{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:57:17Z","timestamp":1787731037413,"version":"build-2784847793"},"reference-count":103,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,2,12]],"date-time":"2021-02-12T00:00:00Z","timestamp":1613088000000},"content-version":"vor","delay-in-days":3,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"National Synchrotron Light Source II"},{"DOI":"10.13039\/100000015","name":"U.S. Department of Energy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000015","id-type":"DOI","asserted-by":"publisher"}]},{"name":"DOE Office of Science by Brookhaven National Laboratory","award":["DE-SC0012704"],"award-info":[{"award-number":["DE-SC0012704"]}]},{"name":"Cornell High Energy Synchrotron Source"},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-1332208"],"award-info":[{"award-number":["DMR-1332208"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Cornell NanoScale Facility"},{"DOI":"10.13039\/100000001","name":"NSF","doi-asserted-by":"publisher","award":["NNCI-2025233"],"award-info":[{"award-number":["NNCI-2025233"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008585","name":"Cornell Center for Materials Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008585","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR-1719875"],"award-info":[{"award-number":["DMR-1719875"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["#31301349"],"award-info":[{"award-number":["#31301349"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30870154"],"award-info":[{"award-number":["30870154"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30901052"],"award-info":[{"award-number":["30901052"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["30900087"],"award-info":[{"award-number":["30900087"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Schwartz Research Fund for Women in Life Sciences awarded"},{"name":"Agriculture and Food Research Initiative Awards","award":["# 2018-67013-27418"],"award-info":[{"award-number":["# 2018-67013-27418"]}]},{"name":"Agriculture and Food Research Initiative Awards","award":["2021-67013-33798"],"award-info":[{"award-number":["2021-67013-33798"]}]},{"DOI":"10.13039\/100005825","name":"USDA National Institute of Food and Agriculture","doi-asserted-by":"crossref","award":["#1656321"],"award-info":[{"award-number":["#1656321"]}],"id":[{"id":"10.13039\/100005825","id-type":"DOI","asserted-by":"crossref"}]},{"name":"U.S.\u2013Ukraine Competition","award":["OISE-9531011"],"award-info":[{"award-number":["OISE-9531011"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,5,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Addressing the looming global food security crisis requires the development of high-yielding crops. In agricultural soils, deficiency in the micronutrient copper significantly decreases grain yield in wheat (Triticum aestivum), a globally important crop. In cereals, grain yield is determined by inflorescence architecture, flower fertility, grain size, and weight. Whether copper is involved in these processes, and how it is delivered to the reproductive organs is not well understood. We show that copper deficiency alters not only the grain set but also flower development in both wheat and its recognized model, Brachypodium distachyon. We then show that the Brachypodium yellow stripe-like 3 (YSL3) transporter localizes to the phloem, transports copper in frog (Xenopus laevis) oocytes, and facilitates copper delivery to reproductive organs and grains. Failure to deliver copper, but not iron, zinc, or manganese to these structures in the ysl3 CRISPR-Cas9 mutant results in delayed flowering, altered inflorescence architecture, reduced floret fertility, grain size, weight, and protein accumulation. These defects are rescued by copper supplementation and are complemented by YSL3 cDNA. This knowledge will help to devise sustainable approaches for improving grain yield in regions where soil quality is a major obstacle for crop production. Copper distribution by a phloem-localized transporter is essential for the transition to flowering, inflorescence architecture, floret fertility, size, weight, and protein accumulation in seeds.<\/jats:p>","DOI":"10.1093\/plphys\/kiab054","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T05:03:01Z","timestamp":1612414981000},"page":"655-676","source":"Crossref","is-referenced-by-count":53,"title":["YSL3-mediated copper distribution is required for fertility, seed size and protein accumulation in <i>Brachypodium<\/i>"],"prefix":"10.1093","volume":"186","author":[{"given":"Huajin","family":"Sheng","sequence":"first","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"},{"name":"Triticeae Research Institute, Sichuan Agricultural University, Wenjiang, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulin","family":"Jiang","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"},{"name":"Triticeae Research Institute, Sichuan Agricultural