{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:54:41Z","timestamp":1792079681041,"version":"4.4.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T00:00:00Z","timestamp":1792022400000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Stilbenes are inducible plant specialized metabolites, best exemplified by resveratrol, a phytoalexin that links environmental perception, defense responses, and phenylpropanoid resource allocation. Stilbene accumulation may be controlled at three mechanistically distinct levels: signaling cascades that connect environmental and hormonal cues to kinase-dependent activation; combinatorial transcriptional control, which governs the response amplitude and specificity of stilbene synthase (STS) genes; and branch selection together with product disposition, which shapes the final metabolic output. Within this framework, MYB and WRKY proteins serve as major transcriptional nodes as activators or repressors, yet their regulatory effects depend on combinatorial interactions, phosphorylation events, competitive promoter occupancy, and metabolic context. We explicitly distinguish strongly supported mechanisms, defined by genetic perturbation, direct target validation, and metabolite quantification from emerging models built primarily on transient expression assays or co-expression correlations. This distinction avoids equating regulators supported by disparate levels of experimental evidence, identifies the most robust principles governing pathway control, and highlights experiments required to turn descriptive associations into causal mechanistic models. We further highlight conceptual insights extending beyond stilbene metabolism to inducible specialized metabolism in general, and outline research priorities for comparative genetics, cell-resolved analysis, and predictive pathway engineering.<\/jats:p>","DOI":"10.1093\/plcell\/koag315","type":"journal-article","created":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T15:43:34Z","timestamp":1792079014000},"source":"Crossref","is-referenced-by-count":0,"title":["From stress perception to metabolite disposition: dynamic regulation of stilbene biosynthesis in plants"],"prefix":"10.1093","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5575-8041","authenticated-orcid":false,"given":"Yang","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Plant Diversity and Specialty Crops, and Beijing Key Laboratory of Grape Sciences and Enology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 ,","place":["China"]},{"name":"China National Botanical Garden , Beijing 100093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8154-5567","authenticated-orcid":false,"given":"Lingchao","family":"Kong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Diversity and Specialty Crops, and Beijing Key Laboratory of Grape Sciences and Enology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 ,","place":["China"]},{"name":"China National Botanical Garden , Beijing 100093 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4788-0810","authenticated-orcid":false,"given":"Yanshen","family":"Ren","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Diversity and Specialty Crops, and Beijing Key Laboratory of Grape Sciences and Enology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 ,","place":["China"]},{"name":"China National Botanical Garden , Beijing 100093 ,","place":["China"]},{"name":"University of Chinese Academy of Sciences , Beijing 100049 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-8439-9667","authenticated-orcid":false,"given":"Guotian","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Horticulture, Northwest A & F University , Yangling, Shaanxi 712100 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Bogs","sequence":"additional","affiliation":[{"name":"Horticulture and Rural Development, State Education and Research Center of Viticulture , 67435 Neustadt ,","place":["Germany"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4033-477X","authenticated-orcid":false,"given":"Alessandro","family":"Vannozzi","sequence":"additional","affiliation":[{"name":"Department of Agronomy, Food, Natural resources, Animals, and Environment (DAFNAE), University of Padova , Legnaro 35020 ,","place":["Italy"]},{"name":"Centro Interdipartimentale per la Ricerca in Enologia e Viticultura (CIRVE), University of Padova , Via XXVIII Aprile 14, 31015 Conegliano (TV) ,","place":["Italy"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1698-3244","authenticated-orcid":false,"given":"Yuejin","family":"Wang","sequence":"additional","affiliation":[{"name":"College of Horticulture, Northwest A & F University , Yangling, Shaanxi 712100 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4644-4454","authenticated-orcid":false,"given":"Zhenchang","family":"Liang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Diversity and Specialty Crops, and Beijing Key Laboratory of Grape Sciences and Enology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 ,","place":["China"]},{"name":"China National Botanical Garden , Beijing 100093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4767-5761","authenticated-orcid":false,"given":"Ling","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Plant and Soil Sciences, and Kentucky Tobacco Research and Development Center, University of Kentucky , Lexington, Kentucky 40546 ,","place":["USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5973-6053","authenticated-orcid":false,"given":"Lijun","family":"Wang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Plant Diversity and Specialty Crops, and Beijing Key Laboratory of Grape Sciences and Enology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093 ,","place":["China"]},{"name":"China National Botanical Garden , Beijing 100093 ,","place":["China"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2026,10,15]]},"container-title":["The Plant 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