{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T23:41:24Z","timestamp":1791589284711,"version":"4.3.4"},"reference-count":67,"publisher":"Oxford University Press (OUP)","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"am","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Bar Ilan University Core Facility unit for providing RT-qPCR, microscopy, and cytometry services"},{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["938\/11"],"award-info":[{"award-number":["938\/11"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]},{"name":"the Marie Curie Actions\u2014International Career Integration Grant","award":["293999"],"award-info":[{"award-number":["293999"]}]},{"name":"Bi-national Agricultural Research & Development Fund","award":["IS-4652-13 R"],"award-info":[{"award-number":["IS-4652-13 R"]}]},{"name":"US National Science Foundation [Grant IOS"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Age-dependent changes in reactive oxygen species (ROS) levels are critical in leaf senescence. While H2O2-reducing enzymes such as catalases and cytosolic ASCORBATE PEROXIDASE1 (APX1) tightly control the oxidative load during senescence, their regulation and function are not specific to senescence. Previously, we identified the role of ASCORBATE PEROXIDASE6 (APX6) during seed maturation in Arabidopsis (Arabidopsis thaliana). Here, we show that APX6 is a bona fide senescence-associated gene. APX6 expression is specifically induced in aging leaves and in response to senescence-promoting stimuli such as abscisic acid (ABA), extended darkness, and osmotic stress. apx6 mutants showed early developmental senescence and increased sensitivity to dark stress. Reduced APX activity, increased H2O2 level, and altered redox state of the ascorbate pool in mature pre-senescing green leaves of the apx6 mutants correlated with the early onset of senescence. Using transient expression assays in Nicotiana benthamiana leaves, we unraveled the age-dependent post-transcriptional regulation of APX6. We then identified the coding sequence of APX6 as a potential target of miR398, which is a key regulator of copper redistribution. Furthermore, we showed that mutants of SQUAMOSA PROMOTER BINDING PROTEIN-LIKE7 (SPL7), the master regulator of copper homeostasis and miR398 expression, have a higher APX6 level compared with the wild type, which further increased under copper deficiency. Our study suggests that APX6 is a modulator of ROS\/redox homeostasis and signaling in aging leaves that plays an important role in developmental- and stress-induced senescence programs.<\/jats:p>","DOI":"10.1093\/plphys\/kiaa031","type":"journal-article","created":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T04:12:43Z","timestamp":1609474363000},"source":"Crossref","is-referenced-by-count":16,"title":["ASCORBATE PEROXIDASE6 delays the onset of age-dependent leaf senescence"],"prefix":"10.1093","author":[{"given":"Changming","family":"Chen","sequence":"first","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel"},{"name":"Ministry of Agriculture and Rural Affairs Key Laboratory of South China Horticultural Crop Biology and Germplasm Enhancement, College of Horticulture, South China Agricultural University, Guangzhou 510642, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yael","family":"Galon","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5447-643X","authenticated-orcid":false,"given":"Maryam","family":"Rahmati Ishka","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, New York 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shimrit","family":"Malihi","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladislava","family":"Shimanovsky","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shir","family":"Twito","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Rath","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-3797","authenticated-orcid":false,"given":"Olena K","family":"Vatamaniuk","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, New York 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7196-6529","authenticated-orcid":false,"given":"Gad","family":"Miller","sequence":"additional","affiliation":[{"name":"The Mina and Everard Goodman Faculty of Life Sciences, Bar-Ilan University, Ramat-Gan 5290002, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,11,27]]},"reference":[{"key":"2021010802201513400_kiaa031-B1","doi-asserted-by":"crossref","first-page":"3993","DOI":"10.1093\/jxb\/eru173","article-title":"Salt stress and senescence: identification of cross-talk regulatory components","volume":"65","author":"Allu","year":"2014","journal-title":"J Exp Bot"},{"key":"2021010802201513400_kiaa031-B2","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1111\/tpj.13261","article-title":"New BAR tools for mining expression data and exploring Cis-elements in Arabidopsis 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