University, Wenjiang, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Rahmati","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-5071","authenticated-orcid":false,"given":"Ju-Chen","family":"Chia","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0744-7169","authenticated-orcid":false,"given":"Tatyana","family":"Dokuchayeva","sequence":"additional","affiliation":[{"name":"Cornell Nutrient Analysis Laboratory, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6140-635X","authenticated-orcid":false,"given":"Yana","family":"Kavulych","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"},{"name":"Department of Biology, Ivan Franko National University of Lviv, Lviv 79005, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetiana-Olena","family":"Zavodna","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7624-3338","authenticated-orcid":false,"given":"Patrick N","family":"Mendoza","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"},{"name":"Plant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0215-4823","authenticated-orcid":false,"given":"Rong","family":"Huang","sequence":"additional","affiliation":[{"name":"Cornell University, Cornell High Energy Synchrotron Source (CHESS), Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louisa M","family":"Smieshka","sequence":"additional","affiliation":[{"name":"Cornell University, Cornell High Energy Synchrotron Source (CHESS), Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Miller","sequence":"additional","affiliation":[{"name":"Plant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"},{"name":"Robert W. Holley Center for Agriculture and Health, USDA-ARS, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur R","family":"Woll","sequence":"additional","affiliation":[{"name":"Cornell University, Cornell High Energy Synchrotron Source (CHESS), Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olga I","family":"Terek","sequence":"additional","affiliation":[{"name":"Department of Biology, Ivan Franko National University of Lviv, Lviv 79005, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3662-8874","authenticated-orcid":false,"given":"Nataliya D","family":"Romanyuk","sequence":"additional","affiliation":[{"name":"Department of Biology, Ivan Franko National University of Lviv, Lviv 79005, Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Pi\u00f1eros","sequence":"additional","affiliation":[{"name":"Plant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"},{"name":"Robert W. Holley Center for Agriculture and Health, USDA-ARS, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonghong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Triticeae Research Institute, Sichuan Agricultural University, Wenjiang, Sichuan 611130, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2713-3797","authenticated-orcid":false,"given":"Olena K","family":"Vatamaniuk","sequence":"additional","affiliation":[{"name":"Soil and Crop Sciences Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"},{"name":"Plant Biology Section, School of Integrative Plant Science, Cornell University, Ithaca, NY 14853, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2021,2,9]]},"reference":[{"key":"2022020906200071800_kiab054-B1","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1105\/tpc.104.030452","article-title":"Two P-type ATPases are required for copper delivery in Arabidopsis thaliana chloroplasts","volume":"17","author":"Abdel-Ghany","year":"2005","journal-title":"The Plant Cell"},{"key":"2022020906200071800_kiab054-B2","article-title":"Germanium collimating micro-channel arrays for high resolution, high energy confocal X-ray fluorescence microscopy","volume":"1764","author":"Agyeman-Budu","year":"2016","journal-title":"Icxom23: International Conference on X-Ray Optics and Microanalysis"},{"key":"2022020906200071800_kiab054-B3","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1365-313X.2005.02601.x","article-title":"The Arabidopsis heavy metal P-type ATPase HMA5 interacts with metallochaperones and functions in copper detoxification of roots","volume":"45","author":"Andres-Colas","year":"2006","journal-title":"Plant J"},{"key":"2022020906200071800_kiab054-B4","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1038\/s41586-019-1679-0","article-title":"Genetic strategies for improving crop yields","volume":"575","author":"Bailey-Serres","year":"2019","journal-title":"Nature"},{"key":"2022020906200071800_kiab054-B5","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1016\/j.tplants.2008.09.007","article-title":"Hormonal control of grass inflorescence development","volume":"13","author":"Barazesh","year":"2008","journal-title":"Trends in Plant Science"},{"key":"2022020906200071800_kiab054-B6","doi-asserted-by":"crossref","first-page":"E450","DOI":"10.1073\/pnas.1100659108","article-title":"Monoubiquitin-dependent endocytosis of the iron-regulated transporter 1 (IRT1) transporter controls iron uptake in plants","volume":"108","author":"Barberon","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022020906200071800_kiab054-B7","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1111\/nph.12718","article-title":"Metallothionein