{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T02:08:23Z","timestamp":1772071703356,"version":"3.50.1"},"reference-count":55,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Plant Fellows fellowship program"},{"DOI":"10.13039\/501100004063","name":"Knut and Alice Wallenberg Foundation","doi-asserted-by":"publisher","award":["2012.0050"],"award-info":[{"award-number":["2012.0050"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004200","name":"Stiftelsen Olle Engkvist Byggm\u00e4stare","doi-asserted-by":"publisher","award":["185 595"],"award-info":[{"award-number":["185 595"]}],"id":[{"id":"10.13039\/501100004200","id-type":"DOI","asserted-by":"publisher"}]},{"name":"VINNOVA\/Vetenskapsr\u00e5det","award":["VR 2013-4632"],"award-info":[{"award-number":["VR 2013-4632"]}]},{"name":"Belgian Science Policy organization for a postdoctoral fellowship (A.Rit.), and the Research Foundation Flanders for a postdoctoral fellowship (L.P.) and for research","award":["1507013N"],"award-info":[{"award-number":["1507013N"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2021,9,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The plant hormone auxin, a master coordinator of development, regulates hypocotyl elongation during seedling growth. We previously identified the synthetic molecule RubNeddin 1 (RN1), which induces degradation of the AUXIN\/INDOLE-3-ACETIC ACID (AUX\/IAA) transcriptional repressors INDOLE-3-ACETIC ACID-INDUCIBLE3 (IAA3) and IAA7 in planta and strongly promotes hypocotyl elongation. In the present study, we show that despite the structural similarity of RN1 to the synthetic auxin 2,4-dichlorophenoxyacetic-acid (2,4-D), direct treatments with these compounds in Arabidopsis (Arabidopsis thaliana) result in distinct effects, possibly due to enhanced uptake of RN1 and low-level, chronic release of 2,4-D from RN1 in planta. We confirm RN1-induced hypocotyl elongation occurs via specific TRANSPORT INHIBITOR RESISTANT1 (TIR1)\/AUXIN SIGNALING F-BOX (AFB) receptor-mediated auxin signaling involving TIR1, AFB2, and AFB5. Using a transcriptome profiling strategy and candidate gene approach, we identify the genes ZINC FINGER OF ARABIDOPSIS THALIANA10 (ZAT10), ARABIDOPSIS TOXICOS EN LEVADURA31 (ATL31), and WRKY DNA-BINDING PROTEIN33 (WRKY33) as being rapidly upregulated by RN1, despite being downregulated by 2,4-D treatment. RN1-induced expression of these genes also occurs via TIR1\/AFB-mediated auxin signaling. Our results suggest both hypocotyl elongation and transcription of these genes are induced by RN1 via the promoted degradation of the AUX\/IAA transcriptional repressor IAA7. Moreover, these three genes, which are known to be stress-related, act in an inter-dependent transcriptional regulatory network controlling hypocotyl elongation. Together, our results suggest ZAT10, ATL31, and WRKY33 take part in a common gene network regulating hypocotyl elongation in Arabidopsis downstream of a selective auxin perception module likely involving TIR1, AFB2, and AFB5 and inducing the degradation of IAA7.<\/jats:p>","DOI":"10.1093\/plphys\/kiab269","type":"journal-article","created":{"date-parts":[[2021,6,10]],"date-time":"2021-06-10T19:13:19Z","timestamp":1623352399000},"page":"430-445","source":"Crossref","is-referenced-by-count":15,"title":["A network of stress-related genes regulates hypocotyl elongation downstream of selective auxin perception"],"prefix":"10.1093","volume":"187","author":[{"given":"Adeline","family":"Rigal","sequence":"first","affiliation":[{"name":"Ume\u00e5 Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 90183 Ume\u00e5, 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Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 90183 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8153-907X","authenticated-orcid":false,"given":"Thomas","family":"Vain","sequence":"additional","affiliation":[{"name":"Ume\u00e5 Plant Science Centre, Department of Forest Genetics and Plant Physiology, Swedish University of Agricultural Sciences, 90183 Ume\u00e5, Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 Antonio","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Departamento de Gen\u00e9tica Molecular y Microbiolog\u00eda, Facultad de Ciencias Biol\u00f3gicas, Santiago, 8331150, Chile"},{"name":"Departamento de Fruticultura y Enolog\u00eda, Facultad de Agronom\u00eda e Ingenier\u00eda Forestal, Pontificia Universidad Cat\u00f3lica de Chile, Avenida Libertador Bernardo O\u2019Higgins 340, Santiago, 8331150, Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1599-551X","authenticated-orcid":false,"given":"Alain","family":"Goossens","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium"},{"name":"VIB Center for Plant Systems Biology, 9052 Ghent, Belgium"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0221-9052","authenticated-orcid":false,"given":"Laurens","family":"Pauwels","sequence":"additional","affiliation":[{"name":"Department of Plant Biotechnology and Bioinformatics, Ghent University, 9052 Ghent, Belgium"},{"name":"VIB Center for Plant Systems Biology, 9052 Ghent, 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