/plcell\/koag287\/71225975\/koag287.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plcell\/article-pdf\/38\/10\/koag287\/71225975\/koag287.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plcell\/article-pdf\/38\/10\/koag287\/71225975\/koag287.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T11:57:18Z","timestamp":1791460638000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plcell\/article\/doi\/10.1093\/plcell\/koag287\/8817280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,18]]},"references-count":83,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,10,5]]}},"URL":"https:\/\/doi.org\/10.1093\/plcell\/koag287","relation":{},"ISSN":["1040-4651","1532-298X"],"issn-type":[{"value":"1040-4651","type":"print"},{"value":"1532-298X","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2026,10]]},"published":{"date-parts":[[2026,9,18]]},"article-number":"koag287"}}