deficiency impacts copper accumulation and redistribution in leaves and seeds of Arabidopsis","volume":"202","author":"Benatti","year":"2014","journal-title":"New Phytologist"},{"key":"2022020906200071800_kiab054-B8","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1105\/tpc.111.090431","article-title":"Transcriptome sequencing identifies SPL7-regulated copper acquisition genes FRO4\/FRO5 and the copper dependence of iron homeostasis in arabidopsis","volume":"24","author":"Bernal","year":"2012","journal-title":"The Plant Cell Online"},{"key":"2022020906200071800_kiab054-B9","doi-asserted-by":"crossref","first-page":"E5480","DOI":"10.1073\/pnas.1421545111","article-title":"Evolution of a plant-specific copper chaperone family for chloroplast copper homeostasis","volume":"111","author":"Blaby-Haas","year":"2014","journal-title":"Proc Natl Acad Sci"},{"key":"2022020906200071800_kiab054-B10","first-page":"0445","article-title":"The development of the wheat spike","volume":"53","author":"Bonnett","year":"1936","journal-title":"J Agricult Res"},{"key":"2022020906200071800_kiab054-B11","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1105\/tpc.105.039032","article-title":"ramosa2 encodes a lateral organ boundary domain protein that determines the fate of stem cells in branch meristems of maize","volume":"18","author":"Bortiri","year":"2006","journal-title":"Plant Cell"},{"key":"2022020906200071800_kiab054-B12","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/jipb.12741","article-title":"A reductionist approach to dissecting grain weight and yield in wheat","volume":"61","author":"Brinton","year":"2019","journal-title":"J Integrat Plant Biol"},{"key":"2022020906200071800_kiab054-B13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/B978-0-12-384905-2.00007-8","volume-title":"In Marschner's Mineral Nutrition of Higher Plants","author":"Broadley","year":"2012","edition":"Third Edition)."},{"key":"2022020906200071800_kiab054-B14","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.1104\/pp.114.247577","article-title":"Efficient gene editing in tomato in the first generation using the clustered regularly interspaced short palindromic repeats\/CRISPR-associated9 system","volume":"166","author":"Brooks","year":"2014","journal-title":"Plant Physiol"},{"key":"2022020906200071800_kiab054-B15","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1111\/j.1469-8137.2009.02846.x","article-title":"Copper homeostasis","volume":"182","author":"Burkhead","year":"2009","journal-title":"New Phytologist"},{"key":"2022020906200071800_kiab054-B16","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1105\/tpc.16.00922","article-title":"A multipurpose toolkit to enable advanced genome engineering in plants","volume":"29","author":"\u010cerm\u00e1k","year":"2017","journal-title":"The Plant Cell"},{"key":"2022020906200071800_kiab054-B17","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1104\/pp.110.159103","article-title":"Successful reproduction requires the function of Arabidopsis Yellow Stripe-Like1 and Yellow Stripe-Like3 metal-nicotianamine transporters in both vegetative and reproductive structures","volume":"154","author":"Chu","year":"2010","journal-title":"Plant Physiol"},{"key":"2022020906200071800_kiab054-B18","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1038\/s41477-019-0394-z","article-title":"Control of meristem determinacy by trehalose 6-phosphate phosphatases is uncoupled from enzymatic activity","volume":"5","author":"Claeys","year":"2019","journal-title":"Nature Plants"},{"key":"2022020906200071800_kiab054-B19","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1105\/tpc.001263","article-title":"Expression of the IRT1 metal transporter is controlled by metals at the levels of transcript and protein accumulation","volume":"14","author":"Connolly","year":"2002","journal-title":"The Plant Cell"},{"key":"2022020906200071800_kiab054-B20","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3389\/fpls.2013.00283","article-title":"Arabidopsis thaliana Yellow Stripe1-Like4 and Yellow Stripe1-Like6 localize to internal cellular membranes and are involved in metal ion homeostasis","volume":"4","author":"Conte","year":"2013","journal-title":"Front Plant Sci"},{"key":"2022020906200071800_kiab054-B21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/aob\/mcn207","article-title":"Metal movement within the plant: contribution of nicotianamine and yellow stripe 1-like transporters","volume":"103","author":"Curie","year":"2008","journal-title":"Ann Botany"},{"key":"2022020906200071800_kiab054-B22","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1104\/pp.103.027979","article-title":"A gateway cloning vector set for high-throughput functional analysis of genes in planta","volume":"133","author":"Curtis","year":"2003","journal-title":"Plant Physiol"},{"key":"2022020906200071800_kiab054-B23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1016\/j.tplants.2017.09.009","article-title":"Small RNAs: big impact on plant development","volume":"22","author":"D'Ario","year":"2017","journal-title":"Trends Plant Sci"},{"key":"2022020906200071800_kiab054-B24","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/S0300-9084(86)80013-X","article-title":"Structure and function of cytochrome-c oxidase","volume":"68","author":"Denis","year":"1986","journal-title":"Biochimie"},{"key":"2022020906200071800_kiab054-B25","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1104\/pp.112.212340","article-title":"MORE SPIKELETS1 is required for spikelet fate in the inflorescence of Brachypodium distachyon","volume":"161","author":"Derbyshire","year":"2013","journal-title":"Plant Physiology"},{"key":"2022020906200071800_kiab054-B26","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1111\/j.1365-313X.2004.02128.x","article-title":"Arabidopsis Yellow Stripe-Like2 (YSL2): a metal-regulated gene encoding a plasma membrane transporter of nicotianamine\u2013metal complexes","volume":"39","author":"DiDonato","year":"2004","journal-title":"Plant J"},{"key":"2022020906200071800_kiab054-B27","doi-asserted-by":"crossref","first-page":"3783","DOI":"10.1093\/jxb\/ert477","article-title":"Senescence, nutrient remobilization, and yield in wheat and barley","volume":"65","author":"Distelfeld","year":"2014","journal-title":"J Exp Botany"},{"key":"2022020906200071800_kiab054-B28","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1105\/tpc.112.107672","article-title":"The Arabidopsis YELLOW STRIPE LIKE4 and 6 transporters control iron release from the chloroplast","volume":"25","author":"Divol","year":"2013","journal-title":"Plant cell"},{"key":"2022020906200071800_kiab054-B29","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1002\/cphy.c170045","article-title":"Intersection of iron and copper metabolism in the mammalian intestine and liver","volume":"8","author":"Doguer","year":"2018","journal-title":"Comprehens Physiol"},{"key":"2022020906200071800_kiab054-B30","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.eja.2006.04.003","article-title":"Protein accumulation and composition in wheat grains: effects of mineral nutrients and high temperature","volume":"25","author":"Dupont","year":"2006","journal-title":"Eur J Agron"},{"key":"2022020906200071800_kiab054-B31","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1105\/tpc.015800","article-title":"Pollen and stigma structure and function: the role of diversity in pollination","volume":"16","author":"Edlund","year":"2004","journal-title":"Plant Cell"},{"key":"2022020906200071800_kiab054-B32","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/B978-0-12-384905-2.00005-4","volume-title":"Marschner\u2019s Mineral Nutrition of Higher Plants","author":"Engels","year":"2012","edition":"Third Edition)."},{"key":"2022020906200071800_kiab054-B33","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1039\/c3mt00111c","article-title":"The CTR\/COPT-dependent copper uptake and SPL7-dependent copper deficiency responses are required for basal cadmium tolerance in A. thaliana","volume":"5","author":"Gayomba","year":"2013","journal-title":"Metallomics"},{"key":"2022020906200071800_kiab054-B34","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1093\/mp\/ssp040","article-title":"New GATEWAY vectors for high throughput analyses of protein-protein interactions by bimolecular fluorescence complementation","volume":"2","author":"Gehl","year":"2009","journal-title":"Mol Plant"},{"key":"2022020906200071800_kiab054-B35","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1126\/science.1185383","article-title":"Food security: the challenge of feeding 9 billion people","volume":"327","author":"Godfray","year":"2010","journal-title":"Science"},{"key":"2022020906200071800_kiab054-B36","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1038\/271542a0","article-title":"Tolerance of triticale, wheat and rye to copper deficiency","volume":"271","author":"Graham","year":"1978","journal-title":"Nature"},{"key":"2022020906200071800_kiab054-B37","doi-asserted-by":"crossref","first-page":"115","DOI":"10.3109\/10520297009085351","article-title":"Evaluation of pollen viability by enzymatically induced fluorescence; intracellular hydrolysis of fluorescein diacetate","volume":"45","author":"Heslop-Harrison","year":"1970","journal-title":"Stain Technol"},{"key":"2022020906200071800_kiab054-B38","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0092-8674(00)80747-3","article-title":"RESPONSIVE-TO-ANTAGONIST1, a Menkes\/Wilson disease-related copper transporter, is required for ethylene signaling in Arabidopsis","volume":"97","author":"Hirayama","year":"1999","journal-title":"Cell"},{"key":"2022020906200071800_kiab054-B39","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pbi.2013.11.011","article-title":"Signaling in shoot and flower meristems of Arabidopsis thaliana","volume":"17","author":"Holt","year":"2014","journal-title":"Curr Opin Plant Biol"},{"key":"2022020906200071800_kiab054-B40","doi-asserted-by":"crossref","first-page":"15173","DOI":"10.1038\/nplants.2015.173","article-title":"Plant science and the food security agenda","volume":"1","author":"Ingram","year":"2015","journal-title":"Nature Plants"},{"key":"2022020906200071800_kiab054-B41","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1046\/j.1365-313X.2003.01878.x","article-title":"Three rice nicotianamine synthase genes, OsNAS1, OsNAS2, and OsNAS3 are expressed in cells involved in long-distance transport of iron and differentially regulated by iron","volume":"36","author":"Inoue","year":"2003","journal-title":"Plant Journal"},{"key":"2022020906200071800_kiab054-B42","doi-asserted-by":"crossref","first-page":"236","DOI":"10.3389\/fpls.2014.00236","article-title":"Brachypodium distachyon as a model system for studies of copper transport in cereal crops","volume":"5","author":"Jung","year":"2014","journal-title":"Front Plant Sci"},{"key":"2022020906200071800_kiab054-B43","doi-asserted-by":"crossref","first-page":"33252","DOI":"10.1074\/jbc.M112.397810","article-title":"COPT6 is a plasma membrane transporter that functions in copper homeostasis in arabidopsis and is a novel target of SQUAMOSA promoter-binding protein-like 7","volume":"287","author":"Jung","year":"2012","journal-title":"J Biol Chem"},{"key":"2022020906200071800_kiab054-B44","doi-asserted-by":"crossref","first-page":"33252","DOI":"10.1074\/jbc.M112.397810","article-title":"COPT6 is a plasma membrane transporter that functions in copper homeostasis in Arabidopsis and is a novel target of SQUAMOSA promoter-binding protein-like 7","volume":"287","author":"Jung","year":"2012","journal-title":"J Biol Chem"},{"key":"2022020906200071800_kiab054-B45","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11103-012-9930-1","article-title":"OsYSL16 plays a role in the allocation of iron","volume":"79","author":"Kakei","year":"2012","journal-title":"Plant Mol Biol"},{"key":"2022020906200071800_kiab054-B46","doi-asserted-by":"crossref","first-page":"28479","DOI":"10.1074\/jbc.270.47.28479","article-title":"Molecular characterization of a putative Arabidopsis thaliana copper transporter and its yeast homologue","volume":"270","author":"Kampfenkel","year":"1995","journal-title":"J Biol Chem"},{"key":"2022020906200071800_kiab054-B47","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.pbi.2006.11.009","article-title":"Floral displays: genetic control of grass inflorescences","volume":"10","author":"Kellogg","year":"2007","journal-title":"Curr Opin Plant Biol"},{"key":"2022020906200071800_kiab054-B48","doi-asserted-by":"crossref","first-page":"24933","DOI":"10.1073\/pnas.1916892116","article-title":"The iron deficiency response in Arabidopsis thaliana requires the phosphorylated transcription factor URI","volume":"116","author":"Kim","year":"2019","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022020906200071800_kiab054-B49","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1073\/pnas.1718670115","article-title":"Nitrate modulates stem cell dynamics in Arabidopsis shoot meristems through cytokinins","volume":"115","author":"Landrein","year":"2018","journal-title":"Proc Natl Acad Sci"},{"key":"2022020906200071800_kiab054-B50","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10059-012-2165-9","article-title":"Activation of rice Yellow Stripe1-Like 16 (OsYSL16) enhances iron efficiency","volume":"33","author":"Lee","year":"2012","journal-title":"Molecules and cells"},{"key":"2022020906200071800_kiab054-B51","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.1093\/mp\/ssu044","article-title":"CRISPR-P: a web tool for synthetic single-guide RNA design of CRISPR-system in plants","volume":"7","author":"Lei","year":"2014","journal-title":"Mol Plant"},{"key":"2022020906200071800_kiab054-B52","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00497-018-0333-6","article-title":"Control of grain size in rice","volume":"31","author":"Li","year":"2018","journal-title":"Plant Reprod"},{"key":"2022020906200071800_kiab054-B53","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1023\/A:1009658310154","article-title":"The extent of parental genotypic divergence determines maximal heterosis by increasing fertility in inter-subspecific hybrids of rice (Oryza sativa L","volume":"4","author":"Li","year":"1998","journal-title":"Mol Breeding"},{"key":"2022020906200071800_kiab054-B54","doi-asserted-by":"crossref","first-page":"e1006703","DOI":"10.1371\/journal.pgen.1006703","article-title":"Triplin, a small molecule, reveals copper ion transport in ethylene signaling from ATX1 to RAN1","volume":"13","author":"Li","year":"2017","journal-title":"PLOS Genet"},{"key":"2022020906200071800_kiab054-B55","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s11103-014-0188-7","article-title":"CRISPR\u2013Cas system: a powerful tool for genome engineering","volume":"85","author":"Liu","year":"2014","journal-title":"Plant Mol Biol"},{"key":"2022020906200071800_kiab054-B56","doi-asserted-by":"crossref","first-page":"851","DOI":"10.1104\/pp.108.132597","article-title":"MYB108 acts together with MYB24 to regulate jasmonate-mediated stamen maturation in Arabidopsis","volume":"149","author":"Mandaokar","year":"2009","journal-title":"Plant Physiol"},{"key":"2022020906200071800_kiab054-B57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.sab.2012.08.002","article-title":"Quantification for 3D micro X-ray fluorescence","volume":"77","author":"Mantouvalou","year":"2012","journal-title":"Spectrochimica Acta Part B-Atomic Spectrosc"},{"key":"2022020906200071800_kiab054-B58","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1046\/j.1365-313x.2001.00985.x","article-title":"Evidence for the plant-specific intercellular transport of the Arabidopsis copper chaperone CCH","volume":"25","author":"Mira","year":"2001","journal-title":"Plant Journal"},{"key":"2022020906200071800_kiab054-B59","volume-title":"A Biochemical and Molecular Approach","author":"Mitra","year":"2015"},{"key":"2022020906200071800_kiab054-B60","doi-asserted-by":"crossref","first-page":"e122","DOI":"10.1093\/nar\/gkl635","article-title":"Advancing uracil-excision based cloning towards an ideal technique for cloning PCR fragments","volume":"34","author":"Nour-Eldin","year":"2006","journal-title":"Nucleic Acids Res"},{"key":"2022020906200071800_kiab054-B61","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1093\/pcp\/pct025","article-title":"Grass meristems I: shoot apical meristem maintenance,","volume":"54","author":"Pautler","year":"2013","journal-title":"axillary meristem determinacy and the floral transition. Plant Cell Physiol"},{"key":"2022020906200071800_kiab054-B62","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fpls.2015.00255","article-title":"Temporal aspects of copper homeostasis and its crosstalk with hormones","volume":"6","author":"Pe\u00f1arrubia","year":"2015","journal-title":"Front Plant Sci"},{"key":"2022020906200071800_kiab054-B63","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1093\/jxb\/erv474","article-title":"Modulation of copper deficiency responses by diurnal and circadian rhythms in Arabidopsis thaliana","volume":"67","author":"Perea-Garc\u00eda","year":"2016","journal-title":"J Exp Botany"},{"key":"2022020906200071800_kiab054-B64","doi-asserted-by":"crossref","first-page":"1030","DOI":"10.1111\/nph.14244","article-title":"The copper microRNAs","volume":"213","author":"Pilon","year":"2017","journal-title":"New Phytologist"},{"key":"2022020906200071800_kiab054-B65","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.bbabio.2010.11.002","article-title":"The biogenesis and physiological function of chloroplast superoxide dismutases","volume":"1807","author":"Pilon","year":"2011","journal-title":"Biochim Biophys Acta"},{"key":"2022020906200071800_kiab054-B66","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF02772108","article-title":"Modification of a CTAB DNA extraction protocol for plants containing high polysaccharide and polyphenol components","volume":"15","author":"Porebski","year":"1997","journal-title":"Plant Mol Biol Reporter"},{"key":"2022020906200071800_kiab054-B67","doi-asserted-by":"crossref","first-page":"601","DOI":"10.3389\/fpls.2016.00601","article-title":"Copper trafficking in plants and its implication on cell wall dynamics","volume":"7","author":"Printz","year":"2016","journal-title":"Front Plant Sci"},{"key":"2022020906200071800_kiab054-B68","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1016\/j.bbrc.2006.12.215","article-title":"Higher plants possess two different types of ATX1-like copper chaperones","volume":"354","author":"Puig","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"2022020906200071800_kiab054-B69","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.3389\/fpls.2015.01091","article-title":"The arabidopsis COX11 homolog is essential for cytochrome c oxidase activity","volume":"6","author":"Radin","year":"2015","journal-title":"Front Plant Sci"},{"key":"2022020906200071800_kiab054-B70","doi-asserted-by":"crossref","first-page":"e00288","DOI":"10.1002\/pld3.288","article-title":"Copper deficiency alters shoot architecture and reduces fertility of both gynoecium and androecium in Arabidopsis thaliana","volume":"4","author":"Rahmati Ishka","year":"2020","journal-title":"Plant Direct"},{"key":"2022020906200071800_kiab054-B71","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.3389\/fpls.2017.01003","article-title":"Mapping and characterization of the fefe gene that controls iron uptake in melon (Cucumis melo L.)","volume":"8","author":"Ramamurthy","year":"2017","journal-title":"Front Plant Sci"},{"key":"2022020906200071800_kiab054-B72","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1089\/ars.2012.5084","article-title":"Copper and iron homeostasis in plants: the challenges of oxidative stress","volume":"19","author":"Ravet","year":"2013","journal-title":"Antioxid Redox Signal"},{"key":"2022020906200071800_kiab054-B73","doi-asserted-by":"crossref","first-page":"877","DOI":"10.2307\/3869324","article-title":"Cytochemical analysis of pollen development in wild-type arabidopsis and a male-sterile mutant","volume":"2","author":"Regan","year":"1990","journal-title":"Plant Cell"},{"key":"2022020906200071800_kiab054-B74","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1023\/A:1022345507112","article-title":"Identification of a copper transporter family in Arabidopsis thaliana","volume":"51","author":"Sancenon","year":"2003","journal-title":"Plant Mol Biol"},{"key":"2022020906200071800_kiab054-B75","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nature04725","article-title":"A trehalose metabolic enzyme controls inflorescence architecture in maize","volume":"441","author":"Satoh-Nagasawa","year":"2006","journal-title":"Nature"},{"key":"2022020906200071800_kiab054-B76","doi-asserted-by":"crossref","first-page":"9091","DOI":"10.1074\/jbc.M311799200","article-title":"ZmYS1 functions as a proton-coupled symporter for phytosiderophore- and nicotianamine-chelated metals","volume":"279","author":"Schaaf","year":"2004","journal-title":"J Biol Chem"},{"key":"2022020906200071800_kiab054-B77","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1105\/tpc.18.00083","article-title":"Brachypodium: a monocot grass model genus for plant biology","volume":"30","author":"Scholthof","year":"2018","journal-title":"Plant Cell"},{"key":"2022020906200071800_kiab054-B78","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1038\/nature11909","article-title":"Using membrane transporters to improve crops for sustainable food production","volume":"497","author":"Schroeder","year":"2013","journal-title":"Nature"},{"key":"2022020906200071800_kiab054-B79","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1104\/pp.011577","article-title":"ARAMEMNON, a novel database for arabidopsis integral membrane proteins","volume":"131","author":"Schwacke","year":"2003","journal-title":"Plant Physiol"},{"key":"2022020906200071800_kiab054-B80","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1093\/jexbot\/53.370.947","article-title":"Cereal seed storage proteins: structures, properties and role in grain utilization","volume":"53","author":"Shewry","year":"2002","journal-title":"J Exp Botany"},{"key":"2022020906200071800_kiab054-B81","author":"Shorrocks","year":"1988"},{"key":"2022020906200071800_kiab054-B82","first-page":"1","article-title":"Copper deficiency: diagnosis and correction","volume":"532\u20133","author":"Solberg","year":"1999","journal-title":"Agri-facts. Soil Fertility\/Crop Nutrition. Alberta Agriculture, Food and Rural Development, Agdex"},{"key":"2022020906200071800_kiab054-B83","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1093\/pcp\/pct016","article-title":"Grass meristems II: inflorescence architecture, flower development and meristem fate","volume":"54","author":"Tanaka","year":"2013","journal-title":"Plant Cell Physiol"},{"key":"2022020906200071800_kiab054-B84","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nature08747","article-title":"Genome sequencing and analysis of the model grass Brachypodium distachyon","volume":"463","author":"The International Brachypodium","year":"2010","journal-title":"Nature"},{"key":"2022020906200071800_kiab054-B85","first-page":"1428","article-title":"Agronomic and physiological traits, and associated quantitative trait loci (qtl) affecting yield response in wheat (","volume":"10","author":"Tshikunde","year":"2019","journal-title":"Triticum aestivum L.): a review. Front Plant Sci"},{"key":"2022020906200071800_kiab054-B86","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/s10815-014-0344-7","article-title":"Iron and copper in male reproduction: a double-edged sword","volume":"32","author":"Tvrda","year":"2015","journal-title":"J Assisted Reprod Genetics"},{"key":"2022020906200071800_kiab054-B87","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1007\/s00299-007-0472-y","article-title":"High-efficiency agrobacterium-mediated transformation of Brachypodium distachyon inbred line Bd21-3","volume":"27","author":"Vogel","year":"2008","journal-title":"Plant Cell Reports"},{"key":"2022020906200071800_kiab054-B88","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1038\/nature03892","article-title":"Architecture of floral branch systems in maize and related grasses","volume":"436","author":"Vollbrecht","year":"2005","journal-title":"Nature"},{"key":"2022020906200071800_kiab054-B89","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1104\/pp.106.082586","article-title":"Mutations in Arabidopsis yellow stripe-like 1 and yellow stripe-like 3 reveal their roles in metal ion homeostasis ans loading of metal ions in seeds","volume":"141","author":"Waters","year":"2006","journal-title":"Plant Physiol"},{"key":"2022020906200071800_kiab054-B90","doi-asserted-by":"crossref","first-page":"e19722","DOI":"10.1371\/journal.pone.0019722","article-title":"Assembly of designer TAL effectors by golden gate cloning","volume":"6","author":"Weber","year":"2011","journal-title":"PLOS ONE"},{"key":"2022020906200071800_kiab054-B91","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/B978-0-12-384905-2.00003-0","volume-title":"In Marschner\u2019s Mineral Nutrition of Higher Plants","author":"White","year":"2012","edition":"Third Edition)."},{"key":"2022020906200071800_kiab054-B92","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1111\/j.1469-8137.2008.02738.x","article-title":"Biofortification of crops with seven mineral elements often lacking in human diets\u2014iron, zinc, copper, calcium, magnesium, selenium and iodine","volume":"182","author":"White","year":"2009","journal-title":"New Phytologist"},{"key":"2022020906200071800_kiab054-B93","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1094\/CCHEM.1998.75.5.644","article-title":"Quantitative determination of gluten protein types in wheat flour by reversed-phase high-performance liquid chromatography","volume":"75","author":"Wieser","year":"1998","journal-title":"Cereal Chem"},{"key":"2022020906200071800_kiab054-B94","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1016\/j.tplants.2014.05.007","article-title":"The node, a hub for mineral nutrient distribution in graminaceous plants","volume":"19","author":"Yamaji","year":"2014","journal-title":"Trends Plant Sci"},{"key":"2022020906200071800_kiab054-B95","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1105\/tpc.108.060137","article-title":"SQUAMOSA promoter binding protein\u2013like7 is a central regulator for copper homeostasis in Arabidopsis","volume":"21","author":"Yamasaki","year":"2009","journal-title":"Plant Cell"},{"key":"2022020906200071800_kiab054-B96","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1105\/tpc.17.00363","article-title":"Arabidopsis pollen fertility requires the transcription factors CITF1 and SPL7 that regulate copper delivery to anthers and jasmonic acid synthesis","volume":"29","author":"Yan","year":"2017","journal-title":"Plant Cell"},{"key":"2022020906200071800_kiab054-B97","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1093\/aob\/mcr200","article-title":"Brachypodium distachyon as a new model system for understanding iron homeostasis in grasses: phylogenetic and expression analysis of Yellow Stripe-Like (YSL) transporters","volume":"108","author":"Yordem","year":"2011","journal-title":"Ann Botany"},{"key":"2022020906200071800_kiab054-B98","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1471-2229-11-69","article-title":"Molecular and functional analyses of COPT\/Ctr-type copper transporter-like gene family in rice","volume":"11","author":"Yuan","year":"2011","journal-title":"BMC Plant Biol"},{"key":"2022020906200071800_kiab054-B99","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1105\/tpc.114.123737","article-title":"OPT3 is a phloem-specific iron transporter that is essential for systemic iron signaling and redistribution of iron and cadmium in Arabidopsis","volume":"26","author":"Zhai","year":"2014","journal-title":"Plant Cell"},{"key":"2022020906200071800_kiab054-B100","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1104\/pp.108.130260","article-title":"Establishing RNA interference as a reverse-genetic approach for gene functional analysis in protoplasts","volume":"149","author":"Zhai","year":"2009","journal-title":"Plant Physiol"},{"issue":"2","key":"2022020906200071800_kiab054-B101","article-title":"Genetic analysis of flag leaf size and candidate genes determination of a major QTL for flag leaf width in rice","volume":"8","author":"Zhang","year":"2015","journal-title":"Rice"},{"key":"2022020906200071800_kiab054-B102","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1093\/pcp\/pcy124","article-title":"OsYSL16 is required for preferential Cu distribution to floral organs in rice","volume":"59","author":"Zhang","year":"2018","journal-title":"Plant Cell Physiol"},{"key":"2022020906200071800_kiab054-B103","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1105\/tpc.112.103820","article-title":"YSL16 is a phloem-localized transporter of the copper-nicotianamine complex that is responsible for copper distribution in rice","volume":"24","author":"Zheng","year":"2012","journal-title":"Plant Cell"}],"container-title":["Plant Physiology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/academic.oup.com\/plphys\/advance-article-pdf\/doi\/10.1093\/plphys\/kiab054\/36415507\/kiab054.pdf","content-type":"application\/pdf","content-version":"am","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/186\/1\/655\/40531371\/kiab054.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/plphys\/article-pdf\/186\/1\/655\/40531371\/kiab054.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,2,9]],"date-time":"2022-02-09T06:22:13Z","timestamp":1644387733000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/plphys\/article\/186\/1\/655\/6134087"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,9]]},"references-count":103,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2021,2,9]]},"published-print":{"date-parts":[[2021,5,27]]}},"URL":"https:\/\/doi.org\/10.1093\/plphys\/kiab054","relation":{},"ISSN":["0032-0889","1532-2548"],"issn-type":[{"value":"0032-0889","type":"print"},{"value":"1532-2548","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2021,5,1]]},"published":{"date-parts":[[2021,2,9]]}}}